HUP9902437A3 - Gamma-hydroxybutyric acid amides, process to prepare them, use gamma-hydroxybutyric acid amides, and pharmaceuticals contg. them - Google Patents

Gamma-hydroxybutyric acid amides, process to prepare them, use gamma-hydroxybutyric acid amides, and pharmaceuticals contg. them

Info

Publication number
HUP9902437A3
HUP9902437A3 HU9902437A HUP9902437A HUP9902437A3 HU P9902437 A3 HUP9902437 A3 HU P9902437A3 HU 9902437 A HU9902437 A HU 9902437A HU P9902437 A HUP9902437 A HU P9902437A HU P9902437 A3 HUP9902437 A3 HU P9902437A3
Authority
HU
Hungary
Prior art keywords
acid amides
hydroxybutyric acid
gamma
contg
pharmaceuticals
Prior art date
Application number
HU9902437A
Other languages
English (en)
Original Assignee
Ct Lab Farm Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ct Lab Farm Srl filed Critical Ct Lab Farm Srl
Publication of HUP9902437A2 publication Critical patent/HUP9902437A2/hu
Publication of HUP9902437A3 publication Critical patent/HUP9902437A3/hu
Publication of HU228595B1 publication Critical patent/HU228595B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/40—Acylated substituent nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Addiction (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
HU9902437A 1996-08-09 1997-08-07 Gamma-hydroxybutyric acid amides, process to prepare them, use gamma-hydroxybutyric acid amides, and pharmaceuticals contg. them for the treatmant of drug abusing HU228595B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT96MI001732A IT1283782B1 (it) 1996-08-09 1996-08-09 Uso di ammidi dell'acido gamma-idrossibutirrico nel trattamento di tossicodipendenze,ed in particolare sell'alcolismo
PCT/EP1997/004309 WO1998006690A1 (en) 1996-08-09 1997-08-07 USE OF η-HYDROXYBUTYRIC ACID AMIDES IN THE TREATMENT OF DRUG ADDICTION AND IN PARTICULAR OF ALCOHOLISM

Publications (3)

Publication Number Publication Date
HUP9902437A2 HUP9902437A2 (hu) 1999-12-28
HUP9902437A3 true HUP9902437A3 (en) 2001-07-30
HU228595B1 HU228595B1 (en) 2013-04-29

Family

ID=11374795

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9902437A HU228595B1 (en) 1996-08-09 1997-08-07 Gamma-hydroxybutyric acid amides, process to prepare them, use gamma-hydroxybutyric acid amides, and pharmaceuticals contg. them for the treatmant of drug abusing

Country Status (13)

