HUP0401629A2 - Antiangiogén aktivitással rendelkező peptidek és ezeket tartalmazó gyógyászati készítmények - Google Patents
Antiangiogén aktivitással rendelkező peptidek és ezeket tartalmazó gyógyászati készítményekInfo
- Publication number
- HUP0401629A2 HUP0401629A2 HU0401629A HUP0401629A HUP0401629A2 HU P0401629 A2 HUP0401629 A2 HU P0401629A2 HU 0401629 A HU0401629 A HU 0401629A HU P0401629 A HUP0401629 A HU P0401629A HU P0401629 A2 HUP0401629 A2 HU P0401629A2
- Authority
- HU
- Hungary
- Prior art keywords
- alanyl
- carbonyl
- isoleucyl
- glutaminyl
- acetyl
- Prior art date
Links
- 230000001772 anti-angiogenic effect Effects 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 title 1
- -1 N-acetylazetidine-2 -carbonyl Chemical group 0.000 abstract 27
- 125000001939 glutaminyl group Chemical group 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000001500 prolyl group Chemical group [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 3
- 125000000249 D-isoleucyl group Chemical group N[C@@H](C(=O)*)[C@@H](CC)C 0.000 abstract 2
- 125000001942 asparaginyl group Chemical group 0.000 abstract 2
- 125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 abstract 2
- 125000000741 isoleucyl group Chemical group [H]N([H])C(C(C([H])([H])[H])C([H])([H])C([H])([H])[H])C(=O)O* 0.000 abstract 2
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 2
- 125000002072 seryl group Chemical group 0.000 abstract 2
- 125000001239 threonyl group Chemical group 0.000 abstract 2
- JLLYLQLDYORLBB-UHFFFAOYSA-N 5-bromo-n-methylthiophene-2-sulfonamide Chemical compound CNS(=O)(=O)C1=CC=C(Br)S1 JLLYLQLDYORLBB-UHFFFAOYSA-N 0.000 abstract 1
- 125000003182 D-alloisoleucine group Chemical group [H]N([H])[C@@]([H])(C(=O)[*])[C@](C([H])([H])[H])([H])C(C([H])([H])[H])([H])[H] 0.000 abstract 1
- 125000003301 D-leucyl group Chemical group N[C@@H](C(=O)*)CC(C)C 0.000 abstract 1
- 125000002058 D-lysyl group Chemical group N[C@@H](C(=O)*)CCCCN 0.000 abstract 1
- 125000003047 N-acetyl group Chemical group 0.000 abstract 1
- 125000000066 S-methyl group Chemical group [H]C([H])([H])S* 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 230000033115 angiogenesis Effects 0.000 abstract 1
- 125000000637 arginyl group Chemical group N[C@@H](CCCNC(N)=N)C(=O)* 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 229950003188 isovaleryl diethylamide Drugs 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- OGQDIIKRQRZXJH-UHFFFAOYSA-N protriptyline hydrochloride Chemical group [Cl-].C1=CC2=CC=CC=C2C(CCC[NH2+]C)C2=CC=CC=C21 OGQDIIKRQRZXJH-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000002114 valyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06086—Dipeptides with the first amino acid being basic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A találmány az A1-A2-A3-A4-A5-A6-A7-A8-A9-A10 (I) általános képletűvegyületekre és gyógyászatilag elfogadható sóikra vonatkozik, ahol aképletben A0 nincs jelen vagy jelentése N-acetil-, N-acetilazetidin-2-karbonil-, N-acetilazetidin-3-karbonil-, N-acetilnipekotil-, N-acetilpiperidin-4-acetil- vagy N-acetilprolil-csoport; A1 jelentése D-alanil-, (1R,3S)-1-aminociklopentán-3-karbonil-, (1S,4R)-1-aminociklopent-2-én-4-karbonil-, 1-amino-l-ciklopropánkarbonil-, 3-(4-klórfenil)alanil-, 4-hidroxiprolil-, N-metilnorvalil-, 3-(4-metilfenil)alanil-, N-metilprolil-; N-metiltreonil(benzil)-,norleucil-, propargilglicil-, szarkozil- vagy (2,3,5,6-tetrahidro-1-tiopirán-4-il)glicil-csoport; A2 jelentése[(1S,3R)-1-aminociklopentán-3-karbonil]-,[(1R,4S)-1- aminociklopent-2-én-4-karbonil]-,[(1S,4R)-1-aminociklopent- 2-én-4-karbonil]-,aszparaginil-, 3-(3-cianofenil)alanil-, 3-(4-cianofenil)alanil-, 3-(3,4-dimetoxifenil)alanil-, 3-(4-fluorfenil)alanil-, 3-(2-furil)alanil-, glutaminil-, glicil-, 3-(4-metilfenil)alanil-,norvalil- vagy 3-(tiazol-5-il)alanil-csoport; A3 jelentéseaszparaginil-, glutaminil-, izoleucil- vagy valilcsoport; A4 jelentéseD-alloizoleucil-, D-izoleucil-, D-leucil- vagy D-penicillaminil(S-metil)-csoport; A5 jelentése allotreonil-, aszpartil-, 4-hidroxiprolil-, szeril-, treonil- vagy treonil(O-acetil)-csoport; A6jelentése allotreonil-, glutaminil-, 4-hidroxiprolil-, norvalil-,ornitil(N-delta-acetil)-, prolil-, szeril- vagy triptil-csoport; A7jelentése izoleucil-, D-izoleucil- vagy prolilcsoport; A8 jelentésearginil-, glutaminil- vagy ornitilcsoport; A9 jelentése prolilcsoport;és A10 jelentése D-alanilamid-, D-lizil(N-epszilon-acetil)amid,etilamid vagy N-metil-D-alanilamidcsoport. A találmány tárgyát képezikaz (I) általános képletű vegyületeket tartalmazó gyógyászatikészítmények, valamint az (I) általános képletű vegyületek alkalmazásaangingenezis gátlására szolgáló gyógyászati készítményekelőállítására. Ó
