IL129083A0 - Methods and compounds for inhibiting beta-amyloid peptide release and/or its synthesis - Google Patents
Methods and compounds for inhibiting beta-amyloid peptide release and/or its synthesisInfo
- Publication number
- IL129083A0 IL129083A0 IL12908397A IL12908397A IL129083A0 IL 129083 A0 IL129083 A0 IL 129083A0 IL 12908397 A IL12908397 A IL 12908397A IL 12908397 A IL12908397 A IL 12908397A IL 129083 A0 IL129083 A0 IL 129083A0
- Authority
- IL
- Israel
- Prior art keywords
- synthesis
- compounds
- methods
- amyloid peptide
- peptide release
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
- C07K5/06043—Leu-amino acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/0606—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing heteroatoms not provided for by C07K5/06086 - C07K5/06139, e.g. Ser, Met, Cys, Thr
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Psychiatry (AREA)
- Pharmacology & Pharmacy (AREA)
- Hospice & Palliative Care (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US75544296A | 1996-11-22 | 1996-11-22 | |
US80852897A | 1997-02-28 | 1997-02-28 | |
US80742797A | 1997-02-28 | 1997-02-28 | |
US80752897A | 1997-02-28 | 1997-02-28 | |
PCT/US1997/020804 WO1998022494A2 (en) | 1996-11-22 | 1997-11-21 | METHODS AND COMPOUNDS FOR INHIBITING β-AMYLOID PEPTIDE RELEASE AND/OR SYNTHESIS |
Publications (1)
Publication Number | Publication Date |
---|---|
IL129083A0 true IL129083A0 (en) | 2000-02-17 |
Family
ID=27505670
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL12908397A IL129083A0 (en) | 1996-11-22 | 1997-11-21 | Methods and compounds for inhibiting beta-amyloid peptide release and/or its synthesis |
Country Status (21)
Country | Link |
---|---|
EP (1) | EP0942924A2 (en) |
JP (1) | JP2001503782A (en) |
KR (1) | KR20000069064A (en) |
CN (1) | CN1238779A (en) |
AR (1) | AR016751A1 (en) |
AU (1) | AU5356198A (en) |
BR (1) | BR9713400A (en) |
CA (1) | CA2267634A1 (en) |
CO (1) | CO4910156A1 (en) |
CZ (1) | CZ122899A3 (en) |
EA (1) | EA199900490A1 (en) |
HR (1) | HRP970627A2 (en) |
HU (1) | HUP0100270A3 (en) |
ID (1) | ID22044A (en) |
IL (1) | IL129083A0 (en) |
NO (1) | NO992368L (en) |
NZ (1) | NZ334690A (en) |
PE (1) | PE16999A1 (en) |
TR (3) | TR199901133T2 (en) |
WO (1) | WO1998022494A2 (en) |
YU (1) | YU46097A (en) |
Families Citing this family (50)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19616486C5 (en) | 1996-04-25 | 2016-06-30 | Royalty Pharma Collection Trust | Method for lowering the blood glucose level in mammals |
US6191166B1 (en) * | 1997-11-21 | 2001-02-20 | Elan Pharmaceuticals, Inc. | Methods and compounds for inhibiting β-amyloid peptide release and/or its synthesis |
US6635632B1 (en) | 1996-12-23 | 2003-10-21 | Athena Neurosciences, Inc. | Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds |
DE19823831A1 (en) | 1998-05-28 | 1999-12-02 | Probiodrug Ges Fuer Arzneim | New pharmaceutical use of isoleucyl thiazolidide and its salts |
US6552013B1 (en) | 1998-06-22 | 2003-04-22 | Elan Pharmaceuticals, Inc. | Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds |
US6958330B1 (en) | 1998-06-22 | 2005-10-25 | Elan Pharmaceuticals, Inc. | Polycyclic α-amino-ε-caprolactams and related compounds |
WO1999067219A1 (en) * | 1998-06-22 | 1999-12-29 | Elan Pharmaceuticals, Inc. | Compounds for inhibiting beta-amyloid peptide release and/or its synthesis |
EP1089980A1 (en) * | 1998-06-22 | 2001-04-11 | Elan Pharmaceuticals, Inc. | Compounds for inhibiting beta-amyloid peptide release and/or its synthesis |
AU4710499A (en) * | 1998-06-22 | 2000-01-10 | Elan Pharmaceuticals, Inc. | Cyclic amino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use ofsuch compounds |
