HUP0800762A2 - Process for the preparation of trans-4-amino-cyclohexyl aceticacid-ethyl-ester hydrochloric salt - Google Patents
Process for the preparation of trans-4-amino-cyclohexyl aceticacid-ethyl-ester hydrochloric saltInfo
- Publication number
- HUP0800762A2 HUP0800762A2 HU0800762A HUP0800762A HUP0800762A2 HU P0800762 A2 HUP0800762 A2 HU P0800762A2 HU 0800762 A HU0800762 A HU 0800762A HU P0800762 A HUP0800762 A HU P0800762A HU P0800762 A2 HUP0800762 A2 HU P0800762A2
- Authority
- HU
- Hungary
- Prior art keywords
- aceticacid
- cyclohexyl
- trans
- ethyl
- amino
- Prior art date
Links
- SBVCDGKSVSHGFL-KYZUINATSA-N CCOC(=O)C[C@H]1CC[C@H](N)CC1 Chemical compound CCOC(=O)C[C@H]1CC[C@H](N)CC1 SBVCDGKSVSHGFL-KYZUINATSA-N 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/46—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/04—Formation of amino groups in compounds containing carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/16—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions not involving the amino or carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/40—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C61/08—Saturated compounds having a carboxyl group bound to a six-membered ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Priority Applications (26)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU0800762A HU229858B1 (en) | 2008-12-17 | 2008-12-17 | Process for the preparation of trans 4-amino-cyclohexyl acetic acid ethyl ester hcl |
| TW098142928A TWI465428B (zh) | 2008-12-17 | 2009-12-15 | 製備反式４－胺基－環己基乙酸乙酯ｈｃ１之方法 |
| NZ592753A NZ592753A (en) | 2008-12-17 | 2009-12-17 | Process for the preparation of trans 4-amino-cyclohexyl acetic acid ethyl ester hcl |
| PL09797144T PL2358661T3 (pl) | 2008-12-17 | 2009-12-17 | Sposób otrzymywania chlorowodorku estru etylowego kwasu trans 4- amino-cykloheksylooctowego |
| EA201170811A EA020350B1 (ru) | 2008-12-17 | 2009-12-17 | СПОСОБ ПОЛУЧЕНИЯ ЭТИЛОВОГО ЭФИРА ТРАНС-4-АМИНОЦИКЛОГЕКСИЛУКСУСНОЙ КИСЛОТЫ∙HCl |
| CN200980146417.6A CN102224130B (zh) | 2008-12-17 | 2009-12-17 | 反式4-氨基-环己基乙酸乙酯HCl的制备方法 |
| ES09797144.4T ES2468365T3 (es) | 2008-12-17 | 2009-12-17 | Procedimiento de preparación de HCl del éster etílico del ácido trans 4-amino-ciclohexil acético |
| AU2009329293A AU2009329293B2 (en) | 2008-12-17 | 2009-12-17 | Process for the preparation of trans 4-amino-cyclohexyl acetic acid ethyl ester HCl |
| SG2011029204A SG171715A1 (en) | 2008-12-17 | 2009-12-17 | Process for the preparation of trans 4-amino-cyclohexyl acetic acid ethyl ester hcl |
| SI200930947T SI2358661T1 (sl) | 2008-12-17 | 2009-12-17 | Postopek za pripravo HC1 etil estra trans 4-amino-cikloheksil ocetne kisline |
| JP2011541612A JP5667576B2 (ja) | 2008-12-17 | 2009-12-17 | トランス４−アミノ−シクロヘキシル酢酸エチル・エステルＨＣｌの製法 |
| UAA201109014A UA107073C2 (uk) | 2008-12-17 | 2009-12-17 | СПОСІБ ОДЕРЖАННЯ ЕТИЛОВОГО ЕФІРУ ТРАНС-4-АМІНОЦИКЛОГЕКСИЛОЦТОВОЇ КИСЛОТИ•HCl |
| RS20140244A RS53311B (en) | 2008-12-17 | 2009-12-17 | PROCEDURE FOR THE PREPARATION OF TRANS 4-AMINO-CYCLOHEXYL ACID ACID ETYL ESTAR HCL |
| EP09797144.4A EP2358661B1 (en) | 2008-12-17 | 2009-12-17 | Process for the preparation of trans 4-amino-cyclohexyl acetic acid ethyl ester hcl |
| US13/140,237 US8802888B2 (en) | 2008-12-17 | 2009-12-17 | Process for the preparation of trans 4-amino-cyclohexyl acetic acid ethyl ester HCl |
