HUP0500642A2 - Csökkentett toxicitású ciszplatin készítmények és eljárás alkalmazásukra - Google Patents
Csökkentett toxicitású ciszplatin készítmények és eljárás alkalmazásukraInfo
- Publication number
- HUP0500642A2 HUP0500642A2 HU0500642A HUP0500642A HUP0500642A2 HU P0500642 A2 HUP0500642 A2 HU P0500642A2 HU 0500642 A HU0500642 A HU 0500642A HU P0500642 A HUP0500642 A HU P0500642A HU P0500642 A2 HUP0500642 A2 HU P0500642A2
- Authority
- HU
- Hungary
- Prior art keywords
- cisplatin
- toxicity
- methods
- agent
- reduces
- Prior art date
Links
- DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 title abstract 7
- 229960004316 cisplatin Drugs 0.000 title abstract 7
- 238000000034 method Methods 0.000 title abstract 6
- 230000001988 toxicity Effects 0.000 title abstract 5
- 231100000419 toxicity Toxicity 0.000 title abstract 5
- 239000000203 mixture Substances 0.000 title abstract 3
- 238000009472 formulation Methods 0.000 title 1
- 239000003795 chemical substances by application Substances 0.000 abstract 3
- 239000004480 active ingredient Substances 0.000 abstract 2
- 239000013543 active substance Substances 0.000 abstract 1
- 230000001028 anti-proliverative effect Effects 0.000 abstract 1
- 208000034404 cisplatin toxicity Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4462—Non condensed piperidines, e.g. piperocaine only substituted in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/243—Platinum; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Inorganic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
A találmány olyan ciszplatin hatóanyagot alkalmazó eljárásokat bocsátrendelkezésre, amelyek során a gazdát érintő toxicitás csökkentmértékű. A találmány szerinti eljárásokban a gazdának egy ciszplatinhatóanyag hatékony mennyiségét egy találmány szerinti, a ciszplatintoxicitását csökkentő szerrel együtt adagolják. A találmánykészítményekre is vonatkozik a találmány szerinti eljárás gyakorlatimegvalósításához, például olyan gyógyászati készítményekre, amelyeknekcsökkent mértékű a toxicitása, és amelyekben a ciszplatin hatóanyagegy a ciszplatin toxicitását csökkentő szerrel van kombinálva, ez aszer csökkenti a ciszplatin nemkívánt toxicitásának szintjét, miközbenmegtartja a ciszplatin proliferációellenes hatékonyságát. A találmánytárgyát képezik továbbá a találmány szerinti eljárások és készítményekkülönböző betegségállapotok kezelésére való alkalmazási eljárásai is.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US32456601P | 2001-09-24 | 2001-09-24 | |
PCT/US2002/029669 WO2003026570A2 (en) | 2001-09-24 | 2002-09-20 | Reduced toxicity cisplatin formulations and methods for using the same |
Publications (1)
Publication Number | Publication Date |
---|---|
HUP0500642A2 true HUP0500642A2 (hu) | 2005-11-28 |
Family
ID=23264163
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0500642A HUP0500642A2 (hu) | 2001-09-24 | 2002-09-20 | Csökkentett toxicitású ciszplatin készítmények és eljárás alkalmazásukra |
Country Status (18)
Country | Link |
---|---|
US (1) | US20040258771A1 (hu) |
EP (1) | EP1435963A4 (hu) |
JP (1) | JP2005510471A (hu) |
KR (1) | KR20040048900A (hu) |
CN (2) | CN1589149A (hu) |
AU (1) | AU2002334595B2 (hu) |
BR (1) | BR0212744A (hu) |
CA (1) | CA2461219A1 (hu) |
EA (1) | EA007481B1 (hu) |
HU (1) | HUP0500642A2 (hu) |
IL (1) | IL160960A0 (hu) |
MX (1) | MXPA04002707A (hu) |
NO (1) | NO20041484L (hu) |
NZ (1) | NZ531936A (hu) |
PL (1) | PL370867A1 (hu) |
SK (1) | SK1472004A3 (hu) |
WO (1) | WO2003026570A2 (hu) |
ZA (1) | ZA200402229B (hu) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008060441A2 (en) | 2006-11-09 | 2008-05-22 | Scidose Llc | Stable amifostine liquid concentrate |
