HUP0203496A2 - Új ciklopropánszármazékok, ezeket tartalmazó gyógyszerkészítmények és eljárás előállításukra - Google Patents

Új ciklopropánszármazékok, ezeket tartalmazó gyógyszerkészítmények és eljárás előállításukra

Info

Publication number
HUP0203496A2
HUP0203496A2 HU0203496A HUP0203496A HUP0203496A2 HU P0203496 A2 HUP0203496 A2 HU P0203496A2 HU 0203496 A HU0203496 A HU 0203496A HU P0203496 A HUP0203496 A HU P0203496A HU P0203496 A2 HUP0203496 A2 HU P0203496A2
Authority
HU
Hungary
Prior art keywords
production
groups
cyclopropane derivatives
mono
nitrogen atom
Prior art date
Application number
HU0203496A
Other languages
English (en)
Inventor
Eckhart Bauer
Henri Doods
Wolfgang Eberlein
Wolfhard Engel
Gerhard Hallermayer
Klaus Rudolf
Original Assignee
Boehringer Ingelheim Pharma Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma Kg filed Critical Boehringer Ingelheim Pharma Kg
Publication of HUP0203496A2 publication Critical patent/HUP0203496A2/hu
Publication of HUP0203496A3 publication Critical patent/HUP0203496A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Otolaryngology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Toxicology (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)

Abstract

A talámány tárgyát az általános képletű ciklopropánszármazékok - aholR telített, egy- vagy kétszeresen telítetlen öt-héttagú, adott esetbenszubsztituált heterociklusos csoport, ahol a heterociklusos csoportokszén- vagy nitrogénatomon keresztül kapcsolódhatnak egymáshoz, ésvalamelyik nitrogénatom mellett egy vagy két karbonilcsoportottartalmazhatnak, és ahol az előzőekben megadott telítetlenheterociklusos csoportok valamelyikének egyik olefines kettőskötésebenzol- vagy heterociklusos gyűrűvel lehet kondenzált; és R1 azonosvagy különböző szubsztituensekkel mono-, di- vagy triszubsztituáltaromás vagy heteroaromás csoport és tautomer, diasztereomer ésenantiomer formáik, ezek keverékei és sóik, elsősorban szervetlen vagyszerves savakkal vagy bázisokkal képezhető fiziológiailag elfogadhatósóik, ezeket tartalmazó gyógyszerkészítmények, alkalmazásuk éselőállításuk képezik. Ó
HU0203496A 1999-10-29 2000-10-21 Novel cyclopropane derivatives, pharmaceutical compositions containing them and method for the production thereof HUP0203496A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19952147A DE19952147A1 (de) 1999-10-29 1999-10-29 Neue Cyclopropane, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
PCT/EP2000/010391 WO2001032648A1 (de) 1999-10-29 2000-10-21 Neue cyclopropane als cgrp-antagonisten, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung

Publications (2)

Publication Number Publication Date
HUP0203496A2 true HUP0203496A2 (hu) 2003-02-28
HUP0203496A3 HUP0203496A3 (en) 2004-01-28

Family

ID=7927315

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0203496A HUP0203496A3 (en) 1999-10-29 2000-10-21 Novel cyclopropane derivatives, pharmaceutical compositions containing them and method for the production thereof

Country Status (27)

