HUP0401229A2 - Egy feniletanolamin-hidroklorid kristályformája, előállítása és az ezt tartalmazó gyógyszerkészítmények - Google Patents

Egy feniletanolamin-hidroklorid kristályformája, előállítása és az ezt tartalmazó gyógyszerkészítmények

Info

Publication number
HUP0401229A2
HUP0401229A2 HU0401229A HUP0401229A HUP0401229A2 HU P0401229 A2 HUP0401229 A2 HU P0401229A2 HU 0401229 A HU0401229 A HU 0401229A HU P0401229 A HUP0401229 A HU P0401229A HU P0401229 A2 HUP0401229 A2 HU P0401229A2
Authority
HU
Hungary
Prior art keywords
hydrokloride
phenylethanolamine
preparation
same
pharmaceutical compositions
Prior art date
Application number
HU0401229A
Other languages
English (en)
Inventor
Antoine Caron
Olivier Monnier
Sabrina Obert
Jérome Roche
Isabelle Ziri
Original Assignee
Sanofi-Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi-Synthelabo filed Critical Sanofi-Synthelabo
Publication of HUP0401229A2 publication Critical patent/HUP0401229A2/hu
Publication of HUP0401229A3 publication Critical patent/HUP0401229A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/74—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C219/26—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Jelen találmány tárgya a gyógyszerként hasznos etil-[(7S)-7-[(2R)-2-(3-klórfenil)-2hidroxietilamino]-5,6,7,8-tetrahidronaft-2-iloxi]-acetát-hidroklorid B formája, amely a következő fizikai jellemzőketmutatja: jellegzetes IR abszorpciós csúcsok (cm-1): 2780, 2736, 1722,1211; olvadáspont: 129 +/- 2 °C; a röntgen-pordiffrakciós diagramjellegzetes vonalai: (0,1 fok 20 értéken belül): 7,69-9,83-13,95-16,58- 18,70 20,40-21,57-23,40-24,15-25,64. A terméket a bázisbólsóképzéssel vagy a sónak alkoholban való átkristályosításávalkaphatják. Ó
HU0401229A 2001-06-28 2002-06-27 Crystal form of a phenylethanolamine hydrokloride, the preparation thereof and pharmaceutical compositions comprising the same HUP0401229A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0108562A FR2826651B1 (fr) 2001-06-28 2001-06-28 Forme cristalline d'une phenylethanolamine, sa preparation et compositions pharmaceutiques la contenant
PCT/FR2002/002235 WO2003002510A1 (fr) 2001-06-28 2002-06-27 Forme cristalline d'une phenylethanolamine, sa preparation et compositions pharmaceutiques la contenant

Publications (2)

Publication Number Publication Date
HUP0401229A2 true HUP0401229A2 (hu) 2004-10-28
HUP0401229A3 HUP0401229A3 (en) 2008-03-28

Family

ID=8864888

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0401229A HUP0401229A3 (en) 2001-06-28 2002-06-27 Crystal form of a phenylethanolamine hydrokloride, the preparation thereof and pharmaceutical compositions comprising the same

Country Status (30)

Country Link
US (1) US6992211B2 (hu)
EP (1) EP1404641B1 (hu)
JP (2) JP4171413B2 (hu)
KR (1) KR100869017B1 (hu)
CN (1) CN1269797C (hu)
AR (1) AR034648A1 (hu)
AT (1) ATE403642T1 (hu)
AU (1) AU2002333942B2 (hu)
BR (1) BR0210661A (hu)
CA (1) CA2450213C (hu)
CY (1) CY1110099T1 (hu)
CZ (1) CZ301450B6 (hu)
DE (1) DE60228088D1 (hu)
DK (1) DK1404641T3 (hu)
EE (1) EE05380B1 (hu)
ES (1) ES2307798T3 (hu)
FR (1) FR2826651B1 (hu)
HK (1) HK1063621A1 (hu)
HU (1) HUP0401229A3 (hu)
IL (2) IL159134A0 (hu)
MX (1) MXPA03011742A (hu)
NO (1) NO331169B1 (hu)
NZ (1) NZ530140A (hu)
PL (1) PL206680B1 (hu)
PT (1) PT1404641E (hu)
SI (1) SI1404641T1 (hu)
SK (1) SK287355B6 (hu)
TW (1) TWI286129B (hu)
WO (1) WO2003002510A1 (hu)
ZA (1) ZA200309512B (hu)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2826651B1 (fr) * 2001-06-28 2005-09-02 Sanofi Synthelabo Forme cristalline d'une phenylethanolamine, sa preparation et compositions pharmaceutiques la contenant
EP1623705A1 (en) * 2004-07-09 2006-02-08 Sanofi-Aventis Use of phenylethanolaminotetralines for preparing anxiolytic drugs
FR2890862B1 (fr) * 2005-09-19 2008-01-25 Sanofi Aventis Sa Association d'agoniste aux recepteurs beta 3 et d'inhibiteur de la recapture de monoamnies, compostion pharmaceutique la contenant et son utilisation en therapeutique.
EP3397765B1 (en) 2015-12-30 2023-02-01 Bio-Rad Laboratories, Inc. Method for quantitating the frequency of wild-type and mutant fragments in a nucleic acid sample

