HUP0105477A2 - Metalloproteináz mátrixok reverz hidroxamát inhibitorai és alkalmazásuk gyógyszerkészítmények előállítására - Google Patents

Info

Publication number

HUP0105477A2

HUP0105477A2 HU0105477A HUP0105477A HUP0105477A2 HU P0105477 A2 HUP0105477 A2 HU P0105477A2 HU 0105477 A HU0105477 A HU 0105477A HU P0105477 A HUP0105477 A HU P0105477A HU P0105477 A2 HUP0105477 A2 HU P0105477A2

Authority

HU

Hungary

Prior art keywords

propionic acid

acetylamino

ylamino

nitrophenyl

methylpyridin

Prior art date

1999-01-27

Links

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• 239000003112 inhibitor Substances 0.000 title claims description 33
• 238000002360 preparation method Methods 0.000 title claims description 22
• 239000008194 pharmaceutical composition Substances 0.000 title claims description 3
• 102000002274 Matrix Metalloproteinases Human genes 0.000 title abstract 2
• 108010000684 Matrix Metalloproteinases Proteins 0.000 title abstract 2
• 150000001875 compounds Chemical class 0.000 claims abstract description 123
• 239000001257 hydrogen Substances 0.000 claims abstract description 18
• 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 18
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract description 18
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims abstract description 13
• 108010044426 integrins Proteins 0.000 claims description 80
• 102000006495 integrins Human genes 0.000 claims description 80
• 206010028980 Neoplasm Diseases 0.000 claims description 43
• 150000003839 salts Chemical class 0.000 claims description 33
• 239000012453 solvate Substances 0.000 claims description 29
• XBDQKXXYIPTUBI-UHFFFAOYSA-N Propionic acid Substances CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 claims description 21
• 239000004480 active ingredient Substances 0.000 claims description 20
• 239000003814 drug Substances 0.000 claims description 20
• 230000002401 inhibitory effect Effects 0.000 claims description 20
• 239000002253 acid Substances 0.000 claims description 17
• 238000000034 method Methods 0.000 claims description 15
• 210000004204 blood vessel Anatomy 0.000 claims description 14
• FYIHTCMAMIFUDF-UHFFFAOYSA-N 3-[[2-[5-[(4-methylpyridin-2-yl)amino]pentanoylamino]acetyl]amino]-3-(3-nitrophenyl)propanoic acid;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.CC1=CC=NC(NCCCCC(=O)NCC(=O)NC(CC(O)=O)C=2C=C(C=CC=2)[N+]([O-])=O)=C1 FYIHTCMAMIFUDF-UHFFFAOYSA-N 0.000 claims description 12
• YYZIYTNXNDEEJN-UHFFFAOYSA-N 3-[[2-[4-[(4-methylpyridin-2-yl)amino]butanoylamino]acetyl]amino]-3-(3-nitrophenyl)propanoic acid;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.CC1=CC=NC(NCCCC(=O)NCC(=O)NC(CC(O)=O)C=2C=C(C=CC=2)[N+]([O-])=O)=C1 YYZIYTNXNDEEJN-UHFFFAOYSA-N 0.000 claims description 11
• 230000033115 angiogenesis Effects 0.000 claims description 11