Country Link
US (2) US6436998B1 (hu)
EP (1) EP0932597B1 (hu)
JP (1) JP4259615B2 (hu)
AT (1) ATE215065T1 (hu)
AU (1) AU4379097A (hu)
CA (1) CA2263328C (hu)
DE (1) DE69711411T2 (hu)
DK (1) DK0932597T3 (hu)
ES (1) ES2174287T3 (hu)
HU (1) HU228595B1 (hu)
IT (1) IT1283782B1 (hu)
PT (1) PT932597E (hu)
WO (1) WO1998006690A1 (hu)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000038672A2 (en) * 1998-12-23 2000-07-06 Orphan Medical, Inc. Microbiologically sound and stable solutions of gamma-hydroxybutyrate salt for the treatment of narcolepsy
FR2827859B1 (fr) 2001-07-30 2005-09-23 Lipha Derives 4-(arylthio) - ou 4-(heteroarylthio) -butyrique dans la preparation de medicaments destines au traitement du diabete
AU2003295393A1 (en) * 2002-11-01 2004-06-07 Baylor Research Institute Ghb treatment methods
US7838556B2 (en) * 2006-02-21 2010-11-23 University Of Maryland, Baltimore Ethers of 3-hydroxyphenylacetic acid as selective gamma-hydroxybutyric acid receptor ligands
EP2062875A1 (en) * 2007-11-13 2009-05-27 LABORATORIO FARMACEUTICO C.T. S.r.l. New polymorphic forms of n-[4-(trifluoromethyl)benzyl]-4-methoxybutyramide
US8778398B2 (en) * 2008-11-04 2014-07-15 Jazz Pharmaceuticals, Inc. Immediate release formulations and dosage forms of gamma-hydroxybutyrate
US8771735B2 (en) * 2008-11-04 2014-07-08 Jazz Pharmaceuticals, Inc. Immediate release dosage forms of sodium oxybate
BR112012024019B1 (pt) 2010-03-24 2021-10-19 Jazz Phamaceuticals, Inc Forma de dosagem de liberação controlada para administração oral
US8591922B1 (en) 2012-12-14 2013-11-26 Jazz Pharmacuticals, Inc. Gamma-hydroxybutyrate compositions and their use for the treatment of disorders
ITMI20132041A1 (it) * 2013-12-06 2015-06-07 Ct Lab Farm Srl Derivati dell'acido gamma-idrossibutirrico, loro preparazione e loro uso medico.
US10398662B1 (en) 2015-02-18 2019-09-03 Jazz Pharma Ireland Limited GHB formulation and method for its manufacture
ITUB20152860A1 (it) 2015-08-04 2017-02-04 Laboratorio Farm C T S R L Selezionata amide dell?acido ?-idrossibutirrico e suoi usi nel trattamento dell?abuso da alcool
ITUA20164040A1 (it) * 2016-06-01 2017-12-01 Laboratorio Farm C T S R L Procedimento per la preparazione di polimorfo a
US11602512B1 (en) 2016-07-22 2023-03-14 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US11602513B1 (en) 2016-07-22 2023-03-14 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US11986451B1 (en) 2016-07-22 2024-05-21 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
UY37341A (es) 2016-07-22 2017-11-30 Flamel Ireland Ltd Formulaciones de gamma-hidroxibutirato de liberación modificada con farmacocinética mejorada
US11504347B1 (en) 2016-07-22 2022-11-22 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US20180263936A1 (en) 2017-03-17 2018-09-20 Jazz Pharmaceuticals Ireland Limited Gamma-hydroxybutyrate compositions and their use for the treatment of disorders
KR20210094513A (ko) 2018-11-19 2021-07-29 재즈 파마슈티칼즈 아일랜드 리미티드 알코올-내성 약물 제형
JP7553453B2 (ja) 2019-03-01 2024-09-18 フラメル アイルランド リミテッド 食事摂取状態における改善された薬物動態を有するガンマ－ヒドロキシ酪酸塩組成物
WO2023126076A1 (en) 2022-01-03 2023-07-06 Laboratorio Farmaceutico C.T. S.R.L. Medical use of an amide of y-hydroxybutyric acid in the treatment of fragile x syndrome
US11779557B1 (en) 2022-02-07 2023-10-10 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US11583510B1 (en) 2022-02-07 2023-02-21 Flamel Ireland Limited Methods of administering gamma hydroxybutyrate formulations after a high-fat meal

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3940258A (en) * 1971-11-26 1976-02-24 Gaf Corporation Method for controlling aquatic weeds with N-phenylalkyl-γ-hydroxybutyramide
JPS6016432B2 (ja) * 1977-07-26 1985-04-25 グレラン製薬株式会社 複素環式化合物類およびその製造法
ES2052619T3 (es) * 1987-02-23 1994-07-16 Ono Pharmaceutical Co Un procedimiento para la preparacion de los nuevos derivados de tiazolidina.
IT1217783B (it) 1988-06-03 1990-03-30 Farmaceutico Ct S R L Lab Impiego di salo dell,acido gamma idrossi butirrico per la preparazione di composizioni farmaceutiche adatta ad essereimpiegate nella terapia dell,alcolismo e composizioni relative
IT1248588B (it) 1991-06-28 1995-01-19 Gaetano Crepaldi Composizioni farmaceutiche per la terapia dell'astinenza, del " craving", della dipendenza da sostanze stupefacenti, da sostanze psicoattive, da nicotina e dei disturbi alimentari.
EP0763016B1 (en) * 1994-06-01 2000-01-26 Axys Pharmaceuticals, Inc. Compositions and methods for treating mast-cell mediated conditions
CZ272296A3 (en) * 1995-09-18 1997-04-16 Sankyo Co Novel derivatives of urea exhibiting acat inhibition activity, their preparation and therapeutic and prophylactic application
ES2237850T3 (es) * 1997-10-14 2005-08-01 Mitsubishi Pharma Corporation Compuestos de piperazina y su uso medicinal.

