HUP0600194A3 - Process for producing the polymorphic i form of (s)-(+)-methyl-(2-chlorophenyl)-(6,7-dihydro-4h-thieno[3,2-c]pyridin-5-yl)-acetate hydrogen sulfate - Google Patents

Process for producing the polymorphic i form of (s)-(+)-methyl-(2-chlorophenyl)-(6,7-dihydro-4h-thieno[3,2-c]pyridin-5-yl)-acetate hydrogen sulfate

Info

Publication number
HUP0600194A3
HUP0600194A3 HU0600194A HUP0600194A HUP0600194A3 HU P0600194 A3 HUP0600194 A3 HU P0600194A3 HU 0600194 A HU0600194 A HU 0600194A HU P0600194 A HUP0600194 A HU P0600194A HU P0600194 A3 HUP0600194 A3 HU P0600194A3
Authority
HU
Hungary
Prior art keywords
thieno
polymorphic
pyridin
chlorophenyl
dihydro
Prior art date
Application number
HU0600194A
Other languages
English (en)
Original Assignee
Richter Gedeon Nyrt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US12/282,037 priority Critical patent/US20090093635A1/en
Application filed by Richter Gedeon Nyrt filed Critical Richter Gedeon Nyrt
Priority to HU0600194A priority patent/HU228030B1/hu
Publication of HU0600194D0 publication Critical patent/HU0600194D0/hu
Priority to CA002640242A priority patent/CA2640242A1/en
Priority to MX2008011485A priority patent/MX2008011485A/es
Priority to JP2008557836A priority patent/JP2009529521A/ja
Priority to EA200801963A priority patent/EA013543B1/ru
Priority to CNA2007800074408A priority patent/CN101600721A/zh
Priority to KR1020087024578A priority patent/KR20080110795A/ko
Priority to GEAP200710929A priority patent/GEP20104957B/en
Priority to AU2007222234A priority patent/AU2007222234A1/en
Priority to PCT/HU2007/000021 priority patent/WO2007102037A2/en
Priority to EP07733839A priority patent/EP2010545A2/en
Publication of HUP0600194A2 publication Critical patent/HUP0600194A2/hu
Publication of HUP0600194A3 publication Critical patent/HUP0600194A3/hu
Priority to IL192825A priority patent/IL192825A0/en
Priority to NO20084217A priority patent/NO20084217L/no
Publication of HU228030B1 publication Critical patent/HU228030B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HU0600194A 2006-03-09 2006-03-09 Process for producing the polymorphic i form of (s)-(+)-methyl-2-(2-chlorophenyl)-2-(6,7-dihydro-4h-thieno[3,2-c]pyridin-5- yl)-acetate HU228030B1 (en)

Priority Applications (14)