• KKDCLXHJKZLXTA-UHFFFAOYSA-N 3-(4-chloro-3-nitrophenyl)-3-[[2-[5-[(4-methylpyridin-2-yl)amino]pentanoylamino]acetyl]amino]propanoic acid;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.CC1=CC=NC(NCCCCC(=O)NCC(=O)NC(CC(O)=O)C=2C=C(C(Cl)=CC=2)[N+]([O-])=O)=C1 KKDCLXHJKZLXTA-UHFFFAOYSA-N 0.000 claims description 10
• XYTIMKXICDYNHJ-UHFFFAOYSA-N 3-(4-methyl-3-nitrophenyl)-3-[[2-[4-[(4-methylpyridin-2-yl)amino]butanoylamino]acetyl]amino]propanoic acid;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.CC1=CC=NC(NCCCC(=O)NCC(=O)NC(CC(O)=O)C=2C=C(C(C)=CC=2)[N+]([O-])=O)=C1 XYTIMKXICDYNHJ-UHFFFAOYSA-N 0.000 claims description 10
• QOMIFPHUHICKBV-UHFFFAOYSA-N 3-(4-methyl-3-nitrophenyl)-3-[[2-[5-[(4-methylpyridin-2-yl)amino]pentanoylamino]acetyl]amino]propanoic acid;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.CC1=CC=NC(NCCCCC(=O)NCC(=O)NC(CC(O)=O)C=2C=C(C(C)=CC=2)[N+]([O-])=O)=C1 QOMIFPHUHICKBV-UHFFFAOYSA-N 0.000 claims description 10
• RQBNHKDCKYJIDJ-UHFFFAOYSA-N 3-[[2-[4-[(4-methylpyridin-2-yl)amino]butanoylamino]acetyl]amino]-3-[3-(trifluoromethoxy)phenyl]propanoic acid;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.CC1=CC=NC(NCCCC(=O)NCC(=O)NC(CC(O)=O)C=2C=C(OC(F)(F)F)C=CC=2)=C1 RQBNHKDCKYJIDJ-UHFFFAOYSA-N 0.000 claims description 10
• UEIDNUBXBVAVDO-UHFFFAOYSA-N 3-[[2-[4-[(4-methylpyridin-2-yl)amino]butanoylamino]acetyl]amino]-3-[4-(trifluoromethoxy)phenyl]propanoic acid;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.CC1=CC=NC(NCCCC(=O)NCC(=O)NC(CC(O)=O)C=2C=CC(OC(F)(F)F)=CC=2)=C1 UEIDNUBXBVAVDO-UHFFFAOYSA-N 0.000 claims description 10
• OOCSCNMJMIRGJX-UHFFFAOYSA-N 3-[[2-[5-[(4-methylpyridin-2-yl)amino]pentanoylamino]acetyl]amino]-3-(3-nitrophenyl)propanoic acid;hydrochloride Chemical compound Cl.CC1=CC=NC(NCCCCC(=O)NCC(=O)NC(CC(O)=O)C=2C=C(C=CC=2)[N+]([O-])=O)=C1 OOCSCNMJMIRGJX-UHFFFAOYSA-N 0.000 claims description 10
• FRJQHRRZJHPQHX-UHFFFAOYSA-N 3-[[2-[5-[(4-methylpyridin-2-yl)amino]pentanoylamino]acetyl]amino]-3-[3-(trifluoromethoxy)phenyl]propanoic acid;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.CC1=CC=NC(NCCCCC(=O)NCC(=O)NC(CC(O)=O)C=2C=C(OC(F)(F)F)C=CC=2)=C1 FRJQHRRZJHPQHX-UHFFFAOYSA-N 0.000 claims description 10
• VLWAQQIADOVADC-UHFFFAOYSA-N 3-[[2-[5-[(4-methylpyridin-2-yl)amino]pentanoylamino]acetyl]amino]-3-[4-(trifluoromethoxy)phenyl]propanoic acid;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.CC1=CC=NC(NCCCCC(=O)NCC(=O)NC(CC(O)=O)C=2C=CC(OC(F)(F)F)=CC=2)=C1 VLWAQQIADOVADC-UHFFFAOYSA-N 0.000 claims description 10
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• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 10
• 238000011275 oncology therapy Methods 0.000 claims description 10
• HPLDPJYYPVNUFY-UHFFFAOYSA-N 3-(4-methyl-3-nitrophenyl)-3-[[2-[4-(pyridin-2-ylamino)butanoylamino]acetyl]amino]propanoic acid;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.C1=C([N+]([O-])=O)C(C)=CC=C1C(CC(O)=O)NC(=O)CNC(=O)CCCNC1=CC=CC=N1 HPLDPJYYPVNUFY-UHFFFAOYSA-N 0.000 claims description 9
