IE31935B1 - Process for the manufacture of benzodiazepine derivatives - Google Patents

Process for the manufacture of benzodiazepine derivatives

Info

Publication number
IE31935B1
IE31935B1 IE13868A IE13868A IE31935B1 IE 31935 B1 IE31935 B1 IE 31935B1 IE 13868 A IE13868 A IE 13868A IE 13868 A IE13868 A IE 13868A IE 31935 B1 IE31935 B1 IE 31935B1
Authority
IE
Ireland
Prior art keywords
formula
feb
alkyl
compound
base
Prior art date
Application number
IE13868A
Other versions
IE31935L (en
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Priority to IE1012/70A priority Critical patent/IE31937B1/en
Priority to IE1011/70A priority patent/IE31936B1/en
Publication of IE31935L publication Critical patent/IE31935L/en
Publication of IE31935B1 publication Critical patent/IE31935B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

1,199,862. Benzodiazepine derivatives preparation. F. HOFFMANN-LA ROCHE & CO. A.G. 5 Feb., 1968 [6 Feb., 1967], No. 5706/68. Heading C2C. Compounds of the general Formula (I) (A = phenyl, pyridyl, halophenyl; B=CO, CH 2 ; R, R<SP>1</SP> = halogen, CF 3 , NO 2 ; R<SP>2</SP> = C 1-7 alkyl, C 2-7 alkenyl; R<SP>3</SP> = C 1-7 alkyl; broken lines denote optional substituents) and their acid addition salts are prepared by treating a compound of the Formula (II) with a base (X = arylsulphonyl, C 1-7 alkanesulphonyl) or alkali metal C 1-7 alkoxide or hydride (X = C 1-7 alkanoyl) in the presence of an inert organic solvent, optionally followed by salt formation. When B=CO a compound of the Formula (III): may be obtained as an intermediate and can be converted, with or without isolation, to (I) by treatment with a base. The preparation of starting materials of Formula (II) is described. [GB1199862A]
IE13868A 1967-02-06 1968-02-05 Process for the manufacture of benzodiazepine derivatives IE31935B1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
IE1012/70A IE31937B1 (en) 1967-02-06 1968-02-05 Benzdiaz (1,4)epinone-(2) derivatives
IE1011/70A IE31936B1 (en) 1967-02-06 1968-02-05 Tetrahydro-benzdiaz(1,4)epine derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US61400967A 1967-02-06 1967-02-06

Publications (2)

Publication Number Publication Date
IE31935L IE31935L (en) 1968-08-06
IE31935B1 true IE31935B1 (en) 1973-02-21

Family

ID=24459538

Family Applications (1)

Application Number Title Priority Date Filing Date
IE13868A IE31935B1 (en) 1967-02-06 1968-02-05 Process for the manufacture of benzodiazepine derivatives

Country Status (13)

Country Link
BE (1) BE710301A (en)
CH (1) CH492723A (en)
DE (1) DE1695223A1 (en)
DK (1) DK137494B (en)
ES (1) ES350159A1 (en)
FI (1) FI48469C (en)
FR (1) FR1553404A (en)
GB (3) GB1199862A (en)
IE (1) IE31935B1 (en)
NL (2) NL143567B (en)
NO (1) NO121545B (en)
SE (1) SE341190B (en)
YU (1) YU34128B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1906256A1 (en) * 1968-02-13 1970-02-26 Sumitomo Chemical Co Process for the preparation of benzodiazepine derivatives and their salts
JPS515395B1 (en) * 1971-04-12 1976-02-19

Also Published As

Publication number Publication date
DK137494B (en) 1978-03-13
FI48469C (en) 1974-10-10
ES350159A1 (en) 1969-04-16
YU25768A (en) 1978-05-15
GB1199863A (en) 1970-07-22
GB1199862A (en) 1970-07-22
DE1695223A1 (en) 1972-02-03
BE710301A (en) 1968-08-05
DK137494C (en) 1978-08-28
IE31935L (en) 1968-08-06
NL6801612A (en) 1968-08-07
CH492723A (en) 1970-06-30
FI48469B (en) 1974-07-01
YU34128B (en) 1978-12-31
GB1199864A (en) 1970-07-22
NL143567B (en) 1974-10-15
NL143567C (en)
NO121545B (en) 1971-03-15
FR1553404A (en) 1969-01-10
SE341190B (en) 1971-12-20

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