HUP0301668A2 - Hidrofób hatóanyagok javított szilárd adagolási formái - Google Patents

Hidrofób hatóanyagok javított szilárd adagolási formái

Info

Publication number
HUP0301668A2
HUP0301668A2 HU0301668A HUP0301668A HUP0301668A2 HU P0301668 A2 HUP0301668 A2 HU P0301668A2 HU 0301668 A HU0301668 A HU 0301668A HU P0301668 A HUP0301668 A HU P0301668A HU P0301668 A2 HUP0301668 A2 HU P0301668A2
Authority
HU
Hungary
Prior art keywords
deposit
solid pharmaceutical
pharmaceutical dosage
hydrophobic active
base substrate
Prior art date
Application number
HU0301668A
Other languages
English (en)
Inventor
Jen-Chi Chen
Suggy S. Chrai
Marc S. Karetny
Ashok Katdare
Ramaswamy Murari
Gregory E. Parry
Original Assignee
Delsys Pharmaceutical Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Delsys Pharmaceutical Corporation filed Critical Delsys Pharmaceutical Corporation
Publication of HUP0301668A2 publication Critical patent/HUP0301668A2/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7007—Drug-containing films, membranes or sheets

Landscapes

  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

A találmány hidrofób hatóanyagok új szilárd gyógyászati adagolásiformájára vonatkozik, amely javított kioldódási és javított biológiaielérhetőségi tulajdonságokkal rendelkezik. A készítmény az alábbiakattartalmazza: egy első polimert tartalmazó alapszubsztrát; egy aszubsztrátra deponált, egy hidrofób hatóanyag terápiás mennyiségéttartalmazó depozit; egy második polimert tartalmazó fedőszubsztrát,mely fedőszubsztrát lefedi a depozitot és kapcsolódik azalapszubsztráthoz egy, a depozitot körülvevő kötéssel; és egy oldódástfokozó mennyiségű felületaktív anyag egy hordozóanyagon belül, amelyelkülönül a depozittól, de kapcsolatban van vele. Egy másikmegvalósítási módban az adagolási forma tartalmazhat bármilyengyógyászatilag elfogadható adalékanyagot, amely elhelyezkedhet egyhordozóban, amely elkülönül, de érintkezésben van a depozittal. Egyelőnyös megvalósítási módban a hidrofób hatóanyagot elektrosztatikusandeponálják az alapszubsztrátra. Ó
HU0301668A 2000-08-10 2001-08-09 Hidrofób hatóanyagok javított szilárd adagolási formái HUP0301668A2 (hu)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22427500P 2000-08-10 2000-08-10
PCT/US2001/024949 WO2002013762A2 (en) 2000-08-10 2001-08-09 Improved solid pharmaceutical dosage formulation of hydrophobic drugs

Publications (1)

Publication Number Publication Date
HUP0301668A2 true HUP0301668A2 (hu) 2003-09-29

Family

ID=22839969

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0301668A HUP0301668A2 (hu) 2000-08-10 2001-08-09 Hidrofób hatóanyagok javított szilárd adagolási formái

Country Status (10)

Country Link
US (1) US20020036154A1 (hu)
EP (1) EP1307097A4 (hu)
JP (1) JP2004505996A (hu)
KR (1) KR20030024849A (hu)
CN (1) CN1469707A (hu)
AU (1) AU2001284772A1 (hu)
CA (1) CA2417813A1 (hu)
HU (1) HUP0301668A2 (hu)
IL (1) IL154268A0 (hu)
WO (1) WO2002013762A2 (hu)

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GB0114532D0 (en) * 2001-06-14 2001-08-08 Jagotec Ag Novel compositions
US20030068375A1 (en) 2001-08-06 2003-04-10 Curtis Wright Pharmaceutical formulation containing gelling agent
SI21402A (sl) * 2003-02-12 2004-08-31 LEK farmacevtska dru�ba d.d. Obloženi delci in farmacevtske oblike
EP1699436A2 (en) * 2003-12-12 2006-09-13 Myogen, Inc. Enoximone formulations and their use in the treatment of cardiac hypertrophy and heart failure
LT1765292T (lt) 2004-06-12 2018-01-10 Collegium Pharmaceutical, Inc. Nuo piktnaudžiavimo apsaugotos vaistų formos
DE102004056576A1 (de) * 2004-11-23 2006-05-24 LABTEC Gesellschaft für technologische Forschung und Entwicklung mbH Rapidcard
JP5292105B2 (ja) * 2007-01-11 2013-09-18 株式会社カネカ 補酵素ｑ１０粒子の製造方法
KR20080076382A (ko) * 2007-02-15 2008-08-20 (주)아모레퍼시픽 실로스타졸의 제어방출 제제 및 그 제조방법
EP2200613B1 (en) 2007-09-21 2018-09-05 The Johns Hopkins University Phenazine derivatives and uses thereof
US10668060B2 (en) 2009-12-10 2020-06-02 Collegium Pharmaceutical, Inc. Tamper-resistant pharmaceutical compositions of opioids and other drugs
WO2017222575A1 (en) 2016-06-23 2017-12-28 Collegium Pharmaceutical, Inc. Process of making more stable abuse-deterrent oral formulations
US11077134B1 (en) * 2020-11-10 2021-08-03 Mountain Valley Md Inc Water dissolvable macrocyclic lactone cyclodextrin complexes

