HUP0401204A2 - Immunrendszerre ható új, heterokondenzált pirazol-3-on-származékok és az ezeket tartalmazó gyógyszerkészítmények - Google Patents
Immunrendszerre ható új, heterokondenzált pirazol-3-on-származékok és az ezeket tartalmazó gyógyszerkészítményekInfo
- Publication number
- HUP0401204A2 HUP0401204A2 HU0401204A HUP0401204A HUP0401204A2 HU P0401204 A2 HUP0401204 A2 HU P0401204A2 HU 0401204 A HU0401204 A HU 0401204A HU P0401204 A HUP0401204 A HU P0401204A HU P0401204 A2 HUP0401204 A2 HU P0401204A2
- Authority
- HU
- Hungary
- Prior art keywords
- chain
- lower alkyl
- alkyl
- halogen
- alkoxy group
- Prior art date
Links
- 230000002519 immonomodulatory effect Effects 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- JEXVQSWXXUJEMA-UHFFFAOYSA-N pyrazol-3-one Chemical class O=C1C=CN=N1 JEXVQSWXXUJEMA-UHFFFAOYSA-N 0.000 title 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 101000914484 Homo sapiens T-lymphocyte activation antigen CD80 Proteins 0.000 abstract 2
- 102100027222 T-lymphocyte activation antigen CD80 Human genes 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 229920006395 saturated elastomer Polymers 0.000 abstract 2
- 239000000126 substance Substances 0.000 abstract 2
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 abstract 1
- 201000004681 Psoriasis Diseases 0.000 abstract 1
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 125000006165 cyclic alkyl group Chemical group 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 150000002391 heterocyclic compounds Chemical class 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 210000000987 immune system Anatomy 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000003993 interaction Effects 0.000 abstract 1
- 201000006417 multiple sclerosis Diseases 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 201000000596 systemic lupus erythematosus Diseases 0.000 abstract 1
- 238000002054 transplantation Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Endocrinology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Physical Education & Sports Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
A találmány tárgya az (I) általános képletű heterociklusos vegyületek- a képletben X jelentése kémiai kötés vagy szubsztituált vagyszubsztituálatlan 1-3 szénatomos alkil-, NH-C(O)-(1-3 szénatomosalkil), NH-C(O)-CH2-O-CH2 és C(O)-NH-(aminosavmaradék) közülválasztott csoport; Y jelentése NR4, O vagy S; R1 jelentése H,halogénatom, CF3, rövid szénláncú alkil- vagy rövid szénláncúalkoxicsoport; R2 és R4 jelentése egymástól függetlenül H vagy rövidszénláncú alkilcsoport; és R3 jelentése H, halogénatom, rövidszénláncú alkil- vagy rövid szénláncú alkoxicsoport; ahol ahalogénatom jelentése F, Cl vagy Br; a rövid szénláncú alkilcsoporttelített vagy telítetlen, egyenes vagy elágazó láncú vagy gyűrűsalkilcsoportot jelent, amely 1-6 szénatomot tartalmaz; és a rövidszénláncú alkoxicsoport telített vagy telítetlen, egyenes vagy elágazóláncú vagy gyűrűs alkoxicsoportot jelent, amely 1-6 szénatomottartalmaz; azzal a megkötéssel, hogy R2 jelentése hidrogénatomtóleltérő, ha X jelentése kémiai kötés és Y jelentése NH és R3 jelentéseH -, gyógyászatilag elfogadható sóik, valamint immunrendszermódosításával előnyösen befolyásolható állapotok, például a reumásarthritis, szklerózis multiplex, cukorbaj, asztma, transzplantáció,szisztémás lupus erythemaitosis vagy psoriasis kezelésére alkalmasgyógyszerek, melyek hatóanyagai a fenti vegyületeket tartalmazzák. Atalálmány szerinti vegyületek a CD80 és CD28 közötti kölcsönhatásokgátlására képes CD80 antagonisták. Ó
