IE34871L - Dibenzocycloheptenylidene - piperidine derivatives - Google Patents

Dibenzocycloheptenylidene - piperidine derivatives

Info

Publication number
IE34871L
IE34871L IE710032A IE3271A IE34871L IE 34871 L IE34871 L IE 34871L IE 710032 A IE710032 A IE 710032A IE 3271 A IE3271 A IE 3271A IE 34871 L IE34871 L IE 34871L
Authority
IE
Ireland
Prior art keywords
alkyl
compound
formula
compounds
carbamoyl
Prior art date
Application number
IE710032A
Other versions
IE34871B1 (en
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of IE34871L publication Critical patent/IE34871L/en
Publication of IE34871B1 publication Critical patent/IE34871B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1336334 Dibenzocycloheptenylidene-piperidine derivatives MERCK & CO Inc 15 Jan 1971 [19 Jan 1970 5 Feb 1970] 2168/71 Heading C2C The invention comprises compounds of the Formula (I): in which Z is -CO- or -CH(OH)-, R 2 is C 1-6 alkyl or C 2-6 alkenyl, R is CH<SP>3</SP> or C 2 H 5 and replaces one or more of the H atoms in positions 2, 3, 5 or 6 of the piperidine ring, provided that only one of positions 3 and 5 is substituted in any one compound, n is 0, 1 or 2, each of X and X<SP>1</SP>, which are similar or dissimilar, is H or halogen, or a C 1-6 alkyl, C 1-4 perfluoroalkyl, phenyl, substituted phenyl, C 1-4 acyl, C 1-4 perfluoroaeyl, amino, C 1-4 alkylamino, di-(C 1-4 alkyl)amino, C 1-4 acylamino, C 1-4 perfluoroacylamino, C 1-4 alkylsulphonylamino, hydroxy- C 1-4 alkoxy, C 1-4 perfluoroalkoxy, cyano, carb, oxy, formyl, carbamoyl, C 2-5 alkylcarbamoyl, di-(C 1-4 alkyl)-carbamoyl, C 2-6 alkoxycarbonyl, mercapto, C 1-4 alkylthio, C 1-4 perfluoroalkylthio, aralkylthio, C 1-4 alkylsulphonyl, C 1-4 perfluoroalkylsulphonyl, C 1-4 alkylsulphinyl, sulphamoyl, C 1-4 alkylsulphamoyl, or di-(C 1-4 alkyl)sulphamoyl group, and more than one of these substituents may be on each benzenoid ring, but with the proviso that when Z is carbonyl, n is 0 and X and X<SP>1</SP> are hydrogen, R 2 contains at least two carbon atoms. Compounds of Formula (I) in which R 2 is replaced by R 1 which has the same value as R 2 but with no provisos, may be prepared by hydrolysing an enamine compound of the formula to form a compound of Formula (I) in which Z is -CO- and optionally reducing this 10-oxo compound to the corresponding 10-hydroxy compound where Z is -CH(OH)-. The enamine compound may be obtained as described in U.K. Specification 1,336,336. Pharmaceutical compositions useful for the treatment of allergic conditions comprise compounds of Formula (I) together with a non- toxic diluent, carrier or coating, in forms suitable for administration orally or parenterally. [GB1336334A]
IE32/71A 1970-01-19 1971-01-12 Dibenzocycloheptenylidene-piperidine derivatives IE34871B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US412370A 1970-01-19 1970-01-19
US904970A 1970-02-05 1970-02-05

Publications (2)

Publication Number Publication Date
IE34871L true IE34871L (en) 1971-07-19
IE34871B1 IE34871B1 (en) 1975-09-03

Family

ID=26672646

Family Applications (1)

Application Number Title Priority Date Filing Date
IE32/71A IE34871B1 (en) 1970-01-19 1971-01-12 Dibenzocycloheptenylidene-piperidine derivatives

Country Status (7)

Country Link
BE (1) BE761758A (en)
DE (1) DE2102196A1 (en)
FR (1) FR2081443B1 (en)
GB (2) GB1336334A (en)
IE (1) IE34871B1 (en)
IL (1) IL35977A (en)
NL (1) NL7100184A (en)

Also Published As

Publication number Publication date
GB1336335A (en) 1973-11-07
BE761758A (en) 1971-07-19
DE2102196A1 (en) 1971-07-29
IL35977A (en) 1974-07-31
GB1336334A (en) 1973-11-07
IL35977A0 (en) 1971-03-24
FR2081443B1 (en) 1975-04-18
IE34871B1 (en) 1975-09-03
FR2081443A1 (en) 1971-12-03
NL7100184A (en) 1971-07-21

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