Application Number Priority Date Filing Date Title
US12/282,037 US20090093635A1 (en) 2006-03-09 2006-03-08 PROCESS FOR MAKING POLYMORPH FROM I OF (S) - (+) -METHYL-ALPHA- (2-CHLOROPHENYL) -6, 7-DYHIDRO-THIENO- [3, 2-c] PYRIDINE-5 (4H) -ACETATE HYDROGEN SULFATE
HU0600194A HU228030B1 (en) 2006-03-09 2006-03-09 Process for producing the polymorphic i form of (s)-(+)-methyl-2-(2-chlorophenyl)-2-(6,7-dihydro-4h-thieno[3,2-c]pyridin-5- yl)-acetate
EP07733839A EP2010545A2 (en) 2006-03-09 2007-03-08 A process for the preparation of polymorph form i of (s)-(+)-methyl-alpha-(2-chlorophenyl)-6,7-dihydro-thieno-[3,2-c]pyridine-5(4h)-acetate hydrogen sulfate
CNA2007800074408A CN101600721A (zh) 2006-03-09 2007-03-08 (S)-(+)-甲基-α-(2-氯苯基)-6,7-二氢-噻吩并[3,2-c]吡啶-5(4H)-乙酸酯硫酸氢盐的多晶型物形式I的制备方法
AU2007222234A AU2007222234A1 (en) 2006-03-09 2007-03-08 A process for the preparation of polymorph Form I of (S)-(+)-methyl-alpha-(2-chlorophenyl)-6,7-dyhidro-thieno-[3,2-c]pyridine-5(4H)-acetate hydrogen sulfate
JP2008557836A JP2009529521A (ja) 2006-03-09 2007-03-08 （Ｓ）−（＋）−メチル−α−（２−クロロフェニル）−６，７−ジヒドロチエノ［３，２−ｃ］ピリジン−５（４Ｈ）−アセテート・硫化水素塩の多型Ｉの製造法
EA200801963A EA013543B1 (ru) 2006-03-09 2007-03-08 СПОСОБ ПОЛУЧЕНИЯ ПОЛИМОРФНОЙ ФОРМЫ I ГИДРОСУЛЬФАТА (S)-(+)-МЕТИЛ-α-(2-ХЛОРФЕНИЛ)-6,7-ДИГИДРОТИЕНО[3,2-c]ПИРИДИН-5(4H)-АЦЕТАТА
CA002640242A CA2640242A1 (en) 2006-03-09 2007-03-08 A process for the preparation of polymorph form i of (s)-(+)-methyl-a-(2-chlorophenyl)-6,7-dyhidro-thieno-[3,2-c]pyridine-5(4h)-acetate hydrogen sulfate
KR1020087024578A KR20080110795A (ko) 2006-03-09 2007-03-08 （Ｓ）―（＋）―메틸―α―（２―클로로페닐）―６，７―디히드로―티에노―〔３，２―ｃ〕피리딘―５（４Ｈ）―아세테이트 수소 설페이트의 다형태 Ｉ의 제조방법
GEAP200710929A GEP20104957B (en) 2006-03-09 2007-03-08 A PROCESS FOR THE PREPARATION OF POLYMORPH FORM I OF (S)-(+)-METHYL-ά-(2-CHLOROPHENYL)-6,7-DYHIDRO-THIENO-[3,2-c]PYRIDINE-5(4H)-ACETATE HYDROGEN SULFATE
MX2008011485A MX2008011485A (es) 2006-03-09 2007-03-08 Procedimiento para la preparacion de la forma polimorfa i de sulfato hidrogenado de (s)-{+)-metil-a-(2-clorofenil)-6,7-dihidro- tieno-[3,2-c]piridin-5{4h)-acetato.
PCT/HU2007/000021 WO2007102037A2 (en) 2006-03-09 2007-03-08 A PROCESS FOR THE PREPARATION OF POLYMORPH FORM I OF (S)-(+)-METHYL-α-(2-CHLOROPHENYL)-6,7-DYHIDRO-THIENO-[3,2-c]PYRIDINE-5(4H)-ACETATE HYDROGEN SULFATE
IL192825A IL192825A0 (en) 2006-03-09 2008-07-15 A PROCESS FOR THE PREPARATION OF POLYMORPH FORM I OF (S)-(+)-METHYL-ßé?- (2-CHLOROPHENYL)-6,7-DYHIDRO-THIENO-[3,2-C]PYRIDINE-5(4H)-ACETATE HYDROGEN SULFATE
NO20084217A NO20084217L (no) 2006-03-09 2008-10-08 Fremgangsmate for fremstilling av polymorf form I av (S)-(+)-metyl-α-(2-klorfenyl)-6,7-dihydrotieno-[3,2-c]pyridin-5(4H)-acetathydrogensulfat

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU0600194A HU228030B1 (en) 2006-03-09 2006-03-09 Process for producing the polymorphic i form of (s)-(+)-methyl-2-(2-chlorophenyl)-2-(6,7-dihydro-4h-thieno[3,2-c]pyridin-5- yl)-acetate

Publications (4)

