HUP0301660A2 - Neutrális endropeptidáz inhibitor (NEPI) vegyületek alkalmazása férfi szexuális mżködési zavar kezelésére és az azokat tartalmazó gyógyszerkészítmények - Google Patents

Neutrális endropeptidáz inhibitor (NEPI) vegyületek alkalmazása férfi szexuális mżködési zavar kezelésére és az azokat tartalmazó gyógyszerkészítmények

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Publication number
HUP0301660A2
HUP0301660A2 HU0301660A HUP0301660A HUP0301660A2 HU P0301660 A2 HUP0301660 A2 HU P0301660A2 HU 0301660 A HU0301660 A HU 0301660A HU P0301660 A HUP0301660 A HU P0301660A HU P0301660 A2 HUP0301660 A2 HU P0301660A2
Authority
HU
Hungary
Prior art keywords
treatment
sexual dysfunction
neutral endopeptidase
nepi
pharmaceutical compositions
Prior art date
Application number
HU0301660A
Other languages
English (en)
Inventor
Alasdair Mark Naylor
Christopher Peter Wayman
Pieter Hadewijn Van Der Graaf
Original Assignee
Pfizer Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0016684A external-priority patent/GB0016684D0/en
Priority claimed from GB0030647A external-priority patent/GB0030647D0/en
Priority claimed from GB0106167A external-priority patent/GB0106167D0/en
Priority claimed from GB0108483A external-priority patent/GB0108483D0/en
Application filed by Pfizer Inc. filed Critical Pfizer Inc.
Publication of HUP0301660A2 publication Critical patent/HUP0301660A2/hu

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
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    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
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    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/58—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/34—Genitourinary disorders
    • G01N2800/344—Disorders of the penis and the scrotum and erectile dysfuncrion

Abstract

A találmány neutrális endopeptidáz inhibitor (NEDI) vegyületek férfiszexuális működési zavar, különösen férfi erekciós zavar (MED)kezelésében való alkalmazására és ezeket tartalmazógyógyszerkészítményekre vonatkozik. A találmány megvalósításában olyan(I) általános képletű vegyületet alkalmaznak, amelynek képletében aszubsztituensek különböző szerves csoportot jelentenek. Ó
HU0301660A 2000-07-06 2001-07-02 Neutrális endropeptidáz inhibitor (NEPI) vegyületek alkalmazása férfi szexuális mżködési zavar kezelésére és az azokat tartalmazó gyógyszerkészítmények HUP0301660A2 (hu)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB0016684A GB0016684D0 (en) 2000-07-06 2000-07-06 Pharmaceutical composition
GB0030647A GB0030647D0 (en) 2000-12-15 2000-12-15 Treatment of male sexual dysfunction
GB0106167A GB0106167D0 (en) 2001-03-13 2001-03-13 Treatment of male sexual dysfunction
GB0108483A GB0108483D0 (en) 2001-04-04 2001-04-04 Treatment of male sexual dysfunction
PCT/IB2001/001187 WO2002003995A2 (en) 2000-07-06 2001-07-02 Treatment of male sexual dysfunction

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HUP0301660A2 true HUP0301660A2 (hu) 2003-09-29

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US (2) US20020028799A1 (hu)
EP (1) EP1296687A2 (hu)
JP (1) JP2004502735A (hu)
KR (1) KR20030016376A (hu)
AU (1) AU2001269353A1 (hu)
CA (1) CA2414112A1 (hu)
HU (1) HUP0301660A2 (hu)
IL (1) IL153492A0 (hu)
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WO (1) WO2002003995A2 (hu)

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IL153492A0 (en) 2003-07-06
NZ522931A (en) 2005-03-24
KR20030016376A (ko) 2003-02-26
JP2004502735A (ja) 2004-01-29
US20060041014A1 (en) 2006-02-23
WO2002003995A3 (en) 2002-04-18
CA2414112A1 (en) 2002-01-17
WO2002003995A2 (en) 2002-01-17
AU2001269353A1 (en) 2002-01-21
US20020028799A1 (en) 2002-03-07
EP1296687A2 (en) 2003-04-02

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