HUT62555A - Process for producing 3-cycloalkylprop-2-eneamide derivatives and pharmaceutical compositions comprising same - Google Patents

Process for producing 3-cycloalkylprop-2-eneamide derivatives and pharmaceutical compositions comprising same

Info

Publication number
HUT62555A
HUT62555A HU929202942A HU9202942A HUT62555A HU T62555 A HUT62555 A HU T62555A HU 929202942 A HU929202942 A HU 929202942A HU 9202942 A HU9202942 A HU 9202942A HU T62555 A HUT62555 A HU T62555A
Authority
HU
Hungary
Prior art keywords
derivatives
cycloalkylprop
eneamide
producing
same
Prior art date
Application number
HU929202942A
Other languages
English (en)
Other versions
HU210164B (en
HU9202942D0 (en
Inventor
Elizabeth Anne Kuo
Original Assignee
Roussel Uclaf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB919119874A external-priority patent/GB9119874D0/en
Application filed by Roussel Uclaf filed Critical Roussel Uclaf
Publication of HU9202942D0 publication Critical patent/HU9202942D0/hu
Publication of HUT62555A publication Critical patent/HUT62555A/hu
Publication of HU210164B publication Critical patent/HU210164B/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/31—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C317/34—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring
    • C07C317/38—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring with the nitrogen atom of at least one amino group being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfones
    • C07C317/40—Y being a hydrogen or a carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C07C323/40—Y being a hydrogen or a carbon atom
    • C07C323/41—Y being a hydrogen or an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/58—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Pyridine Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Detergent Compositions (AREA)
HU9202942A 1991-09-17 1992-09-15 Process for preparing 3-cycloalkyl-prop-2-enamide derivatives and pharmaceutical compn. contg. them HU210164B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB919119874A GB9119874D0 (en) 1991-09-17 1991-09-17 3-cylopropyl-prop-2-enamide derivatives
GB929213972A GB9213972D0 (en) 1991-09-17 1992-07-01 3-cycloalkyl-prop-2-enamide derivatives

Publications (3)

Publication Number Publication Date
HU9202942D0 HU9202942D0 (en) 1992-11-30
HUT62555A true HUT62555A (en) 1993-05-28
HU210164B HU210164B (en) 1995-02-28

Family

ID=26299550

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9202942A HU210164B (en) 1991-09-17 1992-09-15 Process for preparing 3-cycloalkyl-prop-2-enamide derivatives and pharmaceutical compn. contg. them

Country Status (19)

Country Link
US (2) US5312830A (hu)
EP (1) EP0533573B1 (hu)
JP (1) JP3145803B2 (hu)
CN (1) CN1028863C (hu)
AT (1) ATE145893T1 (hu)
AU (1) AU649881B2 (hu)
BR (1) BR9203643A (hu)
CA (1) CA2078466C (hu)
CZ (1) CZ281674B6 (hu)
DE (1) DE69215625T2 (hu)
DK (1) DK0533573T3 (hu)
ES (1) ES2095434T3 (hu)
FI (1) FI111248B (hu)
GR (1) GR3022423T3 (hu)
HU (1) HU210164B (hu)
IL (1) IL102790A (hu)
MX (1) MX9205246A (hu)
NO (1) NO178299C (hu)
NZ (1) NZ244329A (hu)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9300083D0 (en) * 1993-01-05 1993-03-03 Roussel Lab Ltd Chemical compounds
GB9313365D0 (en) * 1993-06-29 1993-08-11 Roussel Lab Ltd Chemical compounds
GB9520092D0 (en) * 1995-10-02 1995-12-06 Hoechst Roussel Ltd Chemical compounds
MX2016006678A (es) 2013-11-22 2016-09-13 Genzyme Corp Nuevos metodos para tratar enfermedades neurodegenerativas.
WO2018144869A1 (en) * 2017-02-03 2018-08-09 The Regents Of The University Of California Compositons and methods for modulating uba5
BR112019016132A2 (pt) * 2017-02-03 2020-04-07 Univ California composições e métodos para a inibição de reticulon 4
GB2588707B (en) * 2019-08-21 2022-06-15 William Page Roland Improved containers

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL186239B (nl) * 1975-06-05 Hoechst Ag Werkwijze voor de bereiding van een geneesmiddel met antiflogistische en/of analgetische werking, alsmede werkwijze voor de bereiding van een 2-hydroxyethylideencyaanazijnzuuranilide geschikt voor toepassing bij deze werkwijze.
DE2555789A1 (de) * 1975-12-11 1977-07-07 Hoechst Ag Neue cyanessigsaeureanilid-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende mittel
US4414395A (en) * 1980-03-13 1983-11-08 Ciba-Geigy Corporation Process for the manufacture of hydrazono-isoindolines
US4435407A (en) * 1982-01-07 1984-03-06 Ciba-Geigy Corporation Certain substituted β-oxo-α-carbamoylpyrrolepropionitriles
GB8619432D0 (en) * 1986-08-08 1986-09-17 Lilly Industries Ltd Pharmaceutical compounds
US4888357A (en) * 1988-01-26 1989-12-19 Bristol-Myers Company Antiarthritic β-cycloalkyl-β-oxopropionitriles
DE69002792T2 (de) * 1989-05-09 1993-12-09 Sds Biotech Corp Crotonsäureamidderivate und sie enthaltende Insektizide.
US5034410A (en) * 1989-10-11 1991-07-23 Syntex (U.S.A.) Inc. Anthelmintically active benzenepropanamide derivatives
IL99811A (en) * 1990-10-30 1996-03-31 Roussel Uclaf 3-Cycloalkyl-propanamides, tautomeric forms of these, their salts, method of preparation, use as drugs and preparations containing them

Also Published As

Publication number Publication date
ATE145893T1 (de) 1996-12-15
HU210164B (en) 1995-02-28
US5312830A (en) 1994-05-17
MX9205246A (es) 1994-06-30
CA2078466A1 (fr) 1993-03-18
FI111248B (fi) 2003-06-30
CN1028863C (zh) 1995-06-14
CN1070637A (zh) 1993-04-07
HU9202942D0 (en) 1992-11-30
FI924145A (fi) 1993-03-18
DE69215625D1 (de) 1997-01-16
US5389652A (en) 1995-02-14
JP3145803B2 (ja) 2001-03-12
AU649881B2 (en) 1994-06-02
GR3022423T3 (en) 1997-04-30
CZ265392A3 (en) 1993-06-16
EP0533573A3 (fr) 1993-05-19
IL102790A (en) 1996-01-31
FI924145A0 (fi) 1992-09-16
DE69215625T2 (de) 1997-04-17
NO178299B (no) 1995-11-20
AU2451692A (en) 1993-03-18
NO178299C (no) 1996-02-28
BR9203643A (pt) 1993-04-13
DK0533573T3 (da) 1997-04-07
CZ281674B6 (cs) 1996-12-11
EP0533573A2 (fr) 1993-03-24
NZ244329A (en) 1994-09-27
JPH05230008A (ja) 1993-09-07
CA2078466C (fr) 2003-04-15
NO923603D0 (no) 1992-09-16
IL102790A0 (en) 1993-01-31
ES2095434T3 (es) 1997-02-16
EP0533573B1 (fr) 1996-12-04
NO923603L (no) 1993-03-18

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Legal Events

Date Code Title Description
HPC4 Succession in title of patentee

Owner name: HOECHST MARION ROUSSEL, FR

HPC4 Succession in title of patentee

Owner name: AVENTIS PHARMA S.A., FR