HUT44614A - Process for preparing fusional proteins comprising eucaryotic ballast parts - Google Patents

Process for preparing fusional proteins comprising eucaryotic ballast parts

Info

Publication number
HUT44614A
HUT44614A HU865354A HU535486A HUT44614A HU T44614 A HUT44614 A HU T44614A HU 865354 A HU865354 A HU 865354A HU 535486 A HU535486 A HU 535486A HU T44614 A HUT44614 A HU T44614A
Authority
HU
Hungary
Prior art keywords
proteins
fusional
eucaryotic
preparing
ballast parts
Prior art date
Application number
HU865354A
Other languages
English (en)
Other versions
HU209747B (en
Inventor
Paul Habermann
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of HUT44614A publication Critical patent/HUT44614A/hu
Publication of HU209747B publication Critical patent/HU209747B/hu

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81Protease inhibitors
    • C07K14/815Protease inhibitors from leeches, e.g. hirudin, eglin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/53Colony-stimulating factor [CSF]
    • C07K14/535Granulocyte CSF; Granulocyte-macrophage CSF
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/54Interleukins [IL]
    • C07K14/55IL-2
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/62Insulins
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/70Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
HU865354A 1985-12-21 1986-12-19 Process for producing fusion proteins with eukaryotic ballastparts HU209747B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3545565 1985-12-21
DE19863636903 DE3636903A1 (de) 1985-12-21 1986-10-30 Fusionsproteine mit eukaryotischem ballastanteil

Publications (2)

Publication Number Publication Date
HUT44614A true HUT44614A (en) 1988-03-28
HU209747B HU209747B (en) 1994-10-28

Family

ID=25839208

Family Applications (1)

Application Number Title Priority Date Filing Date
HU865354A HU209747B (en) 1985-12-21 1986-12-19 Process for producing fusion proteins with eukaryotic ballastparts

Country Status (16)

Country Link
EP (1) EP0229998B1 (hu)
JP (2) JP2553058B2 (hu)
KR (1) KR950000301B1 (hu)
AT (1) ATE78296T1 (hu)
AU (1) AU599943B2 (hu)
CA (1) CA1339894C (hu)
DE (1) DE3636903A1 (hu)
DK (1) DK168823B1 (hu)
ES (1) ES2033678T3 (hu)
FI (1) FI93734C (hu)
GR (1) GR3005985T3 (hu)
HU (1) HU209747B (hu)
IE (1) IE58935B1 (hu)
IL (1) IL81018A (hu)
NO (1) NO175003C (hu)
PT (1) PT83973B (hu)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3545568A1 (de) * 1985-12-21 1987-07-16 Hoechst Ag Gm-csf-protein, seine derivate, herstellung solcher proteine und ihre verwendung
DE3844211A1 (de) * 1988-12-29 1990-07-05 Hoechst Ag Neue insulinderivate, verfahren zu deren herstellung, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung
FR2643646B1 (fr) * 1989-02-27 1993-09-17 Pasteur Institut Expression de sequences de nucleotides codant pour des vesicules a gaz
CU22222A1 (es) * 1989-08-03 1995-01-31 Cigb Procedimiento para la expresion de proteinas heterologicas producidas de forma fusionada en escherichia coli, su uso, vectores de expresion y cepas recombinantes
DE3942580A1 (de) * 1989-12-22 1991-06-27 Basf Ag Verfahren zur herstellung von hirudin
DE4105480A1 (de) * 1991-02-21 1992-08-27 Boehringer Mannheim Gmbh Verbesserte aktivierung von rekombinanten proteinen
PT821006E (pt) 1996-07-26 2004-09-30 Aventis Pharma Gmbh Derivados de insulina com ligacao a zinco aumentada
DE19825447A1 (de) 1998-06-06 1999-12-09 Hoechst Marion Roussel De Gmbh Neue Insulinanaloga mit erhöhter Zinkbildung
DE102006031955A1 (de) 2006-07-11 2008-01-17 Sanofi-Aventis Deutschland Gmbh Verfahren zur Herstellung von Insulinanaloga mit dibasischem B-Kettenende
DE102006031962A1 (de) 2006-07-11 2008-01-17 Sanofi-Aventis Deutschland Gmbh Amidiertes Insulin Glargin
PT2349324T (pt) 2008-10-17 2017-12-06 Sanofi Aventis Deutschland Combinação de uma insulina e de um agonista do glp-1
PL2498802T3 (pl) 2009-11-13 2015-06-30 Sanofi Aventis Deutschland Kompozycja farmaceutyczna zawierająca agonistę GLP-1, insulinę i metioninę
EP2498801B1 (de) 2009-11-13 2018-01-24 Sanofi-Aventis Deutschland GmbH HARMAZEUTISCHE ZUSAMMENSETZUNG UMFASSEND desPro36Exendin-4(1-39)-Lys6-NH2 UND METHIONIN
EP2611458B1 (en) 2010-08-30 2016-09-21 Sanofi-Aventis Deutschland GmbH Use of ave0010 for the manufacture of a medicament for the treatment of diabetes mellitus type 2
US9821032B2 (en) 2011-05-13 2017-11-21 Sanofi-Aventis Deutschland Gmbh Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
BR112014004726A2 (pt) 2011-08-29 2017-04-04 Sanofi Aventis Deutschland combinação farmacêutica para uso no controle glicêmico em pacientes de diabetes tipo 2
AR087744A1 (es) 2011-09-01 2014-04-16 Sanofi Aventis Deutschland Composicion farmaceutica para uso en el tratamiento de una enfermedad neurodegenerativa
EP3229828B1 (en) 2014-12-12 2023-04-05 Sanofi-Aventis Deutschland GmbH Insulin glargine/lixisenatide fixed ratio formulation
TWI748945B (zh) 2015-03-13 2021-12-11 德商賽諾菲阿凡提斯德意志有限公司 第2型糖尿病病患治療
TW201705975A (zh) 2015-03-18 2017-02-16 賽諾菲阿凡提斯德意志有限公司 第2型糖尿病病患之治療
KR20200080748A (ko) 2018-12-27 2020-07-07 주식회사 폴루스 음이온 교환 크로마토그래피를 이용한 인슐린 전구체의 정제방법
KR20200080747A (ko) 2018-12-27 2020-07-07 주식회사 폴루스 인슐린 전구체의 인슐린 효소 전환용 조성물 및 이를 이용하여 인슐린 전구체를 인슐린으로 전환하는 방법

