GB1338124A - Phenothiazine derivatives - Google Patents
Phenothiazine derivativesInfo
- Publication number
- GB1338124A GB1338124A GB3985471A GB3985471A GB1338124A GB 1338124 A GB1338124 A GB 1338124A GB 3985471 A GB3985471 A GB 3985471A GB 3985471 A GB3985471 A GB 3985471A GB 1338124 A GB1338124 A GB 1338124A
- Authority
- GB
- United Kingdom
- Prior art keywords
- acetyl
- chloro
- formula
- compound
- phenothiazine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 125000001484 phenothiazinyl group Chemical class C1(=CC=CC=2SC3=CC=CC=C3NC12)* 0.000 title 1
- 229940066767 systemic antihistamines phenothiazine derivative Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 5
- ROSDSFDQCJNGOL-UHFFFAOYSA-N Dimethylamine Chemical compound CNC ROSDSFDQCJNGOL-UHFFFAOYSA-N 0.000 abstract 2
- 150000002148 esters Chemical group 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- YHHHRNFBFZLDOY-UHFFFAOYSA-N 1-(8-chloro-10H-phenothiazin-2-yl)propan-1-one Chemical compound ClC1=CC=C2SC=3C=CC(=CC3NC2=C1)C(CC)=O YHHHRNFBFZLDOY-UHFFFAOYSA-N 0.000 abstract 1
- JOYCPFCSBMCDCJ-UHFFFAOYSA-N 1-(8-chloro-10h-phenothiazin-2-yl)ethanone Chemical compound C1=C(Cl)C=C2NC3=CC(C(=O)C)=CC=C3SC2=C1 JOYCPFCSBMCDCJ-UHFFFAOYSA-N 0.000 abstract 1
- PCELRNVUEVIXOB-UHFFFAOYSA-N 1-[8-chloro-10-(3-chloro-2-methylpropyl)phenothiazin-2-yl]ethanone Chemical compound C(C)(=O)C1=CC=2N(C3=CC(=CC=C3SC2C=C1)Cl)CC(CCl)C PCELRNVUEVIXOB-UHFFFAOYSA-N 0.000 abstract 1
- DJOJOEZOIDZFOI-UHFFFAOYSA-N 2-acetyl-8-chlorophenothiazine-10-carbonyl chloride Chemical compound C(C)(=O)C1=CC=2N(C3=CC(=CC=C3SC2C=C1)Cl)C(=O)Cl DJOJOEZOIDZFOI-UHFFFAOYSA-N 0.000 abstract 1
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 1
- 208000008238 Muscle Spasticity Diseases 0.000 abstract 1
- VTOVWLPGIJDGJI-UHFFFAOYSA-N [3-(dimethylamino)-2-methylpropyl] 2-acetyl-8-chlorophenothiazine-10-carboxylate Chemical compound C(C)(=O)C1=CC=2N(C3=CC(=CC=C3SC2C=C1)Cl)C(=O)OCC(CN(C)C)C VTOVWLPGIJDGJI-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000005910 alkyl carbonate group Chemical group 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 230000000911 decarboxylating effect Effects 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 150000002990 phenothiazines Chemical class 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
- 208000018198 spasticity Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
- C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
- C07D279/18—[b, e]-condensed with two six-membered rings
- C07D279/22—[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom
- C07D279/24—[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom with hydrocarbon radicals, substituted by amino radicals, attached to the ring nitrogen atom
- C07D279/28—[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom with hydrocarbon radicals, substituted by amino radicals, attached to the ring nitrogen atom with other substituents attached to the ring system
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Priority Applications (20)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BE787967D BE787967A (fr) | 1971-08-25 | Derives de la phenothiazine antispastiques | |
| GB3985471A GB1338124A (en) | 1971-08-25 | 1971-08-25 | Phenothiazine derivatives |
| NL7211278A NL7211278A (enrdf_load_stackoverflow) | 1971-08-25 | 1972-08-17 | |
| ZA725807A ZA725807B (en) | 1971-08-25 | 1972-08-23 | New phenothiazine derivatives |
| OA54675A OA04162A (fr) | 1971-08-25 | 1972-08-23 | Procédé de préparation de dérivés de la phénothiazine antispastiques. |
| FR7230093A FR2150836B1 (enrdf_load_stackoverflow) | 1971-08-25 | 1972-08-23 | |
| IE1154/72A IE36892B1 (en) | 1971-08-25 | 1972-08-23 | New phenothiazine derivatives |
| JP47084427A JPS4832884A (enrdf_load_stackoverflow) | 1971-08-25 | 1972-08-23 | |
| AU45909/72A AU459078B2 (en) | 1971-08-25 | 1972-08-23 | New phenothiazine derivatives |
| IL40194A IL40194A (en) | 1971-08-25 | 1972-08-23 | 2-acetyl(or propionyl)-8-chloro-10-(2-methyl-3-dimethylaminopropyl)-phenothiazines,processes for their preparation and pharmaceutical compositions containing the same |
| CH1257372A CH546784A (fr) | 1971-08-25 | 1972-08-24 | Procede de preparation de derives de la phenothiazine antispastiques. |
| CA150,311A CA989401A (fr) | 1971-08-25 | 1972-08-24 | Derives de la phenothiazine antispastiques |
