HUP9701540A1 - A gasztrointesztinális keringést elősegítő gyógyászati készítmény - Google Patents

A gasztrointesztinális keringést elősegítő gyógyászati készítmény

Info

Publication number
HUP9701540A1
HUP9701540A1 HU9701540A HUP9701540A HUP9701540A1 HU P9701540 A1 HUP9701540 A1 HU P9701540A1 HU 9701540 A HU9701540 A HU 9701540A HU P9701540 A HUP9701540 A HU P9701540A HU P9701540 A1 HUP9701540 A1 HU P9701540A1
Authority
HU
Hungary
Prior art keywords
lower alkyl
pharmaceutical composition
blood circulation
improving gastrointestinal
gastrointestinal blood
Prior art date
Application number
HU9701540A
Other languages
English (en)
Inventor
Julius Gy. Papp
Susanna Rózsa
Dirk Thormählen
Harald Waldeck
Original Assignee
Solvay Pharmaceuticals Gmbh.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Solvay Pharmaceuticals Gmbh. filed Critical Solvay Pharmaceuticals Gmbh.
Publication of HU9701540D0 publication Critical patent/HU9701540D0/hu
Publication of HUP9701540A1 publication Critical patent/HUP9701540A1/hu
Publication of HU223752B1 publication Critical patent/HU223752B1/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Az (I) általánős képletű vegyületek (mely képletben R1 jelentése a fenilgyűrűn adőtt esetben kis szénatőmszámúalkilcsőpőrttal, kis szénatőmszámú alkőxicsőpőrttal vagyhalőgénatőmmal helyettesített fenil-(kis szénatőmszámú alkil)-csőpőrtvagy naftil-(kis szénatőmszámú alkil)-csőpőrt; R2 jelentése hidrőgénatőm vagy biőlógiailag labilis észtert képezőcsőpőrt; és R3 jelentése hidrőgénatőm vagy biőlógiailag labilis észtert képezőcsőpőrt) és az (I) általánős képletű karbőnsavak gyógyászatilagalkalmas sói gasztrőintesztinális keringési zavarők kezelésére és/vagymegelőzésére alkalmas gyógyászati készítmények előállításáraalkalmazhatók. ŕ
HU9701540A 1996-09-18 1997-09-15 A gasztrointesztinális keringést elősegítő gyógyászati készítmény HU223752B1 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19638020A DE19638020A1 (de) 1996-09-18 1996-09-18 Die gastrointestinale Durchblutung fördernde Arzneimittel

Publications (3)

Publication Number Publication Date
HU9701540D0 HU9701540D0 (en) 1997-10-28
HUP9701540A1 true HUP9701540A1 (hu) 2000-08-28
HU223752B1 HU223752B1 (hu) 2005-01-28

Family

ID=7805990

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9701540A HU223752B1 (hu) 1996-09-18 1997-09-15 A gasztrointesztinális keringést elősegítő gyógyászati készítmény

Country Status (6)

Country Link
US (1) US5783573A (hu)
EP (1) EP0830863B1 (hu)
JP (1) JP4204083B2 (hu)
DE (2) DE19638020A1 (hu)
ES (1) ES2145545T3 (hu)
HU (1) HU223752B1 (hu)

