IE41615L - Preparation of dihydro-benzo-cyclohepta-thiophen derivatives - Google Patents
Preparation of dihydro-benzo-cyclohepta-thiophen derivativesInfo
- Publication number
- IE41615L IE41615L IE742090A IE209074A IE41615L IE 41615 L IE41615 L IE 41615L IE 742090 A IE742090 A IE 742090A IE 209074 A IE209074 A IE 209074A IE 41615 L IE41615 L IE 41615L
- Authority
- IE
- Ireland
- Prior art keywords
- compound
- formula
- carbon atoms
- cyclohepta
- benzo
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/78—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
- C07D333/80—Seven-membered rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
1489783 Substituted keto-acids and esters and pharmaceutical uses thereof SANDOZ Ltd 10 Oct 1974 [10 Oct 1973] 43893/74 Heading C2C The invention comprises compounds of formula where R 1 is H, F, Cl or an alkyl group of 1 to 4 carbon atoms; R 2 is H or an alkyl group of 1 to 4 carbon atoms; R 3 and R 4 are each hydrogen or together represent oxygen; n represents 2, 3 or 4, and A is ethylene or vinylene, provided that when each of R 1 and R 2 signifies hydrogen, R 3 and R 4 together are oxygen and n is 2 and A is other than ethylene. These compounds may be obtained by reacting a compound of formula wherein R 1 , R 3 , R 4 and A are as defined above with a compound of formula wherein n is as defined above, X is chlorine or bromine, and Y is alkyl of 1 to 5 carbon atoms, or X and Y together form a bond, or (b) hydrolysing a compound of formula 0 wherein R 1 , R 3 , R 4 , A and n are as defined above, and R<SP>1</SP> 2 is an alkyl group of 1 to 4 carbon atoms, to produce a compound of formula wherein R 1 , R 3 , R 4 , A and n are as defined above. The intermediate 9,10 - dihydro - 4H - benzo [4,5]cyclohepta[1,2 - b]thiophene is obtained by the reduction of 9,10-dihydro-4H-benzo[4,5] cyclohepta[1,2 - b]thiophen - 4 - one which compound is prepared by the method described in U.K. patent No. 1,055,057. The invention also comprises a pharmaceutical composition which contains as an active ingredient a compound according to the invention in association with a pharmaceutical carrier of diluent.
[GB1489783A]
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH1439673A CH581130A5 (en) | 1973-10-10 | 1973-10-10 |
Publications (2)
Publication Number | Publication Date |
---|---|
IE41615L true IE41615L (en) | 1975-04-10 |
IE41615B1 IE41615B1 (en) | 1980-02-13 |
Family
ID=4400474
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IE2090/74A IE41615B1 (en) | 1973-10-10 | 1974-10-08 | Substituted keto-acids and esters and pharmaceutical uses therof |
Country Status (21)
Country | Link |
---|---|
JP (1) | JPS5082052A (en) |
AT (1) | AT352107B (en) |
AU (1) | AU498690B2 (en) |
BE (1) | BE820943A (en) |
CA (1) | CA1038876A (en) |
DD (1) | DD113910A5 (en) |
DE (1) | DE2441592A1 (en) |
DK (1) | DK135809B (en) |
ES (2) | ES430790A1 (en) |
FI (1) | FI286574A (en) |
FR (1) | FR2247226B1 (en) |
GB (2) | GB1489784A (en) |
HU (1) | HU170505B (en) |
IE (1) | IE41615B1 (en) |
IL (1) | IL45814A (en) |
NL (1) | NL7413107A (en) |
NO (1) | NO743556L (en) |
PH (1) | PH10997A (en) |
SE (1) | SE392272B (en) |
SU (1) | SU548210A3 (en) |
ZA (1) | ZA746444B (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE7801074L (en) * | 1977-02-08 | 1978-08-09 | Sandoz Ag | ORGANIC ASSOCIATIONS, THEIR PREPARATION AND USE |
EP2460803B1 (en) * | 2009-07-28 | 2016-01-13 | Nippon Zoki Pharmaceutical Co., Ltd. | Method for producing thiabenzoazulene propionic acid derivative |
-
1974
- 1974-08-30 DE DE2441592A patent/DE2441592A1/en not_active Withdrawn
- 1974-09-30 SE SE7412312A patent/SE392272B/en unknown
- 1974-10-01 NO NO743556A patent/NO743556L/no unknown
- 1974-10-01 DK DK516174AA patent/DK135809B/en unknown
- 1974-10-01 FI FI2865/74A patent/FI286574A/fi unknown
- 1974-10-03 PH PH16387A patent/PH10997A/en unknown
- 1974-10-04 NL NL7413107A patent/NL7413107A/en not_active Application Discontinuation
- 1974-10-08 DD DD181560A patent/DD113910A5/xx unknown
- 1974-10-08 IE IE2090/74A patent/IE41615B1/en unknown
- 1974-10-08 ES ES430790A patent/ES430790A1/en not_active Expired
- 1974-10-08 HU HUSA2699A patent/HU170505B/hu unknown
- 1974-10-09 AT AT810174A patent/AT352107B/en not_active IP Right Cessation
- 1974-10-09 AU AU74141/74A patent/AU498690B2/en not_active Expired
- 1974-10-09 SU SU2065450A patent/SU548210A3/en active
- 1974-10-09 ZA ZA00746444A patent/ZA746444B/en unknown
- 1974-10-09 CA CA211,060A patent/CA1038876A/en not_active Expired
- 1974-10-09 IL IL45814A patent/IL45814A/en unknown
- 1974-10-09 JP JP49115668A patent/JPS5082052A/ja active Pending
- 1974-10-10 GB GB22272/77A patent/GB1489784A/en not_active Expired
- 1974-10-10 BE BE149425A patent/BE820943A/en unknown
- 1974-10-10 FR FR7434103A patent/FR2247226B1/fr not_active Expired
- 1974-10-10 GB GB43893/74A patent/GB1489783A/en not_active Expired
-
1976
- 1976-07-01 ES ES449429A patent/ES449429A1/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
IL45814A0 (en) | 1974-12-31 |
NO743556L (en) | 1975-05-05 |
SU548210A3 (en) | 1977-02-25 |
ES430790A1 (en) | 1977-04-16 |
PH10997A (en) | 1977-10-20 |
DE2441592A1 (en) | 1975-04-17 |
NL7413107A (en) | 1975-04-14 |
JPS5082052A (en) | 1975-07-03 |
HU170505B (en) | 1977-06-28 |
GB1489784A (en) | 1977-10-26 |
IE41615B1 (en) | 1980-02-13 |
AU498690B2 (en) | 1979-03-22 |
FI286574A (en) | 1975-04-11 |
GB1489783A (en) | 1977-10-26 |
DK135809C (en) | 1977-11-28 |
FR2247226A1 (en) | 1975-05-09 |
AU7414174A (en) | 1976-04-15 |
ES449429A1 (en) | 1977-12-01 |
IL45814A (en) | 1978-06-15 |
AT352107B (en) | 1979-09-10 |
BE820943A (en) | 1975-04-10 |
DK516174A (en) | 1975-06-09 |
DD113910A5 (en) | 1975-07-05 |
ZA746444B (en) | 1976-05-26 |
CA1038876A (en) | 1978-09-19 |
FR2247226B1 (en) | 1978-07-28 |
SE392272B (en) | 1977-03-21 |
ATA810174A (en) | 1979-02-15 |
DK135809B (en) | 1977-06-27 |
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