ID22044A - Metode dan senyawa untuk menghambat pelepasan betha-amiloid peptida dan atau sintesisnya - Google Patents
Metode dan senyawa untuk menghambat pelepasan betha-amiloid peptida dan atau sintesisnyaInfo
- Publication number
- ID22044A ID22044A IDW990394A ID990394A ID22044A ID 22044 A ID22044 A ID 22044A ID W990394 A IDW990394 A ID W990394A ID 990394 A ID990394 A ID 990394A ID 22044 A ID22044 A ID 22044A
- Authority
- ID
- Indonesia
- Prior art keywords
- amiloid
- betha
- inhibit
- synthesis
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
- C07K5/06043—Leu-amino acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/0606—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing heteroatoms not provided for by C07K5/06086 - C07K5/06139, e.g. Ser, Met, Cys, Thr
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US75544296A | 1996-11-22 | 1996-11-22 | |
US80852897A | 1997-02-28 | 1997-02-28 | |
US80752897A | 1997-02-28 | 1997-02-28 | |
US80742797A | 1997-02-28 | 1997-02-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
ID22044A true ID22044A (id) | 1999-08-26 |
Family
ID=27505670
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IDW990394A ID22044A (id) | 1996-11-22 | 1997-11-21 | Metode dan senyawa untuk menghambat pelepasan betha-amiloid peptida dan atau sintesisnya |
Country Status (21)
Country | Link |
---|---|
EP (1) | EP0942924A2 (id) |
JP (1) | JP2001503782A (id) |
KR (1) | KR20000069064A (id) |
CN (1) | CN1238779A (id) |
AR (1) | AR016751A1 (id) |
AU (1) | AU5356198A (id) |
BR (1) | BR9713400A (id) |
CA (1) | CA2267634A1 (id) |
CO (1) | CO4910156A1 (id) |
CZ (1) | CZ122899A3 (id) |
EA (1) | EA199900490A1 (id) |
HR (1) | HRP970627A2 (id) |
HU (1) | HUP0100270A3 (id) |
ID (1) | ID22044A (id) |
IL (1) | IL129083A0 (id) |
NO (1) | NO992368L (id) |
NZ (1) | NZ334690A (id) |
PE (1) | PE16999A1 (id) |
TR (3) | TR199902938T2 (id) |
WO (1) | WO1998022494A2 (id) |
YU (1) | YU46097A (id) |
Families Citing this family (49)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE122010000020I1 (de) | 1996-04-25 | 2010-07-08 | Prosidion Ltd | Verfahren zur Senkung des Blutglukosespiegels in Säugern |
US6191166B1 (en) * | 1997-11-21 | 2001-02-20 | Elan Pharmaceuticals, Inc. | Methods and compounds for inhibiting β-amyloid peptide release and/or its synthesis |
US6635632B1 (en) | 1996-12-23 | 2003-10-21 | Athena Neurosciences, Inc. | Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds |
DE19823831A1 (de) | 1998-05-28 | 1999-12-02 | Probiodrug Ges Fuer Arzneim | Neue pharmazeutische Verwendung von Isoleucyl Thiazolidid und seinen Salzen |
US6552013B1 (en) | 1998-06-22 | 2003-04-22 | Elan Pharmaceuticals, Inc. | Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds |
WO1999067221A1 (en) * | 1998-06-22 | 1999-12-29 | Elan Pharmaceuticals, Inc. | Compounds for inhibiting beta-amyloid peptide release and/or its synthesis |
AU4707999A (en) * | 1998-06-22 | 2000-01-10 | Elan Pharmaceuticals, Inc. | Compounds for inhibiting beta-amyloid peptide release and/or its synthesis |
