GB1327707A - Benzene derivatives - Google Patents

Benzene derivatives

Info

Publication number
GB1327707A
GB1327707A GB2572671A GB2572671A GB1327707A GB 1327707 A GB1327707 A GB 1327707A GB 2572671 A GB2572671 A GB 2572671A GB 2572671 A GB2572671 A GB 2572671A GB 1327707 A GB1327707 A GB 1327707A
Authority
GB
United Kingdom
Prior art keywords
formula
compound
reacting
compounds
prepared
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2572671A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
May and Baker Ltd
Original Assignee
May and Baker Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by May and Baker Ltd filed Critical May and Baker Ltd
Publication of GB1327707A publication Critical patent/GB1327707A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Abstract

1327707 Imines MAY & BAKER Ltd 19 April 1971 [8 April 1970] 25726/71 Addition to 1231783 Heading C2C Novel compounds of Formula I (in which R 8 is H and R 9 is isopropyl, or R 8 and R 9 are both ethyl, or -NR 8 R 9 is morpholino, R 10 is H and R 11 is benzyloxy or, when R 8 and R 9 are both ethyl, R 10 is methyl and R 11 is hydroxy or, when -NR 8 R 9 is morpholino. R 10 is methyl and R 11 is benzyloxy) and acid addition salts thereof, are prepared by (a) reacting a compound of Formula II with an amine of formula HNR 8 R 9 , or (b) reacting a compound of Formula III with a compound of formula H 2 NR 11 , or (c) reacting a compound of Formula IV (in which X is the acid residue of a reactive ester) with an amine of formula HNR 8 R 9 . Compounds of Formula II are prepared by reacting a compound of Formula V with epichlorhydrin, or reacting a compound of Formula VI with a compound of formula H 2 NR 11 . Compounds of Formula V are prepared by reacting 2-(formyl or acetyl)-phenol with a compound of formula H 2 NR 11 . Compounds of Formula III are prepared by reacting a compound of Formula VI with an amine HNR 8 R 9 . Pharmaceutical compositions for oral or parenteral administration comprise a compound I, or a non-toxic acid addition salt thereof, together with a pharmaceutical carrier or coating. The active compounds I have antiarrhythmic and #-adrenoceptor blocking activity.
GB2572671A 1970-04-08 1971-04-19 Benzene derivatives Expired GB1327707A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK224470 1970-04-08

Publications (1)

Publication Number Publication Date
GB1327707A true GB1327707A (en) 1973-08-22

Family

ID=8111038

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2572671A Expired GB1327707A (en) 1970-04-08 1971-04-19 Benzene derivatives

Country Status (1)

Country Link
GB (1) GB1327707A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT401726B (en) * 1993-05-17 1996-11-25 Gerhard Dr Ecker O-acylaryloxypropanolamines with tertiary or quaternary nitrogen as reversion modulators for p-glycoprotein- mediated multidrug resistance

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT401726B (en) * 1993-05-17 1996-11-25 Gerhard Dr Ecker O-acylaryloxypropanolamines with tertiary or quaternary nitrogen as reversion modulators for p-glycoprotein- mediated multidrug resistance

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee