HUP0302104A2 - Új farnezil-protein-transzferáz inhibitorok - Google Patents

Új farnezil-protein-transzferáz inhibitorok

Info

Publication number
HUP0302104A2
HUP0302104A2 HU0302104A HUP0302104A HUP0302104A2 HU P0302104 A2 HUP0302104 A2 HU P0302104A2 HU 0302104 A HU0302104 A HU 0302104A HU P0302104 A HUP0302104 A HU P0302104A HU P0302104 A2 HUP0302104 A2 HU P0302104A2
Authority
HU
Hungary
Prior art keywords
protein transferase
farnesyl protein
transferase inhibitors
novel
novel farnesyl
Prior art date
Application number
HU0302104A
Other languages
English (en)
Inventor
Viyyoor M. Girijavallabhan
F. George Njoroge
Xiongwei Shi
Bancha Vibulbhan
Original Assignee
Schering Corp.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp. filed Critical Schering Corp.
Publication of HUP0302104A2 publication Critical patent/HUP0302104A2/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

A találmány tárgyát farnezil-protein-transzferáz inhibitor hatású, új4-(3,10-dibróm-6,11-dihidro-10-klór-5H-benzo[5,6]ciklohepta[1,2-b]piridin-ll-il)-piperidin-származékok, továbbá a szintézisük soránköztitermékként hasznosítható 4-(3,10-dibróm-6,11-dihidro-10-klór-5H-benzo[5,6]ciklohepta[1,2-b]piridin-11-il)-1-metil-piperedinelőállítására szolgáló eljárás, az új vegyületeket tartalmazógyógyszerkészítmények, és a farnezil-protein-transzferázzalösszefüggésbe hozható betegségek, például daganatos betegségekkezelésére való alkalmazásuk képezik. Ó
HU0302104A 2000-11-29 2001-11-27 Új farnezil-protein-transzferáz inhibitorok HUP0302104A2 (hu)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25397100P 2000-11-29 2000-11-29
PCT/US2001/044333 WO2002044164A1 (en) 2000-11-29 2001-11-27 0ovel farnesyl protein transferase inhibitors

Publications (1)

Publication Number Publication Date
HUP0302104A2 true HUP0302104A2 (hu) 2003-09-29

Family

ID=22962414

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0302104A HUP0302104A2 (hu) 2000-11-29 2001-11-27 Új farnezil-protein-transzferáz inhibitorok

Country Status (20)

Country Link
US (1) US6528523B2 (hu)
EP (1) EP1337522B1 (hu)
JP (1) JP2004514717A (hu)
KR (1) KR20030060939A (hu)
CN (1) CN1198816C (hu)
AR (1) AR035660A1 (hu)
AT (1) ATE371655T1 (hu)
AU (2) AU3514302A (hu)
CA (1) CA2429720C (hu)
DE (1) DE60130239T2 (hu)
ES (1) ES2291368T3 (hu)
HK (1) HK1054226A1 (hu)
HU (1) HUP0302104A2 (hu)
IL (1) IL155668A0 (hu)
MX (1) MXPA03004878A (hu)
NZ (1) NZ525572A (hu)
PE (1) PE20020635A1 (hu)
TW (1) TWI225058B (hu)
WO (1) WO2002044164A1 (hu)
ZA (1) ZA200303635B (hu)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7517890B2 (en) 2003-11-20 2009-04-14 Children's Hospital Medical Center GTPase inhibitors and methods of use
CA2617056A1 (en) 2005-07-29 2007-02-08 Children's Hospital Medical Center Gtpase inhibitors and methods of use and crystal structure of rac-1 gtpase
WO2013166043A1 (en) 2012-05-02 2013-11-07 Children's Hospital Medical Center Rejuvenation of precursor cells
US10028503B2 (en) 2014-06-18 2018-07-24 Children's Hospital Medical Center Platelet storage methods and compositions for same