US6958330B1 (en) | 1998-06-22 | 2005-10-25 | Elan Pharmaceuticals, Inc. | Polycyclic α-amino-ε-caprolactams and related compounds |
AU4710499A (en) * | 1998-06-22 | 2000-01-10 | Elan Pharmaceuticals, Inc. | Cyclic amino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use ofsuch compounds |
DE19828114A1 (de) | 1998-06-24 | 2000-01-27 | Probiodrug Ges Fuer Arzneim | Produgs instabiler Inhibitoren der Dipeptidyl Peptidase IV |
DE19828113A1 (de) | 1998-06-24 | 2000-01-05 | Probiodrug Ges Fuer Arzneim | Prodrugs von Inhibitoren der Dipeptidyl Peptidase IV |
DE19834591A1 (de) | 1998-07-31 | 2000-02-03 | Probiodrug Ges Fuer Arzneim | Verfahren zur Steigerung des Blutglukosespiegels in Säugern |
JP2003524601A (ja) | 1998-09-30 | 2003-08-19 | エラン ファーマシューティカルズ,インコーポレイテッド | 生物学的試薬およびβ−アミロイドペプチドの生成機構の決定法 |
US6737038B1 (en) | 1998-11-12 | 2004-05-18 | Bristol-Myers Squibb Company | Use of small molecule radioligands to discover inhibitors of amyloid-beta peptide production and for diagnostic imaging |
EP1137661A1 (en) | 1998-12-10 | 2001-10-04 | F. Hoffmann-La Roche Ag | Procollagen c-proteinase inhibitors |
US6723711B2 (en) | 1999-05-07 | 2004-04-20 | Texas Biotechnology Corporation | Propanoic acid derivatives that inhibit the binding of integrins to their receptors |
US6972296B2 (en) | 1999-05-07 | 2005-12-06 | Encysive Pharmaceuticals Inc. | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors |
RU2255933C9 (ru) * | 1999-05-07 | 2005-11-20 | Тексэс Байотекнолоджи Копэрейшн | ПРОИЗВОДНЫЕ ПРОПИОНОВОЙ КИСЛОТЫ (ВАРИАНТЫ), ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ И СПОСОБ СЕЛЕКТИВНОГО ИНГИБИРОВАНИЯ СВЯЗЫВАНИЯ α4β1 ИНТЕГРИНА |
DE19926233C1 (de) | 1999-06-10 | 2000-10-19 | Probiodrug Ges Fuer Arzneim | Verfahren zur Herstellung von Thiazolidin |
DE19940130A1 (de) | 1999-08-24 | 2001-03-01 | Probiodrug Ges Fuer Arzneim | Neue Effektoren der Dipeptidyl Peptidase IV zur topischen Anwendung |
AU1569401A (en) * | 1999-11-09 | 2001-06-06 | Eli Lilly And Company | Beta-aminoacid compounds useful for inhibiting beta-amyloid peptide release and/or its synthesis |
US6500804B2 (en) | 2000-03-31 | 2002-12-31 | Probiodrug Ag | Method for the improvement of islet signaling in diabetes mellitus and for its prevention |
AU2001261728A1 (en) | 2000-05-17 | 2001-11-26 | Bristol-Myers Squibb Pharma Company | Use of small molecule radioligands for diagnostic imaging |
NZ516746A (en) | 2000-06-01 | 2004-02-27 | Bristol Myers Squibb Pharma | Lactams substituted by cyclic succinates as inhibitors of A-beta protein production |
FR2832152A1 (fr) * | 2001-11-09 | 2003-05-16 | Aventis Pharma Sa | Utilisation de derives de 2-amino-thiazoline comme inhibiteurs de no-synthase inductible |
US6432944B1 (en) | 2000-07-06 | 2002-08-13 | Bristol-Myers Squibb Company | Benzodiazepinone β-amyloid inhibitors: arylacetamidoalanyl derivatives |
GB0016681D0 (en) | 2000-07-06 | 2000-08-23 | Merck Sharp & Dohme | Therapeutic compounds |
