IE36892B1 - New phenothiazine derivatives - Google Patents
New phenothiazine derivativesInfo
- Publication number
- IE36892B1 IE36892B1 IE1154/72A IE115472A IE36892B1 IE 36892 B1 IE36892 B1 IE 36892B1 IE 1154/72 A IE1154/72 A IE 1154/72A IE 115472 A IE115472 A IE 115472A IE 36892 B1 IE36892 B1 IE 36892B1
- Authority
- IE
- Ireland
- Prior art keywords
- acetyl
- chloro
- formula
- compound
- phenothiazine
- Prior art date
Links
- 125000001484 phenothiazinyl group Chemical class C1(=CC=CC=2SC3=CC=CC=C3NC12)* 0.000 title 1
- 229940066767 systemic antihistamines phenothiazine derivative Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 5
- ROSDSFDQCJNGOL-UHFFFAOYSA-N Dimethylamine Chemical compound CNC ROSDSFDQCJNGOL-UHFFFAOYSA-N 0.000 abstract 2
- 150000002148 esters Chemical group 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- YHHHRNFBFZLDOY-UHFFFAOYSA-N 1-(8-chloro-10H-phenothiazin-2-yl)propan-1-one Chemical compound ClC1=CC=C2SC=3C=CC(=CC3NC2=C1)C(CC)=O YHHHRNFBFZLDOY-UHFFFAOYSA-N 0.000 abstract 1
- JOYCPFCSBMCDCJ-UHFFFAOYSA-N 1-(8-chloro-10h-phenothiazin-2-yl)ethanone Chemical compound C1=C(Cl)C=C2NC3=CC(C(=O)C)=CC=C3SC2=C1 JOYCPFCSBMCDCJ-UHFFFAOYSA-N 0.000 abstract 1
- PCELRNVUEVIXOB-UHFFFAOYSA-N 1-[8-chloro-10-(3-chloro-2-methylpropyl)phenothiazin-2-yl]ethanone Chemical compound C(C)(=O)C1=CC=2N(C3=CC(=CC=C3SC2C=C1)Cl)CC(CCl)C PCELRNVUEVIXOB-UHFFFAOYSA-N 0.000 abstract 1
- DJOJOEZOIDZFOI-UHFFFAOYSA-N 2-acetyl-8-chlorophenothiazine-10-carbonyl chloride Chemical compound C(C)(=O)C1=CC=2N(C3=CC(=CC=C3SC2C=C1)Cl)C(=O)Cl DJOJOEZOIDZFOI-UHFFFAOYSA-N 0.000 abstract 1
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 1
- 208000008238 Muscle Spasticity Diseases 0.000 abstract 1
- VTOVWLPGIJDGJI-UHFFFAOYSA-N [3-(dimethylamino)-2-methylpropyl] 2-acetyl-8-chlorophenothiazine-10-carboxylate Chemical compound C(C)(=O)C1=CC=2N(C3=CC(=CC=C3SC2C=C1)Cl)C(=O)OCC(CN(C)C)C VTOVWLPGIJDGJI-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000005910 alkyl carbonate group Chemical group 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 230000000911 decarboxylating effect Effects 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 150000002990 phenothiazines Chemical class 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
- 208000018198 spasticity Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
- C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
- C07D279/18—[b, e]-condensed with two six-membered rings
- C07D279/22—[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom
- C07D279/24—[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom with hydrocarbon radicals, substituted by amino radicals, attached to the ring nitrogen atom
- C07D279/28—[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom with hydrocarbon radicals, substituted by amino radicals, attached to the ring nitrogen atom with other substituents attached to the ring system
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3985471A GB1338124A (en) | 1971-08-25 | 1971-08-25 | Phenothiazine derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE36892L IE36892L (en) | 1973-02-25 |
