IE31935B1 - Process for the manufacture of benzodiazepine derivatives - Google Patents
Process for the manufacture of benzodiazepine derivativesInfo
- Publication number
- IE31935B1 IE31935B1 IE13868A IE13868A IE31935B1 IE 31935 B1 IE31935 B1 IE 31935B1 IE 13868 A IE13868 A IE 13868A IE 13868 A IE13868 A IE 13868A IE 31935 B1 IE31935 B1 IE 31935B1
- Authority
- IE
- Ireland
- Prior art keywords
- formula
- feb
- alkyl
- compound
- base
- Prior art date
Links
- 229940053197 benzodiazepine derivative antiepileptics Drugs 0.000 title abstract 2
- 125000003310 benzodiazepinyl group Chemical class N1N=C(C=CC2=C1C=CC=C2)* 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 239000002585 base Substances 0.000 abstract 2
- 238000002360 preparation method Methods 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- -1 CF 3 Inorganic materials 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 150000001340 alkali metals Chemical class 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 150000004703 alkoxides Chemical class 0.000 abstract 1
- 125000004391 aryl sulfonyl group Chemical group 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 125000001589 carboacyl group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000005059 halophenyl group Chemical group 0.000 abstract 1
- 150000004678 hydrides Chemical class 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
- C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
- C07D243/24—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IE1011/70A IE31936B1 (en) | 1967-02-06 | 1968-02-05 | Tetrahydro-benzdiaz(1,4)epine derivatives |
| IE1012/70A IE31937B1 (en) | 1967-02-06 | 1968-02-05 | Benzdiaz (1,4)epinone-(2) derivatives |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US61400967A | 1967-02-06 | 1967-02-06 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE31935L IE31935L (en) | 1968-08-06 |
| IE31935B1 true IE31935B1 (en) | 1973-02-21 |
Family
ID=24459538
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE13868A IE31935B1 (en) | 1967-02-06 | 1968-02-05 | Process for the manufacture of benzodiazepine derivatives |
Country Status (13)
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1906256A1 (de) * | 1968-02-13 | 1970-02-26 | Sumitomo Chemical Co | Verfahren zur Herstellung von Benzodiazepin-Derivaten und ihren Salzen |
| JPS515395B1 (enrdf_load_stackoverflow) * | 1971-04-12 | 1976-02-19 |
-
0
- NL NL143567D patent/NL143567C/xx active
-
1968
- 1968-02-01 CH CH163468A patent/CH492723A/de not_active IP Right Cessation
- 1968-02-03 DE DE19681695223 patent/DE1695223A1/de active Pending
- 1968-02-05 YU YU25768A patent/YU34128B/xx unknown
- 1968-02-05 ES ES350159A patent/ES350159A1/es not_active Expired
- 1968-02-05 GB GB3851069A patent/GB1199864A/en not_active Expired
- 1968-02-05 NO NO45068A patent/NO121545B/no unknown
- 1968-02-05 IE IE13868A patent/IE31935B1/xx unknown
- 1968-02-05 DK DK43768A patent/DK137494B/da not_active IP Right Cessation
- 1968-02-05 NL NL6801612A patent/NL143567B/xx not_active IP Right Cessation
- 1968-02-05 GB GB570668A patent/GB1199862A/en not_active Expired
- 1968-02-05 BE BE710301D patent/BE710301A/xx unknown
- 1968-02-05 FR FR1553404D patent/FR1553404A/fr not_active Expired
- 1968-02-05 GB GB3850969A patent/GB1199863A/en not_active Expired
- 1968-02-06 FI FI30068A patent/FI48469C/fi active
- 1968-02-06 SE SE154068A patent/SE341190B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NL6801612A (enrdf_load_stackoverflow) | 1968-08-07 |
| FR1553404A (enrdf_load_stackoverflow) | 1969-01-10 |
| NL143567B (nl) | 1974-10-15 |
| GB1199863A (en) | 1970-07-22 |
| GB1199864A (en) | 1970-07-22 |
| FI48469B (enrdf_load_stackoverflow) | 1974-07-01 |
| ES350159A1 (es) | 1969-04-16 |
| GB1199862A (en) | 1970-07-22 |
| DK137494B (da) | 1978-03-13 |
| CH492723A (de) | 1970-06-30 |
| NO121545B (enrdf_load_stackoverflow) | 1971-03-15 |
| NL143567C (enrdf_load_stackoverflow) | |
| YU25768A (en) | 1978-05-15 |
| FI48469C (fi) | 1974-10-10 |
| BE710301A (enrdf_load_stackoverflow) | 1968-08-05 |
| DK137494C (enrdf_load_stackoverflow) | 1978-08-28 |
| IE31935L (en) | 1968-08-06 |
| YU34128B (en) | 1978-12-31 |
| SE341190B (enrdf_load_stackoverflow) | 1971-12-20 |
| DE1695223A1 (de) | 1972-02-03 |
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