• SYFQRVXEJFYGLH-UHFFFAOYSA-N 3-(4-phenylphenyl)-3-[[2-[5-(pyridin-2-ylamino)pentanoylamino]acetyl]amino]propanoic acid;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.C=1C=C(C=2C=CC=CC=2)C=CC=1C(CC(=O)O)NC(=O)CNC(=O)CCCCNC1=CC=CC=N1 SYFQRVXEJFYGLH-UHFFFAOYSA-N 0.000 claims description 9
• 238000011282 treatment Methods 0.000 claims description 9
• 230000005748 tumor development Effects 0.000 claims description 9
• 208000037273 Pathologic Processes Diseases 0.000 claims description 8
• 230000009054 pathological process Effects 0.000 claims description 8
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 7
• 206010027476 Metastases Diseases 0.000 claims description 6
• 201000011510 cancer Diseases 0.000 claims description 6
• 230000008569 process Effects 0.000 claims description 6
• WUECWVGVZHUEMO-UHFFFAOYSA-N 3-(4-chloro-3-nitrophenyl)-3-[[2-[5-[(4-methylpyridin-2-yl)amino]pentanoylamino]acetyl]amino]propanoic acid Chemical compound CC1=CC=NC(NCCCCC(=O)NCC(=O)NC(CC(O)=O)C=2C=C(C(Cl)=CC=2)[N+]([O-])=O)=C1 WUECWVGVZHUEMO-UHFFFAOYSA-N 0.000 claims description 5
• GYLCDLSBEJAWGJ-UHFFFAOYSA-N 3-[[2-[4-[(4-methylpyridin-2-yl)amino]butanoylamino]acetyl]amino]-3-(4-phenylphenyl)propanoic acid Chemical compound CC1=CC=NC(NCCCC(=O)NCC(=O)NC(CC(O)=O)C=2C=CC(=CC=2)C=2C=CC=CC=2)=C1 GYLCDLSBEJAWGJ-UHFFFAOYSA-N 0.000 claims description 5
• 150000007513 acids Chemical class 0.000 claims description 5
• 125000003277 amino group Chemical group 0.000 claims description 5
• HTSOLGUXHISWOP-UHFFFAOYSA-N 3-(2-nitrophenyl)-3-[[2-[5-(pyridin-2-ylamino)pentanoylamino]acetyl]amino]propanoic acid Chemical compound C=1C=CC=C([N+]([O-])=O)C=1C(CC(=O)O)NC(=O)CNC(=O)CCCCNC1=CC=CC=N1 HTSOLGUXHISWOP-UHFFFAOYSA-N 0.000 claims description 4
• JQHXZVTVZSDJAK-UHFFFAOYSA-N 3-(4-methyl-3-nitrophenyl)-3-[[2-[4-(pyridin-2-ylamino)butanoylamino]acetyl]amino]propanoic acid Chemical compound C1=C([N+]([O-])=O)C(C)=CC=C1C(CC(O)=O)NC(=O)CNC(=O)CCCNC1=CC=CC=N1 JQHXZVTVZSDJAK-UHFFFAOYSA-N 0.000 claims description 4
• CPSWAONHXSSUHD-UHFFFAOYSA-N 3-(4-methyl-3-nitrophenyl)-3-[[2-[5-(pyridin-2-ylamino)pentanoylamino]acetyl]amino]propanoic acid Chemical compound C1=C([N+]([O-])=O)C(C)=CC=C1C(CC(O)=O)NC(=O)CNC(=O)CCCCNC1=CC=CC=N1 CPSWAONHXSSUHD-UHFFFAOYSA-N 0.000 claims description 4
• ONPHZVYMHGRMPD-UHFFFAOYSA-N 3-(4-methyl-3-nitrophenyl)-3-[[2-[5-(pyrimidin-2-ylamino)pentanoylamino]acetyl]amino]propanoic acid Chemical compound C1=C([N+]([O-])=O)C(C)=CC=C1C(CC(O)=O)NC(=O)CNC(=O)CCCCNC1=NC=CC=N1 ONPHZVYMHGRMPD-UHFFFAOYSA-N 0.000 claims description 4
• NPNJGYONFSPRNJ-UHFFFAOYSA-N 3-(4-methyl-3-nitrophenyl)-3-[[2-[5-[(4-methylpyridin-2-yl)amino]pentanoylamino]acetyl]amino]propanoic acid Chemical compound CC1=CC=NC(NCCCCC(=O)NCC(=O)NC(CC(O)=O)C=2C=C(C(C)=CC=2)[N+]([O-])=O)=C1 NPNJGYONFSPRNJ-UHFFFAOYSA-N 0.000 claims description 4
• JMORLVGMBRXKHM-UHFFFAOYSA-N 3-[[2-[4-[(4-methylpyridin-2-yl)amino]butanoylamino]acetyl]amino]-3-(2-nitrophenyl)propanoic acid Chemical compound CC1=CC=NC(NCCCC(=O)NCC(=O)NC(CC(O)=O)C=2C(=CC=CC=2)[N+]([O-])=O)=C1 JMORLVGMBRXKHM-UHFFFAOYSA-N 0.000 claims description 4
