HUP0301982A2 - Eljárás nagy tisztaságú d-(17alfa)-13-etil-17-hidroxi-18,19-dinor-pregn-4-én-20-in-3-on-oxim előállítására - Google Patents
Eljárás nagy tisztaságú d-(17alfa)-13-etil-17-hidroxi-18,19-dinor-pregn-4-én-20-in-3-on-oxim előállításáraInfo
- Publication number
- HUP0301982A2 HUP0301982A2 HU0301982A HUP0301982A HUP0301982A2 HU P0301982 A2 HUP0301982 A2 HU P0301982A2 HU 0301982 A HU0301982 A HU 0301982A HU P0301982 A HUP0301982 A HU P0301982A HU P0301982 A2 HUP0301982 A2 HU P0301982A2
- Authority
- HU
- Hungary
- Prior art keywords
- ethyl
- water
- oxime
- dinor
- pregn
- Prior art date
Links
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 8
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 7
- WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical compound CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 abstract 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 6
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 4
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 abstract 3
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 abstract 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 3
- 229960000583 acetic acid Drugs 0.000 abstract 3
- 238000006243 chemical reaction Methods 0.000 abstract 3
- 238000005056 compaction Methods 0.000 abstract 3
- 239000002244 precipitate Substances 0.000 abstract 3
- 239000011541 reaction mixture Substances 0.000 abstract 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- ZAFNJMIOTHYJRJ-UHFFFAOYSA-N Diisopropyl ether Chemical compound CC(C)OC(C)C ZAFNJMIOTHYJRJ-UHFFFAOYSA-N 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 239000012362 glacial acetic acid Substances 0.000 abstract 2
- 229960004400 levonorgestrel Drugs 0.000 abstract 2
- 230000007935 neutral effect Effects 0.000 abstract 2
- 238000003756 stirring Methods 0.000 abstract 2
- JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 abstract 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 abstract 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 abstract 1
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 abstract 1
- HMNQNULAYXDEEQ-UHFFFAOYSA-N acetic acid;hydroxylamine Chemical compound ON.CC(O)=O HMNQNULAYXDEEQ-UHFFFAOYSA-N 0.000 abstract 1
- 230000021736 acetylation Effects 0.000 abstract 1
- 238000006640 acetylation reaction Methods 0.000 abstract 1
- 125000003668 acetyloxy group Chemical group [H]C([H])([H])C(=O)O[*] 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000003463 adsorbent Substances 0.000 abstract 1
- 150000008044 alkali metal hydroxides Chemical class 0.000 abstract 1
- 239000012298 atmosphere Substances 0.000 abstract 1
- 210000000988 bone and bone Anatomy 0.000 abstract 1
- 239000006227 byproduct Substances 0.000 abstract 1
- 239000012043 crude product Substances 0.000 abstract 1
- 238000002425 crystallisation Methods 0.000 abstract 1
- -1 enol acetate Chemical class 0.000 abstract 1
- 238000001914 filtration Methods 0.000 abstract 1
- 239000007789 gas Substances 0.000 abstract 1
- IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 abstract 1
- 229910000041 hydrogen chloride Inorganic materials 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 239000005457 ice water Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000012452 mother liquor Substances 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 239000012299 nitrogen atmosphere Substances 0.000 abstract 1
- 238000006146 oximation reaction Methods 0.000 abstract 1
- 125000004043 oxo group Chemical group O=* 0.000 abstract 1
- TWNQGVIAIRXVLR-UHFFFAOYSA-N oxo(oxoalumanyloxy)alumane Chemical compound O=[Al]O[Al]=O TWNQGVIAIRXVLR-UHFFFAOYSA-N 0.000 abstract 1
