HUT72027A - Insecticidal compositions - Google Patents

Description

The present invention relates to novel insecticidal compositions. More particularly, the present invention relates to compositions which are useful for the control of insect pests, particularly those involved in the transmission of diseases, and thus human and animal health.

are effective against both adult and immature forms of dipteran insect pests (diptera).

It is well known that certain species of flying insects contribute to the transmission of disease and thus endanger the health and well-being of humans and animals. Typical examples of such pests are dipterous insects, such as domestic flies (Musca domestica), which feed on food waste, faeces, animal carcasses and the like, contaminating bacteria and similar microorganisms, some of which may subsequently be transmitted for human or animal consumption; and meat flies (Chrysoma megacephala), which parasitize food-producing domestic animals such as cattle, sheep, goats, pigs and poultry, especially when they are reared indoors.

To date, such insect pests have typically been treated with adult flying insect attack treatments, such as spraying insecticidal insecticide on insect feeding sites (such as rubbish heaps), or draping with paper adhesives in dwelling houses or sheds. However, these treatments are less suitable for controlling insect larvae because they are usually hidden during feeding and do not easily come into contact with the deposited spray material. For example, larval insects can be controlled by so-called insect growth regulators (RNAs), which act by interrupting the normal process of molting that leads to the transition from one larval state to another and thus the development of a puppet state and an infant state. However, these treatments are completely ineffective against adult insects.

FIELD OF THE INVENTION The present invention relates to novel compositions comprising insecticidal active ingredients in combination with each other, which are suitable for combating both the larvae and the adult forms of the aforementioned insect pests.

The present invention thus relates to a solid insecticidal composition comprising two insecticidal agents together with bait attracting insects. In the composition of the present invention, one insecticidal agent is an insecticidal agent effective against larval insects, the other insecticidal agent is a direct insecticidal, insecticidal and insecticidal agent, and insect-attracting baits for larvae and adult insects. material.

These compositions are preferably used in the form of granules to be applied to the area to be treated.

A wide variety of insecticidal agents can be used in the compositions of the invention. Examples of insecticidal active ingredients (insecticidal active ingredients as ISO Internationally Accepted Names) include flufenoxuron, triflumuron, ciromazine, diafenthiuron, hexaflumuron, diflubenzuron, piriproxuron, hydramethylone, methoprene and hydroprene. Examples of direct toxic insecticidal agents include carbamate insecticides such as propoxur, carbosulfan and bendiocarb; organophosphorus compounds having insecticidal activity, such as fenthion, azamethiphos, diazinon, chlorpyrifos, methomyl, propetamphos, pyrimiphos-methyl and phenitrothion; and pyrethroid insecticides such as permethrin, cypermethrin, alpha-cypermethrin, zeta-cypermethrin, deltamethrin, tralomethrin, cyfluthrin, beta-cyfluthrin, cyhalothrin, lambda-cyhalothrin, flucitrinate, fenvalerate, and esfenvalerate. The foregoing is intended only to illustrate the insecticidal agents useful in the compositions of the present invention and is not to be construed as an exhaustive list, so that one of the classes of insecticides listed above exemplifying each class may be substituted by one skilled in the art.

A preferred representative of the RNAs for use in the compositions of the present invention is piriproxyphene (Chemical name: 2- (1-methyl-2- / 4-phenoxyphenoxy / ethoxy) pyridine). Preferred toxic agents include cypermethrin, permethrin, fenvalerate, deltamethrin, lambdacihalotrin, pyrimiphos-methyl and chlorpyrifos-methyl.

The insect-attracting baits may preferably be sucrose or other crystalline sugars attractive to insects.

A particularly advantageous combination is obtained using piriproxifene as the RNA substance, lambda-cyhalothrin or pirimiphos-methyl as the toxic agent, and sucrose as the bait.

The compositions of the invention may be in the form of solid powders or, preferably, granules. Sugar-based granules containing precisely controlled amounts of the two active ingredients can produce optimum effect even after a single application. Not only do these granules act as highly attractive food for adult insects, they also provide a soluble, slowly depleting carrier for the active ingredients.

