IE35146B1 - A new oestradiol derivative and a process for its manufacture - Google Patents

A new oestradiol derivative and a process for its manufacture

Info

Publication number
IE35146B1
IE35146B1 IE490/71A IE49071A IE35146B1 IE 35146 B1 IE35146 B1 IE 35146B1 IE 490/71 A IE490/71 A IE 490/71A IE 49071 A IE49071 A IE 49071A IE 35146 B1 IE35146 B1 IE 35146B1
Authority
IE
Ireland
Prior art keywords
methyl
manufacture
new
estradiol
ethynyl
Prior art date
Application number
IE490/71A
Other versions
IE35146L (en
Inventor
G Anner
J Kalvoda
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of IE35146L publication Critical patent/IE35146L/en
Publication of IE35146B1 publication Critical patent/IE35146B1/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/567Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23KFODDER
    • A23K20/00Accessory food factors for animal feeding-stuffs
    • A23K20/10Organic substances
    • A23K20/168Steroids
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23KFODDER
    • A23K20/00Accessory food factors for animal feeding-stuffs
    • A23K20/10Organic substances
    • A23K20/184Hormones
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J1/00Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J51/00Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J75/00Processes for the preparation of steroids in general

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Husbandry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)

Abstract

1330072 The 3-cyclopentyl ether of 7α-methyl- 17α - ethynyl - estradiol CIBA - GEIGY AG 21 April 1971 [24 April 1970] 10428/71 Heading C2U The title compound is prepared by etherification of 7α-methyl-17α-ethynyl-estradiol, by reacting the diol or a salt thereof with a reactive ester of cyclopentanol, or by ethynylation with an acetylene metal compound of 3-cyclopentyloxy - 7α - methyl - 17 - oxo - #<SP>1,3,5(10)</SP> - estratriene. The novel steroid is stated to have estrogenic, uterotropic and blastocyte implantation inhibiting action, and it may be made up into pharmaceutical and veterinary compositions with suitable carriers. Specification 1,330,071 is referred to. [GB1330072A]
IE490/71A 1970-04-24 1971-04-20 A new oestradiol derivative and a process for its manufacture IE35146B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH621870A CH536291A (en) 1970-04-24 1970-04-24 Process for the production of a new, highly estrogenic steroid

Publications (2)

Publication Number Publication Date
IE35146L IE35146L (en) 1971-10-24
IE35146B1 true IE35146B1 (en) 1975-11-26

Family

ID=4306140

Family Applications (1)

Application Number Title Priority Date Filing Date
IE490/71A IE35146B1 (en) 1970-04-24 1971-04-20 A new oestradiol derivative and a process for its manufacture

Country Status (19)

Country Link
AT (2) AT306261B (en)
BE (1) BE766183A (en)
CA (1) CA921022A (en)
CH (2) CH536291A (en)
CS (2) CS161776B2 (en)
DE (1) DE2118997A1 (en)
DK (2) DK129580B (en)
ES (2) ES390460A1 (en)
FI (1) FI48826C (en)
FR (1) FR2092081B1 (en)
GB (1) GB1330072A (en)
HU (1) HU162383B (en)
IE (1) IE35146B1 (en)
IL (1) IL36653A (en)
NL (1) NL7105577A (en)
PL (2) PL71122B1 (en)
SE (1) SE373576B (en)
SU (2) SU383287A3 (en)
ZA (1) ZA712524B (en)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1434174A (en) * 1963-12-24 1966-04-08 Ciba Geigy Process for the preparation of new steroids of the estrane series
BE755689A (en) * 1969-09-03 1971-03-03 Upjohn Co NEW 7 BETA-ALKYL-19- NORTESTOSTERONES MANUFACTURING PROCESS

Also Published As

Publication number Publication date
AT315394B (en) 1974-05-27
PL71122B1 (en) 1974-04-30
DE2118997A1 (en) 1971-11-11
FR2092081A1 (en) 1972-01-21
FI48826B (en) 1974-09-30
AT306261B (en) 1973-04-10
IE35146L (en) 1971-10-24
GB1330072A (en) 1973-09-12
SE373576B (en) 1975-02-10
CH536291A (en) 1973-04-30
CS161775B2 (en) 1975-06-10
DK128316B (en) 1974-04-08
IL36653A (en) 1974-07-31
BE766183A (en) 1971-10-25
ZA712524B (en) 1972-01-26
FR2092081B1 (en) 1974-10-18
IL36653A0 (en) 1971-06-23
DK129580C (en) 1975-04-28
ES416953A1 (en) 1976-03-16
CH536293A (en) 1973-04-30
CA921022A (en) 1973-02-13
ES390460A1 (en) 1974-07-01
PL83828B1 (en) 1976-02-28
HU162383B (en) 1973-02-28
SU399116A3 (en) 1973-09-27
SU383287A3 (en) 1973-05-25
NL7105577A (en) 1971-10-26
DK129580B (en) 1974-10-28
CS161776B2 (en) 1975-06-10
FI48826C (en) 1975-01-10

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