| IE36892B1 true IE36892B1 (en) | 1977-03-16 |
Family
ID=10411854
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE1154/72A IE36892B1 (en) | 1971-08-25 | 1972-08-23 | New phenothiazine derivatives |
Country Status (15)
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1460713A (en) * | 1973-06-08 | 1977-01-06 | Kefalas As | 7-fluoro substituted phenothiazines method for preparation thereof and compositions bladed rotor for a gas turbine engine |
| JPS52123914A (en) * | 1976-04-12 | 1977-10-18 | Furukawa Electric Co Ltd:The | Production of high tensile al alloy conductor |
| DE3139238A1 (de) * | 1981-10-02 | 1983-04-21 | Basf Ag, 6700 Ludwigshafen | Optisch aktive bausteine fuer die synthese der seitenkette von (r,r,r)-(alpha)-tocopherol sowie verfahren zu deren herstellung |
-
0
- BE BE787967D patent/BE787967A/xx unknown
-
1971
- 1971-08-25 GB GB3985471A patent/GB1338124A/en not_active Expired
-
1972
- 1972-08-17 NL NL7211278A patent/NL7211278A/xx not_active Application Discontinuation
- 1972-08-23 FR FR7230093A patent/FR2150836B1/fr not_active Expired
- 1972-08-23 IL IL40194A patent/IL40194A/xx unknown
- 1972-08-23 ZA ZA725807A patent/ZA725807B/xx unknown
- 1972-08-23 AU AU45909/72A patent/AU459078B2/en not_active Expired
- 1972-08-23 JP JP47084427A patent/JPS4832884A/ja active Pending
- 1972-08-23 OA OA54675A patent/OA04162A/xx unknown
- 1972-08-23 IE IE1154/72A patent/IE36892B1/xx unknown
- 1972-08-24 CH CH1393573A patent/CH546785A/fr not_active IP Right Cessation
- 1972-08-24 CH CH1257372A patent/CH546784A/fr not_active IP Right Cessation
- 1972-08-24 CA CA150,311A patent/CA989401A/fr not_active Expired
- 1972-08-25 AR AR243753A patent/AR194385A1/es active
- 1972-08-25 AT AT910673A patent/AT317908B/de not_active IP Right Cessation
- 1972-08-25 AT AT737172A patent/AT318644B/de not_active IP Right Cessation
- 1972-08-25 AT AT910573A patent/AT317907B/de not_active IP Right Cessation
- 1972-08-25 DE DE2241730A patent/DE2241730A1/de active Pending
-
1973
- 1973-05-22 AR AR248164A patent/AR197229A1/es active
- 1973-05-22 AR AR241863A patent/AR197228A1/es active
Also Published As
| Publication number | Publication date |
|---|---|
| CH546785A (fr) | 1974-03-15 |
| NL7211278A (enrdf_load_stackoverflow) | 1973-02-27 |
| AU459078B2 (en) | 1975-03-13 |
| IE36892L (en) | 1973-02-25 |
| CH546784A (fr) | 1974-03-15 |
| IL40194A (en) | 1975-06-25 |
| OA04162A (fr) | 1979-12-15 |
| AR194385A1 (es) | 1973-07-13 |
| AU4590972A (en) | 1974-02-28 |
| AR197228A1 (es) | 1974-03-22 |
| FR2150836A1 (enrdf_load_stackoverflow) | 1973-04-13 |
| FR2150836B1 (enrdf_load_stackoverflow) | 1976-04-16 |
| DE2241730A1 (de) | 1973-03-08 |
| AR197229A1 (es) | 1974-03-22 |
| AT317907B (de) | 1974-09-25 |
| CA989401A (fr) | 1976-05-18 |
| IL40194A0 (en) | 1972-10-29 |
| GB1338124A (en) | 1973-11-21 |
| JPS4832884A (enrdf_load_stackoverflow) | 1973-05-02 |
| AT318644B (de) | 1974-11-11 |
| AT317908B (de) | 1974-09-25 |
| BE787967A (fr) | 1973-02-26 |
| ZA725807B (en) | 1973-05-30 |
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