HUP9904359A2 - Eljárás metilidén-malonát nanorészecskék előállítására, és adott esetben egy vagy több biológiai hatással rendelkező molekulát tartalmazó nanorészecskék - Google Patents

Eljárás metilidén-malonát nanorészecskék előállítására, és adott esetben egy vagy több biológiai hatással rendelkező molekulát tartalmazó nanorészecskék

Info

Publication number
HUP9904359A2
HUP9904359A2 HU9904359A HUP9904359A HUP9904359A2 HU P9904359 A2 HUP9904359 A2 HU P9904359A2 HU 9904359 A HU9904359 A HU 9904359A HU P9904359 A HUP9904359 A HU P9904359A HU P9904359 A2 HUP9904359 A2 HU P9904359A2
Authority
HU
Hungary
Prior art keywords
nanoparticles
methylidene
biologically active
general formula
optionally containing
Prior art date
Application number
HU9904359A
Other languages
English (en)
Inventor
Pascal Breton
Nicole Bru-Magniez
Patrick Couvreur
Xavier Guillon
Francois Lescure
Gérard Riess
Claude Roques-Carmes
Original Assignee
Virsol
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Virsol filed Critical Virsol
Publication of HUP9904359A2 publication Critical patent/HUP9904359A2/hu
Publication of HUP9904359A3 publication Critical patent/HUP9904359A3/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5138—Organic macromolecular compounds; Dendrimers obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F22/00—Homopolymers and copolymers of compounds having one or more unsaturated aliphatic radicals each having only one carbon-to-carbon double bond, and at least one being terminated by a carboxyl radical and containing at least one other carboxyl radical in the molecule; Salts, anhydrides, esters, amides, imides or nitriles thereof
    • C08F22/10—Esters
    • C08F22/12—Esters of phenols or saturated alcohols
    • C08F22/14—Esters having no free carboxylic acid groups
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Nanotechnology (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Oncology (AREA)
  • Optics & Photonics (AREA)
  • Biomedical Technology (AREA)
  • Polymers & Plastics (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicinal Preparation (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)

Abstract

A találmány tárgya eljárás legalább egy (I) általánős képletűvegyületek statisztikűs pőlimerjéből álló nanőrészecskékelőállítására, ahől A jelentése (a) általánős képletű csőpőrt vagy (b) általánős képletűcsőpőrt, R1 és R2 jelentése egymástól függetlenül egyenes vagy elágazószénláncú 1-6 szénatőmős alkilcsőpőrt, n értéke 1, 2, 3, 4 vagy 5,amelyet úgy végeznek, hőgy az egy vagy több mőnőmert a pőlimerizációelőtt őlyan aprőtikűs szerves őldószerben őldják, amely vízzelelegyedő, és amely a pőlimerizációs közeggel a képződött pőlimert nemőldó elegyet alkőt,. A találmány az előállítőtt, adőtt esetben egyvagy több, biőlógiailag hatásős mőlekűlát is tartalmazónanőrészecskékre és az ezeket tartalmazó gyógyszerkészítményekre isvőnatkőzik. (I) (a) ŕ
HU9904359A 1996-10-25 1997-10-24 Method for preparing malonate methylidene nanoparticles, nanoparticles optionally containing one or several biologically active molecules HUP9904359A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9613039A FR2755136B1 (fr) 1996-10-25 1996-10-25 Procede de preparation de nanoparticules de methylidene malonate, nanoparticules contenant eventuellement une ou plusieurs molecules biologiquement actives et compositions pharmaceutiques les contenant

Publications (2)

Publication Number Publication Date
HUP9904359A2 true HUP9904359A2 (hu) 2000-05-28
HUP9904359A3 HUP9904359A3 (en) 2000-11-28

Family

ID=9497032

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9904359A HUP9904359A3 (en) 1996-10-25 1997-10-24 Method for preparing malonate methylidene nanoparticles, nanoparticles optionally containing one or several biologically active molecules

Country Status (23)

