IE32639B1 - Indole derivatives and a process for the production thereof - Google Patents

Indole derivatives and a process for the production thereof

Info

Publication number
IE32639B1
IE32639B1 IE156/69A IE15669A IE32639B1 IE 32639 B1 IE32639 B1 IE 32639B1 IE 156/69 A IE156/69 A IE 156/69A IE 15669 A IE15669 A IE 15669A IE 32639 B1 IE32639 B1 IE 32639B1
Authority
IE
Ireland
Prior art keywords
compounds
laevorotatory
possibly
substituted
methyl
Prior art date
Application number
IE156/69A
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Ag filed Critical Sandoz Ag
Priority to IE1664/71A priority Critical patent/IE32640B1/en
Publication of IE32639B1 publication Critical patent/IE32639B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1,251,716. Indole-derived hydroxyamines. SANDOZ Ltd. 13 Jan., 1969 [9 Feb., 1968], No. 1853/69. Addition to 1,138,968. Heading C2C. The invention comprises laevorotatory compounds of formula wherein one of R 1 , R 2 is H or CH 3 and the other is CH 3 , and their acid addition salts. These compounds are prepared by reacting 4-hydroxyindole (possibly 2- or 3-methyl-substituted), in an alkaline medium and in absence of O 2 , with laevorotatory epichlorohydrin or bromohydrin, heating the reaction product [presumably optically active 4:-glycidyloxyindole (possibly 2- or 3-methyl-substituted)] with (CH 3 ) 2 CR 2 NHR 3 (R 3 being H or benzyl), splitting off any benzyl radical which may be present, and optionally converting the product to an acid addition salt by reaction with an inorganic or organic acid. Therapeutic compositions comprise compounds of the above formula, which are #-receptor blockers, and may be used in the form of tablets, dragees, suppositories or injectable solutions. [GB1251716A]
IE156/69A 1968-02-09 1969-02-06 Indole derivatives and a process for the production thereof IE32639B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
IE1664/71A IE32640B1 (en) 1968-02-09 1969-02-06 An indole derivative and a process for the production thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH198768A CH495983A (en) 1968-02-09 1968-02-09 Process for the preparation of levorotatory 4- (2-hydroxy-3-isopropylaminopropoxy) indole

Publications (1)

Publication Number Publication Date
IE32639B1 true IE32639B1 (en) 1973-10-17

Family

ID=4223253

Family Applications (1)

Application Number Title Priority Date Filing Date
IE156/69A IE32639B1 (en) 1968-02-09 1969-02-06 Indole derivatives and a process for the production thereof

Country Status (14)

Country Link
AT (1) AT299188B (en)
BE (1) BE728142A (en)
BR (1) BR6906200D0 (en)
CH (1) CH495983A (en)
DE (1) DE1905881C2 (en)
DK (1) DK119110B (en)
FI (1) FI50972C (en)
FR (2) FR1598040A (en)
GB (2) GB1251716A (en)
IE (1) IE32639B1 (en)
IL (1) IL31570A (en)
NL (1) NL6900797A (en)
NO (1) NO125590B (en)
SE (1) SE340621B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4182911A (en) 1973-11-09 1980-01-08 Imperial Chemical Industries Limited Optically-active 1-aryloxy-2-propanol intermediates of (S)-absolute configuration
DE2454198C2 (en) * 1974-11-15 1986-08-07 Knoll Ag, 6700 Ludwigshafen Isoquinoline derivatives, processes for their preparation and medicines
CA1116598A (en) * 1977-07-13 1982-01-19 William T. Comer 3-indolyl-tertiary butylaminopropanols
DE2905053A1 (en) * 1979-02-08 1980-08-14 Schering Ag 1-Methyl:indolyl:oxy-2,3-epoxy-propane prodn. - from 4-hydroxy-2-methyl:indole and epichlorohydrin in protic solvent
DE3029980A1 (en) * 1980-08-08 1982-03-11 Boehringer Mannheim Gmbh, 6800 Mannheim INDOLDER DERIVATIVES AND METHOD FOR THEIR PRODUCTION
DE3030047A1 (en) * 1980-08-08 1982-03-11 Boehringer Mannheim Gmbh, 6800 Mannheim NEW AMINOPROPANOL DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1129072A (en) * 1966-02-01 1968-10-02 Ici Ltd Benzofuran and indole derivatives
NL131726C (en) * 1965-02-01

Also Published As

Publication number Publication date
BR6906200D0 (en) 1973-02-27
BE728142A (en) 1969-08-07
NL6900797A (en) 1969-08-12
DE1905881C2 (en) 1984-03-08
FI50972B (en) 1976-05-31
SE340621B (en) 1971-11-29
NO125590B (en) 1972-10-02
GB1251716A (en) 1971-10-27
DK119110B (en) 1970-11-16
AT299188B (en) 1972-06-12
IL31570A (en) 1972-03-28
DE1905881A1 (en) 1969-09-25
FR1598040A (en) 1970-06-29
FR8067M (en) 1970-07-06
FI50972C (en) 1976-09-10
GB1252399A (en) 1971-11-03
IL31570A0 (en) 1969-11-12
CH495983A (en) 1970-09-15

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