Country Link
US (2) US20030139417A1 (hu)
EP (1) EP1228059B1 (hu)
JP (1) JP3869721B2 (hu)
KR (1) KR20020047290A (hu)
CN (1) CN1177844C (hu)
AT (1) ATE301117T1 (hu)
AU (1) AU781856B2 (hu)
BG (1) BG106638A (hu)
BR (1) BR0015147A (hu)
CA (1) CA2387134C (hu)
CZ (1) CZ20021812A3 (hu)
DE (2) DE19952147A1 (hu)
EA (1) EA005137B1 (hu)
EE (1) EE200200220A (hu)
HK (1) HK1051858A1 (hu)
HR (1) HRP20020373A2 (hu)
HU (1) HUP0203496A3 (hu)
IL (1) IL148975A0 (hu)
MX (1) MXPA02004119A (hu)
NO (1) NO20021799L (hu)
NZ (1) NZ518698A (hu)
PL (1) PL354715A1 (hu)
SK (1) SK7282002A3 (hu)
TR (1) TR200201168T2 (hu)
WO (1) WO2001032648A1 (hu)
YU (1) YU30902A (hu)
ZA (1) ZA200203256B (hu)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
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US7842808B2 (en) 2002-06-05 2010-11-30 Bristol-Myers Squibb Company Anti-migraine spirocycles
US7220862B2 (en) 2002-06-05 2007-05-22 Bristol-Myers Squibb Company Calcitonin gene related peptide receptor antagonists
CA2487976C (en) 2002-06-05 2011-07-26 Bristol-Myers Squibb Company Calcitonin gene related peptide receptor antagonists
TW200524601A (en) 2003-12-05 2005-08-01 Bristol Myers Squibb Co Heterocyclic anti-migraine agents
EP1689493A4 (en) 2003-12-05 2008-04-23 Bristol Myers Squibb Co ANTAGONISTS OF THE CALCITONIN GENE RELATED PEPTIDE RECEPTOR
TW200533398A (en) 2004-03-29 2005-10-16 Bristol Myers Squibb Co Novel therapeutic agents for the treatment of migraine
WO2006031513A2 (en) * 2004-09-09 2006-03-23 Merck & Co., Inc. Aryl spirolactam cgrp receptor antagonists
US7384930B2 (en) 2004-11-03 2008-06-10 Bristol-Myers Squibb Company Constrained compounds as CGRP-receptor antagonists
US7384931B2 (en) 2004-11-03 2008-06-10 Bristol-Myers Squibb Company Constrained compounds as CGRP-receptor antagonists
US7449586B2 (en) 2004-12-03 2008-11-11 Bristol-Myers Squibb Company Processes for the preparation of CGRP-receptor antagonists and intermediates thereof
US7834007B2 (en) 2005-08-25 2010-11-16 Bristol-Myers Squibb Company CGRP antagonists
CA2629409A1 (en) * 2005-11-18 2007-05-31 Merck & Co., Inc. Spirolactam aryl cgrp receptor antagonists
WO2009034029A2 (de) * 2007-09-07 2009-03-19 Boehringer Ingelheim International Gmbh 1-substituierte 4 -heterocyclylpiperidine als cgrp antagonisten
AU2008313733A1 (en) 2007-10-18 2009-04-23 Boehringer Ingelheim International Gmbh CGRP antagonists
EP2065381A1 (de) 2007-10-18 2009-06-03 Boehringer Ingelheim Pharma GmbH & Co. KG CGRP Antagonisten
CA2705405A1 (en) 2007-11-22 2009-05-28 Boehringer Ingelheim International Gmbh New compounds
US9315449B2 (en) 2008-05-15 2016-04-19 Duke University Substituted pyrazoles as heat shock transcription factor activators
UA105182C2 (ru) 2008-07-03 2014-04-25 Ньюрексон, Інк. Бензоксазины, бензотиазины и родственные соединения, которые имеют ингибирующую nos активность
EP3130583B1 (en) 2012-04-05 2024-01-03 CHDI Foundation, Inc. Kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof
US9884853B2 (en) 2013-09-26 2018-02-06 Chdi Foundation, Inc. Kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof
ES2754473T3 (es) 2013-09-26 2020-04-17 Chdi Foundation Inc Inhibidores de quinurenina-3-monooxigenasa, composiciones farmacéuticas, y método de uso de los mismos
JP2019040859A (ja) * 2017-08-22 2019-03-14 株式会社エンプラス 発光装置、面光源装置および光束制御部材
CN114957145B (zh) * 2022-04-14 2023-07-18 浙江师范大学 一种1,2,4-苯并三嗪衍生物及其制备方法

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US3873707A (en) * 1972-10-02 1975-03-25 Robins Co Inc A H 1-Cyclopropyl-3-mono-(and 2,3-di) substituted-1-propanones in compositions and method for treating pain
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CA2239487A1 (en) * 1995-12-15 1997-06-26 Novo Nordisk A/S Novel method
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Also Published As

Publication number Publication date
CZ20021812A3 (cs) 2002-08-14
CA2387134C (en) 2008-07-08
ATE301117T1 (de) 2005-08-15
DE19952147A1 (de) 2001-05-03
PL354715A1 (en) 2004-02-09
JP3869721B2 (ja) 2007-01-17
CA2387134A1 (en) 2001-05-10
ZA200203256B (en) 2003-04-10
HUP0203496A3 (en) 2004-01-28
EE200200220A (et) 2003-06-16
TR200201168T2 (tr) 2002-08-21
EP1228059B1 (de) 2005-08-03
CN1177844C (zh) 2004-12-01
BG106638A (bg) 2003-01-31
WO2001032648A1 (de) 2001-05-10
BR0015147A (pt) 2002-07-16
NO20021799D0 (no) 2002-04-17
EA005137B1 (ru) 2004-12-30
EA200200447A1 (ru) 2002-10-31
KR20020047290A (ko) 2002-06-21
HK1051858A1 (en) 2003-08-22
US20050267137A1 (en) 2005-12-01
AU7921300A (en) 2001-05-14
MXPA02004119A (es) 2003-10-06
IL148975A0 (en) 2002-11-10
SK7282002A3 (en) 2002-11-06
DE50010886D1 (de) 2005-09-08
EP1228059A1 (de) 2002-08-07
NZ518698A (en) 2004-12-24
HRP20020373A2 (en) 2003-10-31
AU781856B2 (en) 2005-06-16
US7407963B2 (en) 2008-08-05
JP2003513087A (ja) 2003-04-08
NO20021799L (no) 2002-04-17
CN1387526A (zh) 2002-12-25
US20030139417A1 (en) 2003-07-24
YU30902A (sh) 2005-07-19

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Legal Events

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FD9A Lapse of provisional protection due to non-payment of fees