Also Published As

Publication number Publication date
ES2174287T3 (es) 2002-11-01
WO1998006690A1 (en) 1998-02-19
ITMI961732A1 (it) 1998-02-09
JP2000516225A (ja) 2000-12-05
CA2263328C (en) 2006-07-25
EP0932597B1 (en) 2002-03-27
US6436998B1 (en) 2002-08-20
IT1283782B1 (it) 1998-04-30
AU4379097A (en) 1998-03-06
US20020165224A1 (en) 2002-11-07
US6770784B2 (en) 2004-08-03
PT932597E (pt) 2002-09-30
ITMI961732A0 (hu) 1996-08-09
HUP9902437A2 (hu) 1999-12-28
HU228595B1 (en) 2013-04-29
CA2263328A1 (en) 1998-02-19
ATE215065T1 (de) 2002-04-15
DE69711411D1 (de) 2002-05-02
DE69711411T2 (de) 2002-11-07
JP4259615B2 (ja) 2009-04-30
EP0932597A1 (en) 1999-08-04
DK0932597T3 (da) 2002-06-24

Similar Documents

Publication Publication Date Title
HUP9902437A3 (en) Gamma-hydroxybutyric acid amides, process to prepare them, use gamma-hydroxybutyric acid amides, and pharmaceuticals contg. them
HRP970481B1 (en) Modified aminoacids, pharmaceuticals containing these compounds and method for their production
CZ161599A3 (cs) N-substituované 2-kyanopyrrolidiny, způsob jejich přípravy a jejich použití jako léčiv
ZA987428B (en) Succinic acid production and purification
HUT69284A (en) Novel benzoyl amino acid derivs., pharmaceutical compns. conth. them and process to prepare them
GB9412585D0 (en) Microcapsules, their production and use
ZA974574B (en) Novel guanidine derivatives process for their preparations and their use as pharmaceuticals.
EP0793672A4 (en) RECOMBINANT CHEMOKINE, THEIR PRODUCTION AND USE
ZA953110B (en) Pharmaceuticals
HUP9900621A3 (en) 3,4-disubstituted phenylethanolaminotetralincarboxamide derivatives, process to prepare them and pharmaceuticals contg. the said compds.
EP0647066A3 (en) Packet conversion apparatus and system.
SI0951465T1 (en) Alpha-amino acid amides, preparation thereof and the therapeutical use thereof
ZA869074B (en) Imidazopyridazinealkenoic acid amides,processes for their preparation and intermediate products for their preparation
HUT77004A (hu) Antiaritmiás szerekként felhasználható nitro-benzamidok, előállításuk és ezeket tartalmazó gyógyszerkészítmények
ZA9610853B (en) Processes and intermediates for preparing pharmaceuticals.
HUT71606A (en) Amino-ascorbic acid derivatives, halogen-ascorbic acid derivatives and process to prepare them
ZA9510823B (en) Pharmaceuticals
HUT69182A (en) Process to prepare biopolymers with detoxicating activity
HU9401201D0 (en) Quinolyl-dihydropyridin-esters, process for producing and use of them in pharmaceuticals
HU9401212D0 (en) 4-quinoline-dihydropyridin-esters, process for producing them and use as pharmaceuticals
HUP9904501A3 (en) Modified aminoacids, pharmaceuticals containing these compounds and method for their production
GB9422781D0 (en) Pharmaceuticals
SG67361A1 (en) Suflonamidocarbonylpyridine-2-carboxamides and their pyridine-N-oxides process for their preparation and their use as pharmaceuticals
GB9412429D0 (en) Improvements relating to drugs and pharmaceuticals
GB9403239D0 (en) Improvements relating to drugs and pharmaceuticals