US7132104B1 (en) | 2000-10-27 | 2006-11-07 | Probiodrug Ag | Modulation of central nervous system (CNS) dipeptidyl peptidase IV (DPIV) -like activity for the treatment of neurological and neuropsychological disorders |
US6890905B2 (en) | 2001-04-02 | 2005-05-10 | Prosidion Limited | Methods for improving islet signaling in diabetes mellitus and for its prevention |
DE10150203A1 (de) | 2001-10-12 | 2003-04-17 | Probiodrug Ag | Peptidylketone als Inhibitoren der DPIV |
US20030130199A1 (en) | 2001-06-27 | 2003-07-10 | Von Hoersten Stephan | Dipeptidyl peptidase IV inhibitors and their uses as anti-cancer agents |
US7368421B2 (en) | 2001-06-27 | 2008-05-06 | Probiodrug Ag | Use of dipeptidyl peptidase IV inhibitors in the treatment of multiple sclerosis |
FR2840899B1 (fr) * | 2002-06-12 | 2005-02-25 | Sanofi Synthelabo | Derives d'acylaminothiazole, leur preparation et leur utilisation en therapeutique |
AR039059A1 (es) * | 2001-08-06 | 2005-02-09 | Sanofi Aventis | Compuesto derivado de acilaminotiazol, su utilizacion, procedimientos para prepararlo, composicion farmaceutica que lo comprende, y compuestos intermediarios |
DE10143840A1 (de) * | 2001-09-06 | 2003-03-27 | Probiodrug Ag | Neue Inhibitoren der Dipeptidylpeptidase I |
US6844316B2 (en) | 2001-09-06 | 2005-01-18 | Probiodrug Ag | Inhibitors of dipeptidyl peptidase I |
JP2005526005A (ja) | 2001-11-09 | 2005-09-02 | アベンティス・ファーマ・ソシエテ・アノニム | 誘導型noシンターゼの阻害剤としての2−アミノ−チアゾリン誘導体及びその使用 |
PL372316A1 (en) | 2002-02-28 | 2005-07-11 | Prosidion Limited | Glutaminyl based dpiv inhibitors |
US20040229955A1 (en) | 2003-01-08 | 2004-11-18 | Andersen Niels H. | Antibacterial agents |
KR20110059664A (ko) | 2003-05-05 | 2011-06-02 | 프로비오드룩 아게 | 글루타미닐 및 글루타메이트 사이클라제의 이펙터의 용도 |
JP4806628B2 (ja) | 2003-05-05 | 2011-11-02 | プロビオドルグ エージー | グルタミニルシクラーゼ阻害剤 |
EP1666068A4 (en) * | 2003-09-24 | 2010-08-04 | Santen Pharmaceutical Co Ltd | REMEDY FOR EYE DISEASES ACCOMPANIED BY OPTICAL NERVE INJURIES |
KR101121882B1 (ko) | 2003-10-15 | 2012-04-12 | 프로비오드룩 아게 | 글루타미닐 및 글루타메이트 사이클라제 이펙터의 용도 |
JP5539864B2 (ja) | 2007-06-12 | 2014-07-02 | アカオゲン,インコーポレーテッド | 抗菌剤 |
EP2062909A1 (en) * | 2007-11-21 | 2009-05-27 | SOLVAY (Société Anonyme) | Peptide production and purification process |
BG110141A (en) | 2008-05-23 | 2009-12-31 | "Софарма" Ад | GALANTAMINE DERIVATIVES, METHODS FOR THEIR PREPARATION AND USE |
WO2013170165A1 (en) | 2012-05-10 | 2013-11-14 | Achaogen, Inc. | Antibacterial agents |
WO2017004560A1 (en) * | 2015-07-02 | 2017-01-05 | The Regents Of The University Of California | Methods and compositions for amyloid aggregates |
WO2022150314A1 (en) * | 2021-01-05 | 2022-07-14 | Southern Research Institute | Modulators of programmed death-ligand-1 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HUT62312A (en) * | 1990-03-05 | 1993-04-28 | Cephalon Inc | Process for producing chymotrypsin-like proteases and their inhibitors |
WO1995013084A1 (en) * | 1992-05-11 | 1995-05-18 | Miles Inc. | Cathepsin d is an amyloidogenic protease in alzheimer's disease |
CZ184194A3 (en) * | 1993-08-09 | 1995-03-15 | Lilly Co Eli | Aspartylprotease inhibitor and method of identifying thereof |