In addition to the two insecticidal agents and the bait material, the compositions of the present invention may optionally contain other ingredients, such as pheromone-type insecticides and dyes, to enhance the attractiveness of the composition to the target insect. For example, készítmény-9-tricosene may be added to the pheromone composition to enhance the attractiveness of house flies (Musca domestica). The yellow or red color that can be achieved with, for example, oil-soluble dyes (such as the Waxoline-yellow dye from ZENECA Ltd. (trademarked as Waxoline)) also makes the formulation more attractive to target insects.

The compositions of the invention may also contain bitter ingredients to discourage untargeted poultry and mammals (including humans) from accidentally ingesting the granules. An example of a suitable bitter raw material is denatonium benzoate, marketed as Bitrex (trademark).

Additives such as solid diluents and fillers, surfactants, and solvents may also be added to facilitate the processing of the components and to facilitate the formulation process. Surfactants can be anionic, cationic or nonionic. Particularly preferred surfactants have been long-chain phenyl sulfonates, such as calcium dodecylbenzene sulfonate (phenyl sulfonate CALX). Solid diluents and fillers include, for example, powdered silica, diatomaceous earth, and clays (such as montmorillonite). Suitable solvents include solubilizing fluids for insecticidal agents and other compounds to provide a uniform coating on the carrier. Glycol diesters, such as propylene glycol diacetate, are particularly preferred as solvents for formulations containing piriproxifen and a pyrethroid as active ingredients.

The granulate compositions of the present invention can be prepared by conventional mechanical mixing methods, wherein the components are loaded into an apparatus which produces granules after agglomeration. Examples of such equipment are pan granulators, rotary drum granulators, and various mix granules such as Sigma mixers, Lodige mixers, Fielder matrix mixers and Shugi mixers. The granulate formulations may also be formulated using blending gas, such as fluid bed granulators, or compression techniques, such as tabletting or pelleting machines, or extrusion, such as knife, screw, extruder or marummer extrusion.

A typical method of preparing the granules of the invention by the agglomeration method is as follows:

(i) mixing the active ingredients in appropriate proportions with a solid diluent or carrier, such as silica powder, to form a powder concentrate; (ii) mixing the dry ingredients with a granulate method, such as those listed above, while adding the agglomeration to the dry mixture; (iii) the mixing operation is continued until the granules of the desired size range are formed, and (iv) the water is removed from the granules by drying.

In our studies of the efficacy of the compositions of the present invention, it has surprisingly been found that when the composition is used in the form of granules, it is preferred that the size of the majority of the granules be within a predetermined range. This range is determined by the extent to which the target insect has access to a food product that it uses as a food source and to which it can feed sufficiently long enough to consume a lethal dose. The size range of the granules of the composition can be controlled by methods well known in the art of granulation technology.

Preferably, therefore, granules of a size within the defined range that are found to be more attractive to the flies are formed. This size range will vary depending on the species of insect pest to be attracted to the composition. For mature domestic flies (Musca domestica), the granules preferably have a size of 500 to 10,000, especially 2500 to 3500.

Further details of the compositions of the invention are given in the Examples.

When used, the compositions have been shown to be effective against both larvae and adult forms of insect pests, such as Musca domestica and Chrysoma megacephala.

Accordingly, the present invention also relates to a method for combating larval and adult insect pests by treating a pest site with a composition of the invention.

The compositions of the present invention may be well incorporated into bait spraying bait stations or by applying an aqueous solution to the target surface by staining. Because of the presence of a sugar substrate, flies are attracted to the compositions and this attraction can be further enhanced by visual or chemical callouts (dyes or, for example, sex hormones acting on Musca types, such as Z-9-tricosene). Particularly effective are yellow and red preparations.