UY30915A1 (es) * | 2007-02-16 | 2008-09-02 | Smithkline Beecham Corp | Método de tratamiento de canceres |
US20100035853A1 (en) * | 2008-08-07 | 2010-02-11 | Hyogo College Of Medicine | Method for preventing or treating cisplatin-induced nephrotoxicity |
US20120315324A1 (en) * | 2010-02-05 | 2012-12-13 | University Of Louisville Research Foundation, Inc. | Exosomal compositions and methods for the treatment of disease |
CN103044338B (zh) * | 2012-12-12 | 2016-08-03 | 天津医科大学总医院 | miR-21小分子抑制剂及应用 |
US11554138B2 (en) | 2015-07-16 | 2023-01-17 | The University Of Hong Kong | Bismuth(III) complexes as adjuvants in the treatment of cancer using platinum-based chemotherapy |
EP3538074B1 (en) * | 2016-11-11 | 2023-07-26 | Western University Of Health Sciences | Methods of treating upper tract urothelial carcinomas |
CN112574255B (zh) * | 2019-09-27 | 2024-05-10 | 中国科学院上海有机化学研究所 | 一类基于有机胂的cdk抑制剂及其制备方法和用途 |
Family Cites Families (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4310515A (en) * | 1978-05-30 | 1982-01-12 | Bristol-Myers Company | Pharmaceutical compositions of cisplatin |
US4302446A (en) * | 1979-10-02 | 1981-11-24 | Bristol-Myers Company | Pharmaceutical compositions |
US5059591B1 (en) * | 1983-05-26 | 2000-04-25 | Liposome Co Inc | Drug preparations of reduced toxicity |
GB8806224D0 (en) * | 1988-03-16 | 1988-04-13 | Johnson Matthey Plc | Platinum chemotherapeutic product |
US5814307A (en) * | 1989-04-10 | 1998-09-29 | Bristol-Myers Squibb Company | Method for regulating cell growth, leukocyte differentiation and tumor cell growth using Oncostatin M to stimulate synthesis of IL-6 |
US5770576A (en) * | 1989-08-30 | 1998-06-23 | Cytran, Inc. | Pharmaceutical dipeptide compositions and methods of use thereof: systemic toxicity |
DE4024885C2 (de) * | 1990-08-06 | 2002-07-18 | Nattermann A & Cie | Verwendung von 2-Phenyl-1,2-benzisoselenazol-3(2H)-on |
US5366723A (en) * | 1993-03-05 | 1994-11-22 | Istvan Tulok | Method of alleviating toxicity originating from treatment with anticancer platinum compounds |
JPH06321792A (ja) * | 1993-05-18 | 1994-11-22 | Tsumura & Co | 副作用軽減剤 |
US5646011A (en) * | 1994-04-08 | 1997-07-08 | Yokoyama; Shiro | Cisplatin resistance gene and uses therefor |
US5789000A (en) * | 1994-11-14 | 1998-08-04 | Bionumerik Pharmaceuticals, Inc. | Sterile aqueous parenteral formulations of cis-diammine dichloro platinum |
US5792748A (en) * | 1995-06-07 | 1998-08-11 | The General Hospital Corporation | Method for inhibiting neoplastic disease in mammals |
US5922689A (en) * | 1995-09-11 | 1999-07-13 | Unitech Pharmaceuticals, Inc. | Cisplatin analogs for cancer treatment |
US6077545A (en) * | 1995-10-30 | 2000-06-20 | Matrix Pharmaceuticals, Inc. | Process and composition for therapeutic cisplatin (CDDP) |
CA2263455C (en) * | 1996-08-23 | 2002-10-29 | Sequus Pharmaceuticals, Inc. | Liposomes containing a cisplatin compound |
WO1998014182A1 (en) * | 1996-10-03 | 1998-04-09 | Southern Illinois University | Therapeutic use of d-methionine to reduce the toxicity of platinum-containing anti-tumor compounds |
US6187817B1 (en) * | 1996-10-03 | 2001-02-13 | Southern Illinois University School Of Medicine | Therapeutic use of d-methionine to reduce the toxicity of platinum-containing anti-tumor compounds |
TW374078B (en) * | 1996-12-25 | 1999-11-11 | Nippon Kayaku Kk | Cisplatin micropowder and process for making the same |
US6030783A (en) * | 1997-01-31 | 2000-02-29 | Massachusetts Institute Of Technology | Photo-potentiation of cisplatin chemotherapy |
