HUP0303413A2 - Szexuális zavarok kezelésében alkalmazható benzimidazolokat tartalmazó gyógyszerkészítmények - Google Patents

Szexuális zavarok kezelésében alkalmazható benzimidazolokat tartalmazó gyógyszerkészítmények

Info

Publication number
HUP0303413A2
HUP0303413A2 HU0303413A HUP0303413A HUP0303413A2 HU P0303413 A2 HUP0303413 A2 HU P0303413A2 HU 0303413 A HU0303413 A HU 0303413A HU P0303413 A HUP0303413 A HU P0303413A HU P0303413 A2 HUP0303413 A2 HU P0303413A2
Authority
HU
Hungary
Prior art keywords
group
general formula
compounds
useful
alkyl
Prior art date
Application number
HU0303413A
Other languages
English (en)
Inventor
Pramila Bhatia
Jorge D. Brioni
Marlon D. Cowart
Jerome F. Daanen
Teodozyj Kolasa
Meena V. Patel
Jeffrey J. Rohde
Andrew O. Stewart
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/874,484 external-priority patent/US20030008878A1/en
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Publication of HUP0303413A2 publication Critical patent/HUP0303413A2/hu
Publication of HUP0303413A3 publication Critical patent/HUP0303413A3/hu

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/14—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Addiction (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Discharging, Photosensitive Material Shape In Electrophotography (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

A találmány tárgya az (I) általános képletű vegyületek alkalmazásaszexuális zavarok kezelésére egy emlősben. Az ilyen kezelésre szorulóemlősnek az (I) általános képletű vegyületek, azok gyógyászatilagelfogadható sója, észtere, amidja vagy elővegyülete gyógyászatilaghatásos mennyiségét adják be - ahol a képletben A jelentése (1), (2),(3), (4), (5), (6), (7), (8), (9), (10), (11), (12), (13), (14), (15),(16), (17), (18), (19), (20) vagy (21) általános képletű csoport, Xjelentése NH-csoport, O- vagy S-atom, L jelentése CH2-, CH2CH2-,CH2CH2CH2- vagy CH2CH2CH2CH2-csoport, . R1, R2, R3, R4 és R5 jelentése- egyebek mellett - hidrogénatom és alkilcsoport, RE jelentésehidrogénatom, alkoxi-karbonil-, alkil-, alkil-karbonil, aril-karbonil-, cikloalkil-karbonil-, heterociklo-karbonil vagy (NZ1Z2)-karbonil-csoport, RF jelentése hidrogénatom vagy alkilcsoport, Zjelentése N-, C-atom vagy CH-csoport, és --- jelentése egy kötés,amikor Z jelentése C-atom és --- hiányzik, amikor Z jelentése N-atomvagy CH-csoport. RA, RB, RC és RD jelentései a leírásban megadottak. Atalálmány tárgyát képezik továbbá az (I) j általános képletűvegyületek vagy azok gyógyászatilag elfogadható sóit, észtereit,amidjait vagy elővegyületeit tartalmazó gyógyszerkészítmények is. Ó
HU0303413A 2001-03-09 2002-03-06 Pharmaceutical compositions containing benzimidazoles that are useful in treating sexual dysfunction HUP0303413A3 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US80353701A 2001-03-09 2001-03-09
US09/874,484 US20030008878A1 (en) 2001-03-09 2001-06-05 Benzimidazoles that are useful in treating sexual dysfunction
US10/017,939 US20020169166A1 (en) 2001-03-09 2001-12-14 Benzimidazoles that are useful in treating sexual dysfunction
PCT/US2002/007791 WO2002088093A1 (en) 2001-03-09 2002-03-06 Benzimidazoles that are useful in treating sexual dysfunction

Publications (2)

Publication Number Publication Date
HUP0303413A2 true HUP0303413A2 (hu) 2004-01-28
HUP0303413A3 HUP0303413A3 (en) 2007-08-28

Family

ID=27360930

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0303413A HUP0303413A3 (en) 2001-03-09 2002-03-06 Pharmaceutical compositions containing benzimidazoles that are useful in treating sexual dysfunction

Country Status (23)