• PPTVBIGTCDEIDR-UHFFFAOYSA-N 3-[[2-[4-[(4-methylpyridin-2-yl)amino]butanoylamino]acetyl]amino]-3-[4-(trifluoromethoxy)phenyl]propanoic acid Chemical compound CC1=CC=NC(NCCCC(=O)NCC(=O)NC(CC(O)=O)C=2C=CC(OC(F)(F)F)=CC=2)=C1 PPTVBIGTCDEIDR-UHFFFAOYSA-N 0.000 claims description 4
• KGCHTCYSXYHFBH-UHFFFAOYSA-N 3-[[2-[5-[(4-methylpyridin-2-yl)amino]pentanoylamino]acetyl]amino]-3-(2-nitrophenyl)propanoic acid Chemical compound CC1=CC=NC(NCCCCC(=O)NCC(=O)NC(CC(O)=O)C=2C(=CC=CC=2)[N+]([O-])=O)=C1 KGCHTCYSXYHFBH-UHFFFAOYSA-N 0.000 claims description 4
• RWCIGBSETCPUBU-UHFFFAOYSA-N 3-[[2-[5-[(4-methylpyridin-2-yl)amino]pentanoylamino]acetyl]amino]-3-[3-(trifluoromethoxy)phenyl]propanoic acid Chemical compound CC1=CC=NC(NCCCCC(=O)NCC(=O)NC(CC(O)=O)C=2C=C(OC(F)(F)F)C=CC=2)=C1 RWCIGBSETCPUBU-UHFFFAOYSA-N 0.000 claims description 4
• 230000002152 alkylating effect Effects 0.000 claims description 4
• GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical compound BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims description 4
• GHXRHORZCPRBTJ-UHFFFAOYSA-N 3-(4-methyl-3-nitrophenyl)-3-[[2-[5-[(6-methylpyridin-2-yl)amino]pentanoylamino]acetyl]amino]propanoic acid Chemical compound CC1=CC=CC(NCCCCC(=O)NCC(=O)NC(CC(O)=O)C=2C=C(C(C)=CC=2)[N+]([O-])=O)=N1 GHXRHORZCPRBTJ-UHFFFAOYSA-N 0.000 claims description 3
• WBMCRUQGUOQSHE-UHFFFAOYSA-N 3-[[2-[5-[(4-methylpyridin-2-yl)amino]pentanoylamino]acetyl]amino]-3-[4-(trifluoromethoxy)phenyl]propanoic acid Chemical compound CC1=CC=NC(NCCCCC(=O)NCC(=O)NC(CC(O)=O)C=2C=CC(OC(F)(F)F)=CC=2)=C1 WBMCRUQGUOQSHE-UHFFFAOYSA-N 0.000 claims description 3
• 206010003210 Arteriosclerosis Diseases 0.000 claims description 3
• KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical compound ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 claims description 3
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• 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims description 3
• 239000000460 chlorine Substances 0.000 claims description 3
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• 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 2
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• FJLUATLTXUNBOT-UHFFFAOYSA-N 1-Hexadecylamine Chemical compound CCCCCCCCCCCCCCCCN FJLUATLTXUNBOT-UHFFFAOYSA-N 0.000 claims 1
• 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract description 10
• 125000000217 alkyl group Chemical group 0.000 abstract description 8
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• LVAYLWBIZLWXHI-UHFFFAOYSA-N 3-(4-chloro-3-nitrophenyl)-3-[[2-[4-(pyridin-2-ylamino)butanoylamino]acetyl]amino]propanoic acid;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.C=1C=C(Cl)C([N+]([O-])=O)=CC=1C(CC(=O)O)NC(=O)CNC(=O)CCCNC1=CC=CC=N1 LVAYLWBIZLWXHI-UHFFFAOYSA-N 0.000 description 1
