HUP9903525A2 - Nalfa-2-(4-nitro-fenil-szulfonil)-etoxi-karbonil-aminosavak és eljárások ilyen aminosavak előállítására - Google Patents
Nalfa-2-(4-nitro-fenil-szulfonil)-etoxi-karbonil-aminosavak és eljárások ilyen aminosavak előállításáraInfo
- Publication number
- HUP9903525A2 HUP9903525A2 HU9903525A HUP9903525A HUP9903525A2 HU P9903525 A2 HUP9903525 A2 HU P9903525A2 HU 9903525 A HU9903525 A HU 9903525A HU P9903525 A HUP9903525 A HU P9903525A HU P9903525 A2 HUP9903525 A2 HU P9903525A2
- Authority
- HU
- Hungary
- Prior art keywords
- propyl
- nitrophenylsulfonyl
- butyl
- amino acids
- guanidino
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 125000006627 ethoxycarbonylamino group Chemical group 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- -1 hydroxymethyl- Chemical group 0.000 abstract 13
- 150000001413 amino acids Chemical class 0.000 abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 3
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 3
- 238000003786 synthesis reaction Methods 0.000 abstract 3
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 2
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 125000005518 carboxamido group Chemical group 0.000 abstract 1
- AOGYCOYQMAVAFD-UHFFFAOYSA-N chlorocarbonic acid Chemical compound OC(Cl)=O AOGYCOYQMAVAFD-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 239000007791 liquid phase Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 238000010647 peptide synthesis reaction Methods 0.000 abstract 1
- 239000007790 solid phase Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/16—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C317/18—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to acyclic carbon atoms of the carbon skeleton
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
A találmány Na-2-(4-nitro-fenil-szulfonil)-etoxi-karbonil-aminosavakraés ilyen aminosavak előállítására alkalmas eljárásokra vonatkozik. Atalálmány szerinti Na-2-(4-nitro-fenil-szulfonil)-etoxi-karbonil-aminosavak (I) általános képletében R1 jelentése hidrogénatom; és R2jelentése hidroxi-metil-, 1-hidroxi-etil-, 4-hidroxi-benzil-,imidazolil-2-metil-, benzil-oxi-metil-, 1-benzil-oxi-etil-, 4-benzil-oxi-benzil-, venzil-oxi-karbonil-metil-, 2-(benzil-oxi-karbonil)-etil-, S-benzil-tio-metil-, S-(difenil-metil)-tio-metil-, 4-(benzil-oxi-karbamido)-butil-, 3-guanidi-no-propil-, 3-(NG-toluolszulfonil)-guanidino-propil-, 3-(NG-nitro)-guanidino-propil-, 3-[NG-(4-metoxi-2,3,6-trimetil-benzolszulfonil)]-guanidino-propil, N-(4,4'-dimetoxi-difenil-metil)-karboxamido-metil-, 2-[N-(4,4'-dimetoxi-difenil-metil)-karboxamido]-etil-, S-(terc-butil)-ditio-metil-, 4-[2-(4-nitro-fenil-szulfonil)-etoxi-karbamido]-butil-, propil-, butil-, etil-, 3-(benzil-oxi-karbamido)-propil- vagy 3-(terc-butoxi-karbamido)-propil-csoport.A találmány szerinti eljárások egyikével például úgy állítanak elő (I)általános képletű vegyületeket, hogy (II) általános képletűaminosavakat - a (II) általános képletben R1 és R2 jelentése afentiekben megadott - vizet és szerves oldószert tartalmazó elegyben,bázis jelenlétében klór-hangyasav[2-(4-nitro-fenil-szulfonil)-etoxi-karbonil]-észterrel kezelnek. A találmány előnye, hogy növeli apeptidszintézisekhez rendelkezésre álló aminosavak körét, különbözőmódszerek alkalmazását teszi lehetővé a peptidszintézisek során azoldalláncok megvédésére és a szilárd fázisú peptidszintézisen kívül újlehetőségeket kínál a folyadékfázisú peptidszintézisekmegvalósításához is. Ó