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0102404A SE0102404D0 (sv) | 2001-07-04 | 2001-07-04 | Novel immunomodulating compounds |
| PCT/SE2002/001309 WO2003004495A1 (en) | 2001-07-04 | 2002-07-02 | Novel immunomodulating compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0401204A2 true HUP0401204A2 (hu) | 2004-10-28 |
| HUP0401204A3 HUP0401204A3 (en) | 2008-03-28 |
Family
ID=20284743
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0401204A HUP0401204A3 (en) | 2001-07-04 | 2002-07-02 | Novel immunomodulating heterocondensated pyrazol-3-one derivatives and pharmaceutical compositions containing them |
Country Status (21)
| Country | Link |
|---|---|
| EP (1) | EP1409485B1 (hu) |
| JP (1) | JP2005501033A (hu) |
| CN (1) | CN1249063C (hu) |
| AT (1) | ATE324373T1 (hu) |
| AU (1) | AU2002315996B2 (hu) |
| BR (1) | BR0210776A (hu) |
| CA (1) | CA2451749A1 (hu) |
| DE (1) | DE60210977T2 (hu) |
| ES (1) | ES2258150T3 (hu) |
| HK (1) | HK1066809A1 (hu) |
| HR (1) | HRP20031055B1 (hu) |
| HU (1) | HUP0401204A3 (hu) |
| MX (1) | MXPA04000017A (hu) |
| NO (1) | NO20035684L (hu) |
| NZ (1) | NZ530316A (hu) |
| PL (1) | PL367637A1 (hu) |
| RU (1) | RU2004103079A (hu) |
| SE (1) | SE0102404D0 (hu) |
| WO (1) | WO2003004495A1 (hu) |
| YU (1) | YU101603A (hu) |
| ZA (1) | ZA200309806B (hu) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7081456B2 (en) * | 2002-11-22 | 2006-07-25 | Active Biotech Ab | Immunomodulatory compounds |
| WO2004055014A1 (en) * | 2002-12-16 | 2004-07-01 | Active Biotech Ab | Tetracyclic immunomodulatory compounds |
| PL1603917T3 (pl) * | 2003-03-14 | 2011-12-30 | Medigene Ag | Związki heterocykliczne o właściwościach immunomodulujących |
| GB0305876D0 (en) * | 2003-03-14 | 2003-04-16 | Avidex Ltd | Immuno inhibitory heterocyclic compounds |
| GB0325644D0 (en) | 2003-11-04 | 2003-12-10 | Avidex Ltd | Immuno ihibitory pyrazolone compounds |
| JPWO2005068467A1 (ja) | 2004-01-14 | 2007-12-27 | 味の素株式会社 | 新規縮環化合物 |
| GB0411770D0 (en) | 2004-05-26 | 2004-06-30 | Avidex Ltd | Immuno inhibitory heterocyclic compouds |
| DK1776366T3 (da) * | 2004-08-09 | 2009-02-16 | Medigene Ltd | Immunomodulerende oxopyrazolocinnoliner som CD80-inhibitorer |
| CN101863903B (zh) * | 2010-06-08 | 2014-03-12 | 沈阳药科大学 | 1,4-二氢噻吩并[3’,2’:5,6]噻喃并[4,3-c]吡唑-3-羧酸衍生物及其应用 |
| WO2014209980A1 (en) * | 2013-06-24 | 2014-12-31 | Merck Patent Gmbh | Pyrazole compounds as modulators of fshr and uses thereof |
| EP2883883A1 (en) | 2013-12-16 | 2015-06-17 | Cardio3 Biosciences S.A. | Therapeutic targets and agents useful in treating ischemia reperfusion injury |