| DK09797144.4T DK2358661T3 (da) | 2008-12-17 | 2009-12-17 | Fremgangsmåde til fremstilling af trans-4-amino-cyclohexyl-eddikesyreethylester-hcl |
| MX2011006584A MX2011006584A (es) | 2008-12-17 | 2009-12-17 | Procedimiento de preparacion de clorhidrato del ester etilico del acido trans 4-amino-ciclohexil acetico. |
| PT97971444T PT2358661E (pt) | 2008-12-17 | 2009-12-17 | Processo para a preparação do éster etílico do ácido trans 4-amino-ciclohexilacético hcl |
| GEAP200912299A GEP20125710B (en) | 2008-12-17 | 2009-12-17 | Methog of trans-4-amino-cyclohexyl acetic acid ethyl ester hcl preparation |
| BRPI0923004A BRPI0923004A2 (pt) | 2008-12-17 | 2009-12-17 | processo para a preparação de hlc de éster etílico de ácido trans 4-amino-ciclohexil acético |
| CA2743921A CA2743921C (en) | 2008-12-17 | 2009-12-17 | Process for the preparation of trans 4-amino-cyclohexyl acetic acid ethyl ester hcl |
| PCT/HU2009/000107 WO2010070368A1 (en) | 2008-12-17 | 2009-12-17 | Process for the preparation of trans 4-amino-cyclohexyl acetic acid ethyl ester hcl |
| IL212597A IL212597A (en) | 2008-12-17 | 2011-05-01 | Process for making trans 4-amino-cyclohexyl acetic acid ethyl ester chloride acid |
| HK12101218.0A HK1160836A1 (en) | 2008-12-17 | 2012-02-08 | Process for the preparation of trans 4-amino-cyclohexyl acetic acid ethyl ester hcl 4-- hc1 |
| CY20141100322T CY1115047T1 (el) | 2008-12-17 | 2014-05-06 | Μεθοδος παρασκευης hcl αιθυλεστερα trans 4-αμινο-κυκλοεξυλ οξεικου οξεος |
| HRP20140532AT HRP20140532T1 (hr) | 2008-12-17 | 2014-06-06 | Postupak pripreme trans-4-amino-cikloheksil etil ester acetata hcl |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU0800762A HU229858B1 (en) | 2008-12-17 | 2008-12-17 | Process for the preparation of trans 4-amino-cyclohexyl acetic acid ethyl ester hcl |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| HU0800762D0 HU0800762D0 (en) | 2009-03-02 |
| HUP0800762A2 true HUP0800762A2 (en) | 2010-11-29 |
| HU229858B1 HU229858B1 (en) | 2014-10-28 |
Family
ID=89988671
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0800762A HU229858B1 (en) | 2008-12-17 | 2008-12-17 | Process for the preparation of trans 4-amino-cyclohexyl acetic acid ethyl ester hcl |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US8802888B2 (hu) |
| EP (1) | EP2358661B1 (hu) |
| JP (1) | JP5667576B2 (hu) |
| CN (1) | CN102224130B (hu) |
| AU (1) | AU2009329293B2 (hu) |
| BR (1) | BRPI0923004A2 (hu) |
| CA (1) | CA2743921C (hu) |
| CY (1) | CY1115047T1 (hu) |
| DK (1) | DK2358661T3 (hu) |
| EA (1) | EA020350B1 (hu) |
| ES (1) | ES2468365T3 (hu) |
| GE (1) | GEP20125710B (hu) |
| HK (1) | HK1160836A1 (hu) |
| HR (1) | HRP20140532T1 (hu) |
| HU (1) | HU229858B1 (hu) |
| IL (1) | IL212597A (hu) |
| MX (1) | MX2011006584A (hu) |
| NZ (1) | NZ592753A (hu) |
| PL (1) | PL2358661T3 (hu) |
| PT (1) | PT2358661E (hu) |
| RS (1) | RS53311B (hu) |
| SG (1) | SG171715A1 (hu) |
| SI (1) | SI2358661T1 (hu) |
| TW (1) | TWI465428B (hu) |
| UA (1) | UA107073C2 (hu) |
| WO (1) | WO2010070368A1 (hu) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2317852T3 (en) | 2008-07-16 | 2015-03-23 | Richter Gedeon Nyrt | PHARMACEUTICAL FORMULATIONS CONTAINING dopamine receptor ligands |
| CN103214384B (zh) * | 2013-04-10 | 2015-04-01 | 淮阴师范学院 | 对氨基苯乙酸的制备方法 |
| ITMI20131693A1 (it) | 2013-10-14 | 2015-04-15 | Chemo Res S L | Derivati della 1,4-cicloesilammina e loro preparazione |