| CH1393573A CH546785A (fr) | 1971-08-25 | 1972-08-24 | Procede de preparation de derives de la phenothiazine antispastiques. |
| AT737172A AT318644B (de) | 1971-08-25 | 1972-08-25 | Verfahren zur Herstellung von neuen Phenothiazinderivaten und ihren Salzen |
| DE2241730A DE2241730A1 (de) | 1971-08-25 | 1972-08-25 | Neue phenothiazinderivate |
| AT910673A AT317908B (de) | 1971-08-25 | 1972-08-25 | Verfahren zur Herstellung von neuen Phenothiazinderivaten und ihren Salzen |
| AR243753A AR194385A1 (es) | 1971-08-25 | 1972-08-25 | Procedimiento para la preparacion de derivados de la fenotiazina bajo forma racemica u opticamente activa |
| AT910573A AT317907B (de) | 1971-08-25 | 1972-08-25 | Verfahren zur Herstellung von neuen Phenothiazinderivaten und ihren Salzen |
| AR241863A AR197228A1 (es) | 1971-08-25 | 1973-05-22 | Procedimiento de preparacion de acil-2-cloro-8-(dimetilamino-3-metil-2-propil)-10-fenotiazina y sus sales |
| AR248164A AR197229A1 (es) | 1971-08-25 | 1973-05-22 | Procedimiento de preparacion de acil-2-cloro-8-(dimetilamino-3-metil-2-propil)-10-fenotiazina y sus sales |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3985471A GB1338124A (en) | 1971-08-25 | 1971-08-25 | Phenothiazine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1338124A true GB1338124A (en) | 1973-11-21 |
Family
ID=10411854
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3985471A Expired GB1338124A (en) | 1971-08-25 | 1971-08-25 | Phenothiazine derivatives |
Country Status (15)
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1460713A (en) * | 1973-06-08 | 1977-01-06 | Kefalas As | 7-fluoro substituted phenothiazines method for preparation thereof and compositions bladed rotor for a gas turbine engine |
| JPS52123914A (en) * | 1976-04-12 | 1977-10-18 | Furukawa Electric Co Ltd:The | Production of high tensile al alloy conductor |
| DE3139238A1 (de) * | 1981-10-02 | 1983-04-21 | Basf Ag, 6700 Ludwigshafen | Optisch aktive bausteine fuer die synthese der seitenkette von (r,r,r)-(alpha)-tocopherol sowie verfahren zu deren herstellung |
-
0
- BE BE787967D patent/BE787967A/xx unknown
-
1971
- 1971-08-25 GB GB3985471A patent/GB1338124A/en not_active Expired
-
1972
- 1972-08-17 NL NL7211278A patent/NL7211278A/xx not_active Application Discontinuation
- 1972-08-23 FR FR7230093A patent/FR2150836B1/fr not_active Expired
- 1972-08-23 IL IL40194A patent/IL40194A/xx unknown
- 1972-08-23 ZA ZA725807A patent/ZA725807B/xx unknown
- 1972-08-23 AU AU45909/72A patent/AU459078B2/en not_active Expired
- 1972-08-23 JP JP47084427A patent/JPS4832884A/ja active Pending
- 1972-08-23 OA OA54675A patent/OA04162A/xx unknown
- 1972-08-23 IE IE1154/72A patent/IE36892B1/xx unknown
- 1972-08-24 CH CH1393573A patent/CH546785A/fr not_active IP Right Cessation
- 1972-08-24 CH CH1257372A patent/CH546784A/fr not_active IP Right Cessation
- 1972-08-24 CA CA150,311A patent/CA989401A/fr not_active Expired
- 1972-08-25 AR AR243753A patent/AR194385A1/es active
- 1972-08-25 AT AT910673A patent/AT317908B/de not_active IP Right Cessation
- 1972-08-25 AT AT737172A patent/AT318644B/de not_active IP Right Cessation
- 1972-08-25 AT AT910573A patent/AT317907B/de not_active IP Right Cessation
- 1972-08-25 DE DE2241730A patent/DE2241730A1/de active Pending
-
1973
- 1973-05-22 AR AR248164A patent/AR197229A1/es active
- 1973-05-22 AR AR241863A patent/AR197228A1/es active
Also Published As
| Publication number | Publication date |
|---|---|
| CH546785A (fr) | 1974-03-15 |
| NL7211278A (enrdf_load_stackoverflow) | 1973-02-27 |
| AU459078B2 (en) | 1975-03-13 |
| IE36892L (en) | 1973-02-25 |
| CH546784A (fr) | 1974-03-15 |
| IL40194A (en) | 1975-06-25 |
| OA04162A (fr) | 1979-12-15 |
| AR194385A1 (es) | 1973-07-13 |
| AU4590972A (en) | 1974-02-28 |
| IE36892B1 (en) | 1977-03-16 |
| AR197228A1 (es) | 1974-03-22 |
| FR2150836A1 (enrdf_load_stackoverflow) | 1973-04-13 |
| FR2150836B1 (enrdf_load_stackoverflow) | 1976-04-16 |
| DE2241730A1 (de) | 1973-03-08 |
| AR197229A1 (es) | 1974-03-22 |
| AT317907B (de) | 1974-09-25 |
| CA989401A (fr) | 1976-05-18 |
| IL40194A0 (en) | 1972-10-29 |
| JPS4832884A (enrdf_load_stackoverflow) | 1973-05-02 |
| AT318644B (de) | 1974-11-11 |
| AT317908B (de) | 1974-09-25 |
| BE787967A (fr) | 1973-02-26 |
| ZA725807B (en) | 1973-05-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |