HUT64328A - Process for producing angiotensine ii antagonist imidazole derivatives and pharmaceutical preparations containing these compounds - Google Patents
Process for producing angiotensine ii antagonist imidazole derivatives and pharmaceutical preparations containing these compoundsInfo
- Publication number
- HUT64328A HUT64328A HU9301603A HU9301603A HUT64328A HU T64328 A HUT64328 A HU T64328A HU 9301603 A HU9301603 A HU 9301603A HU 9301603 A HU9301603 A HU 9301603A HU T64328 A HUT64328 A HU T64328A
- Authority
- HU
- Hungary
- Prior art keywords
- angiotensine
- antagonist
- compounds
- producing
- pharmaceutical preparations
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/88—Nitrogen atoms, e.g. allantoin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Diabetes (AREA)
- Psychiatry (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US89286792A | 1992-06-03 | 1992-06-03 | |
US08/049,917 US5401851A (en) | 1992-06-03 | 1993-04-20 | Angiotensin II antagonists |
Publications (2)
Publication Number | Publication Date |
---|---|
HU9301603D0 HU9301603D0 (en) | 1993-09-28 |
HUT64328A true HUT64328A (en) | 1993-12-28 |
Family
ID=26727701
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU9301603A HUT64328A (en) | 1992-06-03 | 1993-06-01 | Process for producing angiotensine ii antagonist imidazole derivatives and pharmaceutical preparations containing these compounds |
Country Status (16)
Country | Link |
---|---|
US (2) | US5401851A (hu) |
EP (1) | EP0573271A1 (hu) |
JP (1) | JPH07304752A (hu) |
CN (1) | CN1045768C (hu) |
AU (1) | AU667903B2 (hu) |
CA (1) | CA2097462A1 (hu) |
CZ (1) | CZ104493A3 (hu) |
FI (1) | FI932517A (hu) |
HU (1) | HUT64328A (hu) |
IL (1) | IL105877A (hu) |
MY (1) | MY131434A (hu) |
NO (1) | NO932005L (hu) |
NZ (1) | NZ247769A (hu) |
PL (1) | PL173340B1 (hu) |
RU (1) | RU2110515C1 (hu) |
TW (1) | TW235295B (hu) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0656356A1 (en) * | 1992-08-21 | 1995-06-07 | Japan Tobacco Inc. | Dioxacycloalkane compound with renin-inhibiting activity |
DE4302957A1 (de) * | 1993-02-03 | 1994-08-04 | Bayer Ag | Imidazolyl-substituierte Phenylessigsäureprolinamide |
US5344937A (en) * | 1993-04-20 | 1994-09-06 | Eli Lilly And Company | Alkyl substituted nitroimidazole acetic acids |
ES2076085B1 (es) * | 1993-06-15 | 1997-03-01 | Lilly Co Eli | Antagonistas de angiotensina ii. |
FR2728570B1 (fr) * | 1994-12-23 | 1997-04-11 | Synthelabo | Derives de 1-oxo-2-(phenylsulfonylamino)pentylpiperidine, leur preparation et leur application en therapeutique |
TW375612B (en) * | 1995-04-06 | 1999-12-01 | Janssen Pharmaceutica Nv | 1,3-dihydro-2H-imidazol-2-one derivatives for the treatment of disease states related to an abnormal enzymatic or catalytic activity of phosphodiesterase type IV, preparation thereof and pharmaceutical composition containing the same |
US5972984A (en) * | 1995-06-06 | 1999-10-26 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
EP0881218B1 (en) * | 1995-12-27 | 2003-10-22 | Mitsubishi Pharma Corporation | Preventives/remedies for complications of diabetes |
AU716381B2 (en) * | 1996-04-03 | 2000-02-24 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
US5874452A (en) * | 1996-04-03 | 1999-02-23 | Merck & Co., Inc. | Biheteroaryl inhibitors of farnesyl-protein transferase |
JP2000507589A (ja) * | 1996-04-03 | 2000-06-20 | メルク エンド カンパニー インコーポレーテッド | ファルネシル―タンパク質転移酵素の阻害剤 |
US6309975B1 (en) | 1997-03-14 | 2001-10-30 | Micron Technology, Inc. | Methods of making implanted structures |
US6329342B1 (en) | 1997-08-19 | 2001-12-11 | Eli Lilly And Company | Treatment of congestive heart failure with growth hormone secretagogues |
US6639076B1 (en) | 1998-08-18 | 2003-10-28 | Eli Lilly And Company | Growth hormone secretagogues |
US6828331B1 (en) | 1999-02-19 | 2004-12-07 | Eli Lilly And Company | Growth hormone secretagogues |
CA2363792C (en) | 1999-02-19 | 2009-10-27 | Takeda Chemical Industries, Ltd. | Percutaneous absorption preparation of compound having angiotensin ii antagonistic activity |
WO2001096313A1 (en) * | 2000-06-14 | 2001-12-20 | The Scripps Research Institute | Distamycin a analogs |
GT200100147A (es) * | 2000-07-31 | 2002-06-25 | Derivados de imidazol | |
US6756385B2 (en) * | 2000-07-31 | 2004-06-29 | Pfizer Inc. | Imidazole derivatives |
JP2004525155A (ja) * | 2001-03-29 | 2004-08-19 | スミスクライン・ビーチャム・コーポレイション | ピロリジンスルホンアミド |
EP1379519A1 (en) * | 2001-03-29 | 2004-01-14 | SmithKline Beecham Corporation | Pyrrolidine sulfonamides |
US7125840B2 (en) * | 2001-10-09 | 2006-10-24 | Eli Lilly And Company | Substituted dipeptides as growth hormone secretagogues |
US20060167268A1 (en) * | 2002-04-09 | 2006-07-27 | Eli Lilly And Company, Patent Division, | Growth hormone secretagogues |
ES2271557T3 (es) * | 2002-04-09 | 2007-04-16 | Eli Lilly And Company | Secretagogos dipeptidicos de la hormona del crecimiento. |
US20050113450A1 (en) * | 2002-08-23 | 2005-05-26 | Atli Thorarensen | Antibacterial agents |
WO2004031118A1 (ja) * | 2002-10-03 | 2004-04-15 | Ono Pharmaceutical Co., Ltd. | Lpa受容体拮抗剤 |
RS50595B (sr) | 2004-03-23 | 2010-05-07 | Pfizer Products Incorporated | Jedinjenja imidazola za lečenje neurodegenerativnih poremećaja |
US20070010454A1 (en) * | 2005-07-06 | 2007-01-11 | Moridani Majid Y | Method for treating tumor cells resulting in minimal liver toxicity |
EP1940802A2 (en) | 2005-09-22 | 2008-07-09 | Pfizer Products Inc. | Imidazole compounds for the treatment of neurological disorders |
US20110098482A1 (en) * | 2009-10-26 | 2011-04-28 | Wenxue Wu | Methods of preparing 1-(4-((1r,2s,3r)-1,2,3,4-tetrahydroxybutyl)-1h-imidazol-2-yl)ethanone |
EP2937330A1 (en) * | 2010-11-22 | 2015-10-28 | Invista Technologies S.a r.l. | Production of aromatic carboxylic acids |
NL1038473C2 (en) * | 2010-12-24 | 2012-06-27 | Centre Nat Rech Scient | Cancer targeting using carbonic anhydrase isoform ix inhibitors. |
CN102219636A (zh) * | 2011-04-26 | 2011-10-19 | 巨化集团公司 | 一种含氟碘代烷的合成方法 |
CN107011229B (zh) * | 2012-01-06 | 2019-11-05 | 诺华股份有限公司 | 杂环化合物和它们的使用方法 |
RU2475243C1 (ru) * | 2012-02-16 | 2013-02-20 | Федеральное государственное бюджетное учреждение науки Новосибирский институт органической химии им. Н.Н. Ворожцова Сибирского отделения Российской академии наук (НИОХ СО РАН) | Средство, обладающее антигипертензивной активностью |
JP6667551B2 (ja) * | 2015-01-13 | 2020-03-18 | ノバルティス アーゲー | アンジオテンシンii2型拮抗薬としてのピロリジン誘導体 |
CN107857691A (zh) * | 2017-10-30 | 2018-03-30 | 大丰跃龙化学有限公司 | 一种一氟一碘甲烷制备的新方法 |
Family Cites Families (42)
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CH528514A (de) * | 1969-05-22 | 1972-09-30 | Bayer Ag | Verfahren zur Herstellung von Acylimidazolen |
US3737422A (en) * | 1970-02-04 | 1973-06-05 | Abbott Lab | L-histidyl-l-proline amide |
DE2220906A1 (de) * | 1972-04-28 | 1973-11-15 | Boehringer Sohn Ingelheim | Neue substituierte 2-phenylaminoimidazoline-(2), deren saeureadditionssalze sowie verfahren zu deren herstellung |