Publication Number Publication Date
HU0600194D0 HU0600194D0 (en) 2006-05-29
HUP0600194A2 HUP0600194A2 (en) 2007-09-28
HUP0600194A3 true HUP0600194A3 (en) 2007-12-28
HU228030B1 HU228030B1 (en) 2012-08-28

Family

ID=89986636

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0600194A HU228030B1 (en) 2006-03-09 2006-03-09 Process for producing the polymorphic i form of (s)-(+)-methyl-2-(2-chlorophenyl)-2-(6,7-dihydro-4h-thieno[3,2-c]pyridin-5- yl)-acetate

Country Status (14)

Country Link
US (1) US20090093635A1 (hu)
EP (1) EP2010545A2 (hu)
JP (1) JP2009529521A (hu)
KR (1) KR20080110795A (hu)
CN (1) CN101600721A (hu)
AU (1) AU2007222234A1 (hu)
CA (1) CA2640242A1 (hu)
EA (1) EA013543B1 (hu)
GE (1) GEP20104957B (hu)
HU (1) HU228030B1 (hu)
IL (1) IL192825A0 (hu)
MX (1) MX2008011485A (hu)
NO (1) NO20084217L (hu)
WO (1) WO2007102037A2 (hu)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011042804A2 (en) * 2009-10-08 2011-04-14 Jubliant Life Sciences Limited An improved process for the preparation of clopidogrel hydrogen sulfate form i
WO2011051976A2 (en) * 2009-10-30 2011-05-05 Matrix Laboratories Ltd An improved process for the preparation of clopidogrel bisulfate form i
CN103951675A (zh) * 2014-04-29 2014-07-30 浙江华海药业股份有限公司 一种硫酸氢氯吡格雷的制备方法
KR102188371B1 (ko) 2020-09-09 2020-12-08 (주)세명이앤씨 발전효율 증대 및 안전사고 예방 태양광 발전 시스템

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6767913B2 (en) * 2001-12-18 2004-07-27 Teva Pharmaceutical Industries Ltd. Crystal forms iii, iv, v, and novel amorphous form of clopidogrel hydrogensulfate, processes for their preparation, processes for the preparation of form i, compositions containing the new forms and methods of administering the new forms
PL370802A1 (en) * 2001-12-18 2005-05-30 Teva Pharmaceutical Industries Ltd. Polymorphs of clopidogrel hydrogensulfate
US7074928B2 (en) * 2002-01-11 2006-07-11 Teva Pharmaceutical Industries, Ltd. Polymorphs of clopidogrel hydrogensulfate
ATE455778T1 (de) * 2003-11-03 2010-02-15 Cadila Healthcare Ltd Verfahren zur herstellung form i von (s)-(+)- clopidogrelbisulfat
EP1723141A4 (en) * 2004-03-05 2007-10-10 Ipca Lab Ltd MOST TECHNICAL PROCESS FOR THE PREPARATION OF CLOPIDOGRAPHYDROGENSULFATE
PL1740593T3 (pl) * 2004-04-19 2016-09-30 Sposoby wytwarzania wodorosiarczanu klopidogrelu w formie polimorficznej I

Also Published As

Publication number Publication date
EA013543B1 (ru) 2010-06-30
EA200801963A1 (ru) 2009-02-27
NO20084217L (no) 2008-12-08
IL192825A0 (en) 2009-08-03
US20090093635A1 (en) 2009-04-09
CA2640242A1 (en) 2007-09-13
JP2009529521A (ja) 2009-08-20
KR20080110795A (ko) 2008-12-19
GEP20104957B (en) 2010-04-12
MX2008011485A (es) 2009-03-05
AU2007222234A1 (en) 2007-09-13
HU228030B1 (en) 2012-08-28
HUP0600194A2 (en) 2007-09-28
HU0600194D0 (en) 2006-05-29
WO2007102037A3 (en) 2008-11-13
CN101600721A (zh) 2009-12-09
EP2010545A2 (en) 2009-01-07
WO2007102037A2 (en) 2007-09-13

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