AT323744B - PROCESS FOR THE PREPARATION OF NEW BENZYLPYRIMIDINE AND THEIR ACID ADDITION SALTS - Google Patents

PROCESS FOR THE PREPARATION OF NEW BENZYLPYRIMIDINE AND THEIR ACID ADDITION SALTS

Info

Publication number
AT323744B
AT323744B AT102273A AT102273A AT323744B AT 323744 B AT323744 B AT 323744B AT 102273 A AT102273 A AT 102273A AT 102273 A AT102273 A AT 102273A AT 323744 B AT323744 B AT 323744B
Authority
AT
Austria
Prior art keywords
benzylpyrimidine
preparation
new
acid addition
addition salts
Prior art date
Application number
AT102273A
Other languages
German (de)
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of AT323744B publication Critical patent/AT323744B/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48Two nitrogen atoms
    • C07D239/49Two nitrogen atoms with an aralkyl radical, or substituted aralkyl radical, attached in position 5, e.g. trimethoprim
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/63Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/65Tetracyclines

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
AT102273A 1972-02-07 1973-02-06 PROCESS FOR THE PREPARATION OF NEW BENZYLPYRIMIDINE AND THEIR ACID ADDITION SALTS AT323744B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US22429272A 1972-02-07 1972-02-07

Publications (1)

Publication Number Publication Date
AT323744B true AT323744B (en) 1975-07-25

Family

ID=22840026

Family Applications (1)

Application Number Title Priority Date Filing Date
AT102273A AT323744B (en) 1972-02-07 1973-02-06 PROCESS FOR THE PREPARATION OF NEW BENZYLPYRIMIDINE AND THEIR ACID ADDITION SALTS

Country Status (15)

Country Link
JP (1) JPS4886880A (en)
KR (1) KR780000029B1 (en)
AR (1) AR195821A1 (en)
AT (1) AT323744B (en)
AU (1) AU5191873A (en)
BE (1) BE795023A (en)
DD (1) DD103644A5 (en)
DE (1) DE2303838C2 (en)
FR (1) FR2181709B1 (en)
GB (2) GB1388214A (en)
IE (1) IE37259B1 (en)
IL (1) IL41463A0 (en)
LU (1) LU66964A1 (en)
NL (1) NL7301650A (en)
ZA (1) ZA73137B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA738760B (en) * 1972-12-21 1974-08-28 Hoffmann La Roche Process for the manufacture of benzyl pyrimidines
GB1582245A (en) * 1976-06-09 1981-01-07 Wellcome Found Benzyl cyanoacetal derivatives and their conversion to pyrimidine derivatives
LU77268A1 (en) * 1977-05-05 1979-01-18
CA1084498A (en) * 1977-05-05 1980-08-26 Alexander E. Wick Benzylpyrimidines and process for the preparation thereof
DE2910510A1 (en) * 1979-03-16 1980-09-25 Heumann Ludwig & Co Gmbh 2,4-Di:amino-5-benzyl pyrimidine derivs. - are antibacterial cpds., prepd. by acylation of a 2,4-di:amino-5-(4'-hydroxy-benzyl) -pyrimidine cpd.

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1453056A (en) * 1964-11-12 1966-04-15 Hoffmann La Roche Process for the preparation of pyrimidine derivatives
US3485840A (en) * 1964-11-12 1969-12-23 Hoffmann La Roche 2,4-diamino - 5 - (2',4',5'-substituted benzyl) pyrimidines,intermediates and processes
DE1620729A1 (en) * 1965-07-08 1970-08-20 Wellcome Found Process for the preparation of substituted benzylpyrimidines
US3715433A (en) * 1969-06-02 1973-02-06 Hoffmann La Roche Growth promotion in swine

Also Published As

Publication number Publication date
JPS4886880A (en) 1973-11-15
IL41463A0 (en) 1973-04-30
BE795023A (en) 1973-08-06
LU66964A1 (en) 1974-09-25
IE37259L (en) 1973-08-07
AU5191873A (en) 1974-08-08
KR780000029B1 (en) 1978-03-10
DE2303838A1 (en) 1973-08-16
AR195821A1 (en) 1973-11-09
FR2181709A1 (en) 1973-12-07
FR2181709B1 (en) 1975-10-10
ZA73137B (en) 1973-09-26
NL7301650A (en) 1973-08-09
GB1388214A (en) 1975-03-26
DE2303838C2 (en) 1982-09-23
IE37259B1 (en) 1977-06-08
GB1388213A (en) 1975-03-26
DD103644A5 (en) 1974-02-05

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Legal Events

Date Code Title Description
ELJ Ceased due to non-payment of the annual fee