HUP0400540A2 - 2-Pirazolin-5-on-származékok, alkalmazásuk és ezeket tartalmazó gyógyászati készítmények - Google Patents

2-Pirazolin-5-on-származékok, alkalmazásuk és ezeket tartalmazó gyógyászati készítmények

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Publication number
HUP0400540A2
HUP0400540A2 HU0400540A HUP0400540A HUP0400540A2 HU P0400540 A2 HUP0400540 A2 HU P0400540A2 HU 0400540 A HU0400540 A HU 0400540A HU P0400540 A HUP0400540 A HU P0400540A HU P0400540 A2 HUP0400540 A2 HU P0400540A2
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HU
Hungary
Prior art keywords
compounds
nr4r5
triazole
imidazole
pyridine
Prior art date
Application number
HU0400540A
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English (en)
Inventor
Lee Arnold
Jose Maria Castellano Berlanga
David J. Calderwood
Isabel F. Fernandez
Marina M. Moset
Paul Rafferty
Original Assignee
Abbott Gmbh & Co., Kg
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Publication date
Application filed by Abbott Gmbh & Co., Kg filed Critical Abbott Gmbh & Co., Kg
Publication of HUP0400540A2 publication Critical patent/HUP0400540A2/hu
Publication of HUP0400540A3 publication Critical patent/HUP0400540A3/hu

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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
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Abstract

A találmány tárgyát az (I) általános képletű vegyületek, valamint ezekfiziológiailag megfelelő sói, továbbá e vegyületeket tartalmazógyógyászati készítmények képezik; a találmány tárgyához tartozik afenti vegyületek alkalmazása is gyógyászati készítményekelőállítására. Az (I) általános képletben a szubsztituensek jelentéseaz alábbi: R jelentése egy gyűrűs rendszer, például adott esetbenszubsztituált indol, imidazol, 1,2,3-triazol, 1,2,4-triazol,benzimidazol, 4,5,6,7-tetrahidroindol, benzoindol, azaindol, indazol,piridin, kinolin; R1 jelentése hidrogénatom vagy -A-Z; A jelentése -(CH2)n-, -(CH2)nNH-, (CH2)nO-, -(CH2)nS-, -(CH2)nS(O)- vagy -(CH2)nS(O)2-; Z jelentése -H, rövid szénláncú alkil-, aralkil-,trihalogénmetil-, trihalogénmetil-karboil-, R3OC(O)-, -NR4R5, -C(O)NR4R5, R3CO-, R3O- vagy egy gyűrűs rendszer, például adott esetbenszubsztituált 3-6 szénatomos cikloalkán, izoxazol, izotiazol,imidazol, benzol, pirrol, indok piridin, pirazin, vagy ezen gyűrűk N-oxid-származékai. A találmány szerinti vegyületek és ezeket tartalmazógyógyászati készítmények előnyösen alkalmazhatók egy vagy több proteinkináz aktivitásának gátlására. Ó
HU0400540A 1999-07-30 2000-07-28 2-pyrazolin-5-one derivatives, their use and pharmaceutical compositions containing them HUP0400540A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14656399P 1999-07-30 1999-07-30
PCT/US2000/020628 WO2001009121A2 (en) 1999-07-30 2000-07-28 2-pyrazolin-5-ones_as tyrosine kinase inhibitors

Publications (2)

Publication Number Publication Date
HUP0400540A2 true HUP0400540A2 (hu) 2004-06-28
HUP0400540A3 HUP0400540A3 (en) 2004-09-28

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ID=22517965

Family Applications (1)

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HU0400540A HUP0400540A3 (en) 1999-07-30 2000-07-28 2-pyrazolin-5-one derivatives, their use and pharmaceutical compositions containing them

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EP (1) EP1218373A2 (hu)
JP (1) JP2003506368A (hu)
KR (1) KR20020091829A (hu)
CN (1) CN1193026C (hu)
AR (1) AR032279A1 (hu)
AU (1) AU6388900A (hu)
BG (1) BG106392A (hu)
BR (1) BR0012896A (hu)
CA (1) CA2380644A1 (hu)
CZ (1) CZ2002302A3 (hu)
HK (1) HK1049154A1 (hu)
HU (1) HUP0400540A3 (hu)
IL (1) IL147757A0 (hu)
MX (1) MXPA02001088A (hu)
NO (1) NO20020487L (hu)
NZ (1) NZ516850A (hu)
PL (1) PL354144A1 (hu)
SK (1) SK1512002A3 (hu)
TR (1) TR200200928T2 (hu)
WO (1) WO2001009121A2 (hu)
ZA (1) ZA200200477B (hu)

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BR0012896A (pt) 2002-06-18
CZ2002302A3 (cs) 2002-06-12
NO20020487D0 (no) 2002-01-30
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AR032279A1 (es) 2003-11-05
HUP0400540A3 (en) 2004-09-28
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NZ516850A (en) 2004-09-24
MXPA02001088A (es) 2003-09-22
CN1193026C (zh) 2005-03-16
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AU6388900A (en) 2001-02-19
BG106392A (bg) 2002-12-29
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CN1377346A (zh) 2002-10-30
IL147757A0 (en) 2002-08-14
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