| WO2016007022A1 (en) | 2014-07-08 | 2016-01-14 | Avertana Limited | Extraction of products from titanium-bearing minerals |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4268516A (en) * | 1978-10-11 | 1981-05-19 | Pfizer Inc. | [1]Benzothiopyrano[4,3-c]pyrazoles as immunoregulatory agents |
| US4312870A (en) * | 1979-06-21 | 1982-01-26 | Ciba-Geigy Corporation | Pyrazoloquinolines |
| ZA895646B (en) * | 1988-08-09 | 1990-04-25 | Boots Co Plc | Therapeutic agents |
| GB8818895D0 (en) * | 1988-08-09 | 1988-09-14 | Boots Co Plc | Therapeutic agents |
| SE8903564D0 (sv) * | 1989-10-26 | 1989-10-26 | Pharmacia Ab | New use condensed quinoline compound |
| EP0539372A1 (en) * | 1990-02-02 | 1993-05-05 | The Boots Company PLC | Therapeutic agents |
| ID16283A (id) * | 1996-03-20 | 1997-09-18 | Astra Pharma Prod | Senyawa yang berguna dibidang farmasi |
-
2001
- 2001-07-04 SE SE0102404A patent/SE0102404D0/xx unknown
-
2002
- 2002-07-02 DE DE60210977T patent/DE60210977T2/de not_active Expired - Lifetime
- 2002-07-02 ES ES02746260T patent/ES2258150T3/es not_active Expired - Lifetime
- 2002-07-02 HU HU0401204A patent/HUP0401204A3/hu unknown
- 2002-07-02 PL PL02367637A patent/PL367637A1/xx not_active Application Discontinuation
- 2002-07-02 AU AU2002315996A patent/AU2002315996B2/en not_active Ceased
- 2002-07-02 MX MXPA04000017A patent/MXPA04000017A/es active IP Right Grant
- 2002-07-02 BR BR0210776-7A patent/BR0210776A/pt not_active IP Right Cessation
- 2002-07-02 NZ NZ530316A patent/NZ530316A/en unknown
- 2002-07-02 YU YU101603A patent/YU101603A/sh unknown
- 2002-07-02 WO PCT/SE2002/001309 patent/WO2003004495A1/en active IP Right Grant
- 2002-07-02 AT AT02746260T patent/ATE324373T1/de not_active IP Right Cessation
- 2002-07-02 CA CA002451749A patent/CA2451749A1/en not_active Abandoned
- 2002-07-02 EP EP02746260A patent/EP1409485B1/en not_active Expired - Lifetime
- 2002-07-02 CN CNB028132890A patent/CN1249063C/zh not_active Expired - Fee Related
- 2002-07-02 JP JP2003510662A patent/JP2005501033A/ja not_active Withdrawn
- 2002-07-02 RU RU2004103079/04A patent/RU2004103079A/ru not_active Application Discontinuation
-
2003
- 2003-12-17 HR HR20031055A patent/HRP20031055B1/xx not_active IP Right Cessation
- 2003-12-19 ZA ZA200309806A patent/ZA200309806B/en unknown
- 2003-12-19 NO NO20035684A patent/NO20035684L/no not_active Application Discontinuation
-
2004
- 2004-12-14 HK HK04109875A patent/HK1066809A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE60210977D1 (de) | 2006-06-01 |
| HRP20031055B1 (en) | 2008-01-31 |
| CN1522254A (zh) | 2004-08-18 |
| DE60210977T2 (de) | 2006-09-21 |
| NO20035684D0 (no) | 2003-12-19 |
| ZA200309806B (en) | 2004-12-20 |
| YU101603A (en) | 2006-05-25 |
| ATE324373T1 (de) | 2006-05-15 |
| JP2005501033A (ja) | 2005-01-13 |
| NO20035684L (no) | 2004-03-02 |
| PL367637A1 (en) | 2005-03-07 |
| CA2451749A1 (en) | 2003-01-16 |
| HUP0401204A3 (en) | 2008-03-28 |
| HK1066809A1 (en) | 2005-04-01 |
| SE0102404D0 (sv) | 2001-07-04 |
| EP1409485A1 (en) | 2004-04-21 |
| MXPA04000017A (es) | 2004-05-21 |
| AU2002315996B2 (en) | 2007-11-29 |
| HRP20031055A2 (en) | 2004-06-30 |
| BR0210776A (pt) | 2004-07-20 |
| WO2003004495A1 (en) | 2003-01-16 |
| EP1409485B1 (en) | 2006-04-26 |
