WO2002013762A3 - Improved solid pharmaceutical dosage formulation of hydrophobic drugs - Google Patents

Improved solid pharmaceutical dosage formulation of hydrophobic drugs Download PDF

Info

Publication number
WO2002013762A3
WO2002013762A3 PCT/US2001/024949 US0124949W WO0213762A3 WO 2002013762 A3 WO2002013762 A3 WO 2002013762A3 US 0124949 W US0124949 W US 0124949W WO 0213762 A3 WO0213762 A3 WO 0213762A3
Authority
WO
WIPO (PCT)
Prior art keywords
solid pharmaceutical
pharmaceutical dosage
dosage formulation
hydrophobic drugs
improved solid
Prior art date
Application number
PCT/US2001/024949
Other languages
French (fr)
Other versions
WO2002013762A2 (en
Inventor
Ramaswamy Murari
Suggy S Chrai
Jen-Chi Chen
Ashok Katdare
Gregory E Parry
Marc S Karetny
Original Assignee
Delsys Pharmaceutical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Delsys Pharmaceutical Corp filed Critical Delsys Pharmaceutical Corp
Priority to IL15426801A priority Critical patent/IL154268A0/en
Priority to HU0301668A priority patent/HUP0301668A2/en
Priority to CA002417813A priority patent/CA2417813A1/en
Priority to JP2002518910A priority patent/JP2004505996A/en
Priority to KR10-2003-7001940A priority patent/KR20030024849A/en
Priority to AU2001284772A priority patent/AU2001284772A1/en
Priority to EP01963853A priority patent/EP1307097A4/en
Publication of WO2002013762A2 publication Critical patent/WO2002013762A2/en
Publication of WO2002013762A3 publication Critical patent/WO2002013762A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7007—Drug-containing films, membranes or sheets

Landscapes

  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

A novel solid pharmaceutical dosage formulation of hydrophobic drugs is disclosed, which provides enhanced dissolution and improved bioavailability. The hydrophobic drug is deposited electrostatically on the base substrate. The dosage form may include any pharmaceutically acceptable additive, disposed within a carrier that is segregated from, but in contact with, the deposit. Figure No. 1 depicts an isometric view of a product comprising a strip package containing a plurality of unit forms in accordance with the prior art.
PCT/US2001/024949 2000-08-10 2001-08-09 Improved solid pharmaceutical dosage formulation of hydrophobic drugs WO2002013762A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
IL15426801A IL154268A0 (en) 2000-08-10 2001-08-09 Improved solid pharmaceutical dosage formulation of hydrophobic drugs
HU0301668A HUP0301668A2 (en) 2000-08-10 2001-08-09 Improved solid pharmaceutical dosage formulation of hydrophobic drugs
CA002417813A CA2417813A1 (en) 2000-08-10 2001-08-09 Improved solid pharmaceutical dosage formulation of hydrophobic drugs
JP2002518910A JP2004505996A (en) 2000-08-10 2001-08-09 Improved solid pharmaceutical dosage formulations with hydrophobic drugs
KR10-2003-7001940A KR20030024849A (en) 2000-08-10 2001-08-09 Improved solid pharmaceutical dosage formulation of hydrophobic drugs
AU2001284772A AU2001284772A1 (en) 2000-08-10 2001-08-09 Improved solid pharmaceutical dosage formulation of hydrophobic drugs
EP01963853A EP1307097A4 (en) 2000-08-10 2001-08-09 Improved solid pharmaceutical dosage formulation of hydrophobic drugs

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22427500P 2000-08-10 2000-08-10
US60/224,275 2000-08-10

Publications (2)

Publication Number Publication Date
WO2002013762A2 WO2002013762A2 (en) 2002-02-21
WO2002013762A3 true WO2002013762A3 (en) 2002-05-16

Family

ID=22839969

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/024949 WO2002013762A2 (en) 2000-08-10 2001-08-09 Improved solid pharmaceutical dosage formulation of hydrophobic drugs

Country Status (10)

Country Link
US (1) US20020036154A1 (en)
EP (1) EP1307097A4 (en)
JP (1) JP2004505996A (en)
KR (1) KR20030024849A (en)
CN (1) CN1469707A (en)
AU (1) AU2001284772A1 (en)
CA (1) CA2417813A1 (en)
HU (1) HUP0301668A2 (en)
IL (1) IL154268A0 (en)
WO (1) WO2002013762A2 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0114532D0 (en) * 2001-06-14 2001-08-08 Jagotec Ag Novel compositions
US20030068375A1 (en) 2001-08-06 2003-04-10 Curtis Wright Pharmaceutical formulation containing gelling agent
SI21402A (en) * 2003-02-12 2004-08-31 LEK farmacevtska dru�ba d.d. Lined particles and pharmaceutical forms
WO2005058280A2 (en) * 2003-12-12 2005-06-30 Myogen, Inc. Enoximone formulations and their use in the treatment of cardiac hypertrophy and heart failure
SI1765292T1 (en) 2004-06-12 2018-04-30 Collegium Pharmaceutical, Inc. Abuse-deterrent drug formulations
DE102004056576A1 (en) * 2004-11-23 2006-05-24 LABTEC Gesellschaft für technologische Forschung und Entwicklung mbH Rapid Card
US8568779B2 (en) * 2007-01-11 2013-10-29 Kaneka Corporation Method for producing coenzyme Q10 particle
KR20080076382A (en) * 2007-02-15 2008-08-20 (주)아모레퍼시픽 Controlled-release preparation containing cilostazol and process for the preparation thereof
EP2200613B1 (en) 2007-09-21 2018-09-05 The Johns Hopkins University Phenazine derivatives and uses thereof
US10668060B2 (en) 2009-12-10 2020-06-02 Collegium Pharmaceutical, Inc. Tamper-resistant pharmaceutical compositions of opioids and other drugs
US9737530B1 (en) 2016-06-23 2017-08-22 Collegium Pharmaceutical, Inc. Process of making stable abuse-deterrent oral formulations
US11077134B1 (en) * 2020-11-10 2021-08-03 Mountain Valley Md Inc Water dissolvable macrocyclic lactone cyclodextrin complexes

