HUP0204259A2 - Eljárás 1-alkil-pirazol-5-karbonsavészterek előállítására - Google Patents
Eljárás 1-alkil-pirazol-5-karbonsavészterek előállításáraInfo
- Publication number
- HUP0204259A2 HUP0204259A2 HU0204259A HUP0204259A HUP0204259A2 HU P0204259 A2 HUP0204259 A2 HU P0204259A2 HU 0204259 A HU0204259 A HU 0204259A HU P0204259 A HUP0204259 A HU P0204259A HU P0204259 A2 HUP0204259 A2 HU P0204259A2
- Authority
- HU
- Hungary
- Prior art keywords
- alkyl
- formula
- carboxylic acid
- general formula
- acid esters
- Prior art date
Links
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 150000001450 anions Chemical class 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- 150000007524 organic acids Chemical group 0.000 abstract 1
- 239000000376 reactant Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
- C07C69/716—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
A találmány tárgya eljárás (I) általános képletű 1-alkil-, különösen1,3-dialkil-pirazol-5-karbonsavészterek előállítására 2,4-dikarbonsavészterek-enolátból és N-alkil-hidrazíniumsókból. Az (I)általános képletben R1 és R4 jelentése egymástól függetlenül egyenesvagy elágazó szénláncú C1-C6-alkilcsoport, C3-C7-cikloalkilcsoportvagy adott esetben szubsztituált C7-C12-aralkilcsoport és R2 és R3jelentése egymástól függetlenül hidrogénatom, egyenes vagy elágazószénláncú C1-C6-alkilcsoport, C3-C7-cikloalkilcsoport vagy adottesetben szubsztituált C7-C12-aralkilcsoport. Az eljárásra jellemző,hogy egy (II) általános képletű 2,4-diketokarbonsavészterenolátot,amelynek képletében M jelentése fématom egy ekvivalense - oldószer ésvíz jelenlétében egy (III) általános képletű N-alkil-hidrazíniumsóval- e képletben R5 a COOq-résszel együtt szerves sav anionját jelenti -reagáltatnak. Ó
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19829616A DE19829616A1 (de) | 1998-07-02 | 1998-07-02 | Verfahren zur Herstellung von 1-Alkyl-pyrazol-5-carbonsäureestern |
| PCT/EP1999/004297 WO2000001673A2 (de) | 1998-07-02 | 1999-06-21 | Verfahren zur herstellung von 1-alkyl-pyrazol-5-carbonsäureestern |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUP0204259A2 true HUP0204259A2 (hu) | 2003-03-28 |
Family
ID=7872783
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0204259A HUP0204259A2 (hu) | 1998-07-02 | 1999-06-21 | Eljárás 1-alkil-pirazol-5-karbonsavészterek előállítására |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US6297386B1 (hu) |
| EP (1) | EP1091940B1 (hu) |
| JP (1) | JP2003513004A (hu) |
| KR (1) | KR20010053253A (hu) |
| CN (1) | CN1119335C (hu) |
| AT (1) | ATE249441T1 (hu) |
| CA (1) | CA2336310A1 (hu) |
| DE (2) | DE19829616A1 (hu) |
| ES (1) | ES2207952T3 (hu) |
| HU (1) | HUP0204259A2 (hu) |
| IL (1) | IL140156A0 (hu) |
| PL (1) | PL364939A1 (hu) |
| WO (1) | WO2000001673A2 (hu) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0016787D0 (en) | 2000-07-07 | 2000-08-30 | Pfizer Ltd | Compounds useful in therapy |