GB1547564A (en) * | 1975-06-05 | 1979-06-20 | Lilly Industries Ltd | Acylated amino-heteroaryl compounds |
DE2862340D1 (en) * | 1978-02-01 | 1983-11-24 | Wellcome Found | Imidazole derivatives and salts thereof, their synthesis, and pharmaceutical formulations thereof |
JPS54148788A (en) * | 1978-05-15 | 1979-11-21 | Takeda Chem Ind Ltd | 1,2-disubstituted-4-halogenoimidazole-5-acetic acid derivative and its preparation |
JPS55313A (en) * | 1978-06-13 | 1980-01-05 | Kissei Pharmaceut Co Ltd | Imidazole derivative |
DK531479A (da) * | 1979-01-19 | 1980-07-20 | Pfizer | Fremgangsmaade til fremstilling af imidazolderivater og salte deraf |
AU518569B2 (en) * | 1979-08-07 | 1981-10-08 | Farmos-Yhtyma Oy | 4-benzyl- and 4-benzoyl imidazole derivatives |
JPS5671074A (en) * | 1979-11-12 | 1981-06-13 | Takeda Chem Ind Ltd | 1,2-disubstituted-4-halogenoimidazole-5-acetic acid derivative |
JPS5671073A (en) * | 1979-11-12 | 1981-06-13 | Takeda Chem Ind Ltd | Imidazole derivative |
US4299769A (en) * | 1980-04-28 | 1981-11-10 | American Cyanamid Company | ω-Heteroaroyl(propionyl or butyryl)-L-prolines |
GB2092569B (en) * | 1981-02-05 | 1984-09-19 | Farmos Oy | Substituted imidazole derivatives and their preparation and use |
DE3106150A1 (de) * | 1981-02-13 | 1982-09-16 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | "verfahren zur herstellung von imidazolessigsaeurederivaten" |
GB2101114B (en) * | 1981-07-10 | 1985-05-22 | Farmos Group Ltd | Substituted imidazole derivatives and their preparation and use |
JPS58157768A (ja) * | 1982-03-16 | 1983-09-19 | Takeda Chem Ind Ltd | 4−クロロ−2−フエニルイミダゾ−ル−5−酢酸誘導体 |
PT78388B (en) * | 1983-04-12 | 1986-09-15 | Smithkline Beckman Corp | Dopamine-beta-hydroxylase inhibitors |
FI833794A0 (fi) * | 1983-10-18 | 1983-10-18 | Farmos Oy | Substituerade 2-merkapto-imidazoler |
FR2592042B1 (fr) * | 1985-12-19 | 1988-03-25 | Ile De France | Nouveaux ortho-anisamides, leur procede d'obtention, et leurs applications therapeutiques |
CA1334092C (en) * | 1986-07-11 | 1995-01-24 | David John Carini | Angiotensin ii receptor blocking imidazoles |
DK59888A (da) * | 1987-03-20 | 1988-09-21 | Hoffmann La Roche | Imidazolderivater |
CA1338238C (en) * | 1988-01-07 | 1996-04-09 | David John Carini | Angiotensin ii receptor blocking imidazoles and combinations thereof with diuretics and nsaids |
US4880804A (en) * | 1988-01-07 | 1989-11-14 | E. I. Du Pont De Nemours And Company | Angiotensin II receptor blocking benzimidazoles |
US5015651A (en) * | 1988-01-07 | 1991-05-14 | E. I. Du Pont De Nemours And Company | Treatment of hypertension with 1,2,4-angiotensin II antagonists |
US4916129A (en) * | 1989-01-19 | 1990-04-10 | E. I. Du Pont De Nemours And Company | Combination β-blocking/angiotensin II blocking antihypertensives |
US5151497A (en) * | 1989-02-21 | 1992-09-29 | Japan Tobacco Inc. | Histidyl peptide derivatives |
US4962120A (en) * | 1989-03-22 | 1990-10-09 | Sterling Drug Inc. | 1H-imidazole-1-acetamides |
US5102880A (en) * | 1989-05-30 | 1992-04-07 | Merck & Co., Inc. | Substituted imidazo-fused 6-membered heterocycles as angiotensin II antagonists |
US5064825A (en) * | 1989-06-01 | 1991-11-12 | Merck & Co., Inc. | Angiotensin ii antagonists |
US5185351A (en) * | 1989-06-14 | 1993-02-09 | Smithkline Beecham Corporation | Imidazolyl-alkenoic acids useful as angiotensin II receptor antagonists |
US5055467A (en) * | 1989-11-13 | 1991-10-08 | Allergan, Inc. | Pharmaceutical epinephrine-pilocarpine compounds |
