ID26822A - Inhibitor tiol tertentu dari enzim pengubah endotelin - Google Patents

Inhibitor tiol tertentu dari enzim pengubah endotelin

Info

Publication number
ID26822A
ID26822A IDW20002106A ID20002106A ID26822A ID 26822 A ID26822 A ID 26822A ID W20002106 A IDW20002106 A ID W20002106A ID 20002106 A ID20002106 A ID 20002106A ID 26822 A ID26822 A ID 26822A
Authority
ID
Indonesia
Prior art keywords
endotelin
tiol
inhibitors
certain
enzymes
Prior art date
Application number
IDW20002106A
Other languages
English (en)
Inventor
Stephane De Lombaert
Cynthia Anne Fink
Fariborz Firoozina
Denton Wade Hoyer
Arco Yingcheu Jeng
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of ID26822A publication Critical patent/ID26822A/id

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
IDW20002106A 1998-04-23 1999-04-21 Inhibitor tiol tertentu dari enzim pengubah endotelin ID26822A (id)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US6526598A 1998-04-23 1998-04-23

Publications (1)

Publication Number Publication Date
ID26822A true ID26822A (id) 2001-02-15

Family

ID=22061502

Family Applications (1)

Application Number Title Priority Date Filing Date
IDW20002106A ID26822A (id) 1998-04-23 1999-04-21 Inhibitor tiol tertentu dari enzim pengubah endotelin

Country Status (16)

Country Link
EP (1) EP1073674A1 (id)
JP (1) JP4350306B2 (id)
KR (1) KR20010034816A (id)
CN (1) CN1297453A (id)
AU (1) AU3819999A (id)
BR (1) BR9909805A (id)
CA (1) CA2323691A1 (id)
HU (1) HUP0101640A3 (id)
ID (1) ID26822A (id)
IL (1) IL138246A0 (id)
NO (1) NO20005293L (id)
PL (1) PL343594A1 (id)
RU (1) RU2000129510A (id)
SK (1) SK15812000A3 (id)
WO (1) WO1999055726A1 (id)
ZA (1) ZA200004680B (id)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6423727B1 (en) 1998-04-23 2002-07-23 Novartis Ag Certain thiol inhibitors of endothelin-converting enzyme
US6426354B1 (en) 1998-04-23 2002-07-30 Novartis Ag Certain heteroaryl substituted thiol inhibitors of endothelin-converting enzyme
AU2001254776A1 (en) * 2000-04-06 2001-10-23 Novartis Ag Organic compounds
US6777443B2 (en) * 2001-05-15 2004-08-17 Novartis Ag Dipeptide derivatives
CN1304415C (zh) * 2001-09-21 2007-03-14 诺瓦提斯公司 作为ace和nep抑制剂的吡喃衍生物
US6919343B2 (en) 2002-02-08 2005-07-19 Merck & Co., Inc. N-biphenyl(substituted methyl) aminocycloalkane-carboxamide derivatives
CA2473778A1 (en) 2002-02-08 2003-08-14 Merck & Co., Inc. N-biphenylmethyl aminocycloalkanecarboxamide derivatives
EP1481967B1 (en) 2002-03-05 2011-05-04 Sumitomo Chemical Company, Limited Process for the preparation of biaryl compounds
US20060183753A1 (en) * 2002-12-20 2006-08-17 Bayer Healthcare Ag Use of substituted 2,5-diamidoindoles for the treatment of urological diseases
US7262184B2 (en) 2003-09-26 2007-08-28 Solvay Pharmaceuticals Gmbh Amidomethyl-substituted 1-(carboxyalkyl) cyclopentyl-carbonylamino-benzazepine-N-acetic acid compounds, process and intermediate products for their preparation and pharmaceutical compositions containing them
US7427611B2 (en) 2003-09-26 2008-09-23 Solvay Pharmaceuticals Gmbh Amidomethyl-substituted 1-(carboxyalkyl)-cyclopentyl-carbonylamino-benzazepine-N-acetic acid compounds, process and intermediate products for their preparation and pharmaceutical compositions containing them
US7452875B2 (en) 2003-09-26 2008-11-18 Solvay Pharmaceuticals Gmbh Amidomethyl-substituted 1-(carboxyalkyl) cyclopentyl-carbonylamino-benzazepine-N-acetic acid compounds, process and intermediate products for their preparation and pharmaceutical compositions containing them
ATE406899T1 (de) * 2004-01-12 2008-09-15 Solvay Pharm Bv Neutrale endopeptidase (nep) und humane lösliche endopeptidase (hsep) hemmer für die prophylaxe und behandlung von neurodegenerativen erkrankungen
JP4047365B2 (ja) 2006-01-11 2008-02-13 生化学工業株式会社 シクロアルカンカルボキサミド誘導体及びその製造方法
WO2007080884A1 (ja) * 2006-01-11 2007-07-19 Seikagaku Corporation シクロアルキルカルボニルアミノ酸エステル誘導体及びその製造方法
JP3975226B2 (ja) 2006-01-11 2007-09-12 生化学工業株式会社 シクロアルキルカルボニルアミノ酸誘導体及びその製造方法
CA2708281A1 (en) 2007-12-11 2009-08-27 Viamet Pharmaceuticals, Inc. Metalloenzyme inhibitors using metal binding moieties in combination with targeting moieties
CN104725279B (zh) * 2015-02-12 2018-03-02 威海迪素制药有限公司 一种N‑Boc‑联苯丙氨酸衍生物的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2173875A1 (en) * 1993-11-01 1995-05-11 Hideyuki Saika Endothelin receptor antagonists
EP0655461B1 (en) * 1993-11-16 2000-06-07 Novartis AG Cyclic amino acid derivatives having ACE and NEP inhibiting activity
FR2745571B1 (fr) * 1996-03-04 1998-06-19 Inst Nat Sante Rech Med Nouveaux derives soufres comportant une liaison amide, leur procede de preparation, leur application a titre de medicaments, et les compositions pharmaceutiques les renfermant