US5994409A (en) * | 1997-12-09 | 1999-11-30 | U.S. Bioscience, Inc. | Methods for treatment of neuro--and nephro--disorders and therapeutic toxicities using aminothiol compounds |
US6001817A (en) * | 1998-01-12 | 1999-12-14 | Unitech Pharmaceuticals, Inc. | Pharmaceutical composition comprised of cisplatin, and processes for making and using same |
US6074626A (en) * | 1998-03-20 | 2000-06-13 | Molecular Radiation Management, Inc. | Radioactive cisplatin in the treatment of cancer |
CA2347750C (en) * | 1998-10-22 | 2008-01-08 | Binex Co., Ltd. | Pharmaceutical composition containing decursin |
US6130245A (en) * | 1998-10-26 | 2000-10-10 | Unitech Pharmaceuticals, Inc. | Dinuclear platinum complexes as cisplatin analogs for cancer treatment |
BR0110877A (pt) * | 2000-05-15 | 2003-03-11 | Celgene Corp | Métodos de tratamento de câncer primário, de aumento da dosagem de um inibidor de topoisomerase, de redução ou prevenção de um efeito adverso associado com quimioterapia e com terapia de radiação, de aumento da eficácia terapêutica de um inibidor de topoisomerase, e de proteção de um paciente canceroso dos efeitos adversos associados com a administração de uma droga anti-câncer, composição farmacêutica, forma de dosagem, e, kit para uso no tratamento de câncer |
-
2002
- 2002-09-20 AU AU2002334595A patent/AU2002334595B2/en not_active Ceased
- 2002-09-20 EP EP02799593A patent/EP1435963A4/en not_active Withdrawn
- 2002-09-20 SK SK1472004A patent/SK1472004A3/sk not_active Application Discontinuation
- 2002-09-20 HU HU0500642A patent/HUP0500642A2/hu unknown
- 2002-09-20 MX MXPA04002707A patent/MXPA04002707A/es unknown
- 2002-09-20 NZ NZ531936A patent/NZ531936A/en unknown
- 2002-09-20 PL PL02370867A patent/PL370867A1/xx not_active Application Discontinuation
- 2002-09-20 EA EA200400348A patent/EA007481B1/ru unknown
- 2002-09-20 CN CNA028231562A patent/CN1589149A/zh active Pending
- 2002-09-20 JP JP2003530209A patent/JP2005510471A/ja active Pending
- 2002-09-20 BR BR0212744-0A patent/BR0212744A/pt not_active Withdrawn
- 2002-09-20 CA CA002461219A patent/CA2461219A1/en not_active Abandoned
- 2002-09-20 IL IL16096002A patent/IL160960A0/xx unknown
- 2002-09-20 CN CNA2006101425220A patent/CN101062053A/zh active Pending
- 2002-09-20 WO PCT/US2002/029669 patent/WO2003026570A2/en active IP Right Grant
- 2002-09-20 KR KR10-2004-7004268A patent/KR20040048900A/ko not_active Application Discontinuation
-
2004
- 2004-03-17 US US10/803,458 patent/US20040258771A1/en not_active Abandoned
- 2004-03-19 ZA ZA200402229A patent/ZA200402229B/en unknown
- 2004-04-13 NO NO20041484A patent/NO20041484L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
IL160960A0 (en) | 2004-08-31 |
NO20041484L (no) | 2004-04-13 |
US20040258771A1 (en) | 2004-12-23 |
CN1589149A (zh) | 2005-03-02 |
BR0212744A (pt) | 2005-10-25 |
EP1435963A4 (en) | 2005-10-26 |
MXPA04002707A (es) | 2005-06-06 |
EA007481B1 (ru) | 2006-10-27 |
EA200400348A1 (ru) | 2005-04-28 |
ZA200402229B (en) | 2005-03-22 |
KR20040048900A (ko) | 2004-06-10 |
EP1435963A2 (en) | 2004-07-14 |
WO2003026570A2 (en) | 2003-04-03 |
CA2461219A1 (en) | 2003-04-03 |
JP2005510471A (ja) | 2005-04-21 |
AU2002334595B2 (en) | 2007-03-01 |
CN101062053A (zh) | 2007-10-31 |
SK1472004A3 (en) | 2004-10-05 |
WO2003026570A3 (en) | 2004-01-22 |
PL370867A1 (en) | 2005-05-30 |
NZ531936A (en) | 2006-10-27 |
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Legal Events
Date | Code | Title | Description |
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FA9A | Lapse of provisional patent protection due to relinquishment or protection considered relinquished |