PT95899A (pt) * | 1989-11-17 | 1991-09-13 | Glaxo Group Ltd | Processo para a preparacao de derivados indole |
US5073566A (en) * | 1989-11-30 | 1991-12-17 | Eli Lilly And Company | Angiotensin ii antagonist 1,3-imidazoles and use thereas |
US5234917A (en) * | 1989-12-29 | 1993-08-10 | Finkelstein Joseph A | Substituted 5-(alkyl)carboxamide imidazoles |
US5183810A (en) * | 1990-02-13 | 1993-02-02 | Merck & Co., Inc. | Imidazole angiotensin II antagonists incorporating a substituted benzyl element |
US5173494A (en) * | 1990-03-20 | 1992-12-22 | E. I. Du Pont De Nemours And Company | Specific inhibition of angiotensin-II binding to angiotensin-II receptor subtype-2 |
US5102903A (en) * | 1990-05-10 | 1992-04-07 | E. I. Du Pont De Nemours And Company | Treatment of glaucoma and ocular hypertension with pyrazole, pyrrole and triazole angiotensin-II receptor antagonists |
US5053329A (en) * | 1990-07-05 | 1991-10-01 | Merck & Co., Inc. | Process for preparation of novel angiotensin II antagonists |
US5177074A (en) * | 1991-03-26 | 1993-01-05 | Merck & Co., Inc. | Angiotensin ii antagonists incorporating a substituted thiophene or furan |
GB9107398D0 (en) * | 1991-04-09 | 1991-05-22 | British Bio Technology | Compounds |
US5175164A (en) * | 1991-06-05 | 1992-12-29 | Merck & Co., Inc. | Angiotensin ii antagonists incorporating a substituted indole or dihydroindole |
US5210211A (en) * | 1991-06-21 | 1993-05-11 | Warner-Lambert Company | 4-(1h-pyrrol-1-yl) imidazoles with angiotension ii antagonist activity |
-
1993
- 1993-04-20 US US08/049,917 patent/US5401851A/en not_active Expired - Fee Related
- 1993-06-01 IL IL10587793A patent/IL105877A/en not_active IP Right Cessation
- 1993-06-01 TW TW082104354A patent/TW235295B/zh active
- 1993-06-01 CZ CZ931044A patent/CZ104493A3/cs unknown
- 1993-06-01 CA CA002097462A patent/CA2097462A1/en not_active Abandoned
- 1993-06-01 HU HU9301603A patent/HUT64328A/hu unknown
- 1993-06-02 AU AU39985/93A patent/AU667903B2/en not_active Ceased
- 1993-06-02 MY MYPI93001065A patent/MY131434A/en unknown
- 1993-06-02 EP EP93304264A patent/EP0573271A1/en not_active Ceased
- 1993-06-02 FI FI932517A patent/FI932517A/fi unknown
- 1993-06-02 RU RU93046497A patent/RU2110515C1/ru active
- 1993-06-02 NZ NZ247769A patent/NZ247769A/en unknown
- 1993-06-02 NO NO932005A patent/NO932005L/no unknown
- 1993-06-03 JP JP5133212A patent/JPH07304752A/ja active Pending
- 1993-06-03 PL PL93299176A patent/PL173340B1/pl unknown
- 1993-06-03 CN CN93107578A patent/CN1045768C/zh not_active Expired - Fee Related
-
1994
- 1994-12-14 US US08/355,778 patent/US5484780A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
NO932005L (no) | 1993-12-06 |
CN1045768C (zh) | 1999-10-20 |
IL105877A (en) | 1998-07-15 |
TW235295B (hu) | 1994-12-01 |
AU667903B2 (en) | 1996-04-18 |
PL299176A1 (en) | 1994-02-07 |
CZ104493A3 (en) | 1994-01-19 |
MY131434A (en) | 2007-08-30 |
PL173340B1 (pl) | 1998-02-27 |
HU9301603D0 (en) | 1993-09-28 |
CN1085897A (zh) | 1994-04-27 |
EP0573271A1 (en) | 1993-12-08 |
US5484780A (en) | 1996-01-16 |
NZ247769A (en) | 1995-12-21 |
RU2110515C1 (ru) | 1998-05-10 |
AU3998593A (en) | 1994-01-20 |
IL105877A0 (en) | 1993-10-20 |
NO932005D0 (no) | 1993-06-02 |
FI932517A (fi) | 1993-12-04 |
JPH07304752A (ja) | 1995-11-21 |
CA2097462A1 (en) | 1993-12-04 |
US5401851A (en) | 1995-03-28 |
FI932517A0 (fi) | 1993-06-02 |
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