• WPQTWHSJDZOUIT-UHFFFAOYSA-N 3-(4-chloro-3-nitrophenyl)-3-[[2-[4-[(4-methylpyridin-2-yl)amino]butanoylamino]acetyl]amino]propanoic acid Chemical compound CC1=CC=NC(NCCCC(=O)NCC(=O)NC(CC(O)=O)C=2C=C(C(Cl)=CC=2)[N+]([O-])=O)=C1 WPQTWHSJDZOUIT-UHFFFAOYSA-N 0.000 description 1
• TVCYCHCNYUVVMA-UHFFFAOYSA-N 3-(4-chloro-3-nitrophenyl)-3-[[2-[4-[(4-methylpyridin-2-yl)amino]butanoylamino]acetyl]amino]propanoic acid;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.CC1=CC=NC(NCCCC(=O)NCC(=O)NC(CC(O)=O)C=2C=C(C(Cl)=CC=2)[N+]([O-])=O)=C1 TVCYCHCNYUVVMA-UHFFFAOYSA-N 0.000 description 1
• PRCJBRPZTDKZQY-UHFFFAOYSA-N 3-(4-chloro-3-nitrophenyl)-3-[[2-[5-(pyridin-2-ylamino)pentanoylamino]acetyl]amino]propanoic acid Chemical compound C=1C=C(Cl)C([N+]([O-])=O)=CC=1C(CC(=O)O)NC(=O)CNC(=O)CCCCNC1=CC=CC=N1 PRCJBRPZTDKZQY-UHFFFAOYSA-N 0.000 description 1
• OHCUNKSOHFKHFO-UHFFFAOYSA-N 3-(4-chloro-3-nitrophenyl)-3-[[2-[5-(pyridin-2-ylamino)pentanoylamino]acetyl]amino]propanoic acid;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.C=1C=C(Cl)C([N+]([O-])=O)=CC=1C(CC(=O)O)NC(=O)CNC(=O)CCCCNC1=CC=CC=N1 OHCUNKSOHFKHFO-UHFFFAOYSA-N 0.000 description 1
• WOOHBNLMPUMEIG-UHFFFAOYSA-N 3-(4-chloro-3-nitrophenyl)-3-[[2-[6-[(4-methylpyridin-2-yl)amino]hexanoylamino]acetyl]amino]propanoic acid Chemical compound CC1=CC=NC(NCCCCCC(=O)NCC(=O)NC(CC(O)=O)C=2C=C(C(Cl)=CC=2)[N+]([O-])=O)=C1 WOOHBNLMPUMEIG-UHFFFAOYSA-N 0.000 description 1
• OMTCUYHREMXONQ-UHFFFAOYSA-N 3-(4-chloro-3-nitrophenyl)-3-[[2-[6-[(4-methylpyridin-2-yl)amino]hexanoylamino]acetyl]amino]propanoic acid;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.CC1=CC=NC(NCCCCCC(=O)NCC(=O)NC(CC(O)=O)C=2C=C(C(Cl)=CC=2)[N+]([O-])=O)=C1 OMTCUYHREMXONQ-UHFFFAOYSA-N 0.000 description 1
• FNTKHHNOXPFTFF-UHFFFAOYSA-N 3-(4-methyl-3-nitrophenyl)-3-[[2-[4-(pyrimidin-2-ylamino)butanoylamino]acetyl]amino]propanoic acid;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.C1=C([N+]([O-])=O)C(C)=CC=C1C(CC(O)=O)NC(=O)CNC(=O)CCCNC1=NC=CC=N1 FNTKHHNOXPFTFF-UHFFFAOYSA-N 0.000 description 1
• HQYCPQZFRARMAO-UHFFFAOYSA-N 3-(4-methyl-3-nitrophenyl)-3-[[2-[5-(pyridin-2-ylamino)pentanoylamino]acetyl]amino]propanoic acid;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.C1=C([N+]([O-])=O)C(C)=CC=C1C(CC(O)=O)NC(=O)CNC(=O)CCCCNC1=CC=CC=N1 HQYCPQZFRARMAO-UHFFFAOYSA-N 0.000 description 1
• JFQQUJNDKFLPPD-UHFFFAOYSA-N 3-(4-methyl-3-nitrophenyl)-3-[[2-[5-(pyrimidin-2-ylamino)pentanoylamino]acetyl]amino]propanoic acid;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.C1=C([N+]([O-])=O)C(C)=CC=C1C(CC(O)=O)NC(=O)CNC(=O)CCCCNC1=NC=CC=N1 JFQQUJNDKFLPPD-UHFFFAOYSA-N 0.000 description 1
• DUHFDHNIDOBPTC-UHFFFAOYSA-N 3-(4-methyl-3-nitrophenyl)-3-[[2-[5-[(6-methylpyridin-2-yl)amino]pentanoylamino]acetyl]amino]propanoic acid;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.CC1=CC=CC(NCCCCC(=O)NCC(=O)NC(CC(O)=O)C=2C=C(C(C)=CC=2)[N+]([O-])=O)=N1 DUHFDHNIDOBPTC-UHFFFAOYSA-N 0.000 description 1