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5235103A (en) * 1987-08-12 1993-08-10 Sanofi Process for the preparation of phenylethanolaminotetralins
US5198586A (en) * 1987-08-12 1993-03-30 Sanofi Process for the preparation of phenylethanolaminotetralins
ATE116284T1 (de) * 1987-08-12 1995-01-15 Sanofi Sa Verfahren zur o-alkylierung von n- (hydroxy)aralkylphenylethanolamin.
US5202466A (en) 1988-06-14 1993-04-13 Sanofi 2-amino-7-hydroxytetraline ethers
FR2648042B1 (fr) * 1989-06-13 1994-06-10 Midy Spa Utilisation de phenylethanolaminotetralines pour la preparation de medicaments pour le traitement des affections oculaires
US5312961A (en) * 1989-02-14 1994-05-17 Elf Sanofi 2-amino-7-hydroxytetralin carboxylalkyl ethers
FR2643076B1 (fr) * 1989-02-14 1991-06-21 Midy Spa Carboxyalkyl-ethers de la 2-amino-7-hydroxytetraline
FR2669821A1 (fr) * 1990-12-04 1992-06-05 Sanofi Sa Utilisation de phenylethanolaminotetralines pour la preparation de medicaments destines au traitement de la depression.
FR2826651B1 (fr) * 2001-06-28 2005-09-02 Sanofi Synthelabo Forme cristalline d'une phenylethanolamine, sa preparation et compositions pharmaceutiques la contenant

Also Published As

Publication number Publication date
JP4171413B2 (ja) 2008-10-22
TWI286129B (en) 2007-09-01
CN1269797C (zh) 2006-08-16
PL368055A1 (en) 2005-03-21
EE05380B1 (et) 2011-02-15
EP1404641B1 (fr) 2008-08-06
MXPA03011742A (es) 2004-07-01
ATE403642T1 (de) 2008-08-15
AU2002333942B2 (en) 2008-02-28
IL159134A (en) 2009-07-20
CA2450213A1 (en) 2003-01-09
HUP0401229A3 (en) 2008-03-28
EE200400007A (et) 2004-02-16
EP1404641A1 (fr) 2004-04-07
CZ301450B6 (cs) 2010-03-03
IL159134A0 (en) 2004-05-12
US20040180953A1 (en) 2004-09-16
BR0210661A (pt) 2004-10-05
PL206680B1 (pl) 2010-09-30
JP2009029804A (ja) 2009-02-12
SK287355B6 (sk) 2010-08-09
US6992211B2 (en) 2006-01-31
JP2004530725A (ja) 2004-10-07
NO20035839L (no) 2004-03-01
PT1404641E (pt) 2008-09-22
FR2826651A1 (fr) 2003-01-03
KR20040017817A (ko) 2004-02-27
CA2450213C (en) 2011-02-15
KR100869017B1 (ko) 2008-11-17
DK1404641T3 (da) 2008-12-08
SI1404641T1 (sl) 2008-10-31
SK15932003A3 (sk) 2004-05-04
ES2307798T3 (es) 2008-12-01
AR034648A1 (es) 2004-03-03
CN1522241A (zh) 2004-08-18
CZ20033531A3 (en) 2004-04-14
DE60228088D1 (de) 2008-09-18
FR2826651B1 (fr) 2005-09-02
WO2003002510A1 (fr) 2003-01-09
NZ530140A (en) 2005-05-27
CY1110099T1 (el) 2015-01-14
ZA200309512B (en) 2004-12-08
HK1063621A1 (en) 2005-01-07
JP4799592B2 (ja) 2011-10-26
NO331169B1 (no) 2011-10-24

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Legal Events

Date Code Title Description
FD9A Lapse of provisional protection due to non-payment of fees