CN100355771C - 合成高纯度D－(17α)－13－乙基－17－羟基－18,19－二去甲孕－4－烯－20－炔－3－酮－肟的方法 - Google Patents

合成高纯度D－(17α)－13－乙基－17－羟基－18,19－二去甲孕－4－烯－20－炔－3－酮－肟的方法 Download PDF

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Publication number
CN100355771C
CN100355771C CNB2004800165780A CN200480016578A CN100355771C CN 100355771 C CN100355771 C CN 100355771C CN B2004800165780 A CNB2004800165780 A CN B2004800165780A CN 200480016578 A CN200480016578 A CN 200480016578A CN 100355771 C CN100355771 C CN 100355771C
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China
Prior art keywords
ethyl
water
oxime
acetoxy
reaction
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CNB2004800165780A
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English (en)
Chinese (zh)
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CN1805970A (zh
Inventor
Z·图巴
S·马霍
J·基什
E·毛焦里
L·泰尔迪
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HUANGARY GIRUI GYOGYSZERGYAR
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HUANGARY GIRUI GYOGYSZERGYAR
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C07J41/0016—Oximes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0081—Substituted in position 17 alfa and 17 beta
    • C07J1/0088—Substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being an unsaturated hydrocarbon group
    • C07J1/0096—Alkynyl derivatives

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
CNB2004800165780A 2003-06-30 2004-04-29 合成高纯度D－(17α)－13－乙基－17－羟基－18,19－二去甲孕－4－烯－20－炔－3－酮－肟的方法 Expired - Fee Related CN100355771C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HUP0301982 2003-06-30
HU0301982A HUP0301982A2 (hu) 2003-06-30 2003-06-30 Eljárás nagy tisztaságú d-(17alfa)-13-etil-17-hidroxi-18,19-dinor-pregn-4-én-20-in-3-on-oxim előállítására

Publications (2)

Publication Number Publication Date
CN1805970A CN1805970A (zh) 2006-07-19
CN100355771C true CN100355771C (zh) 2007-12-19

Family

ID=90001694

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB2004800165780A Expired - Fee Related CN100355771C (zh) 2003-06-30 2004-04-29 合成高纯度D－(17α)－13－乙基－17－羟基－18,19－二去甲孕－4－烯－20－炔－3－酮－肟的方法

Country Status (17)

Country Link
EP (1) EP1638988B1 (https=)
JP (1) JP2007516946A (https=)
CN (1) CN100355771C (https=)
AT (1) ATE462712T1 (https=)
AU (1) AU2004251118A1 (https=)
BR (1) BRPI0412186A (https=)
CA (1) CA2528952A1 (https=)
DE (1) DE602004026306D1 (https=)
EA (1) EA008411B1 (https=)
HR (1) HRP20060038A2 (https=)
HU (1) HUP0301982A2 (https=)
MX (1) MXPA05013948A (https=)
NO (1) NO20060455L (https=)
NZ (1) NZ544378A (https=)
RS (1) RS20050897A (https=)
UA (1) UA80059C2 (https=)
WO (1) WO2005000868A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7816546B2 (en) 2003-06-30 2010-10-19 Richter Gedeon Vegyeszeti Gyar Rt. Process for the synthesis of high purity d-(17α)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-ene-20-yn-3-one-oxime
ITMI20052464A1 (it) 2005-12-22 2007-06-23 S N I F F Italia S P A Procedimento per la preparazi9one di norelgestromin norelgestromina
CN108827950B (zh) * 2018-05-31 2020-08-21 成都市科隆化学品有限公司 乙酸中微量乙酸酐的检测方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1190351A (zh) * 1995-06-07 1998-08-12 西格纳斯公司 把17－脱乙酰基诺孕酯单独或与雌激素结合给药的经皮贴片和方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7306609A (https=) * 1972-05-26 1973-11-28
US4027019A (en) * 1975-07-24 1977-05-31 Ortho Pharmaceutical Corporation 3-Oximes of D-17α-ethynyl-19-nortestosterone esters and method

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1190351A (zh) * 1995-06-07 1998-08-12 西格纳斯公司 把17－脱乙酰基诺孕酯单独或与雌激素结合给药的经皮贴片和方法

Also Published As

Publication number Publication date
HUP0301982D0 (en) 2003-09-29
WO2005000868A1 (en) 2005-01-06
HRP20060038A2 (en) 2006-11-30
EA200600119A1 (ru) 2006-06-30
ATE462712T1 (de) 2010-04-15
JP2007516946A (ja) 2007-06-28
NO20060455L (no) 2006-03-29
CN1805970A (zh) 2006-07-19
MXPA05013948A (es) 2006-03-09
HUP0301982A2 (hu) 2005-04-28
NZ544378A (en) 2008-02-29
AU2004251118A1 (en) 2005-01-06
CA2528952A1 (en) 2005-01-06
UA80059C2 (en) 2007-08-10
RS20050897A (sr) 2007-08-03
DE602004026306D1 (de) 2010-05-12
EP1638988B1 (en) 2010-03-31
EP1638988A1 (en) 2006-03-29
EA008411B1 (ru) 2007-04-27
BRPI0412186A (pt) 2006-08-22

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Granted publication date: 20071219

Termination date: 20100429