| CN106543039A (zh) * | 2015-09-22 | 2017-03-29 | 江苏恩华药业股份有限公司 | 一种用于制备卡利拉嗪的化合物及其制备方法 |
| CN106565510B (zh) * | 2015-10-09 | 2018-04-27 | 浙江京新药业股份有限公司 | 反式4-氨基-环己基乙酸酯衍生物的制备方法 |
| CN106083631B (zh) * | 2016-06-02 | 2018-11-16 | 平光制药股份有限公司 | 一种对氨基苯乙酸的制备方法 |
| US11274087B2 (en) | 2016-07-08 | 2022-03-15 | Richter Gedeon Nyrt. | Industrial process for the preparation of cariprazine |
| HU231173B1 (hu) * | 2016-07-08 | 2021-06-28 | Richter Gedeon Nyrt. | Ipari eljárás cariprazine előállítására |
| CN106543017B (zh) * | 2016-11-10 | 2018-04-06 | 中国科学院青岛生物能源与过程研究所 | 一种4‑氨基‑环己乙酸的制备方法 |
| WO2019124011A1 (ja) | 2017-12-22 | 2019-06-27 | 三菱ケミカル株式会社 | 樹脂組成物、塗料組成物、塗装物 |
| CN110240548A (zh) * | 2018-03-09 | 2019-09-17 | 上虞京新药业有限公司 | 一种卡利拉嗪中间体的制备方法 |
| CN108586389B (zh) * | 2018-06-29 | 2020-06-12 | 成都福柯斯医药技术有限公司 | 一种合成卡利拉嗪的方法 |
| US11547707B2 (en) | 2019-04-10 | 2023-01-10 | Richter Gedeon Nyrt. | Carbamoyl cyclohexane derivatives for treating autism spectrum disorder |
| CN114645027A (zh) * | 2020-12-21 | 2022-06-21 | 上海合全药物研发有限公司 | 一种来源于巨大芽孢杆菌的氨基转移酶突变体及其应用 |
| WO2023042081A1 (en) | 2021-09-15 | 2023-03-23 | Richter Gedeon Nyrt. | PROCESS TO PRODUCE (1r,4r)-4-SUBSTITUTED CYCLOHEXANE-1-AMINES |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3540150A1 (de) * | 1985-11-13 | 1987-05-14 | Boehringer Mannheim Gmbh | Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel |
| CN1148344C (zh) * | 2000-09-06 | 2004-05-05 | 胡国宜 | 4，4'－二 氨基苯酰替苯胺的制备方法 |
| KR100641825B1 (ko) | 2003-11-05 | 2006-11-02 | 주식회사 코오롱 | 4-바이페닐아세트산의 제조 방법 |
-
2008
- 2008-12-17 HU HU0800762A patent/HU229858B1/hu not_active IP Right Cessation
-
2009
- 2009-12-15 TW TW098142928A patent/TWI465428B/zh active
- 2009-12-17 AU AU2009329293A patent/AU2009329293B2/en active Active
- 2009-12-17 WO PCT/HU2009/000107 patent/WO2010070368A1/en active Application Filing
- 2009-12-17 PL PL09797144T patent/PL2358661T3/pl unknown
- 2009-12-17 NZ NZ592753A patent/NZ592753A/xx unknown
- 2009-12-17 ES ES09797144.4T patent/ES2468365T3/es active Active
- 2009-12-17 EP EP09797144.4A patent/EP2358661B1/en active Active
- 2009-12-17 RS RS20140244A patent/RS53311B/en unknown
- 2009-12-17 EA EA201170811A patent/EA020350B1/ru unknown
- 2009-12-17 US US13/140,237 patent/US8802888B2/en active Active
- 2009-12-17 CN CN200980146417.6A patent/CN102224130B/zh active Active
- 2009-12-17 DK DK09797144.4T patent/DK2358661T3/da active
- 2009-12-17 UA UAA201109014A patent/UA107073C2/ru unknown
- 2009-12-17 MX MX2011006584A patent/MX2011006584A/es active IP Right Grant
- 2009-12-17 BR BRPI0923004A patent/BRPI0923004A2/pt active IP Right Grant
- 2009-12-17 SI SI200930947T patent/SI2358661T1/sl unknown
- 2009-12-17 CA CA2743921A patent/CA2743921C/en not_active Expired - Fee Related
- 2009-12-17 PT PT97971444T patent/PT2358661E/pt unknown
- 2009-12-17 GE GEAP200912299A patent/GEP20125710B/en unknown
- 2009-12-17 JP JP2011541612A patent/JP5667576B2/ja active Active
- 2009-12-17 SG SG2011029204A patent/SG171715A1/en unknown
-
2011
- 2011-05-01 IL IL212597A patent/IL212597A/en active IP Right Grant
-
2012
- 2012-02-08 HK HK12101218.0A patent/HK1160836A1/xx unknown
-
2014
- 2014-05-06 CY CY20141100322T patent/CY1115047T1/el unknown
- 2014-06-06 HR HRP20140532AT patent/HRP20140532T1/hr unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Lapse of definitive patent protection due to non-payment of fees |