- 239000000047 product Substances 0.000 abstract 1
- 239000000741 silica gel Substances 0.000 abstract 1
- 229910002027 silica gel Inorganic materials 0.000 abstract 1
- 239000001632 sodium acetate Substances 0.000 abstract 1
- 235000017281 sodium acetate Nutrition 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
- 235000005074 zinc chloride Nutrition 0.000 abstract 1
- 239000011592 zinc chloride Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
- C07J41/0016—Oximes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0081—Substituted in position 17 alfa and 17 beta
- C07J1/0088—Substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being an unsaturated hydrocarbon group
- C07J1/0096—Alkynyl derivatives
Abstract
A találmány tárgya eljárás nagy tisztaságú d-(17a)-13-etil-17-hidroxi-18,19-dinorpregn-4-én-20-in-3-on-oxim előállítására d-norgesztrel 17-helyzetben történő acetilezése, a kapott 17-acetiloxi-származék 3-helyzetű oxo-csoportjának oximálása, végül a kapott 3-oximszármazék17-es helyzetű acetil-oxi-csoportjának hidrolizálása útján. Atalálmány szerint úgy járnak el, hogy a kiindulási anyagul szolgáló,legalább 93-94 %-os tisztaságú d-(17a)-17-hidroxi-l3etil-18,19-dinor-pregn-4-én-20-in-3-ont (d-norgesztrelt) semleges gáz atmoszférábanjégecetes közegben cink-korid és hidrogén-klorid, vagy 70 %-osperklórsav jelenlétében ecetsavanhidriddel acetilezik, majd a reakcióteljessé válása után vizes sósav-oldattal az ecetsavanhidridfeleslegét és az <enol-acetát< mellékterméket elbontják, ezt követőena reakcióelegyből jeges vízzel kicsapják a keletkezett d-(17a)-17-acetiloxi-l3-etil-18,19-dinor-pregn-4-én-20-in-3-ont, a kiváltcsapadékot tömörödés után kiszűrik, vízzel savmentesre mossák,szárítják, majd diklór-metánban vagy acetonban feloldják ésszilikagéllel vagy alumínium-oxiddal és csontszénnel derítik, aderített oldatból az oldószert lepárolják és a maradékot előnyösen 9:1térfogatarányú diizopropil-éter/acetonitril vagy diizopropil-éter/etanol elegyből kristályosítva tisztítják, a kapott d-(17a)-17-acetil-oxi-13-etil-18,19-dinor-pregn-4-én-20-in-3-ont jégecetesközegben nitrogénbevezetés közben hidroxil-ammónium-acetáttal, vagynátrium-acetát hozzáadása mellett hidroxil-ammónium-kloriddalreagáltatják mintegy 45 percen át intenzív keverés mellett, majd areakcióelegyet a reakció teljessé válását követően vízzel megbontják,a csapadékot tömörödés után kiszűrik, savmentesre mossák, szárítják,előnyösen etanolból kristályosítják, a kapott d-(17a)-17-acetil-oxi-13-etil-18,19-dinor-pregn-4-én-20-in-3-on-oximot 1-4 szénatomosalkanolos oldatban, nitrogén atmoszférában, 5-35 °C közöttihőmérsékleten valamely alkálifém-hidroxid ekvivalens mennyiségével,hidrolizálják intenzív keverés közben, a reakció teljessé válása utána reakcióelegyet vízzel megbontják és a szuszpenzó pH értékétecetsavval 7,5-9 közé állítják, a kivált terméket tömörödés utánkiszűrik, vízzel semlegesre mossák, szárítják, végül a nyersterméketetanolban feloldják, aktív szénnel derítik, majd az adszorbenskiszűrése után a szűrletből a nagy tisztaságú d-(17a)-17-hidroxi-13-etil-18,19-dinor-pregn-4-én-20-in-3-on-oximot vízzel kicsapják, acsapadékot kiszűrik, vízzel anyalúgmentesre mossák és szükség eseténetanolból átkristályosítják. Ó
Priority Applications (20)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU0301982A HUP0301982A2 (hu) | 2003-06-30 | 2003-06-30 | Eljárás nagy tisztaságú d-(17alfa)-13-etil-17-hidroxi-18,19-dinor-pregn-4-én-20-in-3-on-oxim előállítására |
NZ544378A NZ544378A (en) | 2003-06-30 | 2004-04-29 | Process for the synthesis of high purity norgestrel 3-one-oxime |