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DE19906310A1 (de) * 1999-02-16 2000-08-17 Solvay Pharm Gmbh Arzneimittel zur Behandlung von Bluthochdruck
DE19932555A1 (de) * 1999-07-13 2001-01-18 Solvay Pharm Gmbh Arzneimittel mit protektiver Wirkung gegen oxidativ-toxische und insbesondere gegen kardiotoxische Substanzen
CA2392076A1 (en) * 1999-11-19 2001-05-25 Solvay Pharmaceuticals B.V. Human enzymes of the metalloprotease family
MXPA03010341A (es) * 2001-05-18 2004-03-10 Solvay Pharm Gmbh Uso de compuestos con actividad inhibitoria de epn/mp combinada en la preparacion de medicamentos.
AP1758A (en) * 2001-09-10 2007-07-30 Tibotec Pharm Ltd Method for the preparation of hexahydro-furo [2,3-b]furan-3-ol.
CA2473447A1 (en) * 2002-01-16 2003-07-24 Solvay Pharmaceuticals B.V. Solid salts of benzazepine compounds and their use in the preparation of pharmaceutical compounds
AR038681A1 (es) * 2002-02-14 2005-01-26 Solvay Pharm Bv Formulacion oral de solucion solida de una sustancia activa pobremente soluble en agua
US6842358B2 (en) * 2002-08-01 2005-01-11 Netlogic Microsystems, Inc. Content addressable memory with cascaded array
US7045653B2 (en) * 2002-12-23 2006-05-16 Pfizer, Inc. Pharmaceuticals
US7427611B2 (en) 2003-09-26 2008-09-23 Solvay Pharmaceuticals Gmbh Amidomethyl-substituted 1-(carboxyalkyl)-cyclopentyl-carbonylamino-benzazepine-N-acetic acid compounds, process and intermediate products for their preparation and pharmaceutical compositions containing them
US7262184B2 (en) 2003-09-26 2007-08-28 Solvay Pharmaceuticals Gmbh Amidomethyl-substituted 1-(carboxyalkyl) cyclopentyl-carbonylamino-benzazepine-N-acetic acid compounds, process and intermediate products for their preparation and pharmaceutical compositions containing them
US7452875B2 (en) 2003-09-26 2008-11-18 Solvay Pharmaceuticals Gmbh Amidomethyl-substituted 1-(carboxyalkyl) cyclopentyl-carbonylamino-benzazepine-N-acetic acid compounds, process and intermediate products for their preparation and pharmaceutical compositions containing them
TWI344366B (en) * 2003-11-18 2011-07-01 Solvay Pharm Gmbh Pharmaceutical compositions for the treatment of renal dysfunction, disease or disorder, in particular in diabetic patients
US20050267124A1 (en) * 2004-05-14 2005-12-01 Solvay Pharmaceuticals Gmbh Pharmaceutical compositions comprising NEP-inhibitors, inhibitors of the endogenous producing system and PDEV inhibiitors
US20050267072A1 (en) * 2004-05-14 2005-12-01 Solvay Pharmaceuticals Gmbh Pharmaceutical compositions containing dually acting inhibitors of neutral endopeptidase for the treatment of sexual dysfunction
US20050288272A1 (en) * 2004-06-23 2005-12-29 Solvay Pharmaceuticals Gmbh Pharmaceutical compositions comprising NEP-inhibitors, inhibitors of the endogenous endothelin producing system and AT1 receptor antagonists
US7816347B2 (en) 2004-12-15 2010-10-19 Solvay Pharmaceuticals Gmbh Pharmaceutical compositions comprising NEP-inhibitors, inhibitors of the endogenous endothelin producing system and HMG CoA reductase inhibitors
US20060159748A1 (en) * 2004-12-23 2006-07-20 Rajesh Jain Oral immediate release formulation of a poorly water-soluble active substance
TW200633713A (en) * 2004-12-23 2006-10-01 Solvay Pharm Bv Oral immediate release formulation of a poorly water-soluble active substance
US20060205625A1 (en) * 2005-02-18 2006-09-14 Solvay Pharmaceuticals Gmbh Pharmaceutical compositions comprising NEP-inhibitors, inhibitors of the endogenous endothelin producing system and diuretics
WO2007102171A2 (en) * 2006-03-07 2007-09-13 Panacea Biotec Ltd Novel salts of 1h-1-benzazepine-1-acetic acid, their preparation and pharmaceutical composition
US20070292503A1 (en) * 2006-06-16 2007-12-20 Gorissen Henricus R Oral pharmaceutical composition of poorly water-soluble active substance
US20070299054A1 (en) * 2006-06-22 2007-12-27 Rajesh Jain Oral pharmaceutical composition of a poorly water-soluble active agent
JP2012526810A (ja) 2009-05-13 2012-11-01 イントラ−セルラー・セラピーズ・インコーポレイテッド 有機化合物
AR079059A1 (es) 2009-12-07 2011-12-21 Abbott Healthcare Products Bv Acido ((3s)-3-(((1-(((2r)-2-carboxi-4-(1-naftil) butil) ciclopentil)-carbonil) amino )-2-oxo-2,3,4,5-tetrahidro-1h-1-benzazepin-1-il) acetico cristalino, su preparacion y uso
US9801882B2 (en) 2013-02-17 2017-10-31 Intra-Cellular Therapies, Inc. Phosphodiesterase-1 inhibitors and their use in treatment of cardiovascular diseases
US10131671B2 (en) 2014-08-07 2018-11-20 Intra-Cellular Therapies, Inc. Organic compounds
CN105017154B (zh) * 2015-07-07 2017-10-10 浙江博聚新材料有限公司 一种3‑溴‑1,3,4,5‑四氢‑2h‑1‑苯并氮杂卓‑2‑酮制备方法
CN109071504B (zh) 2016-02-05 2022-03-08 戴纳立制药公司 受体相互作用蛋白激酶1的抑制剂
US10682354B2 (en) 2016-03-28 2020-06-16 Intra-Cellular Therapies, Inc. Compositions and methods
DK3552017T3 (da) 2016-12-09 2022-05-16 Denali Therapeutics Inc Forbindelser, der er anvendelige som ripk1-inhibitorer
JP7401442B2 (ja) 2018-01-31 2023-12-19 イントラ－セルラー・セラピーズ・インコーポレイテッド 新規使用
PL424453A1 (pl) * 2018-01-31 2019-08-12 Forty-Four Pharmaceuticals Spółka Z Ograniczoną Odpowiedzialnością Sposoby zmniejszania szkodliwego działania niedoboru perfuzji narządów miąższowych przez inhibitory obojętnej endopeptydazy (NEP) i ludzkiej rozpuszczalnej endopeptydazy (hSEP)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9310075D0 (en) * 1993-05-17 1993-06-30 Fujisawa Pharmaceutical Co New mercapto-amide derivatives,processes for the preparation thereof and pharmaceutical composition comprising the same
DE19510566A1 (de) * 1995-03-23 1996-09-26 Kali Chemie Pharma Gmbh Benzazepin-, Benzoxazepin- und Benzothiazepin-N-essigsäurederivate sowie Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel

Also Published As

Publication number Publication date
HU9701540D0 (en) 1997-10-28
DE59701631D1 (de) 2000-06-15
EP0830863B1 (de) 2000-05-10
DE19638020A1 (de) 1998-03-19
HU223752B1 (hu) 2005-01-28
EP0830863A1 (de) 1998-03-25
US5783573A (en) 1998-07-21
JPH10101565A (ja) 1998-04-21
ES2145545T3 (es) 2000-07-01
JP4204083B2 (ja) 2009-01-07

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Effective date: 20041122

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