HUP0301982A2 - Eljárás nagy tisztaságú d-(17alfa)-13-etil-17-hidroxi-18,19-dinor-pregn-4-én-20-in-3-on-oxim előállítására - Google Patents

Eljárás nagy tisztaságú d-(17alfa)-13-etil-17-hidroxi-18,19-dinor-pregn-4-én-20-in-3-on-oxim előállítására Download PDF

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Publication number
HUP0301982A2
HUP0301982A2 HU0301982A HUP0301982A HUP0301982A2 HU P0301982 A2 HUP0301982 A2 HU P0301982A2 HU 0301982 A HU0301982 A HU 0301982A HU P0301982 A HUP0301982 A HU P0301982A HU P0301982 A2 HUP0301982 A2 HU P0301982A2
Authority
HU
Hungary
Prior art keywords
ethyl
dinor
pregn
water
oxime
Prior art date
Application number
HU0301982A
Other languages
English (en)
Hungarian (hu)
Inventor
Zoltán Tuba
Sándor Mahó
János Kiss
Endréné Magyari
László Terdy
Original Assignee
Richter Gedeon Vegyészeti Gyár Rt.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyészeti Gyár Rt. filed Critical Richter Gedeon Vegyészeti Gyár Rt.
Priority to HU0301982A priority Critical patent/HUP0301982A2/hu
Publication of HUP0301982D0 publication Critical patent/HUP0301982D0/hu
Priority to CNB2004800165780A priority patent/CN100355771C/zh
Priority to MXPA05013948A priority patent/MXPA05013948A/es
Priority to UAA200600812A priority patent/UA80059C2/uk
Priority to DE602004026306T priority patent/DE602004026306D1/de
Priority to NZ544378A priority patent/NZ544378A/en
Priority to EP04730316A priority patent/EP1638988B1/en
Priority to BRPI0412186-4A priority patent/BRPI0412186A/pt
Priority to CA002528952A priority patent/CA2528952A1/en
Priority to HR20060038A priority patent/HRP20060038A2/xx
Priority to AT04730316T priority patent/ATE462712T1/de
Priority to AU2004251118A priority patent/AU2004251118A1/en
Priority to PCT/HU2004/000031 priority patent/WO2005000868A1/en
Priority to JP2006518378A priority patent/JP2007516946A/ja
Priority to EA200600119A priority patent/EA008411B1/ru
Priority to YUP-2005/0897A priority patent/RS20050897A/sr
Priority to US10/879,710 priority patent/US7576226B2/en
Priority to US10/879,708 priority patent/US7816546B2/en
Publication of HUP0301982A2 publication Critical patent/HUP0301982A2/hu
Priority to NO20060455A priority patent/NO20060455L/no
Priority to US12/500,375 priority patent/US20090312299A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C07J41/0016—Oximes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0081—Substituted in position 17 alfa and 17 beta
    • C07J1/0088—Substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being an unsaturated hydrocarbon group
    • C07J1/0096—Alkynyl derivatives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
HU0301982A 2003-06-30 2003-06-30 Eljárás nagy tisztaságú d-(17alfa)-13-etil-17-hidroxi-18,19-dinor-pregn-4-én-20-in-3-on-oxim előállítására HUP0301982A2 (hu)

Priority Applications (20)