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK108685A (da) * 1984-03-19 1985-09-20 Fujisawa Pharmaceutical Co Vaekstfaktor i
EP0158198A1 (en) * 1984-03-29 1985-10-16 Takeda Chemical Industries, Ltd. DNA and use thereof
GB8412517D0 (en) * 1984-05-16 1984-06-20 Nagai K Recombinant fusion proteins

Also Published As

Publication number Publication date
JPS62167799A (ja) 1987-07-24
KR870006187A (ko) 1987-07-09
FI93734C (fi) 1995-05-26
IL81018A0 (en) 1987-03-31
JP2774260B2 (ja) 1998-07-09
AU6676086A (en) 1987-06-25
AU599943B2 (en) 1990-08-02
DK168823B1 (da) 1994-06-20
NO175003B (no) 1994-05-09
PT83973B (pt) 1989-07-31
NO865192D0 (no) 1986-12-19
GR3005985T3 (hu) 1993-06-07
ATE78296T1 (de) 1992-08-15
FI93734B (fi) 1995-02-15
EP0229998B1 (de) 1992-07-15
DK619186A (da) 1987-06-22
NO865192L (no) 1987-06-22
IE58935B1 (en) 1993-12-01
CA1339894C (en) 1998-06-02
DK619186D0 (da) 1986-12-19
DE3636903A1 (de) 1987-07-02
FI865187A (fi) 1987-06-22
FI865187A0 (fi) 1986-12-18
EP0229998A2 (de) 1987-07-29
NO175003C (no) 1994-08-17
EP0229998A3 (en) 1988-08-03
IL81018A (en) 1992-03-29
IE863334L (en) 1987-06-21
HU209747B (en) 1994-10-28
PT83973A (de) 1987-01-01
JPH08187089A (ja) 1996-07-23
ES2033678T3 (es) 1993-04-01
KR950000301B1 (ko) 1995-01-13
JP2553058B2 (ja) 1996-11-13

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