| CN1249063C (zh) | 2006-04-05 |
| NZ530316A (en) | 2004-08-27 |
| RU2004103079A (ru) | 2005-06-10 |
| ES2258150T3 (es) | 2006-08-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HUP0401204A2 (hu) | Immunrendszerre ható új, heterokondenzált pirazol-3-on-származékok és az ezeket tartalmazó gyógyszerkészítmények | |
| HUP0401982A2 (hu) | Indolizinszármazékok, eljárás előállításukra és a vegyületeket tartalmazó gyógyászati készítmények | |
| HUP0303756A2 (hu) | 1-Aril- vagy 1-alkilszulfonil-heterociklobenzazolok és eljárás ezek elõállítására és ezeket tartalmazó gyógyszerkészítmények | |
| HUP0100394A2 (hu) | 2-es Helyzetben fenil-szubsztituenst hordozó imidazo-triazinon-származékok, eljárás előállításukra és ezeket tartalmazó gyógyszerkészítmények | |
| BG105001A (en) | Oxazolidinone derivatives, process for their preparartion and pharmaceutical compositions containing them | |
| WO2003080580A3 (en) | Quinoline derivatives and their use as 5-ht6 ligands | |
| CA2536870A1 (en) | Phenyl or pyridyl amide compounds as prostaglandin e2 antagonists | |
| HUP9902471A2 (hu) | Piperazin- és piperidinvegyületek, eljárás előállításukra és az ezeket tartalmazó gyógyszerkészítmények | |
| GB0009803D0 (en) | Chemical compounds | |
| HUP0202810A2 (hu) | Szubsztituált 2-tio-3.5-diciano-4-aril-6-aminopiridinek és eljárás az előállításukra, valamint ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk | |
| WO2004089366A8 (en) | Bicyclic compounds as nr2b receptor antagonists | |
| WO2002089800A3 (en) | N-aroyl cyclic amine derivatives as orexin receptor antagonists | |
| MY101359A (en) | 7-acylamino-3-vinylcephalosporanic acid derivatives, processes for their preparation, pharmaceutical compositions containing them, their starting compounds and their preparation | |
| HUP0103404A2 (hu) | Oxazolidinonszármazékok, eljárás előállításukra, és az azokat tartalmazó gyógyászati készítmények | |
| WO2003028459A8 (de) | Nicotinsäure-heterocyclyl-amide und analogue pyrimidin-derivate als schädlingsbekämpfungsmittel | |
| HUT71482A (en) | 4,1-benzoxazepine derivatives, process for preparing them and pharmaceutical compositions containing them | |
| IE810485L (en) | Imidazo compounds | |
| GEP20074256B (en) | Novel benzothiadiazine, process for their preparation and pharmaceutical compositions containing | |
| NZ515407A (en) | 4-Phenyl-pyrimidine derivatives | |
| ATE19773T1 (de) | Nitroaliphatische verbindungen, verfahren zu deren herstellung und deren verwendung. | |
| ES8502093A1 (es) | Derivados de quinolina. | |
| ATE353898T1 (de) | Pyrazolochinoline mit immunmodulierenderwirkung | |
| MX9708110A (es) | Nuevo antiviral sustituido con derivados de nucleosido pirimidindiona homocarbociclica y metodos para la preparacion de los mismos y composiciones que los contienen como ingredientes activos. | |
| ES8701174A1 (es) | Un metodo de preparacion de un compuesto de tiadiazina | |
| AR026222A1 (es) | Compuestos derivados de acido antranilico |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA9A | Lapse of provisional patent protection due to relinquishment or protection considered relinquished |