HUP9900598A2 - Kis nyíróerő alkalmazásával előállított dózisegységek - Google Patents

Kis nyíróerő alkalmazásával előállított dózisegységek

Info

Publication number
HUP9900598A2
HUP9900598A2 HU9900598A HUP9900598A HUP9900598A2 HU P9900598 A2 HUP9900598 A2 HU P9900598A2 HU 9900598 A HU9900598 A HU 9900598A HU P9900598 A HUP9900598 A HU P9900598A HU P9900598 A2 HUP9900598 A2 HU P9900598A2
Authority
HU
Hungary
Prior art keywords
dosage units
low shear
shear granulation
making dosage
granulation
Prior art date
Application number
HU9900598A
Other languages
English (en)
Inventor
Hendrika Gerardina Maria Poels-Janssen
Herman H. Vromans
Original Assignee
Akzo Nobel N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel N.V. filed Critical Akzo Nobel N.V.
Publication of HU9900598D0 publication Critical patent/HU9900598D0/hu
Publication of HUP9900598A2 publication Critical patent/HUP9900598A2/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • A61K31/569—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone substituted in position 17 alpha, e.g. ethisterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Soil Conditioners And Soil-Stabilizing Materials (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

A találmány tárgya eljárás gyógyszerészeti dózis egységekelőállítására, amelyek hatóanyagként 0,005-1 tömeg% mikronizált Org30659-et tartalmaznak, amelynél (a) elkeverik a hatóanyagot és azalkalmas töltőanyagot egymással, és (b) a kapott keveréketgranulálással agglomerátumokká vagy granulátumokká alakítják a keverékkötő folyadékkal való nedvesítésével keverés közben, oly módon, hogy a(b) granulálási lépésnél olyan nyíróerőt alkalmaznak, amely nemhaladja meg az agglomerátumok vagy granulátumok szakítószilárdságát. Ó
HU9900598A 1998-03-12 1999-03-11 Kis nyíróerő alkalmazásával előállított dózisegységek HUP9900598A2 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP98200790 1998-03-12

Publications (2)

Publication Number Publication Date
HU9900598D0 HU9900598D0 (en) 1999-05-28
HUP9900598A2 true HUP9900598A2 (hu) 2001-06-28

Family

ID=8233460

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9900598A HUP9900598A2 (hu) 1998-03-12 1999-03-11 Kis nyíróerő alkalmazásával előállított dózisegységek

Country Status (15)

Country Link
US (1) US6054145A (hu)
JP (1) JPH11319035A (hu)
KR (1) KR19990077775A (hu)
CN (1) CN1238948A (hu)
AR (1) AR016454A1 (hu)
AU (1) AU2118199A (hu)
BR (1) BR9904552A (hu)
CA (1) CA2265211A1 (hu)
CZ (1) CZ88899A3 (hu)
HU (1) HUP9900598A2 (hu)
IL (1) IL128818A0 (hu)
NO (1) NO991195L (hu)
PL (1) PL331961A1 (hu)
SG (1) SG72938A1 (hu)
TR (1) TR199900548A2 (hu)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1177726A1 (en) * 2000-08-04 2002-02-06 Aventis Animal Nutrition S.A. Process for the production of granules of methionine
JP2002326925A (ja) * 2001-04-27 2002-11-15 Asahi Breweries Ltd 造粒物および錠剤の製造方法
WO2005030176A1 (en) * 2003-09-29 2005-04-07 Novo Nordisk Femcare Ag Improved stability of progestogen formulations
AU2004275469B2 (en) * 2003-09-29 2010-07-15 Novo Nordisk Health Care Ag HRT formulations
TWI547431B (zh) * 2004-06-09 2016-09-01 史密斯克萊美占公司 生產藥物之裝置及方法
US20060002986A1 (en) * 2004-06-09 2006-01-05 Smithkline Beecham Corporation Pharmaceutical product
US8715724B2 (en) * 2004-10-29 2014-05-06 Mayne Pharma International Pty Ltd Tabletting process
US20070036859A1 (en) * 2005-08-11 2007-02-15 Perry Ronald L Sustained release antihistamine and decongestant composition
WO2008003050A2 (en) * 2006-06-28 2008-01-03 Emisphere Technologies, Inc. Gallium nitrate formulations
CN101810706B (zh) * 2009-05-26 2011-03-16 成都地奥制药集团有限公司 一种低剂量地榆固体制剂的制备方法
US20170182070A1 (en) 2014-10-08 2017-06-29 Mayne Pharma International Pty Ltd. Controlled Release Doxycycline
WO2020043732A1 (en) * 2018-08-30 2020-03-05 Boehringer Ingelheim International Gmbh Novel, lean and environment-friendly granulation method
US11167256B2 (en) 2019-07-01 2021-11-09 Oakwood Laboratories, Llc System and method for making microspheres and emulsions
US11330838B2 (en) 2019-07-19 2022-05-17 R. J. Reynolds Tobacco Company Holder for aerosol delivery device with detachable cartridge

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0300523B1 (en) * 1987-07-06 1991-08-14 Akzo N.V. Pharmaceutical dosage unit for the prevention or treatment of climacteric complaints
US5098714A (en) * 1989-11-16 1992-03-24 Alza Corporation Osmotic, oral dosage form for fertility control
US5266331A (en) * 1991-11-27 1993-11-30 Euroceltique, S.A. Controlled release oxycodone compositions
US5916593A (en) * 1994-09-22 1999-06-29 Akzo Nobel, N.V. Process of making dosage units by wet granulation
CA2159419C (en) * 1994-10-17 2006-07-04 Pieter De Haan Solid pharmaceutical composition comprising an excipient capable of binding water

Also Published As

Publication number Publication date
SG72938A1 (en) 2000-05-23
IL128818A0 (en) 2000-01-31
TR199900548A3 (tr) 1999-10-21
CA2265211A1 (en) 1999-09-12
JPH11319035A (ja) 1999-11-24
US6054145A (en) 2000-04-25
CZ88899A3 (cs) 1999-11-17
BR9904552A (pt) 2000-09-26
PL331961A1 (en) 1999-09-13
HU9900598D0 (en) 1999-05-28
KR19990077775A (ko) 1999-10-25
NO991195D0 (no) 1999-03-11
AU2118199A (en) 1999-09-23
NO991195L (no) 1999-09-13
AR016454A1 (es) 2001-07-04
TR199900548A2 (xx) 1999-10-21
CN1238948A (zh) 1999-12-22

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