Application Number Priority Date Filing Date Title
HU0301982A HUP0301982A2 (hu) 2003-06-30 2003-06-30 Eljárás nagy tisztaságú d-(17alfa)-13-etil-17-hidroxi-18,19-dinor-pregn-4-én-20-in-3-on-oxim előállítására
YUP-2005/0897A RS20050897A (sr) 2003-06-30 2004-04-29 Postupak za sintezu d-(17-alfa)-13- etil-17-hidroksi-18,19- -dinor-pregn- 4-en-20-in-3-on-oksima visoke čistoće
CA002528952A CA2528952A1 (en) 2003-06-30 2004-04-29 Process for the synthesis of high purity d-(17alpha)-13-ethyl-17­hydroxy-18,19-dinorpre:gn-4-ene-20-yne-3-one-oxime
AT04730316T ATE462712T1 (de) 2003-06-30 2004-04-29 Verfahren zur herstellung von hochreinem d- (17alpha)-13-ethyl-17-hydroxy-18,19-dinor-pregn 4-ene-20-yne-3-one-oxim
UAA200600812A UA80059C2 (en) 2003-06-30 2004-04-29 Process for the synthesis of high purity d-(17alpha)-13-ethyl-17hydroxy-18,19-dinorpregn-4-ene-20-yne-3-one-oxime
DE602004026306T DE602004026306D1 (de) 2003-06-30 2004-04-29 Verfahren zur herstellung von hochreinem d-(17alpha)-13-ethyl-17-hydroxy-18,19-dinor-pregn-4-ene-20-yne-3-one-oxim
NZ544378A NZ544378A (en) 2003-06-30 2004-04-29 Process for the synthesis of high purity norgestrel 3-one-oxime
EP04730316A EP1638988B1 (en) 2003-06-30 2004-04-29 Process for the synthesis of high purity d-(17alpha)-13-ethyl-17hydroxy-18,19-dinorpre:gn-4-ene-20-yne-3-one-oxime
BRPI0412186-4A BRPI0412186A (pt) 2003-06-30 2004-04-29 processo para a sìntese de d-(17alfa)-13-etil-17-hidroxi-18,19-dinorpregn-4-eno-20-i no-3-ona-oxima de pureza elevada
CNB2004800165780A CN100355771C (zh) 2003-06-30 2004-04-29 合成高纯度D－(17α)－13－乙基－17－羟基－18,19－二去甲孕－4－烯－20－炔－3－酮－肟的方法
HR20060038A HRP20060038A2 (en) 2003-06-30 2004-04-29 PROCESS FOR THE SYNTHESIS OF HIGH PURITY D-(17α)-13-ETHYL-17-HYDROXY-18,19-DINOPREGN-4-ENE-20-YNE-3-OXIME
MXPA05013948A MXPA05013948A (es) 2003-06-30 2004-04-29 Proceso para la sintesis de d-(17a)-13-etil-17-hidroxi-18 19-dinor-pregn-4-ene-20-ina-3-ona-oxima.
AU2004251118A AU2004251118A1 (en) 2003-06-30 2004-04-29 Process for the synthesis of high purity d-(17alpha)-13-ethyl-17-hydroxy-18,19-dinorpre:gn-4-ene-20-yne-3-one-oxime
PCT/HU2004/000031 WO2005000868A1 (en) 2003-06-30 2004-04-29 Process for the synthesis of high purity d-(17alpha)-13-ethyl-17­hydroxy-18,19-dinorpre:gn-4-ene-20-yne-3-one-oxime
JP2006518378A JP2007516946A (ja) 2003-06-30 2004-04-29 高純度ｄ−（１７α）−１３−エチル−１７−ヒドロキシ−１８，１９−ジノル−プレグ−４−エン−２０−イン−３−オン−オキシムの合成方法
EA200600119A EA008411B1 (ru) 2003-06-30 2004-04-29 СПОСОБ СИНТЕЗА ВЫСОКОЧИСТОГО ОКСИМА D-(17α)-13-ЭТИЛ-17-ГИДРОКСИ-18,19-ДИНОРПРЕГН-4-ЕН-20-ИН-3-ОНА
US10/879,708 US7816546B2 (en) 2003-06-30 2004-06-30 Process for the synthesis of high purity d-(17α)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-ene-20-yn-3-one-oxime
US10/879,710 US7576226B2 (en) 2003-06-30 2004-06-30 Process of making isomers of norelgestromin and methods using the same
NO20060455A NO20060455L (no) 2003-06-30 2006-01-27 Fremgangsmate for syntesen av hoyrent D-(17alfa)-13-etyl-17-hydroksy-18,19-dinor-pregn-4-en-20-yn-3-on-oksim.
US12/500,375 US20090312299A1 (en) 2003-06-30 2009-07-09 Isolated Isomers of Norelgestromin and Methods of Making and Using the Same