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5046618A (en) * 1990-11-19 1991-09-10 R. P. Scherer Corporation Child-resistant blister pack
WO1994012142A1 (en) * 1992-12-01 1994-06-09 R.P. Scherer Ltd. Improved method for manufacturing freeze dried dosages in a multilaminate blister pack
US5827541A (en) * 1994-10-28 1998-10-27 R. P. Scherer Corporation Process for preparing solid pharmaceutical dosage forms of hydrophobic substances

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4344934A (en) * 1978-11-20 1982-08-17 American Home Products Corporation Therapeutic compositions with enhanced bioavailability
US4690824A (en) * 1983-07-07 1987-09-01 Redi-Rowell, Inc. Solid pharmaceutical formulations for slow, zero order release via controlled surface erosion: expanded range
US4640322A (en) * 1985-06-19 1987-02-03 Cozzoli Machine Co. Method and apparatus for filling a receptacle with a material
JPH02180265A (en) * 1988-12-28 1990-07-13 Nippon Eranko Kk Charging device into capsule
IT1242614B (en) * 1990-12-07 1994-05-16 Macofar Spa MACHINE FOR DOSING AND INTRODUCTION OF POLERULENT PRODUCTS IN CONTAINERS.
US5811120A (en) * 1994-03-02 1998-09-22 Eli Lilly And Company Solid orally administerable raloxifene hydrochloride pharmaceutical formulation
US5972383A (en) * 1994-03-02 1999-10-26 Eli Lilly And Company Solid orally administerable raloxifene hydrochloride pharmaceutical formulation
GB9405304D0 (en) * 1994-03-16 1994-04-27 Scherer Ltd R P Delivery systems for hydrophobic drugs
US5948438A (en) * 1995-01-09 1999-09-07 Edward Mendell Co., Inc. Pharmaceutical formulations having improved disintegration and/or absorptivity
GB9608719D0 (en) * 1996-04-26 1996-07-03 Scherer Ltd R P Pharmaceutical compositions
FR2748989B1 (en) * 1996-05-22 1998-08-21 Henaux Claude MULTI-POCKET BAGING METHOD AND DEVICE AND BAGS THUS OBTAINED
US5993858A (en) * 1996-06-14 1999-11-30 Port Systems L.L.C. Method and formulation for increasing the bioavailability of poorly water-soluble drugs
JP2001507701A (en) * 1996-12-31 2001-06-12 インヘイル・セラピューティック・システムズ・インコーポレーテッド Method for spray drying a solution of a hydrophobic drug having a hydrophilic excipient and a composition made by the method
ES2384551T3 (en) * 1997-03-05 2012-07-06 Sugen, Inc. Formulations for hydrophobic pharmaceutical agents
AU763869B2 (en) * 1998-06-10 2003-07-31 Delsys Pharmaceutical Corporation Pharmaceutical product and methods and apparatus for making same
CA2415080A1 (en) * 2000-07-06 2002-01-17 Delsys Pharmaceutical Corporation Improved thyroid hormone formulations

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5046618A (en) * 1990-11-19 1991-09-10 R. P. Scherer Corporation Child-resistant blister pack
WO1994012142A1 (en) * 1992-12-01 1994-06-09 R.P. Scherer Ltd. Improved method for manufacturing freeze dried dosages in a multilaminate blister pack
US5827541A (en) * 1994-10-28 1998-10-27 R. P. Scherer Corporation Process for preparing solid pharmaceutical dosage forms of hydrophobic substances

Also Published As

Publication number Publication date
EP1307097A2 (en) 2003-05-07
IL154268A0 (en) 2003-09-17
KR20030024849A (en) 2003-03-26
WO2002013762A2 (en) 2002-02-21
CA2417813A1 (en) 2002-02-21
CN1469707A (en) 2004-01-21
EP1307097A4 (en) 2004-01-28
HUP0301668A2 (en) 2003-09-29
JP2004505996A (en) 2004-02-26
US20020036154A1 (en) 2002-03-28
AU2001284772A1 (en) 2002-02-25

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