HUP9900408A3 - Inhibitors of fibrin cross-linking and/or transglutaminases - Google Patents

Inhibitors of fibrin cross-linking and/or transglutaminases

Info

Publication number
HUP9900408A3
HUP9900408A3 HU9900408A HUP9900408A HUP9900408A3 HU P9900408 A3 HUP9900408 A3 HU P9900408A3 HU 9900408 A HU9900408 A HU 9900408A HU P9900408 A HUP9900408 A HU P9900408A HU P9900408 A3 HUP9900408 A3 HU P9900408A3
Authority
HU
Hungary
Prior art keywords
transglutaminases
inhibitors
linking
fibrin cross
fibrin
Prior art date
Application number
HU9900408A
Other languages
English (en)
Original Assignee
Biopharm Res & Dev Ltd St Heli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biopharm Res & Dev Ltd St Heli filed Critical Biopharm Res & Dev Ltd St Heli
Publication of HUP9900408A2 publication Critical patent/HUP9900408A2/hu
Publication of HUP9900408A3 publication Critical patent/HUP9900408A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/104—Aminoacyltransferases (2.3.2)
    • C12N9/1044—Protein-glutamine gamma-glutamyltransferase (2.3.2.13), i.e. transglutaminase or factor XIII
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/164—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • A61K38/166—Streptokinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/49—Urokinase; Tissue plasminogen activator
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/57—Protease inhibitors from animals; from humans
    • A61K38/58—Protease inhibitors from animals; from humans from leeches, e.g. hirudin, eglin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43536—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from worms

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Toxicology (AREA)
  • General Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HU9900408A 1995-05-05 1996-05-07 Inhibitors of fibrin cross-linking and/or transglutaminases HUP9900408A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9509271.4A GB9509271D0 (en) 1995-05-05 1995-05-05 Blood clot stabilisation inhibitors

Publications (2)

Publication Number Publication Date
HUP9900408A2 HUP9900408A2 (hu) 1999-05-28
HUP9900408A3 true HUP9900408A3 (en) 2001-10-29

Family

ID=10774108

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9900408A HUP9900408A3 (en) 1995-05-05 1996-05-07 Inhibitors of fibrin cross-linking and/or transglutaminases

Country Status (14)

Country Link
US (1) US6025330A (hu)
EP (1) EP0848719A2 (hu)
JP (1) JPH11505218A (hu)
KR (1) KR19990008348A (hu)
AU (1) AU723130B2 (hu)
BR (1) BR9608207A (hu)
CA (1) CA2220268A1 (hu)
CZ (1) CZ348197A3 (hu)
GB (1) GB9509271D0 (hu)
HU (1) HUP9900408A3 (hu)
NO (1) NO975080L (hu)
PL (1) PL323252A1 (hu)
SK (1) SK148797A3 (hu)
WO (1) WO1996034890A2 (hu)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002507201A (ja) * 1997-06-11 2002-03-05 スミスクライン・ビーチャム・コーポレイション アテローム性動脈硬化症を治療するためのファクター▲ＸＩＩＩ▼ａ阻害剤の使用
DE10046187A1 (de) * 2000-09-13 2002-03-21 Univ Schiller Jena Verfahren zur Messung der Aktivität von Gerinnungsfaktor XIIIa
DE10163333B4 (de) * 2001-12-21 2007-01-25 Curacyte Ag Modifizierte Tridegine, ihre Herstellung deren Verwendung als Transglutaminase Inhibitoren und diese enthaltende Arzneimittel und Kombinationspräparate
US20060246046A1 (en) * 2001-12-21 2006-11-02 Helmut Giersiefen Modified tridegins, production and use thereof as transglutaminase inihibitors
JP2009510105A (ja) * 2005-09-28 2009-03-12 バイオバスキュラー インコーポレーティッド 血小板および細胞の接着、細胞移動、および炎症を阻止するための方法および組成物
US20110034396A1 (en) * 2005-09-28 2011-02-10 Biovascular, Inc. Methods and compositions for inhibiting cell migration and treatment of inflammatory conditions
US20100316764A1 (en) * 2009-06-10 2010-12-16 Engrain, LLC Flour supplement compositions and methods for preparing wheat flour
GB201318182D0 (en) * 2013-10-14 2013-11-27 Univ Nottingham Trent Inhibitor peptides
KR102131041B1 (ko) 2013-12-03 2020-07-08 (주)아모레퍼시픽 태양광 차단 기능성 물질 스크리닝 방법 및 태양광 차단 효능 평가 방법
WO2017089961A1 (pt) * 2015-11-24 2017-06-01 Universidade De Trás-Os-Montes E Alto Douro Método para a produção de farinhas de cereais e de proteínas enriquecidas em l-teanina e respectivos produtos
TWI825144B (zh) 2018-08-10 2023-12-11 美商思達利醫藥公司 第二型轉麩醯胺酸酶(tg2)抑制劑
CN110174513A (zh) * 2019-04-15 2019-08-27 中山大学附属第一医院 Tgm2在制备监测克罗恩病疾病活动的生物标志物中的应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE58907266T2 (de) * 1988-06-11 1994-09-29 Ciba Geigy Ag Polypeptide mit einer die Koagulierung hemmenden Wirkung.
US5227469A (en) * 1990-02-14 1993-07-13 Genentech, Inc. Platelet aggregation inhibitors from the leech
US5328898A (en) * 1990-06-22 1994-07-12 Duke University Factor XIIIA fibrin binding fragments
WO1992013530A1 (en) * 1991-02-11 1992-08-20 Medicis Corporation Transglutaminase enzyme inhibitors
IT1264084B1 (it) * 1993-12-22 1996-09-10 Raggio Italgene Spa Peptide ad attivita' di substrato e/o inibitore dell'enzima transglutaminasi e suo uso in diagnosi e terapia.
DE4402631A1 (de) * 1994-01-29 1995-08-03 Boehringer Mannheim Gmbh Verfahren zur Bestimmung von Gerinnungsparametern

Also Published As

Publication number Publication date
AU5654696A (en) 1996-11-21
CZ348197A3 (cs) 1998-03-18
BR9608207A (pt) 2000-10-31
JPH11505218A (ja) 1999-05-18
US6025330A (en) 2000-02-15
GB9509271D0 (en) 1995-06-28
NO975080D0 (no) 1997-11-04
SK148797A3 (en) 1998-04-08
WO1996034890A3 (en) 1997-10-23
CA2220268A1 (en) 1996-11-07
HUP9900408A2 (hu) 1999-05-28
EP0848719A2 (en) 1998-06-24
AU723130B2 (en) 2000-08-17
PL323252A1 (en) 1998-03-16
MX9708513A (es) 1998-08-30
NO975080L (no) 1998-01-02
WO1996034890A2 (en) 1996-11-07
KR19990008348A (ko) 1999-01-25

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