Adult flies in contact with or feeding on the compositions of the present invention will rapidly degrade and die. The granules dissolve over time, releasing the active ingredients and dispersing them in the larvae medium, thus killing or interrupting the development of the larvae. In our studies, it was found that applying a composition of piriproxifen and lambda-cyhalothrin according to the invention to a stable fertilizer based substrate at 100 mg / m 2 for 2 months completely inhibited the development of Musca domestica and Chrysoma megacephala.

Further details of the invention are set forth in the Examples. Unless otherwise stated, the portions given in the examples are parts by weight.

Example 1

Preparation of Coated Granules A mixture of one part propylene glycol diacetate, one part calcium dodecylbenzene sulphonate, 5 parts piriproxifen and 1 part lambda-cyhalothrin was kept at 50 ° C until a clear solution was formed, and this solution was slowly added to a rotating drum. sugar granules. Rotation of the drum was continued until the granules were uniformly coated.

. example

Preparation of a composition containing pheromone

The composition was prepared according to the procedure described in Example 1, except that 0.5 parts of Ζ-9-tricosene were added to the mixture prior to coating the granules.

. example

Production of yellow granules

The formulation was prepared according to the procedure described in Example 1, except that 0.1 parts of Waxoline-yellow GFW (trademarked as Waxoline) were added to the mixture prior to coating the granules.

Example 4

Preparation of granules containing bitter raw materials which reduce the risk of accidental consumption by non-target birds and mammals

The composition was prepared according to the procedure described in Example 1, except that 0.025 parts of denatonium benzoate was dissolved in propylene glycol diacetate at room temperature before adding the other components.

Example 5

Preparation of a composition containing an organophosphorus compound

The composition was prepared according to the procedure described in Example 1, except that 10 parts of pirimiphos-methyl was used instead of lambda-cyhalothrin.

Example 6

Granule Preparation Part lambda-cyhalothrin was mixed with 25 parts piriproxyphene and 1000 parts FK320 grade silica and this premix was dry blended with 2.5 parts Ζ-9-tricosene, 0.1 part denatonium benzoate, 0.5 part Monolyte yellow GNV dye (trademarked as Monolyte) and 8967 parts of fine, sucrose of candy sugar. The mixture was filled into a granulating pan, carefully added with little water, and the pan was rotated until most of the granules reached a particle size of 2800-3350 μιη. Then the water was removed from your granulate by drying and the fine particle fraction was sieved.

Claims (12)

CLAIMS 1. A solid insecticidal composition comprising a mixture of two insecticidal agents, together with bait attracting insects, characterized in that the composition is a first insecticidal agent for controlling larval insects and a second insecticidal agent for direct insecticide. contains insecticidal and insecticidal material, and attractant lures for both larvae and adult insects as bait attracting insects. Composition according to claim 1, characterized in that it contains piriproxifene as the first insecticidal agent. 3. A composition according to claim 1, wherein the second insecticidal agent is a pyrethroid or an organophosphorus compound. Composition according to claim 3, characterized in that it contains lambda-cyhalothrin as pyrethroid. Composition according to claim 1, characterized in that it contains sucrose as an attractive bait for insects. Composition according to claim 5, characterized in that the sucrose is in the form of granules. 7. A composition according to claim 6, characterized in that it comprises granules having a size of 2500-3500 μιη. 8. The composition of claim 1 further comprising an insect attractant of the pheromone type which is attractive to insects. 9. The composition of claim 8, wherein the pheromone-type insect attractant is Ζ-9-tricosene. 10. The composition of claim 1, wherein the composition further comprises a colorant red or yellow. 11. A process for preparing a composition according to claim 1 in the form of granules, comprising (a) mixing a first and second insecticidal agent in a suitable proportion with a solid diluent or carrier to form a powder concentrate, (b) mixing the powder concentrate in a granulating device; bait attracting insects and any additional additives, while adding to the dry mixture an amount of water that allows agglomeration, (c) the operation is continued until granules of the desired range are formed, and (d) the water is removed from the granules by drying. 12. A method for co-eradicating larval and adult insect pests comprising treating the pests with an effective amount of a composition according to claim 1.