Country Link
US (1) US20020169166A1 (hu)
EP (1) EP1373220B1 (hu)
JP (1) JP2005507370A (hu)
CN (1) CN100430383C (hu)
AT (1) ATE363474T1 (hu)
AU (1) AU2002303128B2 (hu)
BG (1) BG108230A (hu)
BR (1) BR0205812A (hu)
CA (1) CA2439943A1 (hu)
CZ (1) CZ20032659A3 (hu)
DE (1) DE60220385T2 (hu)
DK (1) DK1373220T3 (hu)
ES (1) ES2287278T3 (hu)
HK (1) HK1062174A1 (hu)
HU (1) HUP0303413A3 (hu)
IL (1) IL157457A0 (hu)
MX (1) MXPA03008151A (hu)
NO (1) NO326686B1 (hu)
NZ (1) NZ527713A (hu)
PL (1) PL371272A1 (hu)
SK (1) SK12612003A3 (hu)
UY (1) UY27203A1 (hu)
WO (1) WO2002088093A1 (hu)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7022728B2 (en) * 2001-03-09 2006-04-04 Abbott Laboratories Benzimidazoles that are useful in treating male sexual dysfunction
US6960589B2 (en) * 2001-03-09 2005-11-01 Abbott Laboratories Benzimidazoles that are useful in treating sexual dysfunction
US20040127504A1 (en) * 2002-09-06 2004-07-01 Cowart Marlon D. Benzimidazoles that are useful in treating sexual dysfunction
TWI345974B (en) 2003-07-30 2011-08-01 Xenon Pharmaceuticals Inc Pyridazine derivatives and their use in the inhibition of stearoyl-coa desaturase
BRPI0412352A (pt) * 2003-07-30 2006-09-05 Xenon Pharmaceuticals Inc processo para a preparação de derivados de tetrazol de azidas de organo boro e organo alumìnio
AR045496A1 (es) * 2003-08-29 2005-11-02 Schering Corp Analolgos de benzimidazolpiperidinas 2- substiyuidas como antagonistas de los receptores de la hormona que concentra melanina selectivos para el tratamiento de la obesidad y trastornos relacionados
CN101083992A (zh) 2004-09-20 2007-12-05 泽农医药公司 抑制人硬脂酰CoA去饱和酶的哒嗪衍生物
CA2580857A1 (en) 2004-09-20 2006-09-28 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors
JP5094398B2 (ja) 2004-09-20 2012-12-12 ゼノン・ファーマシューティカルズ・インコーポレイテッド 複素環式誘導体およびステアロイル−ＣｏＡデサチュラーゼのメディエータとしてのそれらの使用
EP1807085B1 (en) 2004-09-20 2013-08-21 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors
US7919496B2 (en) 2004-09-20 2011-04-05 Xenon Pharmaceuticals Inc. Heterocyclic derivatives for the treatment of diseases mediated by stearoyl-CoA desaturase enzymes
JP5043668B2 (ja) 2004-09-20 2012-10-10 ゼノン・ファーマシューティカルズ・インコーポレイテッド 複素環誘導体および治療薬としてのそれらの使用
BRPI0515489A (pt) 2004-09-20 2008-07-29 Xenon Pharmaceuticals Inc derivados heterocìclicos e sua utilização como inibidores de estearoil-coa desaturase
WO2007130075A1 (en) 2005-06-03 2007-11-15 Xenon Pharmaceuticals Inc. Aminothiazole derivatives as human stearoyl-coa desaturase inhibitors
WO2008079945A2 (en) * 2006-12-20 2008-07-03 University Of South Florida Rock inhibitors and uses thereof
EP2149373A1 (en) * 2008-08-01 2010-02-03 Laboratorios Del. Dr. Esteve, S.A. 5HT7 receptor ligands and compositions comprising the same
EP2545905A1 (en) 2011-07-11 2013-01-16 Britannia Pharmaceuticals Limited A new therapeutical composition containing apomorphine as active ingredient

Family Cites Families (7)

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FR2665161B1 (fr) * 1990-07-26 1992-11-27 Esteve Labor Dr Nouveaux derives de benzimidazole, leur preparation et leur application en tant que medicaments.
GB9306578D0 (en) * 1993-03-30 1993-05-26 Merck Sharp & Dohme Therapeutic agents
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ES2154605B1 (es) * 1999-09-14 2001-11-16 Univ Madrid Complutense Nuevos derivados mixtos de bencimidazol-arilpiperazina con afinidad por los receptores serotoninergicos 5-ht1a y 5-ht3

Also Published As

Publication number Publication date
CA2439943A1 (en) 2002-11-07
EP1373220B1 (en) 2007-05-30
HK1062174A1 (en) 2004-10-21
DK1373220T3 (da) 2007-10-08
MXPA03008151A (es) 2004-03-16
BR0205812A (pt) 2005-05-03
DE60220385D1 (de) 2007-07-12
EP1373220A1 (en) 2004-01-02
US20020169166A1 (en) 2002-11-14
WO2002088093A1 (en) 2002-11-07
DE60220385T2 (de) 2008-04-03
NO20033959L (no) 2003-11-10
CN100430383C (zh) 2008-11-05
UY27203A1 (es) 2002-10-31
AU2002303128B2 (en) 2007-11-29
SK12612003A3 (sk) 2004-04-06
HUP0303413A3 (en) 2007-08-28
CZ20032659A3 (cs) 2004-01-14
ES2287278T3 (es) 2007-12-16
CN1516693A (zh) 2004-07-28
NZ527713A (en) 2006-09-29
ATE363474T1 (de) 2007-06-15
NO326686B1 (no) 2009-01-26
BG108230A (bg) 2005-04-30
NO20033959D0 (no) 2003-09-08
IL157457A0 (en) 2004-03-28
JP2005507370A (ja) 2005-03-17
PL371272A1 (en) 2005-06-13

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