DE19828113A1 (en) | 1998-06-24 | 2000-01-05 | Probiodrug Ges Fuer Arzneim | Prodrugs of Dipeptidyl Peptidase IV Inhibitors |
DE19828114A1 (en) | 1998-06-24 | 2000-01-27 | Probiodrug Ges Fuer Arzneim | Produgs of unstable inhibitors of dipeptidyl peptidase IV |
DE19834591A1 (en) | 1998-07-31 | 2000-02-03 | Probiodrug Ges Fuer Arzneim | Use of substances that decrease the activity of dipeptidyl peptidase IV to increase blood sugar levels, e.g. for treating hypoglycemia |
AU6278099A (en) * | 1998-09-30 | 2000-04-17 | Elan Pharmaceuticals, Inc. | Biological reagents and methods for determining the mechanism in the generation of beta-amyloid peptide |
US6737038B1 (en) | 1998-11-12 | 2004-05-18 | Bristol-Myers Squibb Company | Use of small molecule radioligands to discover inhibitors of amyloid-beta peptide production and for diagnostic imaging |
AU772575B2 (en) | 1998-12-10 | 2004-04-29 | F. Hoffmann-La Roche Ag | Procollagen C-proteinase inhibitors |
US6972296B2 (en) | 1999-05-07 | 2005-12-06 | Encysive Pharmaceuticals Inc. | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors |
US6723711B2 (en) | 1999-05-07 | 2004-04-20 | Texas Biotechnology Corporation | Propanoic acid derivatives that inhibit the binding of integrins to their receptors |
KR100767199B1 (en) * | 1999-05-07 | 2007-10-17 | 엔싸이시브 파마슈티칼즈 인코퍼레이티드 | Propanoic acid derivatives that inhibit the binding of integrins to their receptors |
DE19926233C1 (en) | 1999-06-10 | 2000-10-19 | Probiodrug Ges Fuer Arzneim | Production of thiazolidine, useful as pharmaceutical intermediate, comprises reacting hexamethylenetetramine with cysteamine |
DE19940130A1 (en) | 1999-08-24 | 2001-03-01 | Probiodrug Ges Fuer Arzneim | New effectors of Dipeptidyl Peptidase IV for topical use |
EP1235789A2 (en) * | 1999-11-09 | 2002-09-04 | Eli Lilly And Company | $g(b)-AMINOACID COMPOUNDS USEFUL FOR INHIBITING $g(b)-AMYLOID PEPTIDE RELEASE AND/OR ITS SYNTHESIS |
WO2001072290A2 (en) | 2000-03-31 | 2001-10-04 | Probiodrug Ag | Method for the improvement of islet signaling in diabetes mellitus and for its prevention |
AU2001261728A1 (en) | 2000-05-17 | 2001-11-26 | Bristol-Myers Squibb Pharma Company | Use of small molecule radioligands for diagnostic imaging |
BR0106717A (en) | 2000-06-01 | 2002-04-16 | Bristol Myers Squibb Pharma Co | Compounds, pharmaceutical composition and uses of innovative lactam compounds |
FR2832152A1 (en) * | 2001-11-09 | 2003-05-16 | Aventis Pharma Sa | New 2-amino-thiazoline derivatives having inducible NO-synthase inhibiting activity, useful for treating Parkinson's, cerebral disorders, migraines, depression, diabetes |
GB0016681D0 (en) | 2000-07-06 | 2000-08-23 | Merck Sharp & Dohme | Therapeutic compounds |
US6432944B1 (en) | 2000-07-06 | 2002-08-13 | Bristol-Myers Squibb Company | Benzodiazepinone β-amyloid inhibitors: arylacetamidoalanyl derivatives |
US7132104B1 (en) | 2000-10-27 | 2006-11-07 | Probiodrug Ag | Modulation of central nervous system (CNS) dipeptidyl peptidase IV (DPIV) -like activity for the treatment of neurological and neuropsychological disorders |
US6890905B2 (en) | 2001-04-02 | 2005-05-10 | Prosidion Limited | Methods for improving islet signaling in diabetes mellitus and for its prevention |
US20030130199A1 (en) | 2001-06-27 | 2003-07-10 | Von Hoersten Stephan | Dipeptidyl peptidase IV inhibitors and their uses as anti-cancer agents |
US7368421B2 (en) | 2001-06-27 | 2008-05-06 | Probiodrug Ag | Use of dipeptidyl peptidase IV inhibitors in the treatment of multiple sclerosis |
DE10150203A1 (en) | 2001-10-12 | 2003-04-17 | Probiodrug Ag | Use of dipeptidyl peptidase IV inhibitor in treatment of cancer |
AR039059A1 (en) | 2001-08-06 | 2005-02-09 | Sanofi Aventis | COMPOUND DERIVED FROM ACILAMINOTIAZOL, ITS USE, PROCEDURES TO PREPARE IT, PHARMACEUTICAL COMPOSITION THAT INCLUDES IT, AND INTERMEDIARY COMPOUNDS |