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/KR1996/000179 WO1998017638A1 (en) | 1996-10-19 | 1996-10-19 | Nα-2-(4-NITROPHENYLSULFONYL)ETHOXYCARBONYL-AMINO ACIDS |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| HUP9903525A2 true HUP9903525A2 (hu) | 2001-06-28 |
| HUP9903525A3 HUP9903525A3 (en) | 2001-07-30 |
| HU222843B1 HU222843B1 (hu) | 2003-12-29 |
Family
ID=19449101
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9903525A HU222843B1 (hu) | 1996-10-19 | 1996-10-19 | Nalfa-2-(4-nitro-fenil-szulfonil)-etoxi-karbonil-aminosavak és eljárások ilyen aminosavak előállítására |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6265590B1 (hu) |
| EP (1) | EP0934260A1 (hu) |
| JP (1) | JP2001502686A (hu) |
| AU (1) | AU729889B2 (hu) |
| CA (1) | CA2268544A1 (hu) |
| CZ (1) | CZ293031B6 (hu) |
| HU (1) | HU222843B1 (hu) |
| RU (1) | RU2157365C2 (hu) |
| WO (1) | WO1998017638A1 (hu) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU1894000A (en) * | 1999-12-24 | 2001-07-24 | Hyundai Pharmaceutical Ind. Co., Ltd. | Nalpha-2-(4-nitrophenylsulfonyl)ethoxycarbonyl-amino acid fluorides and process for the preparation thereof |
| KR100418962B1 (ko) * | 2001-06-07 | 2004-02-14 | 김학주 | 2-(4-나이트로페닐설포닐)에톡시카르보닐-아미노산류를사용하여 펩티드를 고수율 및 고순도로 제조하는 방법 |
| US7855612B2 (en) * | 2007-10-18 | 2010-12-21 | Viasat, Inc. | Direct coaxial interface for circuits |
| WO2009114731A2 (en) | 2008-03-13 | 2009-09-17 | Viasat, Inc. | Multi-level power amplification system |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2079491C1 (ru) | 1995-02-15 | 1997-05-20 | Акционерное общество закрытого типа "Вектор-БиоПродукт" | Nα -2-(4-НИТРОФЕНИЛСУЛЬФОНИЛ)ЭТОКСИКАРБОНИЛ-АМИНОКИСЛОТЫ В КАЧЕСТВЕ Nα -ЗАЩИЩЕННЫХ АМИНОКИСЛОТ ДЛЯ ТВЕРДОФАЗНОГО СИНТЕЗА ПЕПТИДОВ |
-
1996
- 1996-10-19 HU HU9903525A patent/HU222843B1/hu not_active IP Right Cessation
- 1996-10-19 CZ CZ19991350A patent/CZ293031B6/cs not_active IP Right Cessation
- 1996-10-19 WO PCT/KR1996/000179 patent/WO1998017638A1/en not_active Application Discontinuation
- 1996-10-19 US US09/284,732 patent/US6265590B1/en not_active Expired - Fee Related
- 1996-10-19 JP JP10519243A patent/JP2001502686A/ja not_active Ceased
- 1996-10-19 AU AU73411/96A patent/AU729889B2/en not_active Ceased
- 1996-10-19 EP EP96935558A patent/EP0934260A1/en not_active Ceased
- 1996-10-19 CA CA002268544A patent/CA2268544A1/en not_active Abandoned
-
1997
- 1997-10-17 RU RU97117893/04A patent/RU2157365C2/ru not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| HU222843B1 (hu) | 2003-12-29 |
| CZ293031B6 (cs) | 2004-01-14 |
| AU7341196A (en) | 1998-05-15 |
| WO1998017638A1 (en) | 1998-04-30 |
| HUP9903525A3 (en) | 2001-07-30 |
| CA2268544A1 (en) | 1998-04-30 |
| US6265590B1 (en) | 2001-07-24 |
| RU2157365C2 (ru) | 2000-10-10 |
| CZ135099A3 (cs) | 1999-09-15 |
| EP0934260A1 (en) | 1999-08-11 |
| AU729889B2 (en) | 2001-02-15 |
| JP2001502686A (ja) | 2001-02-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| HFG4 | Patent granted, date of granting |
Effective date: 20031017 |
|
| MM4A | Lapse of definitive patent protection due to non-payment of fees |