• NTNSFPXULVNKQI-UHFFFAOYSA-N 3-(4-methyl-3-nitrophenyl)-3-[[2-[6-[(4-methylpyridin-2-yl)amino]hexanoylamino]acetyl]amino]propanoic acid Chemical compound CC1=CC=NC(NCCCCCC(=O)NCC(=O)NC(CC(O)=O)C=2C=C(C(C)=CC=2)[N+]([O-])=O)=C1 NTNSFPXULVNKQI-UHFFFAOYSA-N 0.000 description 1
• HJWMQKUNVSJJCO-UHFFFAOYSA-N 3-(4-methyl-3-nitrophenyl)-3-[[2-[6-[(4-methylpyridin-2-yl)amino]hexanoylamino]acetyl]amino]propanoic acid;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.CC1=CC=NC(NCCCCCC(=O)NCC(=O)NC(CC(O)=O)C=2C=C(C(C)=CC=2)[N+]([O-])=O)=C1 HJWMQKUNVSJJCO-UHFFFAOYSA-N 0.000 description 1
• IRBKGJFPMZDORS-UHFFFAOYSA-N 3-(4-naphthalen-1-ylphenyl)-3-[[2-[4-(pyridin-2-ylamino)butanoylamino]acetyl]amino]propanoic acid Chemical compound C=1C=C(C=2C3=CC=CC=C3C=CC=2)C=CC=1C(CC(=O)O)NC(=O)CNC(=O)CCCNC1=CC=CC=N1 IRBKGJFPMZDORS-UHFFFAOYSA-N 0.000 description 1
• QKDQZFBIFCEOMO-UHFFFAOYSA-N 3-(4-naphthalen-1-ylphenyl)-3-[[2-[4-(pyridin-2-ylamino)butanoylamino]acetyl]amino]propanoic acid;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.C=1C=C(C=2C3=CC=CC=C3C=CC=2)C=CC=1C(CC(=O)O)NC(=O)CNC(=O)CCCNC1=CC=CC=N1 QKDQZFBIFCEOMO-UHFFFAOYSA-N 0.000 description 1
• WDXNEYHSAYWDII-UHFFFAOYSA-N 3-(4-naphthalen-1-ylphenyl)-3-[[2-[5-(pyridin-2-ylamino)pentanoylamino]acetyl]amino]propanoic acid Chemical compound C=1C=C(C=2C3=CC=CC=C3C=CC=2)C=CC=1C(CC(=O)O)NC(=O)CNC(=O)CCCCNC1=CC=CC=N1 WDXNEYHSAYWDII-UHFFFAOYSA-N 0.000 description 1
• DTNRXSKQIXIXRQ-UHFFFAOYSA-N 3-(4-naphthalen-1-ylphenyl)-3-[[2-[5-(pyridin-2-ylamino)pentanoylamino]acetyl]amino]propanoic acid;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.C=1C=C(C=2C3=CC=CC=C3C=CC=2)C=CC=1C(CC(=O)O)NC(=O)CNC(=O)CCCCNC1=CC=CC=N1 DTNRXSKQIXIXRQ-UHFFFAOYSA-N 0.000 description 1
• KCBRNCVSGPODEL-UHFFFAOYSA-N 3-(4-naphthalen-2-ylphenyl)-3-[[2-[5-(pyridin-2-ylamino)pentanoylamino]acetyl]amino]propanoic acid Chemical compound C=1C=C(C=2C=C3C=CC=CC3=CC=2)C=CC=1C(CC(=O)O)NC(=O)CNC(=O)CCCCNC1=CC=CC=N1 KCBRNCVSGPODEL-UHFFFAOYSA-N 0.000 description 1
• GMLGEIZNGNJVFM-UHFFFAOYSA-N 3-(4-phenylphenyl)-3-[[2-[4-(pyridin-2-ylamino)butanoylamino]acetyl]amino]propanoic acid;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.C=1C=C(C=2C=CC=CC=2)C=CC=1C(CC(=O)O)NC(=O)CNC(=O)CCCNC1=CC=CC=N1 GMLGEIZNGNJVFM-UHFFFAOYSA-N 0.000 description 1
• MISGMFMEAOPRAE-UHFFFAOYSA-N 3-(4-phenylphenyl)-3-[[2-[4-(pyrimidin-2-ylamino)butanoylamino]acetyl]amino]propanoic acid;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.C=1C=C(C=2C=CC=CC=2)C=CC=1C(CC(=O)O)NC(=O)CNC(=O)CCCNC1=NC=CC=N1 MISGMFMEAOPRAE-UHFFFAOYSA-N 0.000 description 1
• UXIFMPVXVHSOBG-UHFFFAOYSA-N 3-(4-phenylphenyl)-3-[[2-[5-(pyrimidin-2-ylamino)pentanoylamino]acetyl]amino]propanoic acid;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.C=1C=C(C=2C=CC=CC=2)C=CC=1C(CC(=O)O)NC(=O)CNC(=O)CCCCNC1=NC=CC=N1 UXIFMPVXVHSOBG-UHFFFAOYSA-N 0.000 description 1
