GB1336334A - Dibenzocycloheptenylidene-piperidine derivatives - Google Patents

Dibenzocycloheptenylidene-piperidine derivatives

Info

Publication number
GB1336334A
GB1336334A GB126871A GB1336334DA GB1336334A GB 1336334 A GB1336334 A GB 1336334A GB 126871 A GB126871 A GB 126871A GB 1336334D A GB1336334D A GB 1336334DA GB 1336334 A GB1336334 A GB 1336334A
Authority
GB
United Kingdom
Prior art keywords
alkyl
compound
formula
compounds
carbamoyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB126871A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of GB1336334A publication Critical patent/GB1336334A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1336334 Dibenzocycloheptenylidene-piperidine derivatives MERCK & CO Inc 15 Jan 1971 [19 Jan 1970 5 Feb 1970] 2168/71 Heading C2C The invention comprises compounds of the Formula (I): in which Z is -CO- or -CH(OH)-, R 2 is C 1-6 alkyl or C 2-6 alkenyl, R is CH<SP>3</SP> or C 2 H 5 and replaces one or more of the H atoms in positions 2, 3, 5 or 6 of the piperidine ring, provided that only one of positions 3 and 5 is substituted in any one compound, n is 0, 1 or 2, each of X and X<SP>1</SP>, which are similar or dissimilar, is H or halogen, or a C 1-6 alkyl, C 1-4 perfluoroalkyl, phenyl, substituted phenyl, C 1-4 acyl, C 1-4 perfluoroaeyl, amino, C 1-4 alkylamino, di-(C 1-4 alkyl)amino, C 1-4 acylamino, C 1-4 perfluoroacylamino, C 1-4 alkylsulphonylamino, hydroxy- C 1-4 alkoxy, C 1-4 perfluoroalkoxy, cyano, carb, oxy, formyl, carbamoyl, C 2-5 alkylcarbamoyl, di-(C 1-4 alkyl)-carbamoyl, C 2-6 alkoxycarbonyl, mercapto, C 1-4 alkylthio, C 1-4 perfluoroalkylthio, aralkylthio, C 1-4 alkylsulphonyl, C 1-4 perfluoroalkylsulphonyl, C 1-4 alkylsulphinyl, sulphamoyl, C 1-4 alkylsulphamoyl, or di-(C 1-4 alkyl)sulphamoyl group, and more than one of these substituents may be on each benzenoid ring, but with the proviso that when Z is carbonyl, n is 0 and X and X<SP>1</SP> are hydrogen, R 2 contains at least two carbon atoms. Compounds of Formula (I) in which R 2 is replaced by R 1 which has the same value as R 2 but with no provisos, may be prepared by hydrolysing an enamine compound of the formula to form a compound of Formula (I) in which Z is -CO- and optionally reducing this 10-oxo compound to the corresponding 10-hydroxy compound where Z is -CH(OH)-. The enamine compound may be obtained as described in U.K. Specification 1,336,336. Pharmaceutical compositions useful for the treatment of allergic conditions comprise compounds of Formula (I) together with a non- toxic diluent, carrier or coating, in forms suitable for administration orally or parenterally.
GB126871A 1970-01-19 1971-01-15 Dibenzocycloheptenylidene-piperidine derivatives Expired GB1336334A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US412370A 1970-01-19 1970-01-19
US904970A 1970-02-05 1970-02-05

Publications (1)

Publication Number Publication Date
GB1336334A true GB1336334A (en) 1973-11-07

Family

ID=26672646

Family Applications (2)

Application Number Title Priority Date Filing Date
GB126871A Expired GB1336334A (en) 1970-01-19 1971-01-15 Dibenzocycloheptenylidene-piperidine derivatives
GB4484572A Expired GB1336335A (en) 1970-01-19 1971-01-15 Dibenzocycloheptenylidene-piperidine derivatives

Family Applications After (1)

Application Number Title Priority Date Filing Date
GB4484572A Expired GB1336335A (en) 1970-01-19 1971-01-15 Dibenzocycloheptenylidene-piperidine derivatives

Country Status (7)

Country Link
BE (1) BE761758A (en)
DE (1) DE2102196A1 (en)
FR (1) FR2081443B1 (en)
GB (2) GB1336334A (en)
IE (1) IE34871B1 (en)
IL (1) IL35977A (en)
NL (1) NL7100184A (en)

Also Published As

Publication number Publication date
GB1336335A (en) 1973-11-07
BE761758A (en) 1971-07-19
IE34871L (en) 1971-07-19
DE2102196A1 (en) 1971-07-29
IL35977A (en) 1974-07-31
IL35977A0 (en) 1971-03-24
FR2081443B1 (en) 1975-04-18
IE34871B1 (en) 1975-09-03
FR2081443A1 (en) 1971-12-03
NL7100184A (en) 1971-07-21

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PLNP Patent lapsed through nonpayment of renewal fees