Also Published As

Publication number Publication date
RU2000129510A (ru) 2002-11-10
EP1073674A1 (en) 2001-02-07
HUP0101640A2 (hu) 2001-09-28
IL138246A0 (en) 2001-10-31
JP4350306B2 (ja) 2009-10-21
NO20005293L (no) 2000-12-18
AU3819999A (en) 1999-11-16
KR20010034816A (ko) 2001-04-25
CA2323691A1 (en) 1999-11-04
PL343594A1 (en) 2001-08-27
BR9909805A (pt) 2000-12-26
WO1999055726A1 (en) 1999-11-04
NO20005293D0 (no) 2000-10-20
JP2002513032A (ja) 2002-05-08
SK15812000A3 (sk) 2001-03-12
ZA200004680B (en) 2001-04-25
CN1297453A (zh) 2001-05-30
HUP0101640A3 (en) 2002-10-28

Similar Documents

Publication Publication Date Title
ID27574A (id) Inhibitor enzim
ID26822A (id) Inhibitor tiol tertentu dari enzim pengubah endotelin
NO20012980D0 (no) Proteaseinhibitorer
ID26250A (id) Inhibitor-inhibitor dari enzim-enzim fosfolipase
DE60002193T2 (de) Metalloprotease inhibitoren
ID27280A (id) Inhibitor-inhibitor dari enzim-enzim fosfolipase
ID19198A (id) Inhibitor metaloprotease heterosiklik
ID18416A (id) Inhibitor metaloprotease diheterosiklik
IT1298163B1 (it) Inibitori di solfammido-metalloproteasi
NO20005196D0 (no) Substituerte pyrrolidinhydroksamat-metallproteaseinhibitorer
ID27192A (id) Sulfonamida trisiklik dan turunannya sebagai inhibitor metaloproteinase matriks
NO20014243D0 (no) Dihetero-substituerte metalloprotease inhibitorer
DE59806475D1 (de) Urokinase-inhibitoren
NO20003814L (no) Trombininhibitorer
ID30124A (id) INHIBITOR SUCCINAMIDA PADA ENZIM PENGUBAH INTELEUKIN-1β
NO20014875D0 (no) Promedikamenter for trombin inhibitorer
NO20005826D0 (no) Bionedbrytbare korrosjonsinhibitorer
ATE252547T1 (de) Matrixmetalloproteinaseinhibitoren
DE60024101D1 (de) Enzyminhibitoren
GB0030284D0 (en) Enzyme inhibitors
ATE225346T1 (de) Fkbp inhibitoren
DE60009260D1 (de) Thiopyranderivate as mmp-inhibitoren
DK1130214T3 (da) Korrosionsinhibitorer
DE60000819D1 (de) Umgekehrt hydroxamat inhibitoren von matrix metalloproteinasen
DE50005928D1 (de) Enzymatischer vergrauungsinhibitor