• RVNMFTCKFGJBNW-UHFFFAOYSA-N 3-(5-bromo-2-hydroxy-3-nitrophenyl)-3-[[2-[4-[(4-methylpyridin-2-yl)amino]butanoylamino]acetyl]amino]propanoic acid Chemical compound CC1=CC=NC(NCCCC(=O)NCC(=O)NC(CC(O)=O)C=2C(=C(C=C(Br)C=2)[N+]([O-])=O)O)=C1 RVNMFTCKFGJBNW-UHFFFAOYSA-N 0.000 description 1
• SWRNCHJALPPACK-UHFFFAOYSA-N 3-(5-bromo-2-hydroxy-3-nitrophenyl)-3-[[2-[4-[(4-methylpyridin-2-yl)amino]butanoylamino]acetyl]amino]propanoic acid;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.CC1=CC=NC(NCCCC(=O)NCC(=O)NC(CC(O)=O)C=2C(=C(C=C(Br)C=2)[N+]([O-])=O)O)=C1 SWRNCHJALPPACK-UHFFFAOYSA-N 0.000 description 1
• BCEICVBSTLSCBY-UHFFFAOYSA-N 3-[3-(4-fluoro-2-hydroxyphenyl)phenyl]-3-[[2-[4-[(4-methylpyridin-2-yl)amino]butanoylamino]acetyl]amino]propanoic acid Chemical compound CC1=CC=NC(NCCCC(=O)NCC(=O)NC(CC(O)=O)C=2C=C(C=CC=2)C=2C(=CC(F)=CC=2)O)=C1 BCEICVBSTLSCBY-UHFFFAOYSA-N 0.000 description 1
• ZCWLZBZNPOIYJI-UHFFFAOYSA-N 3-[3-(4-fluoro-2-hydroxyphenyl)phenyl]-3-[[2-[4-[(4-methylpyridin-2-yl)amino]butanoylamino]acetyl]amino]propanoic acid;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.CC1=CC=NC(NCCCC(=O)NCC(=O)NC(CC(O)=O)C=2C=C(C=CC=2)C=2C(=CC(F)=CC=2)O)=C1 ZCWLZBZNPOIYJI-UHFFFAOYSA-N 0.000 description 1
• PVXAKHGPZRGXNL-UHFFFAOYSA-N 3-[3-(4-fluorophenyl)phenyl]-3-[[2-[4-(pyridin-2-ylamino)butanoylamino]acetyl]amino]propanoic acid Chemical compound C=1C=CC(C=2C=CC(F)=CC=2)=CC=1C(CC(=O)O)NC(=O)CNC(=O)CCCNC1=CC=CC=N1 PVXAKHGPZRGXNL-UHFFFAOYSA-N 0.000 description 1
• HEFDVTIBIRZHTP-UHFFFAOYSA-N 3-[3-(4-fluorophenyl)phenyl]-3-[[2-[4-(pyridin-2-ylamino)butanoylamino]acetyl]amino]propanoic acid;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.C=1C=CC(C=2C=CC(F)=CC=2)=CC=1C(CC(=O)O)NC(=O)CNC(=O)CCCNC1=CC=CC=N1 HEFDVTIBIRZHTP-UHFFFAOYSA-N 0.000 description 1
• QMLISQATVPCCDJ-UHFFFAOYSA-N 3-[3-(4-fluorophenyl)phenyl]-3-[[2-[4-[(4-methylpyridin-2-yl)amino]butanoylamino]acetyl]amino]propanoic acid Chemical compound CC1=CC=NC(NCCCC(=O)NCC(=O)NC(CC(O)=O)C=2C=C(C=CC=2)C=2C=CC(F)=CC=2)=C1 QMLISQATVPCCDJ-UHFFFAOYSA-N 0.000 description 1
• QEVMUWGKPKYQPW-UHFFFAOYSA-N 3-[3-(4-fluorophenyl)phenyl]-3-[[2-[4-[(4-methylpyridin-2-yl)amino]butanoylamino]acetyl]amino]propanoic acid;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.CC1=CC=NC(NCCCC(=O)NCC(=O)NC(CC(O)=O)C=2C=C(C=CC=2)C=2C=CC(F)=CC=2)=C1 QEVMUWGKPKYQPW-UHFFFAOYSA-N 0.000 description 1
• PCTKCMLVMAPGRM-UHFFFAOYSA-N 3-[3-(4-fluorophenyl)phenyl]-3-[[2-[5-(pyridin-2-ylamino)pentanoylamino]acetyl]amino]propanoic acid;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.C=1C=CC(C=2C=CC(F)=CC=2)=CC=1C(CC(=O)O)NC(=O)CNC(=O)CCCCNC1=CC=CC=N1 PCTKCMLVMAPGRM-UHFFFAOYSA-N 0.000 description 1
• IAEJXDDAIBKPFN-UHFFFAOYSA-N 3-[4-(2-fluorophenyl)phenyl]-3-[[2-[5-(pyridin-2-ylamino)pentanoylamino]acetyl]amino]propanoic acid Chemical compound C=1C=C(C=2C(=CC=CC=2)F)C=CC=1C(CC(=O)O)NC(=O)CNC(=O)CCCCNC1=CC=CC=N1 IAEJXDDAIBKPFN-UHFFFAOYSA-N 0.000 description 1
