HUP9800049A2 - Aminosav(ak)at tartalmazó gyógyszerek és tápanyagkészítmények, valamint az aminosavak alkalmazása a TNF-szint csökkentésére szolgáló gyógyszerkészítmények előállítására - Google Patents
Aminosav(ak)at tartalmazó gyógyszerek és tápanyagkészítmények, valamint az aminosavak alkalmazása a TNF-szint csökkentésére szolgáló gyógyszerkészítmények előállításáraInfo
- Publication number
- HUP9800049A2 HUP9800049A2 HU9800049A HUP9800049A HUP9800049A2 HU P9800049 A2 HUP9800049 A2 HU P9800049A2 HU 9800049 A HU9800049 A HU 9800049A HU P9800049 A HUP9800049 A HU P9800049A HU P9800049 A2 HUP9800049 A2 HU P9800049A2
- Authority
- HU
- Hungary
- Prior art keywords
- amino acid
- preparations
- medicines
- amino acids
- diminution
- Prior art date
Links
- 150000001413 amino acids Chemical class 0.000 title abstract 6
- 235000016709 nutrition Nutrition 0.000 title abstract 4
- 239000000203 mixture Substances 0.000 title abstract 2
- 230000035764 nutrition Effects 0.000 title 1
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 abstract 6
- 238000002360 preparation method Methods 0.000 abstract 5
- 235000001014 amino acid Nutrition 0.000 abstract 4
- 229940079593 drug Drugs 0.000 abstract 3
- 239000003814 drug Substances 0.000 abstract 3
- 229910052500 inorganic mineral Inorganic materials 0.000 abstract 3
- 239000011707 mineral Substances 0.000 abstract 3
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 abstract 2
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 abstract 2
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 abstract 2
- 235000004279 alanine Nutrition 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 206010058822 Bone marrow necrosis Diseases 0.000 abstract 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 abstract 1
- 229930064664 L-arginine Natural products 0.000 abstract 1
- 235000014852 L-arginine Nutrition 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 238000009835 boiling Methods 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000001506 immunosuppresive effect Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 235000020660 omega-3 fatty acid Nutrition 0.000 abstract 1
- 229920000768 polyamine Polymers 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
- A23L33/12—Fatty acids or derivatives thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/13—Nucleic acids or derivatives thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/175—Amino acids
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/40—Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Nutrition Science (AREA)
- Food Science & Technology (AREA)
- Mycology (AREA)
- Polymers & Plastics (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Obesity (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Diabetes (AREA)
- Pediatric Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
a találmány aminősav(ak)at tartalmazó gyógyszerekre éstápanyagkészítményekre, valamint ezeknek a TNF-szint csökkentésétcélzó alkalmazására vőnatkőzik.A találmány szerinti gyógyszerek és tápanyagkészítmények hatásősmennyiségben tartalmaznak:a) szabad főrmában, fiziőlógiai szempőntból elfőgadható só alakjábanvagy keverék főrmájában a glicerin, az alanin és a szerin közül egyvagy több aminősavat[a) kőmpőnens]a következő b), c) és d) kőmpőnensek közül legalább eggyel kőmbinálva:b) őmega-3-PUFA-kat[b) kőmpőnens],c) L-arginint és/vagy más, fiziőlógiai szempőntból elfőgadható, apőliaminők szintézisével kapcsőlatban levő vegyületeket[c)kőmpőnens], ésd) nűkleinbázisfőrrást[d) kőmpőnens].A találmány tárgyát képezi tővábbá a glicerin, az alanin és a szerinközül legalább egy aminősavnak vagy e sav sójának az alkalmazása őlyangyógyszerek vagy tápanyagkészítmények előállítására, amelyekalkalmasak a tűmőrnekrózis-faktőr kőncentrácójának a csökkentésére.A találmány vőnatkőzik őlyan kőmbinált készítményekre is, amelyek atalálmány szerinti aminősav(ak)őn kívül imműngátló típűsú pőlipeptidetis tartalmaznak. Ezeket a készítményeket transzplantált betegekkezelésére is fel lehet használni.ŕ