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU0301982A HUP0301982A2 (hu) 2003-06-30 2003-06-30 Eljárás nagy tisztaságú d-(17alfa)-13-etil-17-hidroxi-18,19-dinor-pregn-4-én-20-in-3-on-oxim előállítására

Publications (2)

Publication Number Publication Date
HUP0301982D0 HUP0301982D0 (en) 2003-09-29
HUP0301982A2 true HUP0301982A2 (hu) 2005-04-28

Family

ID=90001694

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0301982A HUP0301982A2 (hu) 2003-06-30 2003-06-30 Eljárás nagy tisztaságú d-(17alfa)-13-etil-17-hidroxi-18,19-dinor-pregn-4-én-20-in-3-on-oxim előállítására

Country Status (17)

Country Link
EP (1) EP1638988B1 (https=)
JP (1) JP2007516946A (https=)
CN (1) CN100355771C (https=)
AT (1) ATE462712T1 (https=)
AU (1) AU2004251118A1 (https=)
BR (1) BRPI0412186A (https=)
CA (1) CA2528952A1 (https=)
DE (1) DE602004026306D1 (https=)
EA (1) EA008411B1 (https=)
HR (1) HRP20060038A2 (https=)
HU (1) HUP0301982A2 (https=)
MX (1) MXPA05013948A (https=)
NO (1) NO20060455L (https=)
NZ (1) NZ544378A (https=)
RS (1) RS20050897A (https=)
UA (1) UA80059C2 (https=)
WO (1) WO2005000868A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7816546B2 (en) 2003-06-30 2010-10-19 Richter Gedeon Vegyeszeti Gyar Rt. Process for the synthesis of high purity d-(17α)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-ene-20-yn-3-one-oxime
ITMI20052464A1 (it) 2005-12-22 2007-06-23 S N I F F Italia S P A Procedimento per la preparazi9one di norelgestromin norelgestromina
CN108827950B (zh) * 2018-05-31 2020-08-21 成都市科隆化学品有限公司 乙酸中微量乙酸酐的检测方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7306609A (https=) * 1972-05-26 1973-11-28
US4027019A (en) * 1975-07-24 1977-05-31 Ortho Pharmaceutical Corporation 3-Oximes of D-17α-ethynyl-19-nortestosterone esters and method
CA2222133C (en) * 1995-06-07 2002-12-24 Cygnus, Inc. Transdermal patch and method for administering 17-deacetyl norgestimate alone or in combination with an estrogen

Also Published As

Publication number Publication date
HUP0301982D0 (en) 2003-09-29
WO2005000868A1 (en) 2005-01-06
HRP20060038A2 (en) 2006-11-30
EA200600119A1 (ru) 2006-06-30
ATE462712T1 (de) 2010-04-15
JP2007516946A (ja) 2007-06-28
NO20060455L (no) 2006-03-29
CN1805970A (zh) 2006-07-19
MXPA05013948A (es) 2006-03-09
NZ544378A (en) 2008-02-29
CN100355771C (zh) 2007-12-19
AU2004251118A1 (en) 2005-01-06
CA2528952A1 (en) 2005-01-06
UA80059C2 (en) 2007-08-10
RS20050897A (sr) 2007-08-03
DE602004026306D1 (de) 2010-05-12
EP1638988B1 (en) 2010-03-31
EP1638988A1 (en) 2006-03-29
EA008411B1 (ru) 2007-04-27
BRPI0412186A (pt) 2006-08-22

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Legal Events

Date Code Title Description
HC9A Change of name, address

Owner name: RICHTER GEDEON NYRT., HU

Free format text: FORMER OWNER(S): RICHTER GEDEON VEGYESZETI GYAR RT., HU

FA9A Lapse of provisional patent protection due to relinquishment or protection considered relinquished