HUP0800478A2 - Substituted pyrrolidinyl-[1,3]thiazolo[4,5-b]pyridin derivatives as ccr3 receptor ligands - Google Patents

Substituted pyrrolidinyl-[1,3]thiazolo[4,5-b]pyridin derivatives as ccr3 receptor ligands

Info

Publication number
HUP0800478A2
HUP0800478A2 HU0800478A HUP0800478A HUP0800478A2 HU P0800478 A2 HUP0800478 A2 HU P0800478A2 HU 0800478 A HU0800478 A HU 0800478A HU P0800478 A HUP0800478 A HU P0800478A HU P0800478 A2 HUP0800478 A2 HU P0800478A2
Authority
HU
Hungary
Prior art keywords
thiazolo
receptor ligands
substituted pyrrolidinyl
ccr3 receptor
pyridin derivatives
Prior art date
Application number
HU0800478A
Other languages
English (en)
Inventor
Behr Gnes Pappnu
Sandor Batori
Bodor Veronika Bartanu
Zoltan Szlavik
Imre Bata
Szabo Katalin Urban
Zoltan Kapui
Endre Mikus
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Priority to HU0800478A priority Critical patent/HUP0800478A2/hu
Publication of HU0800478D0 publication Critical patent/HU0800478D0/hu
Priority to RU2011107205/04A priority patent/RU2514824C2/ru
Priority to CN200980130148.4A priority patent/CN102112473B/zh
Priority to CA2732631A priority patent/CA2732631A1/en
Priority to ARP090102883A priority patent/AR072623A1/es
Priority to BRPI0916559A priority patent/BRPI0916559A2/pt
Priority to AU2009275626A priority patent/AU2009275626B2/en
Priority to TW098125454A priority patent/TW201018698A/zh
Priority to EP09785768.4A priority patent/EP2318402B1/en
Priority to JP2011520604A priority patent/JP5496199B2/ja
Priority to MX2011001087A priority patent/MX2011001087A/es
Priority to PCT/HU2009/000067 priority patent/WO2010013078A2/en
Priority to ES09785768.4T priority patent/ES2483767T3/es
Publication of HUP0800478A2 publication Critical patent/HUP0800478A2/hu
Priority to IL210827A priority patent/IL210827A0/en
Priority to US13/014,145 priority patent/US8420636B2/en
Priority to HRP20140679AT priority patent/HRP20140679T1/hr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Virology (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • AIDS & HIV (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Otolaryngology (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
HU0800478A 2008-07-31 2008-07-31 Substituted pyrrolidinyl-[1,3]thiazolo[4,5-b]pyridin derivatives as ccr3 receptor ligands HUP0800478A2 (en)

Priority Applications (16)

Application Number Priority Date Filing Date Title
HU0800478A HUP0800478A2 (en) 2008-07-31 2008-07-31 Substituted pyrrolidinyl-[1,3]thiazolo[4,5-b]pyridin derivatives as ccr3 receptor ligands
ES09785768.4T ES2483767T3 (es) 2008-07-31 2009-07-29 Derivados pirrolidinil-alquil-amida, su preparación y su aplicación terapéutica como ligandos del receptor CCR3
AU2009275626A AU2009275626B2 (en) 2008-07-31 2009-07-29 Pyrrolidinyl-alkyl-amide derivatives their preparation and their therapeutic application as CCR3 receptor ligands
EP09785768.4A EP2318402B1 (en) 2008-07-31 2009-07-29 Pyrrolidinyl-alkyl-amide derivatives their preparation and their therapeutic application as CCR3 receptor ligands
CA2732631A CA2732631A1 (en) 2008-07-31 2009-07-29 Pyrrolidinyl-alkyl-amide derivatives their preparation and their therapeutic application as ccr3 receptor ligands
ARP090102883A AR072623A1 (es) 2008-07-31 2009-07-29 Derivados de pirrolidinil-alquil-amida su preparacion y su aplicacion terapeutica comoligandos de los receptores de ccr3
BRPI0916559A BRPI0916559A2 (pt) 2008-07-31 2009-07-29 derivados de pirrolidinil-alquil-amida, sua preparação e sua aplicação terapêutica como ligantes receptores de ccr3
RU2011107205/04A RU2514824C2 (ru) 2008-07-31 2009-07-29 Пирролидинилалкиламидные производные, их получение и терапевтическое применение в качестве лигандов рецептора ccr3
TW098125454A TW201018698A (en) 2008-07-31 2009-07-29 Pyrrolidinyl-alkyl-amide derivatives their preparation and their therapeutic application as CCR3 receptor ligands
CN200980130148.4A CN102112473B (zh) 2008-07-31 2009-07-29 吡咯烷基-烷基-酰胺衍生物及其制备方法以及其作为ccr3受体配体的治疗应用
JP2011520604A JP5496199B2 (ja) 2008-07-31 2009-07-29 ピロリジニル−アルキル−アミド誘導体、これらの調製およびｃｃｒ３受容体リガンドとしてのこれらの治療用途
MX2011001087A MX2011001087A (es) 2008-07-31 2009-07-29 Derivados de pirrolidinil-alquil-amida, su preparacion y su uso terapeutica como ligandos de los receptores de ccr3.
PCT/HU2009/000067 WO2010013078A2 (en) 2008-07-31 2009-07-29 Pyrrolidinyl-alkyl-amide derivatives their preparation and their therapeutic application as ccr3 receptor ligands
IL210827A IL210827A0 (en) 2008-07-31 2011-01-23 Pyrrolidinyl-alkyl-amide derivatives their preparation and their therapeutic application as ccr3 receptor ligands
US13/014,145 US8420636B2 (en) 2008-07-31 2011-01-26 Pyrrolidinyl-alkyl-amide derivatives, their preparation, and their therapeutic application as CCR3 receptor ligands
HRP20140679AT HRP20140679T1 (hr) 2008-07-31 2014-07-15 Derivati pirolodinil-alkil-amida, njihovo dobivanje i njihova upotreba u terapiji kao liganda receptora ccr3