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08392694 US5656608B1 (en) | 1995-02-23 | 1995-02-23 | Amino acid compositions and methods of treatment using same |
| GBGB9512100.0A GB9512100D0 (en) | 1995-06-14 | 1995-06-14 | Improvements in or relating to organic compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP9800049A2 true HUP9800049A2 (hu) | 1998-05-28 |
| HUP9800049A3 HUP9800049A3 (en) | 1999-01-28 |
Family
ID=26307213
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9800049A HUP9800049A3 (en) | 1995-02-23 | 1996-02-22 | Amino acid compositions and use thereof in clinical nutrition, and use of the said amino acids for preparing pharmaceutical compns. for the diminution of tnf |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP0810829B1 (hu) |
| JP (1) | JPH11501301A (hu) |
| KR (1) | KR19980702436A (hu) |
| CN (1) | CN1175887A (hu) |
| AT (1) | ATE191615T1 (hu) |
| AU (1) | AU710527B2 (hu) |
| BR (1) | BR9607336A (hu) |
| CA (1) | CA2210499A1 (hu) |
| CZ (1) | CZ266797A3 (hu) |
| DE (1) | DE69607750T2 (hu) |
| DK (1) | DK0810829T3 (hu) |
| ES (1) | ES2145997T3 (hu) |
| FI (1) | FI972744A (hu) |
| HU (1) | HUP9800049A3 (hu) |
| NO (1) | NO973884L (hu) |
| PL (1) | PL182205B1 (hu) |
| PT (1) | PT810829E (hu) |
| WO (1) | WO1996025861A1 (hu) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9512100D0 (en) * | 1995-06-14 | 1995-08-09 | Sandoz Nutrition Ltd | Improvements in or relating to organic compounds |
| US6096785A (en) * | 1996-07-30 | 2000-08-01 | Novartis Nutrition Ag | Amino acid compositions and use thereof in treating renal dysfunction |
| JP2000515874A (ja) * | 1996-07-30 | 2000-11-28 | ノバルテイス・ニユートリシヨン・アクチエンゲゼルシヤフト | アミノ酸組成物、ならびに腫瘍の成長および転移の処置におけるその使用 |
| GB9701674D0 (en) * | 1997-01-28 | 1997-03-19 | Novartis Nutrition Ag | Use of organic compounds |
| DE69823739T2 (de) * | 1997-06-05 | 2005-04-28 | Novartis Nutrition Ag | Glycin zur Vorbeugung oder Behandlung von Transplantatabstossungen |
| CA2298795A1 (en) * | 1997-07-28 | 1999-02-04 | The Institute Of Physical And Chemical Research | Agent for protecting central nerve cells and enhancing survival thereof |
| US6143786A (en) * | 1999-02-02 | 2000-11-07 | Novartis Nutrition Ag | Oral arginine and insulin secretion |
| US6808902B1 (en) | 1999-11-12 | 2004-10-26 | Amgen Inc. | Process for correction of a disulfide misfold in IL-1Ra Fc fusion molecules |
| DK2295081T3 (en) | 2001-06-26 | 2019-02-18 | Amgen Inc | Antibodies to OPGL |
| NL1019368C2 (nl) | 2001-11-14 | 2003-05-20 | Nutricia Nv | Preparaat voor het verbeteren van receptorwerking. |
| DE10257360A1 (de) * | 2002-12-09 | 2004-07-08 | Fresenius Kabi Deutschland Gmbh | Gastro-intestinal verabreichbare Formulierung und deren Verwendung |
| WO2005023021A1 (ja) | 2003-09-02 | 2005-03-17 | Bbk Bio Corporation | ダイエット食品 |
| EP1591118A1 (en) | 2004-04-27 | 2005-11-02 | Nutri-Fit GmbH & Co. KG | Use of melatonin in preventing postoperative complications |
| KR100555904B1 (ko) * | 2004-05-19 | 2006-03-03 | 주식회사 오스코텍 | 큰느타리버섯과 오가피의 혼합 생약재 추출물 및 이를유효성분으로 하는 골다공증 예방 및 치료용 조성물 |
| US20100215631A1 (en) * | 2006-06-14 | 2010-08-26 | Anita Hartog | Anti-inflammatory composition comprising glycine and lactoferrin and the use thereof |
| CN105267969A (zh) | 2008-01-04 | 2016-01-27 | 雀巢产品技术援助有限公司 | 包含不饱和脂肪酸和一氧化氮释放化合物的组合物及其用于增强认知和相关功能的用途 |
| US20100179089A1 (en) * | 2009-01-13 | 2010-07-15 | Deutz Nicolaas E P | Compositions and Methods to Manage the Inflammatory Basis of Chronic Disease Conditions and Maintain an Optimal Immune Response in Elderly |
| NZ615091A (en) * | 2009-06-08 | 2015-03-27 | Ucl Business Plc | Treatment of portal hypertension and restoration of liver function using l-ornithine phenylacetate |
| KR101213825B1 (ko) * | 2010-07-16 | 2012-12-18 | 서울대학교산학협력단 | 세린을 유효성분으로 함유하는 지방간 질환의 예방 및 치료용 조성물 |