CNB2004800165780A CN100355771C (zh) | 2003-06-30 | 2004-04-29 | 合成高纯度D-(17α)-13-乙基-17-羟基-18,19-二去甲孕-4-烯-20-炔-3-酮-肟的方法 |
EP04730316A EP1638988B1 (en) | 2003-06-30 | 2004-04-29 | Process for the synthesis of high purity d-(17alpha)-13-ethyl-17hydroxy-18,19-dinorpre:gn-4-ene-20-yne-3-one-oxime |
AU2004251118A AU2004251118A1 (en) | 2003-06-30 | 2004-04-29 | Process for the synthesis of high purity d-(17alpha)-13-ethyl-17-hydroxy-18,19-dinorpre:gn-4-ene-20-yne-3-one-oxime |
MXPA05013948A MXPA05013948A (es) | 2003-06-30 | 2004-04-29 | Proceso para la sintesis de d-(17a)-13-etil-17-hidroxi-18 19-dinor-pregn-4-ene-20-ina-3-ona-oxima. |
JP2006518378A JP2007516946A (ja) | 2003-06-30 | 2004-04-29 | 高純度d−(17α)−13−エチル−17−ヒドロキシ−18,19−ジノル−プレグ−4−エン−20−イン−3−オン−オキシムの合成方法 |
YUP-2005/0897A RS20050897A (sr) | 2003-06-30 | 2004-04-29 | Postupak za sintezu d-(17-alfa)-13- etil-17-hidroksi-18,19- -dinor-pregn- 4-en-20-in-3-on-oksima visoke čistoće |
EA200600119A EA008411B1 (ru) | 2003-06-30 | 2004-04-29 | СПОСОБ СИНТЕЗА ВЫСОКОЧИСТОГО ОКСИМА D-(17α)-13-ЭТИЛ-17-ГИДРОКСИ-18,19-ДИНОРПРЕГН-4-ЕН-20-ИН-3-ОНА |
BRPI0412186-4A BRPI0412186A (pt) | 2003-06-30 | 2004-04-29 | processo para a sìntese de d-(17alfa)-13-etil-17-hidroxi-18,19-dinorpregn-4-eno-20-i no-3-ona-oxima de pureza elevada |
DE602004026306T DE602004026306D1 (de) | 2003-06-30 | 2004-04-29 | Verfahren zur herstellung von hochreinem d-(17alpha)-13-ethyl-17-hydroxy-18,19-dinor-pregn-4-ene-20-yne-3-one-oxim |
PCT/HU2004/000031 WO2005000868A1 (en) | 2003-06-30 | 2004-04-29 | Process for the synthesis of high purity d-(17alpha)-13-ethyl-17hydroxy-18,19-dinorpre:gn-4-ene-20-yne-3-one-oxime |
UAA200600812A UA80059C2 (en) | 2003-06-30 | 2004-04-29 | Process for the synthesis of high purity d-(17alpha)-13-ethyl-17hydroxy-18,19-dinorpregn-4-ene-20-yne-3-one-oxime |
CA002528952A CA2528952A1 (en) | 2003-06-30 | 2004-04-29 | Process for the synthesis of high purity d-(17alpha)-13-ethyl-17hydroxy-18,19-dinorpre:gn-4-ene-20-yne-3-one-oxime |
AT04730316T ATE462712T1 (de) | 2003-06-30 | 2004-04-29 | Verfahren zur herstellung von hochreinem d- (17alpha)-13-ethyl-17-hydroxy-18,19-dinor-pregn 4-ene-20-yne-3-one-oxim |
US10/879,710 US7576226B2 (en) | 2003-06-30 | 2004-06-30 | Process of making isomers of norelgestromin and methods using the same |
US10/879,708 US7816546B2 (en) | 2003-06-30 | 2004-06-30 | Process for the synthesis of high purity d-(17α)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-ene-20-yn-3-one-oxime |
NO20060455A NO20060455L (no) | 2003-06-30 | 2006-01-27 | Fremgangsmate for syntesen av hoyrent D-(17alfa)-13-etyl-17-hydroksy-18,19-dinor-pregn-4-en-20-yn-3-on-oksim. |
HR20060038A HRP20060038A2 (en) | 2003-06-30 | 2006-01-27 | PROCESS FOR THE SYNTHESIS OF HIGH PURITY D-(17α)-13-ETHYL-17-HYDROXY-18,19-DINOPREGN-4-ENE-20-YNE-3-OXIME |
US12/500,375 US20090312299A1 (en) | 2003-06-30 | 2009-07-09 | Isolated Isomers of Norelgestromin and Methods of Making and Using the Same |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU0301982A HUP0301982A2 (hu) | 2003-06-30 | 2003-06-30 | Eljárás nagy tisztaságú d-(17alfa)-13-etil-17-hidroxi-18,19-dinor-pregn-4-én-20-in-3-on-oxim előállítására |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP0301982D0 HUP0301982D0 (en) | 2003-09-29 |
HUP0301982A2 true HUP0301982A2 (hu) | 2005-04-28 |
Family
ID=90001694
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0301982A HUP0301982A2 (hu) | 2003-06-30 | 2003-06-30 | Eljárás nagy tisztaságú d-(17alfa)-13-etil-17-hidroxi-18,19-dinor-pregn-4-én-20-in-3-on-oxim előállítására |
Country Status (17)
Country | Link |
---|---|
EP (1) | EP1638988B1 (hu) |