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU0800478A HUP0800478A2 (en) 2008-07-31 2008-07-31 Substituted pyrrolidinyl-[1,3]thiazolo[4,5-b]pyridin derivatives as ccr3 receptor ligands

Publications (2)

Publication Number Publication Date
HU0800478D0 HU0800478D0 (en) 2008-09-29
HUP0800478A2 true HUP0800478A2 (en) 2010-03-01

Family

ID=89988430

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0800478A HUP0800478A2 (en) 2008-07-31 2008-07-31 Substituted pyrrolidinyl-[1,3]thiazolo[4,5-b]pyridin derivatives as ccr3 receptor ligands

Country Status (16)

Country Link
US (1) US8420636B2 (hu)
EP (1) EP2318402B1 (hu)
JP (1) JP5496199B2 (hu)
CN (1) CN102112473B (hu)
AR (1) AR072623A1 (hu)
AU (1) AU2009275626B2 (hu)
BR (1) BRPI0916559A2 (hu)
CA (1) CA2732631A1 (hu)
ES (1) ES2483767T3 (hu)
HR (1) HRP20140679T1 (hu)
HU (1) HUP0800478A2 (hu)
IL (1) IL210827A0 (hu)
MX (1) MX2011001087A (hu)
RU (1) RU2514824C2 (hu)
TW (1) TW201018698A (hu)
WO (1) WO2010013078A2 (hu)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP0800478A2 (en) 2008-07-31 2010-03-01 Sanofi Aventis Substituted pyrrolidinyl-[1,3]thiazolo[4,5-b]pyridin derivatives as ccr3 receptor ligands
EP3050574B1 (en) 2015-01-28 2019-10-09 Universite De Bordeaux Use of plerixafor for treating and/or preventing acute exacerbations of chronic obstructive pulmonary disease

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5767144A (en) * 1994-08-19 1998-06-16 Abbott Laboratories Endothelin antagonists
AR033517A1 (es) * 2000-04-08 2003-12-26 Astrazeneca Ab Derivados de piperidina, proceso para su preparacion y uso de estos derivados en la fabricacion de medicamentos
GB0207449D0 (en) * 2002-03-28 2002-05-08 Glaxo Group Ltd Novel compounds
CN1753891A (zh) * 2003-02-27 2006-03-29 霍夫曼-拉罗奇有限公司 Ccr－3受体拮抗剂
EP1608374B9 (en) 2003-03-24 2009-04-08 Axikin Pharmaceuticals, Inc. 2-phenoxy- and 2-phenylsulfomamide derivatives with ccr3 antagonistic activity for the treatment of asthma and other inflammatory or immunological disorders
HUP0500886A2 (en) * 2005-09-23 2007-05-29 Sanofi Aventis Amide derivatives as ccr3 receptor ligands, process for producing them, pharmaceutical compositions containing them and their use
JP2009508929A (ja) * 2005-09-22 2009-03-05 サノフイ−アベンテイス Ｃｃｒ３受容体リガンドとしてのアミノ−アルキル−アミド誘導体
HUP0800478A2 (en) 2008-07-31 2010-03-01 Sanofi Aventis Substituted pyrrolidinyl-[1,3]thiazolo[4,5-b]pyridin derivatives as ccr3 receptor ligands

Also Published As

Publication number Publication date
MX2011001087A (es) 2011-03-29
US8420636B2 (en) 2013-04-16
BRPI0916559A2 (pt) 2015-11-10
AU2009275626B2 (en) 2013-11-07
US20110144104A1 (en) 2011-06-16
ES2483767T3 (es) 2014-08-07
JP5496199B2 (ja) 2014-05-21
EP2318402B1 (en) 2014-04-30
CN102112473A (zh) 2011-06-29
RU2514824C2 (ru) 2014-05-10
CN102112473B (zh) 2014-08-20
JP2011529482A (ja) 2011-12-08
WO2010013078A3 (en) 2010-03-25
RU2011107205A (ru) 2012-09-10
AU2009275626A1 (en) 2010-02-04
WO2010013078A8 (en) 2010-05-20
TW201018698A (en) 2010-05-16
AR072623A1 (es) 2010-09-08
HRP20140679T1 (hr) 2014-10-10
HU0800478D0 (en) 2008-09-29
IL210827A0 (en) 2011-04-28
CA2732631A1 (en) 2010-02-04
EP2318402A2 (en) 2011-05-11
WO2010013078A2 (en) 2010-02-04

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FD9A Lapse of provisional protection due to non-payment of fees