HUT73419A - Process for preparing [1,2,4]triazolo[4,3-a]quinoxaline derivatives and pharmaceutical compositions containing them - Google Patents

Process for preparing [1,2,4]triazolo[4,3-a]quinoxaline derivatives and pharmaceutical compositions containing them Download PDF

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Publication number
HUT73419A
HUT73419A HU9502726A HU9502726A HUT73419A HU T73419 A HUT73419 A HU T73419A HU 9502726 A HU9502726 A HU 9502726A HU 9502726 A HU9502726 A HU 9502726A HU T73419 A HUT73419 A HU T73419A
Authority
HU
Hungary
Prior art keywords
triazolo
preparing
pharmaceutical compositions
compositions containing
quinoxaline derivatives
Prior art date
Application number
HU9502726A
Other languages
English (en)
Other versions
HU9502726D0 (en
Inventor
Poul Jacobsen
Lone Jeppesen
Flemming Elmelund Nielsen
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Publication of HU9502726D0 publication Critical patent/HU9502726D0/hu
Publication of HUT73419A publication Critical patent/HUT73419A/hu

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Description

Novo Nordisk A/S, BAGSVAERD, DÁNIA
A bejelentés napja: 1994. 02. 25.
Elsőbbsége: 1993. 03. 19. (0310/93)
DÁNIA
A nemzetközi bejelentés száma: PCT/DK94/00077
A nemzetközi közzététel száma: WO 94/21639 t , d'Á /
A találmány tárgya az <(I) általános képlettel jellemezhető vegyületek és azok gyógyszerészetileg elfogadható sói, ahol r1 jelentése COX'-csoport, POX'X''-csoport, vagy olyan egyenesláncú vagy elágazásos 1-6 szénatomot tartalmazó alkil-csoport, mely egy COX'-csoporttal vagy POX'X',-csoporttal van szubsztituálva, ahol X' és X1' jelentése egymástól függetlenül hidroxi-csoport vagy 1-6 szénatomot tartalmazó alkoxi-csoport, és
R6, R7, R3 és R9 jelentése egymástól függetlenül hidrogénatom, 1-6 szénatomot tartalmazó alkil-csoport, halogénatom, ~NH2-csoport, -NO2-csoport, -CN-csoport, -CF3-csoport, -SO2NY'Y''-csoport vagy -COZ'-csoport, ahol Z' jelentése -NY’Y''-csoport vagy 1-6 szénatomot tartalmazó alkil1
-csoport és Y' és Y''egymástól függetlenül hidrogénatom, 1
- 6 szénatomot tartalmazó alkil-csoport, triazolil-csoport, imidazolil-csoport, fenil-csoporttal vagy 1-6 szénatomot tartalmazó alkil-csoporttal szubsztituált imidazolil-csoport, vagy
R6 és R7 vagy R8 és R9 együttesen egy további egybeolvadt gyűrűt alkot.
2. Az 1. igénypont

Claims (2)

  1. jellemezve, hogy bennük szerinti kinoxalin vegyületek, azzal az összeolvadt gyűrű egy benzén-gyúrű.
    3. Egy, az 1. vagy a 2. igénypont szerinti vegyület, mely a következő vegyületek egyike:^ ’ 1 <
    C ru
    KÖZZÉTÉTELI y :
    S.B.G. & K
    Nemzetközi
    Szabadalmi Iroda
    H-1062 Budapest, Andrásey út 113.
    Telefon: 34-24-950, Fax: 34-Í4-3J3
    Novo Nordisk A/S, BAGSVAERD, DÁNIA
    Feltalálók: JACOBSEN Poul,
    SLANGERUP,
    NIELSEN Flemming Elmelund, VIRUM,
    JEPPESEN Lőne,
    VIRUM,
    DÁNIA
    A bejelentés napja: 1994.
  2. 02. 25 .
    Elsőbbsége:
HU9502726A 1993-03-19 1994-02-25 Process for preparing [1,2,4]triazolo[4,3-a]quinoxaline derivatives and pharmaceutical compositions containing them HUT73419A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK93310A DK31093D0 (hu) 1993-03-19 1993-03-19

Publications (2)

Publication Number Publication Date
HU9502726D0 HU9502726D0 (en) 1995-11-28
HUT73419A true HUT73419A (en) 1996-07-29

Family

ID=8092112

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9502726A HUT73419A (en) 1993-03-19 1994-02-25 Process for preparing [1,2,4]triazolo[4,3-a]quinoxaline derivatives and pharmaceutical compositions containing them

Country Status (16)