FR2840899B1 (en) * | 2002-06-12 | 2005-02-25 | Sanofi Synthelabo | ACYLAMINOTHIAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR USE IN THERAPEUTICS |
DE10143840A1 (en) * | 2001-09-06 | 2003-03-27 | Probiodrug Ag | New acylated hydroxamates useful for the treatment of e.g. wound healing |
US6844316B2 (en) | 2001-09-06 | 2005-01-18 | Probiodrug Ag | Inhibitors of dipeptidyl peptidase I |
PL370324A1 (en) | 2001-11-09 | 2005-05-16 | Aventis Pharma S.A. | 2-amino-thiazoline derivatives and their use as inhibitors of inducible no-synthase |
EA007434B1 (en) | 2002-02-28 | 2006-10-27 | Прозидион Лимитед | Glutaminyl based dpiv inhibitors |
CA2512582C (en) * | 2003-01-08 | 2014-07-08 | University Of Washington | Antibacterial agents |
DE602004026289D1 (en) | 2003-05-05 | 2010-05-12 | Probiodrug Ag | Glutaminyl INHIBITORS |
KR20060009902A (en) | 2003-05-05 | 2006-02-01 | 프로비오드룩 아게 | Use of effectors of glutaminyl and glutamate cyclases |
EP1666068A4 (en) * | 2003-09-24 | 2010-08-04 | Santen Pharmaceutical Co Ltd | Remedy for eye diseases accompanied by optic nerve injuries |
KR20120007079A (en) | 2003-10-15 | 2012-01-19 | 프로비오드룩 아게 | Use of effectors of glutaminyl and glutamate cyclases |
CN107021895A (en) | 2007-06-12 | 2017-08-08 | 尔察祯有限公司 | Antiseptic |
EP2062909A1 (en) * | 2007-11-21 | 2009-05-27 | SOLVAY (Société Anonyme) | Peptide production and purification process |
BG110141A (en) | 2008-05-23 | 2009-12-31 | "Софарма" Ад | Galanthamine derivatives, methods for their obtaining and use |
WO2013170165A1 (en) | 2012-05-10 | 2013-11-14 | Achaogen, Inc. | Antibacterial agents |
WO2017004560A1 (en) * | 2015-07-02 | 2017-01-05 | The Regents Of The University Of California | Methods and compositions for amyloid aggregates |
EP4274559A1 (en) * | 2021-01-05 | 2023-11-15 | Southern Research Institute | Modulators of programmed death-ligand-1 |
WO2024076635A2 (en) * | 2022-10-05 | 2024-04-11 | Buck Institute For Research On Aging | Suppressors of site iq electron leak and uses thereof |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1991013904A1 (en) * | 1990-03-05 | 1991-09-19 | Cephalon, Inc. | Chymotrypsin-like proteases and their inhibitors |
WO1995013084A1 (en) * | 1992-05-11 | 1995-05-18 | Miles Inc. | Cathepsin d is an amyloidogenic protease in alzheimer's disease |
CZ184194A3 (en) * | 1993-08-09 | 1995-03-15 | Lilly Co Eli | Aspartylprotease inhibitor and method of identifying thereof |
NZ274074A (en) * | 1993-10-01 | 1997-11-24 | Merrell Pharma Inc | Various dipeptide derivatives having a reduced carboxy group, the aldehyde being optionally substituted; pharmaceutical compositions |
US5804560A (en) * | 1995-01-06 | 1998-09-08 | Sibia Neurosciences, Inc. | Peptide and peptide analog protease inhibitors |
US5872101A (en) * | 1995-01-06 | 1999-02-16 | Sibia Neurosciences, Inc. | Methods of treating neurodegenerative disorders using protease inhibitors |
JPH11506923A (en) * | 1995-06-06 | 1999-06-22 | アセナ ニューロサイエンシーズ,インコーポレイテッド | New cathepsins and methods and compositions for their inhibition |
-
1997
- 1997-11-18 AR ARP970105393A patent/AR016751A1/en not_active Application Discontinuation
- 1997-11-19 HR HR08/808,528A patent/HRP970627A2/en not_active Application Discontinuation
- 1997-11-20 PE PE1997001056A patent/PE16999A1/en not_active Application Discontinuation
- 1997-11-21 CO CO97068215A patent/CO4910156A1/en unknown
- 1997-11-21 YU YU46097A patent/YU46097A/en unknown
- 1997-11-21 CA CA002267634A patent/CA2267634A1/en not_active Abandoned
- 1997-11-21 CN CN97199803A patent/CN1238779A/en active Pending
- 1997-11-21 TR TR1999/01133T patent/TR199901133T2/en unknown
- 1997-11-21 CZ CZ991228A patent/CZ122899A3/en unknown