ES2170104T3 (es) * | 1993-10-01 | 2002-08-01 | Merrell Pharma Inc | Inhibidores de la produccion de proteinas de beta-amiloide. |
US5872101A (en) * | 1995-01-06 | 1999-02-16 | Sibia Neurosciences, Inc. | Methods of treating neurodegenerative disorders using protease inhibitors |
US5804560A (en) * | 1995-01-06 | 1998-09-08 | Sibia Neurosciences, Inc. | Peptide and peptide analog protease inhibitors |
WO1996039194A1 (en) * | 1995-06-06 | 1996-12-12 | Athena Neurosciences, Inc. | Novel cathepsin and methods and compositions for inhibition thereof |
-
1997
- 1997-11-18 AR ARP970105393A patent/AR016751A1/es not_active Application Discontinuation
- 1997-11-19 HR HR08/808,528A patent/HRP970627A2/hr not_active Application Discontinuation
- 1997-11-20 PE PE1997001056A patent/PE16999A1/es not_active Application Discontinuation
- 1997-11-21 YU YU46097A patent/YU46097A/sh unknown
- 1997-11-21 TR TR1999/02938T patent/TR199902938T2/xx unknown
- 1997-11-21 JP JP52375698A patent/JP2001503782A/ja active Pending
- 1997-11-21 CA CA002267634A patent/CA2267634A1/en not_active Abandoned
- 1997-11-21 WO PCT/US1997/020804 patent/WO1998022494A2/en not_active Application Discontinuation
- 1997-11-21 TR TR1999/01133T patent/TR199901133T2/xx unknown
- 1997-11-21 EP EP97950601A patent/EP0942924A2/en not_active Withdrawn
- 1997-11-21 CN CN97199803A patent/CN1238779A/zh active Pending
- 1997-11-21 CO CO97068215A patent/CO4910156A1/es unknown
- 1997-11-21 TR TR1999/02937T patent/TR199902937T2/xx unknown
- 1997-11-21 HU HU0100270A patent/HUP0100270A3/hu unknown
- 1997-11-21 AU AU53561/98A patent/AU5356198A/en not_active Abandoned
- 1997-11-21 ID IDW990394A patent/ID22044A/id unknown
- 1997-11-21 NZ NZ334690A patent/NZ334690A/en unknown
- 1997-11-21 EA EA199900490A patent/EA199900490A1/ru unknown
- 1997-11-21 CZ CZ991228A patent/CZ122899A3/cs unknown
- 1997-11-21 IL IL12908397A patent/IL129083A0/xx unknown
- 1997-11-21 BR BR9713400-7A patent/BR9713400A/pt not_active IP Right Cessation
- 1997-11-21 KR KR1019997004486A patent/KR20000069064A/ko not_active Application Discontinuation
-
1999
- 1999-05-14 NO NO992368A patent/NO992368L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
HUP0100270A2 (hu) | 2001-08-28 |
NO992368D0 (no) | 1999-05-14 |
TR199902938T2 (xx) | 2002-06-21 |
EP0942924A2 (en) | 1999-09-22 |
JP2001503782A (ja) | 2001-03-21 |
IL129083A0 (en) | 2000-02-17 |
HUP0100270A3 (en) | 2001-09-28 |
AR016751A1 (es) | 2001-08-01 |
TR199901133T2 (xx) | 1999-07-21 |
CO4910156A1 (es) | 2000-04-24 |
CZ122899A3 (cs) | 1999-10-13 |
PE16999A1 (es) | 1999-02-19 |
YU46097A (sh) | 2000-10-30 |
EA199900490A1 (ru) | 2000-02-28 |
NO992368L (no) | 1999-06-21 |
WO1998022494A2 (en) | 1998-05-28 |
CN1238779A (zh) | 1999-12-15 |
AU5356198A (en) | 1998-06-10 |
NZ334690A (en) | 2001-09-28 |
WO1998022494A3 (en) | 1998-11-26 |
CA2267634A1 (en) | 1998-05-28 |
BR9713400A (pt) | 2000-01-25 |
KR20000069064A (ko) | 2000-11-25 |
TR199902937T2 (xx) | 2001-01-22 |
HRP970627A2 (en) | 1998-08-31 |
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