JP (1) | JP2007516946A (hu) |
CN (1) | CN100355771C (hu) |
AT (1) | ATE462712T1 (hu) |
AU (1) | AU2004251118A1 (hu) |
BR (1) | BRPI0412186A (hu) |
CA (1) | CA2528952A1 (hu) |
DE (1) | DE602004026306D1 (hu) |
EA (1) | EA008411B1 (hu) |
HR (1) | HRP20060038A2 (hu) |
HU (1) | HUP0301982A2 (hu) |
MX (1) | MXPA05013948A (hu) |
NO (1) | NO20060455L (hu) |
NZ (1) | NZ544378A (hu) |
RS (1) | RS20050897A (hu) |
UA (1) | UA80059C2 (hu) |
WO (1) | WO2005000868A1 (hu) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7816546B2 (en) | 2003-06-30 | 2010-10-19 | Richter Gedeon Vegyeszeti Gyar Rt. | Process for the synthesis of high purity d-(17α)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-ene-20-yn-3-one-oxime |
ITMI20052464A1 (it) * | 2005-12-22 | 2007-06-23 | S N I F F Italia S P A | Procedimento per la preparazi9one di norelgestromin norelgestromina |
CN108827950B (zh) * | 2018-05-31 | 2020-08-21 | 成都市科隆化学品有限公司 | 乙酸中微量乙酸酐的检测方法 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL7306609A (hu) * | 1972-05-26 | 1973-11-28 | ||
US4027019A (en) * | 1975-07-24 | 1977-05-31 | Ortho Pharmaceutical Corporation | 3-Oximes of D-17α-ethynyl-19-nortestosterone esters and method |
EP0836506B2 (en) * | 1995-06-07 | 2011-12-21 | Ortho-McNeil Pharmaceutical, Inc. | Transdermal patch for administering 17-deacetyl norgestimate in combination with an estrogen |
-
2003
- 2003-06-30 HU HU0301982A patent/HUP0301982A2/hu unknown
-
2004
- 2004-04-29 WO PCT/HU2004/000031 patent/WO2005000868A1/en active Application Filing
- 2004-04-29 CN CNB2004800165780A patent/CN100355771C/zh not_active Expired - Fee Related
- 2004-04-29 MX MXPA05013948A patent/MXPA05013948A/es active IP Right Grant
- 2004-04-29 RS YUP-2005/0897A patent/RS20050897A/sr unknown
- 2004-04-29 EA EA200600119A patent/EA008411B1/ru not_active IP Right Cessation
- 2004-04-29 AU AU2004251118A patent/AU2004251118A1/en not_active Abandoned
- 2004-04-29 DE DE602004026306T patent/DE602004026306D1/de not_active Expired - Fee Related
- 2004-04-29 JP JP2006518378A patent/JP2007516946A/ja active Pending
- 2004-04-29 BR BRPI0412186-4A patent/BRPI0412186A/pt not_active IP Right Cessation
- 2004-04-29 AT AT04730316T patent/ATE462712T1/de not_active IP Right Cessation
- 2004-04-29 CA CA002528952A patent/CA2528952A1/en not_active Abandoned
- 2004-04-29 UA UAA200600812A patent/UA80059C2/uk unknown
- 2004-04-29 NZ NZ544378A patent/NZ544378A/en unknown
- 2004-04-29 EP EP04730316A patent/EP1638988B1/en active Active
-
2006
- 2006-01-27 NO NO20060455A patent/NO20060455L/no not_active Application Discontinuation
- 2006-01-27 HR HR20060038A patent/HRP20060038A2/xx not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CN100355771C (zh) | 2007-12-19 |
NZ544378A (en) | 2008-02-29 |
BRPI0412186A (pt) | 2006-08-22 |
AU2004251118A1 (en) | 2005-01-06 |
EP1638988A1 (en) | 2006-03-29 |
CA2528952A1 (en) | 2005-01-06 |
DE602004026306D1 (de) | 2010-05-12 |
EA008411B1 (ru) | 2007-04-27 |
HRP20060038A2 (en) | 2006-11-30 |
UA80059C2 (en) | 2007-08-10 |
EP1638988B1 (en) | 2010-03-31 |
MXPA05013948A (es) | 2006-03-09 |
EA200600119A1 (ru) | 2006-06-30 |
RS20050897A (sr) | 2007-08-03 |
CN1805970A (zh) | 2006-07-19 |
HUP0301982D0 (en) | 2003-09-29 |
JP2007516946A (ja) | 2007-06-28 |
ATE462712T1 (de) | 2010-04-15 |
NO20060455L (no) | 2006-03-29 |
WO2005000868A1 (en) | 2005-01-06 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
HC9A | Change of name, address |
Owner name: RICHTER GEDEON NYRT., HU Free format text: FORMER OWNER(S): RICHTER GEDEON VEGYESZETI GYAR RT., HU |
|
FA9A | Lapse of provisional patent protection due to relinquishment or protection considered relinquished |