- 1997-11-21 HU HU0100270A patent/HUP0100270A3/en unknown
- 1997-11-21 EP EP97950601A patent/EP0942924A2/en not_active Withdrawn
- 1997-11-21 NZ NZ334690A patent/NZ334690A/en unknown
- 1997-11-21 ID IDW990394A patent/ID22044A/en unknown
- 1997-11-21 WO PCT/US1997/020804 patent/WO1998022494A2/en not_active Application Discontinuation
- 1997-11-21 AU AU53561/98A patent/AU5356198A/en not_active Abandoned
- 1997-11-21 BR BR9713400-7A patent/BR9713400A/en not_active IP Right Cessation
- 1997-11-21 TR TR1999/02938T patent/TR199902938T2/en unknown
- 1997-11-21 KR KR1019997004486A patent/KR20000069064A/en not_active Application Discontinuation
- 1997-11-21 EA EA199900490A patent/EA199900490A1/en unknown
- 1997-11-21 IL IL12908397A patent/IL129083A0/en unknown
- 1997-11-21 JP JP52375698A patent/JP2001503782A/en active Pending
- 1997-11-21 TR TR1999/02937T patent/TR199902937T2/en unknown
-
1999
- 1999-05-14 NO NO992368A patent/NO992368L/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
PE16999A1 (en) | 1999-02-19 |
CN1238779A (en) | 1999-12-15 |
CZ122899A3 (en) | 1999-10-13 |
TR199902937T2 (en) | 2001-01-22 |
NZ334690A (en) | 2001-09-28 |
TR199902938T2 (en) | 2002-06-21 |
AR016751A1 (en) | 2001-08-01 |
JP2001503782A (en) | 2001-03-21 |
CA2267634A1 (en) | 1998-05-28 |
HUP0100270A3 (en) | 2001-09-28 |
NO992368D0 (en) | 1999-05-14 |
HUP0100270A2 (en) | 2001-08-28 |
NO992368L (en) | 1999-06-21 |
EA199900490A1 (en) | 2000-02-28 |
CO4910156A1 (en) | 2000-04-24 |
WO1998022494A2 (en) | 1998-05-28 |
EP0942924A2 (en) | 1999-09-22 |
KR20000069064A (en) | 2000-11-25 |
HRP970627A2 (en) | 1998-08-31 |
TR199901133T2 (en) | 1999-07-21 |
AU5356198A (en) | 1998-06-10 |
BR9713400A (en) | 2000-01-25 |
YU46097A (en) | 2000-10-30 |
ID22044A (en) | 1999-08-26 |
WO1998022494A3 (en) | 1998-11-26 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL129083A0 (en) | Methods and compounds for inhibiting beta-amyloid peptide release and/or its synthesis | |
AU4710199A (en) | Compounds for inhibiting beta-amyloid peptide release and/or its synthesis | |
AU4707999A (en) | Compounds for inhibiting beta-amyloid peptide release and/or its synthesis | |
IL129820A0 (en) | Cycloalkyl lactam lactone and related compounds as beta-amyloid peptide release inhibitors | |
HUP9901779A3 (en) | Modified release multiple-units dosage composition | |
IL130851A0 (en) | Heterocyclic compounds and their use for inhibiting beta-amyloid peptide | |
HUP9904697A3 (en) | Methods and compositions for immunomodulation | |
GB9707763D0 (en) | Anti-counterfeiting system | |
EP1015014A4 (en) | Methods and compositions for inhibiting angiogenesis | |
GB2309987B (en) | One-trip window-milling system | |
AU5204799A (en) | Compounds for inhibiting beta-amyloid peptide release and/or its synthesis | |
AU132926S (en) | Set of containers | |
IL126272A0 (en) | Synthesis of indolylmaleimides | |
AU1569501A (en) | Beta-aminoacid compounds useful for inhibiting beta-amyloid peptide release and/or its synthesis | |
IL128376A0 (en) | Synthesis of bisindolylmalimides | |
AU1569401A (en) | Beta-aminoacid compounds useful for inhibiting beta-amyloid peptide release and/or its synthesis | |
EP1038021A4 (en) | Compounds and methods for the inhibition of protein-protein interactions | |
GB9616563D0 (en) | Compounds and methods | |
PL324484A1 (en) | Tampering prevention system | |
GB2287942B (en) | Peptides for inhibiting pepsin release | |
ZA9710470B (en) | Methods and compounds for inhibitin ß-amyloid peptide release and/or its synthesis. | |
EP0934345A4 (en) | Compounds and methods | |
EP0923519A4 (en) | Synthesis of haloalkynol | |
PL313849A1 (en) | Beta-aminoesters of o-hydrobenzylamides | |
ZA979712B (en) | ICE inhibiting peptides |