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4344934A (en) * 1978-11-20 1982-08-17 American Home Products Corporation Therapeutic compositions with enhanced bioavailability
US4690824A (en) * 1983-07-07 1987-09-01 Redi-Rowell, Inc. Solid pharmaceutical formulations for slow, zero order release via controlled surface erosion: expanded range
US4640322A (en) * 1985-06-19 1987-02-03 Cozzoli Machine Co. Method and apparatus for filling a receptacle with a material
JPH02180265A (ja) * 1988-12-28 1990-07-13 Nippon Eranko Kk カプセル充填装置
US5046618A (en) * 1990-11-19 1991-09-10 R. P. Scherer Corporation Child-resistant blister pack
IT1242614B (it) * 1990-12-07 1994-05-16 Macofar Spa Macchina per il dosaggio e l'introduzione di prodotti polerulenti in contenitori.
US5343672A (en) * 1992-12-01 1994-09-06 Scherer Ltd R P Method for manufacturing freeze dried dosages in a multilaminate blister pack
US5811120A (en) * 1994-03-02 1998-09-22 Eli Lilly And Company Solid orally administerable raloxifene hydrochloride pharmaceutical formulation
US5972383A (en) * 1994-03-02 1999-10-26 Eli Lilly And Company Solid orally administerable raloxifene hydrochloride pharmaceutical formulation
GB9405304D0 (en) * 1994-03-16 1994-04-27 Scherer Ltd R P Delivery systems for hydrophobic drugs
GB9421836D0 (en) * 1994-10-28 1994-12-14 Scherer Corp R P Process for preparing solid pharmaceutical dosage forms of hydrophobic substances
US5948438A (en) * 1995-01-09 1999-09-07 Edward Mendell Co., Inc. Pharmaceutical formulations having improved disintegration and/or absorptivity
GB9608719D0 (en) * 1996-04-26 1996-07-03 Scherer Ltd R P Pharmaceutical compositions
FR2748989B1 (fr) * 1996-05-22 1998-08-21 Henaux Claude Procede et dispositif d'ensachage multipoches et sachets ainsi obtenus
US5993858A (en) * 1996-06-14 1999-11-30 Port Systems L.L.C. Method and formulation for increasing the bioavailability of poorly water-soluble drugs
JP2001507702A (ja) * 1996-12-31 2001-06-12 インヘイル・セラピューティックス・システムズ・インコーポレテッド 親水性賦形剤を有する疎水性薬剤の水性懸濁液を噴霧乾燥させる方法およびその方法によって作製された組成物
ATE554750T1 (de) * 1997-03-05 2012-05-15 Sugen Inc Hydrophobe pharmazeutische wirkstoffe enthaltende zubereitungen
CN1312709A (zh) * 1998-06-10 2001-09-12 德尔西斯药品公司 药用制品及其制备方法和装置
CA2415080A1 (en) * 2000-07-06 2002-01-17 Delsys Pharmaceutical Corporation Improved thyroid hormone formulations

Also Published As

Publication number Publication date
WO2002013762A3 (en) 2002-05-16
CA2417813A1 (en) 2002-02-21
EP1307097A4 (en) 2004-01-28
KR20030024849A (ko) 2003-03-26
IL154268A0 (en) 2003-09-17
US20020036154A1 (en) 2002-03-28
EP1307097A2 (en) 2003-05-07
WO2002013762A2 (en) 2002-02-21
JP2004505996A (ja) 2004-02-26
CN1469707A (zh) 2004-01-21
AU2001284772A1 (en) 2002-02-25

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