Country Link
US (1) US5559106A (hu)
EP (1) EP0691969A1 (hu)
JP (1) JPH08507536A (hu)
KR (1) KR100313051B1 (hu)
CN (1) CN1041930C (hu)
AU (1) AU685783B2 (hu)
CA (1) CA2158545A1 (hu)
DK (1) DK31093D0 (hu)
FI (1) FI954386A0 (hu)
HU (1) HUT73419A (hu)
IL (1) IL108800A (hu)
NO (1) NO305286B1 (hu)
NZ (1) NZ262365A (hu)
TW (1) TW304195B (hu)
WO (1) WO1994021639A1 (hu)
ZA (1) ZA941926B (hu)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4314592A1 (de) * 1993-04-28 1994-11-03 Schering Ag Benzo(f)chinoxalindionderivate, deren Herstellung und Verwendung in Arzneimitteln
ATE190616T1 (de) * 1994-09-16 2000-04-15 Novo Nordisk As (1,2,4)triazolo(4,3-a)chinoxylinonderivate, ihre darstellung und verwendung als antagonisten von ampa-rezeptoren
JPH10506620A (ja) * 1994-09-16 1998-06-30 ノボ ノルディスク アクティーゼルスカブ 〔１，２，４〕トリアゾロ〔４，３−ａ〕キノキサリノン誘導体、それらの調製方法及び使用
US5679680A (en) * 1995-02-16 1997-10-21 Warner-Lambert Company α-substituted hydrazides having calpain inhibitory activity
FR2743363A1 (fr) * 1996-01-10 1997-07-11 Rhone Poulenc Rorer Sa 5h,10h-imidazo(1,2-a)indeno(1,2-e)pyrazine-a-ones substituees en position 2, leur preparation et les medicaments les contenant
IL125950A0 (en) * 1997-09-05 1999-04-11 Pfizer Prod Inc Methods of administering ampa receptor antagonists to treat dyskinesias associated with dopamine agonist therapy
WO1999024434A1 (en) 1997-11-11 1999-05-20 Ono Pharmaceutical Co., Ltd. Fused pyrazine compounds
AU2298399A (en) * 1998-02-06 1999-08-23 Yoshitomi Pharmaceutical Industries, Ltd. Novel azapeptide type hydroxamic acid derivatives
US20040152694A1 (en) * 2003-02-04 2004-08-05 Istvan Kurucz Methods and compositions for treating inflammatory disorders of the airways
WO2008072779A1 (ja) * 2006-12-13 2008-06-19 Aska Pharmaceutical Co., Ltd. キノキサリン誘導体
AU2010219598A1 (en) 2009-03-05 2011-09-22 Astellas Pharma Inc. Quinoxaline compounds
EP2338492A1 (en) 2009-12-24 2011-06-29 Universidad del Pais Vasco Methods and compositions for the treatment of alzheimer
CA2810659A1 (en) 2010-09-07 2012-03-15 Astellas Pharma Inc. Quinoxaline compound
EP2723744B1 (en) * 2011-06-27 2016-03-23 Janssen Pharmaceutica, N.V. 1-ARYL-4-METHYL-[1,2,4]TRIAZOLO[4,3-a]QUINOXALINE DERIVATIVES
ES2855575T3 (es) 2012-06-26 2021-09-23 Janssen Pharmaceutica Nv Combinaciones que comprenden compuestos de 4-metil-[1,2,4]triazolo[4,3-a]quinoxalina como inhibidores de PDE2 e inhibidores de PDE10 para su uso en el tratamiento de trastornos neurológicos o metabólicos

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4354027A (en) * 1980-05-19 1982-10-12 Usv Pharmaceutical Corporation Triazoloquinoxalin-4-ones
US4547501A (en) * 1983-09-02 1985-10-15 Pfizer Inc. Method of using [1,2,4]triazolo[4,3-a]quinoxaline-4-amine derivatives as antidepressant and antifatigue agents
US5153196A (en) * 1991-06-05 1992-10-06 Eli Lilly And Company Excitatory amino acid receptor antagonists and methods for the use thereof
AU3767793A (en) * 1992-04-03 1993-11-08 Yamanouchi Pharmaceutical Co., Ltd. Fused quinoxalinone derivative and pharmaceutical composition containing the same

Also Published As

Publication number Publication date
IL108800A (en) 1998-02-22
KR100313051B1 (ko) 2002-02-28
HU9502726D0 (en) 1995-11-28
IL108800A0 (en) 1994-06-24
AU685783B2 (en) 1998-01-29
EP0691969A1 (en) 1996-01-17
US5559106A (en) 1996-09-24
CN1041930C (zh) 1999-02-03
DK31093D0 (hu) 1993-03-19
ZA941926B (en) 1995-09-18
TW304195B (hu) 1997-05-01
NO953673D0 (no) 1995-09-18
WO1994021639A1 (en) 1994-09-29
CN1122601A (zh) 1996-05-15
NO305286B1 (no) 1999-05-03
JPH08507536A (ja) 1996-08-13
FI954386A (fi) 1995-09-18
FI954386A0 (fi) 1995-09-18
NZ262365A (en) 1997-05-26
NO953673L (no) 1995-11-17
KR960701057A (ko) 1996-02-24
CA2158545A1 (en) 1994-09-29
AU6201894A (en) 1994-10-11

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