| KR101211264B1 (ko) * | 2008-03-18 | 2012-12-18 | 미쓰이가가쿠 아그로 가부시키가이샤 | 함불소 아실아세트산 유도체의 제조방법, 함불소 피라졸카르복실산에스테르 유도체의 제조방법 및 함불소 피라졸카르복실산 유도체의 제조방법 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3557095A (en) | 1968-05-31 | 1971-01-19 | Parke Davis & Co | Pyrazolodiazepinone compounds |
| DE2945657A1 (de) * | 1979-11-12 | 1981-05-21 | Bayer Ag, 5090 Leverkusen | Verfahren zur herstellung von pivaloylbrenztraubensaeureestern |
| JPS57106665A (en) * | 1980-12-23 | 1982-07-02 | Showa Denko Kk | 3-pyrazolecarboxamide derivative, its preparation, and herbicide |
| JPS6140266A (ja) * | 1984-08-01 | 1986-02-26 | Morishita Seiyaku Kk | ピラゾ−ル誘導体 |
| JP2861103B2 (ja) * | 1988-10-26 | 1999-02-24 | 日産化学工業株式会社 | ４―メチルピラゾール類の製造方法 |
| JP2743461B2 (ja) | 1989-05-08 | 1998-04-22 | 三菱化学株式会社 | １―メチル―３―アルキル―５―ピラゾールカルボン酸エステル類の製造法 |
| GB9013750D0 (en) | 1990-06-20 | 1990-08-08 | Pfizer Ltd | Therapeutic agents |
| JP3006091B2 (ja) * | 1990-12-25 | 2000-02-07 | 日本ヒドラジン工業株式会社 | 置換ピラゾールの製造方法 |
| GB9114760D0 (en) | 1991-07-09 | 1991-08-28 | Pfizer Ltd | Therapeutic agents |
| JP3491344B2 (ja) * | 1993-08-31 | 2004-01-26 | 宇部興産株式会社 | １−アルキル−５−ピラゾールカルボン酸エステル類の製法 |
| DE19701277A1 (de) | 1997-01-16 | 1998-07-23 | Bayer Ag | Verfahren zur Herstellung von 1-Alkyl-pyrazol-5-carbonsäureestern |
-
1998
- 1998-07-02 DE DE19829616A patent/DE19829616A1/de not_active Withdrawn
-
1999
- 1999-06-21 JP JP2000558078A patent/JP2003513004A/ja active Pending
- 1999-06-21 EP EP99931126A patent/EP1091940B1/de not_active Expired - Lifetime
- 1999-06-21 WO PCT/EP1999/004297 patent/WO2000001673A2/de not_active Application Discontinuation
- 1999-06-21 HU HU0204259A patent/HUP0204259A2/hu unknown
- 1999-06-21 US US09/720,010 patent/US6297386B1/en not_active Expired - Lifetime
- 1999-06-21 IL IL14015699A patent/IL140156A0/xx unknown
- 1999-06-21 DE DE59906968T patent/DE59906968D1/de not_active Expired - Lifetime
- 1999-06-21 KR KR1020007014934A patent/KR20010053253A/ko not_active Application Discontinuation
- 1999-06-21 ES ES99931126T patent/ES2207952T3/es not_active Expired - Lifetime
- 1999-06-21 CN CN99808216A patent/CN1119335C/zh not_active Expired - Fee Related
- 1999-06-21 PL PL99364939A patent/PL364939A1/xx not_active Application Discontinuation
- 1999-06-21 AT AT99931126T patent/ATE249441T1/de not_active IP Right Cessation
- 1999-06-21 CA CA002336310A patent/CA2336310A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| KR20010053253A (ko) | 2001-06-25 |
| CN1308612A (zh) | 2001-08-15 |
| ATE249441T1 (de) | 2003-09-15 |
| ES2207952T3 (es) | 2004-06-01 |
| DE19829616A1 (de) | 2000-01-05 |
| JP2003513004A (ja) | 2003-04-08 |
| IL140156A0 (en) | 2002-02-10 |
| WO2000001673A3 (de) | 2002-09-26 |
| EP1091940A1 (de) | 2001-04-18 |
| EP1091940B1 (de) | 2003-09-10 |
| US6297386B1 (en) | 2001-10-02 |
| CA2336310A1 (en) | 2000-01-13 |
| DE59906968D1 (de) | 2003-10-16 |
| CN1119335C (zh) | 2003-08-27 |
| WO2000001673A2 (de) | 2000-01-13 |
| PL364939A1 (en) | 2004-12-27 |
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