Country Link
US (2) US6211273B1 (hu)
EP (1) EP0934059B1 (hu)
JP (1) JP2001504530A (hu)
KR (1) KR20000052813A (hu)
CN (1) CN1237903A (hu)
AR (1) AR009127A1 (hu)
AT (1) ATE245171T1 (hu)
AU (1) AU736097B2 (hu)
BR (1) BR9712372A (hu)
CA (1) CA2269783C (hu)
CZ (1) CZ144099A3 (hu)
DE (1) DE69723571T2 (hu)
FR (1) FR2755136B1 (hu)
HU (1) HUP9904359A3 (hu)
IL (1) IL129355A0 (hu)
NO (1) NO991942L (hu)
NZ (1) NZ335094A (hu)
PL (1) PL332957A1 (hu)
RU (1) RU2214421C2 (hu)
SK (1) SK55599A3 (hu)
TW (1) TW503109B (hu)
WO (1) WO1998018455A1 (hu)
ZA (1) ZA979550B (hu)

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FR2774096B1 (fr) * 1998-01-29 2000-04-07 Virsol Nouveaux copolymeres tensioactifs a base de methylidene malonate
FR2778100B1 (fr) 1998-04-29 2001-05-04 Virsol Nouvelles microspheres a base de poly(methylidene malonate), leur procede de preparation et compositions pharmaceutiques les contenant
FR2789314B1 (fr) 1999-02-09 2001-04-27 Virsol Materiau de suture de plaies a base de methylidene malonate
US6958366B2 (en) * 2000-04-12 2005-10-25 Dainippon Ink And Chemicals, Inc. Antifouling coating composition and novel resin
JP4611561B2 (ja) * 2000-04-12 2011-01-12 Ｄｉｃ株式会社 新規なビニル系樹脂およびその製造方法
FR2812551B1 (fr) * 2000-08-07 2003-03-28 Virsol Forme pharmaceutique comprenant un materiau support a base de methylidene malonate et un facteur de regulation cellulaire
US20030008015A1 (en) * 2000-10-11 2003-01-09 Levisage Catherine S. Polymer controlled delivery of a therapeutic agent
KR100457824B1 (ko) * 2001-08-10 2004-11-18 한국화학연구원 용액 열분해법에 의한 나노 크기 2가 금속 산화물 분말의제조
JP3961312B2 (ja) 2002-02-26 2007-08-22 株式会社デンソー 内燃機関の制御装置
WO2008018932A2 (en) * 2006-05-01 2008-02-14 The Board Of Trustees Of The Leland Stanford Junior University Method and use of nano-scale devices for reduction of tissue injury in ischemic and reperfusion injury
EP2123262A1 (en) * 2008-05-20 2009-11-25 Consorzio per il Centro di Biomedica Moleculare Scrl Polyelectrolyte-encapsulated gold nanoparticles capable of crossing blood-brain barrier
US8106234B2 (en) * 2009-05-07 2012-01-31 OptMed, Inc Methylidene malonate process
US8993795B2 (en) 2009-05-07 2015-03-31 Optmed Inc Methylidene malonate process
EP3208287A1 (en) 2010-10-20 2017-08-23 Sirrus, Inc. Synthesis of methylene malonates using rapid recovery in the presence of a heat transfer agent
US10414839B2 (en) 2010-10-20 2019-09-17 Sirrus, Inc. Polymers including a methylene beta-ketoester and products formed therefrom
US9828324B2 (en) 2010-10-20 2017-11-28 Sirrus, Inc. Methylene beta-diketone monomers, methods for making methylene beta-diketone monomers, polymerizable compositions and products formed therefrom
US9249265B1 (en) 2014-09-08 2016-02-02 Sirrus, Inc. Emulsion polymers including one or more 1,1-disubstituted alkene compounds, emulsion methods, and polymer compositions
US9279022B1 (en) 2014-09-08 2016-03-08 Sirrus, Inc. Solution polymers including one or more 1,1-disubstituted alkene compounds, solution polymerization methods, and polymer compositions
CA2853073A1 (en) 2011-10-19 2013-04-25 Bioformix Inc. Methylene beta-diketone monomers, methods for making methylene beta-diketone monomers, polymerizable compositions and products formed therefrom
US10913875B2 (en) 2012-03-30 2021-02-09 Sirrus, Inc. Composite and laminate articles and polymerizable systems for producing the same
EP2831185B1 (en) 2012-03-30 2019-09-25 Sirrus, Inc. Ink and coating formulations and polymerizable systems for producing the same
EP2831125B1 (en) 2012-03-30 2016-10-05 Sirrus, Inc. Methods for activating polymerizable compositions, polymerizable systems, and products formed thereby
WO2013181600A2 (en) 2012-06-01 2013-12-05 Bioformix Inc. Optical material and articles formed therefrom
WO2014078689A1 (en) 2012-11-16 2014-05-22 Bioformix Inc. Plastics bonding systems and methods
EP2926368B1 (en) 2012-11-30 2020-04-08 Sirrus, Inc. Electronic assembly
CN105008321A (zh) 2013-01-11 2015-10-28 瑟拉斯公司 经过双(羟甲基)丙二酸酯的途径获得亚甲基丙二酸酯的方法
US9416091B1 (en) 2015-02-04 2016-08-16 Sirrus, Inc. Catalytic transesterification of ester compounds with groups reactive under transesterification conditions
US9315597B2 (en) 2014-09-08 2016-04-19 Sirrus, Inc. Compositions containing 1,1-disubstituted alkene compounds for preparing polymers having enhanced glass transition temperatures
US10501400B2 (en) 2015-02-04 2019-12-10 Sirrus, Inc. Heterogeneous catalytic transesterification of ester compounds with groups reactive under transesterification conditions
US9334430B1 (en) 2015-05-29 2016-05-10 Sirrus, Inc. Encapsulated polymerization initiators, polymerization systems and methods using the same
US9217098B1 (en) 2015-06-01 2015-12-22 Sirrus, Inc. Electroinitiated polymerization of compositions having a 1,1-disubstituted alkene compound
EP3310821B1 (en) * 2015-06-19 2021-02-17 Sirrus, Inc. Compositions containing 1,1-disubstituted alkene compounds for preparing polymers having enhanced glass transition temperatures
US9518001B1 (en) 2016-05-13 2016-12-13 Sirrus, Inc. High purity 1,1-dicarbonyl substituted-1-alkenes and methods for their preparation
US10428177B2 (en) 2016-06-03 2019-10-01 Sirrus, Inc. Water absorbing or water soluble polymers, intermediate compounds, and methods thereof
US9567475B1 (en) 2016-06-03 2017-02-14 Sirrus, Inc. Coatings containing polyester macromers containing 1,1-dicarbonyl-substituted 1 alkenes
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Also Published As