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/915,956 US20030050246A1 (en) | 2001-07-26 | 2001-07-26 | Peptides having antiangiogenic activity |
PCT/US2002/019574 WO2003011896A1 (en) | 2001-07-26 | 2002-06-20 | Peptides having antiangiogenic activity |
Publications (1)
Publication Number | Publication Date |
---|---|
HUP0401629A2 true HUP0401629A2 (hu) | 2004-11-29 |
Family
ID=25436471
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0401629A HUP0401629A2 (hu) | 2001-07-26 | 2002-06-20 | Antiangiogén aktivitással rendelkező peptidek és ezeket tartalmazó gyógyászati készítmények |
Country Status (14)
Country | Link |
---|---|
US (1) | US20030050246A1 (hu) |
EP (1) | EP1421107A1 (hu) |
JP (1) | JP2005507864A (hu) |
AR (1) | AR034890A1 (hu) |
BG (1) | BG108587A (hu) |
CA (1) | CA2454753A1 (hu) |
CZ (1) | CZ2004283A3 (hu) |
HU (1) | HUP0401629A2 (hu) |
MX (1) | MXPA04000805A (hu) |
PE (1) | PE20030302A1 (hu) |
PL (1) | PL368745A1 (hu) |
SK (1) | SK1172004A3 (hu) |
UY (1) | UY27394A1 (hu) |
WO (1) | WO2003011896A1 (hu) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7067490B2 (en) * | 2001-10-31 | 2006-06-27 | Abbott Laboratories | Hepta-, Octa-and nonapeptides having antiangiogenic activity |
US20030228365A1 (en) * | 2002-06-07 | 2003-12-11 | Fortuna Haviv | Pharmaceutical formulation |
US7713937B2 (en) | 2006-11-10 | 2010-05-11 | Cara Therapeutics, Inc. | Synthetic peptide amides and dimeric forms thereof |
WO2008057608A2 (en) | 2006-11-10 | 2008-05-15 | Cara Therapeutics, Inc. | Synthetic peptide amides |
US8906859B2 (en) | 2006-11-10 | 2014-12-09 | Cera Therapeutics, Inc. | Uses of kappa opioid synthetic peptide amides |
US7842662B2 (en) | 2006-11-10 | 2010-11-30 | Cara Therapeutics, Inc. | Synthetic peptide amide dimers |
US8236766B2 (en) | 2006-11-10 | 2012-08-07 | Cara Therapeutics, Inc. | Uses of synthetic peptide amides |
RU2447848C2 (ru) * | 2010-07-26 | 2012-04-20 | Государственное образовательное учреждение высшего профессионального образования "Курский государственный медицинский университет Федерального агентства по здравоохранению и социальному развитию" | Способ профилактики полостных спаек |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5512591A (en) * | 1993-02-18 | 1996-04-30 | President And Fellows Of Harvard College | Treatments for diseases characterized by neovascularization |
CZ299639B6 (cs) * | 1998-05-22 | 2008-10-01 | Abbott Laboratories | Peptidická antiangiogenní léciva |
-
2001
- 2001-07-26 US US09/915,956 patent/US20030050246A1/en not_active Abandoned
-
2002
- 2002-06-20 SK SK117-2004A patent/SK1172004A3/sk unknown
- 2002-06-20 JP JP2003517087A patent/JP2005507864A/ja active Pending
- 2002-06-20 HU HU0401629A patent/HUP0401629A2/hu unknown
- 2002-06-20 WO PCT/US2002/019574 patent/WO2003011896A1/en not_active Application Discontinuation
- 2002-06-20 EP EP02742231A patent/EP1421107A1/en not_active Withdrawn
- 2002-06-20 MX MXPA04000805A patent/MXPA04000805A/es not_active Application Discontinuation
- 2002-06-20 CA CA002454753A patent/CA2454753A1/en not_active Abandoned
- 2002-06-20 PL PL02368745A patent/PL368745A1/xx not_active Application Discontinuation
- 2002-06-20 CZ CZ2004283A patent/CZ2004283A3/cs unknown
- 2002-07-24 AR ARP020102788A patent/AR034890A1/es not_active Application Discontinuation
- 2002-07-25 UY UY27394A patent/UY27394A1/es not_active Application Discontinuation
- 2002-07-25 PE PE2002000665A patent/PE20030302A1/es not_active Application Discontinuation
-
2004
- 2004-02-18 BG BG108587A patent/BG108587A/bg unknown
Also Published As
Publication number | Publication date |
---|---|
MXPA04000805A (es) | 2004-06-03 |
BG108587A (bg) | 2005-03-31 |
CA2454753A1 (en) | 2003-02-13 |
PE20030302A1 (es) | 2003-03-27 |
EP1421107A1 (en) | 2004-05-26 |
SK1172004A3 (en) | 2004-08-03 |
CZ2004283A3 (cs) | 2004-07-14 |
JP2005507864A (ja) | 2005-03-24 |
WO2003011896A1 (en) | 2003-02-13 |
US20030050246A1 (en) | 2003-03-13 |
AR034890A1 (es) | 2004-03-24 |
PL368745A1 (en) | 2005-04-04 |
UY27394A1 (es) | 2003-02-28 |
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