| NZ607189A (en) | 2010-09-24 | 2015-04-24 | Univ Florida | Materials and methods for improving gastrointestinal function |
| WO2014164736A1 (en) | 2013-03-11 | 2014-10-09 | University Of Florida Research Foundation, Incorporated | Materials and methods for improving lung function and for prevention and/or treatment of radiation-induced lung complications |
| MX2017006748A (es) | 2014-11-24 | 2017-08-28 | Entrinsic Health Solutions Inc | Composiciones de aminoácidos para el tratamiento de síntomas de enfermedades. |
| WO2017058016A1 (en) * | 2015-10-02 | 2017-04-06 | N.V. Nutricia | Glycine for use in tolerance induction in allergic patients |
| FR3041882B1 (fr) * | 2015-10-06 | 2019-04-12 | Universite D'angers | Preparation pharmaceutique pour le traitement preventif de lesions d'ischenie reperfusion |
| CA3039514C (en) | 2016-10-04 | 2022-01-25 | University Of Florida Research Foundation, Incorporated | Amino acid compositions and uses thereof |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2591893B1 (fr) * | 1985-12-19 | 1988-11-10 | Centre Nat Rech Scient | Compositions nutritionnelles carencees en methionine destinees a inhiber le developpement et la dissemination des tumeurs malignes chez les mammiferes |
| US4988724A (en) * | 1988-12-09 | 1991-01-29 | Board Of Regents, The University Of Texas System | Methods and improved formulations for the determination and treatment of malignant disease in patients |
| EP0663826B1 (en) * | 1991-09-27 | 1998-12-23 | Board Of Regents The University Of Texas System | Amino acids containing parenteral formulations for the treatment of hypotension and related pathologies |
| US5571783A (en) * | 1993-03-09 | 1996-11-05 | Clintec Nutrition Company | Composition and method for treating patients with hepatic disease |
-
1996
- 1996-02-22 WO PCT/EP1996/000739 patent/WO1996025861A1/en not_active Application Discontinuation
- 1996-02-22 HU HU9800049A patent/HUP9800049A3/hu unknown
- 1996-02-22 KR KR1019970705835A patent/KR19980702436A/ko not_active Application Discontinuation
- 1996-02-22 CN CN96192066A patent/CN1175887A/zh active Pending
- 1996-02-22 PT PT96904849T patent/PT810829E/pt unknown
- 1996-02-22 EP EP96904849A patent/EP0810829B1/en not_active Expired - Lifetime
- 1996-02-22 DK DK96904849T patent/DK0810829T3/da active
- 1996-02-22 CA CA002210499A patent/CA2210499A1/en not_active Abandoned
- 1996-02-22 BR BR9607336A patent/BR9607336A/pt not_active Application Discontinuation
- 1996-02-22 AT AT96904849T patent/ATE191615T1/de not_active IP Right Cessation
- 1996-02-22 DE DE69607750T patent/DE69607750T2/de not_active Expired - Fee Related
- 1996-02-22 ES ES96904849T patent/ES2145997T3/es not_active Expired - Lifetime
- 1996-02-22 JP JP8525404A patent/JPH11501301A/ja active Pending
- 1996-02-22 CZ CZ972667A patent/CZ266797A3/cs unknown
- 1996-02-22 PL PL96321238A patent/PL182205B1/pl unknown
- 1996-02-22 AU AU48795/96A patent/AU710527B2/en not_active Ceased
-
1997
- 1997-06-25 FI FI972744A patent/FI972744A/fi unknown
- 1997-08-22 NO NO973884A patent/NO973884L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| KR19980702436A (ko) | 1998-07-15 |
| FI972744A (fi) | 1997-08-22 |
| HUP9800049A3 (en) | 1999-01-28 |
| ES2145997T3 (es) | 2000-07-16 |
| BR9607336A (pt) | 1997-11-25 |
| NO973884D0 (no) | 1997-08-22 |
| PL182205B1 (pl) | 2001-11-30 |
| WO1996025861A1 (en) | 1996-08-29 |
| MX9706140A (es) | 1997-11-29 |
| ATE191615T1 (de) | 2000-04-15 |
| FI972744A0 (fi) | 1997-06-25 |
| DE69607750D1 (de) | 2000-05-18 |
| NO973884L (no) | 1997-10-17 |
| CZ266797A3 (cs) | 1998-03-18 |
| DE69607750T2 (de) | 2000-08-31 |
| PL321238A1 (en) | 1997-11-24 |
| AU4879596A (en) | 1996-09-11 |
| AU710527B2 (en) | 1999-09-23 |
| EP0810829A1 (en) | 1997-12-10 |
| JPH11501301A (ja) | 1999-02-02 |
| CA2210499A1 (en) | 1996-08-29 |
| PT810829E (pt) | 2000-08-31 |
| CN1175887A (zh) | 1998-03-11 |
| DK0810829T3 (da) | 2000-08-28 |
| EP0810829B1 (en) | 2000-04-12 |
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