HUT73320A - A method of detecting the presence of and converting of a polypeptide - Google Patents

A method of detecting the presence of and converting of a polypeptide Download PDF

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Publication number
HUT73320A
HUT73320A HU9503020A HU9503020A HUT73320A HU T73320 A HUT73320 A HU T73320A HU 9503020 A HU9503020 A HU 9503020A HU 9503020 A HU9503020 A HU 9503020A HU T73320 A HUT73320 A HU T73320A
Authority
HU
Hungary
Prior art keywords
growth hormone
hgh
hydrophobic
derivative
rhgh
Prior art date
Application number
HU9503020A
Other languages
English (en)
Hungarian (hu)
Other versions
HU9503020D0 (en
Inventor
Thorkild Christensen
Hans Holmegaard Sorensen
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Publication of HU9503020D0 publication Critical patent/HU9503020D0/hu
Publication of HUT73320A publication Critical patent/HUT73320A/hu

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormone [GH], i.e. somatotropin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/575—Hormones
    • G01N2333/61—Growth hormones [GH] (Somatotropin)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Endocrinology (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HU9503020A 1993-04-20 1994-04-19 A method of detecting the presence of and converting of a polypeptide HUT73320A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK93445A DK44593D0 (da) 1993-04-20 1993-04-20 Fremgangsmaade til fremstilling af et polypeptid

Publications (2)

Publication Number Publication Date
HU9503020D0 HU9503020D0 (en) 1995-12-28
HUT73320A true HUT73320A (en) 1996-07-29

Family

ID=8093625

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9503020A HUT73320A (en) 1993-04-20 1994-04-19 A method of detecting the presence of and converting of a polypeptide

Country Status (14)

Country Link
EP (1) EP0695310A1 (da)
JP (1) JPH08508735A (da)
KR (1) KR960701891A (da)
AU (1) AU6535594A (da)
BG (1) BG100068A (da)
CA (1) CA2160663A1 (da)
CZ (1) CZ272895A3 (da)
DK (1) DK44593D0 (da)
FI (1) FI955000A0 (da)
HU (1) HUT73320A (da)
IL (1) IL109347A0 (da)
NO (1) NO954181L (da)
PL (1) PL311198A1 (da)
WO (1) WO1994024157A1 (da)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9802454D0 (sv) * 1998-07-08 1998-07-08 Pharmacia & Upjohn Ab Production of peptides
CN1697839B (zh) * 2002-08-28 2010-10-27 法玛西亚公司 同工型杂质水平较低的生长激素及其拮抗剂的制备方法
US20040048315A1 (en) 2002-08-28 2004-03-11 Pharmacia Corporation Method for the preparation of growth hormone and antagonist thereof having lower levels of isoform impurities thereof
HK1079798B (zh) * 2002-09-20 2010-11-19 法玛西亚公司 降低peg化蛋白的聚集体水平的方法
US7470779B2 (en) * 2002-09-20 2008-12-30 Pfizer Inc. Process for decreasing aggregate levels of pegylated protein
ATE463503T1 (de) 2004-12-29 2010-04-15 Novo Nordisk Healthcare Ag Verfahren zur verhinderung der bildung von trisulfidderivaten von polypeptiden
EP2483289B2 (en) 2009-10-02 2025-03-26 Biogen MA Inc. Methods of preventing and removing trisulfide bonds
US9562252B2 (en) 2011-05-13 2017-02-07 Biogen Ma Inc. Methods of preventing and removing trisulfide bonds

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4985544A (en) * 1987-08-04 1991-01-15 Kyowa Hakko Kogyo Co., Ltd. Process for renaturing fish growth hormone
US5079230A (en) * 1988-09-12 1992-01-07 Pitman-Moore, Inc. Stable bioactive somatotropins
ES2119779T3 (es) * 1990-09-05 1998-10-16 Southern Cross Biotech Pty Ltd Solubilizacion de proteinas en formas activas.
US5151501A (en) * 1991-12-20 1992-09-29 American Cyanamid Company Method for solubilization and naturation of somatotropins utilizing sulfolane

Also Published As

Publication number Publication date
JPH08508735A (ja) 1996-09-17
HU9503020D0 (en) 1995-12-28
CZ272895A3 (en) 1996-03-13
FI955000L (fi) 1995-10-19
WO1994024157A1 (en) 1994-10-27
NO954181D0 (no) 1995-10-19
CA2160663A1 (en) 1994-10-27
AU6535594A (en) 1994-11-08
EP0695310A1 (en) 1996-02-07
NO954181L (no) 1995-10-19
IL109347A0 (en) 1994-07-31
DK44593D0 (da) 1993-04-20
PL311198A1 (en) 1996-02-05
FI955000A7 (fi) 1995-10-19
FI955000A0 (fi) 1995-10-19
KR960701891A (ko) 1996-03-28
BG100068A (bg) 1996-12-31

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Legal Events

Date Code Title Description
DFC4 Cancellation of temporary protection due to refusal