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5661152A (en) * 1993-10-15 1997-08-26 Schering Corporation Tricyclic sulfonamide compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
US6365588B1 (en) 1993-10-15 2002-04-02 Schering Corporation Tricyclic amide and urea compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
HUT76057A (en) * 1993-10-15 1997-06-30 Schering Corp Tricyclic sulfonamide compounds, pharmaceutical compositions containing them, which are useful for inhibition of g-protein function and for treatment of proliferative diseases and process for producing them
IL111235A (en) * 1993-10-15 2001-03-19 Schering Plough Corp Medicinal preparations for inhibiting protein G activity and for the treatment of malignant diseases, containing tricyclic compounds, some such new compounds and a process for the preparation of some of them
US5719148A (en) * 1993-10-15 1998-02-17 Schering Corporation Tricyclic amide and urea compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
US5700806A (en) 1995-03-24 1997-12-23 Schering Corporation Tricyclic amide and urea compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
US5684013A (en) 1995-03-24 1997-11-04 Schering Corporation Tricyclic compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
US5801175A (en) 1995-04-07 1998-09-01 Schering Corporation Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
SK86198A3 (en) * 1995-12-22 1999-02-11 Schering Corp Tricyclic amides useful for inhibition of g-protein function and for treatment of proliferative diseases
US5874442A (en) 1995-12-22 1999-02-23 Schering-Plough Corporation Tricyclic amides useful for inhibition of G-protein function and for treatment of proliferative disease
US5784442A (en) 1996-02-02 1998-07-21 Telefonaktiebologet Lm Ericsson (Publ) System and method for real-time billing in a radio telecommunications network
US5925757A (en) * 1996-07-26 1999-07-20 Schering Corporation Method for preparing carboxamides
US5861395A (en) 1996-09-13 1999-01-19 Schering Corporation Compounds useful for inhibition of farnesyl proteins transferase
US5985879A (en) 1996-09-13 1999-11-16 Schering Corporation Compounds useful for inhibition of farnesyl protein transferase
US6040305A (en) 1996-09-13 2000-03-21 Schering Corporation Compounds useful for inhibition of farnesyl protein transferase
US5945429A (en) 1996-09-13 1999-08-31 Schering Corporation Compounds useful for inhibition of farnesyl protein transferase
US6030982A (en) 1996-09-13 2000-02-29 Schering Corporationm Compounds useful for inhibition of farnesyl protein transferase
US6071907A (en) 1996-09-13 2000-06-06 Schering Corporation Tricyclic compounds useful as FPT inhibitors
US6211193B1 (en) 1997-06-17 2001-04-03 Schering Corporation Compounds useful for inhibition of farnesyl protein transferase
US5939416A (en) 1997-06-17 1999-08-17 Schering Corporation Benzo (5,6) cycloheptapyridine compounds useful as farnesyl protein transferase inhibitors
US6358968B1 (en) 1997-06-17 2002-03-19 Schering Corporation N-substituted urea inhibitors of farnesyl-protein transferase
US5852034A (en) 1997-06-17 1998-12-22 Schering Corporation Benzo(5,6)cycloheptapyridine cyclic ureas and lactams useful as farnesyl protein transferase inhibitors
US5925639A (en) 1997-06-17 1999-07-20 Schering Corporation Keto amide derivatives useful as farnesyl protein transferase inhibitors
CA2294347C (en) * 1997-06-17 2008-01-29 Schering Corporation Benzo(5,6)cyclohepta(1,2-b)pyridine derivatives for the inhibition of farnesyl protein transferase
US6228865B1 (en) 1997-06-17 2001-05-08 Schering Corporation Compounds useful for inhibition of farnesyl protein transferase
US6051582A (en) 1997-06-17 2000-04-18 Schering Corporation Compounds useful for inhibition of farnesyl protein transferase
US6239140B1 (en) 1997-06-17 2001-05-29 Schering Corporation Compounds useful for inhibition of farnesyl protein transferase
US6159984A (en) 1997-06-17 2000-12-12 Schering Corporation Farnesyl protein transferase inhibitors
CN1267290A (zh) * 1997-06-17 2000-09-20 先灵公司 新的法呢基－蛋白转移酶的三环磺酰胺抑制剂
US6221322B1 (en) 1997-11-27 2001-04-24 Dowa Mining Co., Ltd Strontium nitrate and method for manufacturing same
US6096757A (en) 1998-12-21 2000-08-01 Schering Corporation Method for treating proliferative diseases
US6372747B1 (en) 1998-12-18 2002-04-16 Schering Corporation Farnesyl protein transferase inhibitors
US6362188B1 (en) 1998-12-18 2002-03-26 Schering Corporation Farnesyl protein transferase inhibitors
US6432959B1 (en) 1998-12-23 2002-08-13 Schering Corporation Inhibitors of farnesyl-protein transferase
US6410451B2 (en) 1999-09-27 2002-06-25 Lam Research Corporation Techniques for improving etching in a plasma processing chamber

Also Published As

Publication number Publication date
DE60130239D1 (en) 2007-10-11
CA2429720C (en) 2009-12-29
CN1198816C (zh) 2005-04-27
WO2002044164A1 (en) 2002-06-06
US20020115679A1 (en) 2002-08-22
NZ525572A (en) 2004-11-26
ZA200303635B (en) 2004-08-12
PE20020635A1 (es) 2002-07-11
DE60130239T2 (de) 2008-05-21
CA2429720A1 (en) 2002-06-06
CN1476444A (zh) 2004-02-18
EP1337522A1 (en) 2003-08-27
US6528523B2 (en) 2003-03-04
AU3514302A (en) 2002-06-11
IL155668A0 (en) 2003-11-23
AU2002235143B2 (en) 2006-03-02
ES2291368T3 (es) 2008-03-01
ATE371655T1 (de) 2007-09-15
EP1337522B1 (en) 2007-08-29
TWI225058B (en) 2004-12-11
JP2004514717A (ja) 2004-05-20
AR035660A1 (es) 2004-06-23
MXPA03004878A (es) 2003-08-19
HK1054226A1 (zh) 2003-11-21
KR20030060939A (ko) 2003-07-16

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Legal Events

Date Code Title Description
FH91 Appointment of a representative

Free format text: FORMER REPRESENTATIVE(S): BELICZAY LASZLO, S.B.G. & K. SZABADALMI UEGYVIVOEI IRODA, HU

Representative=s name: RATHONYI ZOLTAN, S.B.G. & K. SZABADALMI UEGYVI, HU

FH92 Termination of representative

Representative=s name: BELICZAY LASZLO, S.B.G. & K. SZABADALMI UEGYVI, HU

FD9A Lapse of provisional protection due to non-payment of fees