Publication number Publication date
ATE245171T1 (de) 2003-08-15
US6211273B1 (en) 2001-04-03
NZ335094A (en) 2001-05-25
RU2214421C2 (ru) 2003-10-20
KR20000052813A (ko) 2000-08-25
PL332957A1 (en) 1999-10-25
SK55599A3 (en) 2000-03-13
FR2755136A1 (fr) 1998-04-30
NO991942L (no) 1999-06-23
FR2755136B1 (fr) 1999-01-22
CA2269783C (en) 2005-01-11
US6420468B2 (en) 2002-07-16
EP0934059B1 (fr) 2003-07-16
IL129355A0 (en) 2000-02-17
US20010006989A1 (en) 2001-07-05
HUP9904359A3 (en) 2000-11-28
AU736097B2 (en) 2001-07-26
NO991942D0 (no) 1999-04-23
TW503109B (en) 2002-09-21
EP0934059A1 (fr) 1999-08-11
CN1237903A (zh) 1999-12-08
CA2269783A1 (en) 1998-05-07
AR009127A1 (es) 2000-03-08
CZ144099A3 (cs) 1999-09-15
AU4950997A (en) 1998-05-22
DE69723571D1 (de) 2003-08-21
ZA979550B (en) 1998-05-12
DE69723571T2 (de) 2004-06-03
JP2001504530A (ja) 2001-04-03
BR9712372A (pt) 2000-01-25
WO1998018455A1 (fr) 1998-05-07

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