• QHDRWXQRFLBLLM-UHFFFAOYSA-N 3-[4-(3-chloro-4-fluorophenyl)phenyl]-3-[[2-[5-(pyridin-2-ylamino)pentanoylamino]acetyl]amino]propanoic acid Chemical compound C=1C=C(C=2C=C(Cl)C(F)=CC=2)C=CC=1C(CC(=O)O)NC(=O)CNC(=O)CCCCNC1=CC=CC=N1 QHDRWXQRFLBLLM-UHFFFAOYSA-N 0.000 description 1
• HHEDSZSCUXIITG-UHFFFAOYSA-N 3-[4-(3-chloro-4-fluorophenyl)phenyl]-3-[[2-[5-(pyridin-2-ylamino)pentanoylamino]acetyl]amino]propanoic acid;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.C=1C=C(C=2C=C(Cl)C(F)=CC=2)C=CC=1C(CC(=O)O)NC(=O)CNC(=O)CCCCNC1=CC=CC=N1 HHEDSZSCUXIITG-UHFFFAOYSA-N 0.000 description 1
• PKSHVDOVFPPPPD-UHFFFAOYSA-N 3-[4-(3-chlorophenyl)phenyl]-3-[[2-[5-(pyridin-2-ylamino)pentanoylamino]acetyl]amino]propanoic acid Chemical compound C=1C=C(C=2C=C(Cl)C=CC=2)C=CC=1C(CC(=O)O)NC(=O)CNC(=O)CCCCNC1=CC=CC=N1 PKSHVDOVFPPPPD-UHFFFAOYSA-N 0.000 description 1
• XFIQYEBBYRRPLT-UHFFFAOYSA-N 3-[4-(3-chlorophenyl)phenyl]-3-[[2-[5-(pyridin-2-ylamino)pentanoylamino]acetyl]amino]propanoic acid;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.C=1C=C(C=2C=C(Cl)C=CC=2)C=CC=1C(CC(=O)O)NC(=O)CNC(=O)CCCCNC1=CC=CC=N1 XFIQYEBBYRRPLT-UHFFFAOYSA-N 0.000 description 1
• KMOQKOXTHPGCFL-UHFFFAOYSA-N 3-[4-(3-fluorophenyl)phenyl]-3-[[2-[5-(pyridin-2-ylamino)pentanoylamino]acetyl]amino]propanoic acid Chemical compound C=1C=C(C=2C=C(F)C=CC=2)C=CC=1C(CC(=O)O)NC(=O)CNC(=O)CCCCNC1=CC=CC=N1 KMOQKOXTHPGCFL-UHFFFAOYSA-N 0.000 description 1
• YRVDLTJKNNCADT-UHFFFAOYSA-N 3-[4-(3-fluorophenyl)phenyl]-3-[[2-[5-(pyridin-2-ylamino)pentanoylamino]acetyl]amino]propanoic acid;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.C=1C=C(C=2C=C(F)C=CC=2)C=CC=1C(CC(=O)O)NC(=O)CNC(=O)CCCCNC1=CC=CC=N1 YRVDLTJKNNCADT-UHFFFAOYSA-N 0.000 description 1
• NVGOUCICXQPFIB-UHFFFAOYSA-N 3-[4-(4-chlorophenyl)phenyl]-3-[[2-[5-(pyridin-2-ylamino)pentanoylamino]acetyl]amino]propanoic acid Chemical compound C=1C=C(C=2C=CC(Cl)=CC=2)C=CC=1C(CC(=O)O)NC(=O)CNC(=O)CCCCNC1=CC=CC=N1 NVGOUCICXQPFIB-UHFFFAOYSA-N 0.000 description 1
• UWTPASLAKUMBCY-UHFFFAOYSA-N 3-[4-(4-chlorophenyl)phenyl]-3-[[2-[5-(pyridin-2-ylamino)pentanoylamino]acetyl]amino]propanoic acid;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.C=1C=C(C=2C=CC(Cl)=CC=2)C=CC=1C(CC(=O)O)NC(=O)CNC(=O)CCCCNC1=CC=CC=N1 UWTPASLAKUMBCY-UHFFFAOYSA-N 0.000 description 1
• NMXWKEVRIOQLPK-UHFFFAOYSA-N 3-[4-(4-fluoro-2-hydroxyphenyl)phenyl]-3-[[2-[4-[(4-methylpyridin-2-yl)amino]butanoylamino]acetyl]amino]propanoic acid Chemical compound CC1=CC=NC(NCCCC(=O)NCC(=O)NC(CC(O)=O)C=2C=CC(=CC=2)C=2C(=CC(F)=CC=2)O)=C1 NMXWKEVRIOQLPK-UHFFFAOYSA-N 0.000 description 1
• MLFWIWFJBOEUOT-UHFFFAOYSA-N 3-[4-(4-fluoro-2-hydroxyphenyl)phenyl]-3-[[2-[4-[(4-methylpyridin-2-yl)amino]butanoylamino]acetyl]amino]propanoic acid;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.CC1=CC=NC(NCCCC(=O)NCC(=O)NC(CC(O)=O)C=2C=CC(=CC=2)C=2C(=CC(F)=CC=2)O)=C1 MLFWIWFJBOEUOT-UHFFFAOYSA-N 0.000 description 1
• YVEHIKHHTDZPHY-UHFFFAOYSA-N 3-[4-(4-fluorophenyl)-3-hydroxyphenyl]-3-[[2-[5-(pyridin-2-ylamino)pentanoylamino]acetyl]amino]propanoic acid Chemical compound C=1C=C(C=2C=CC(F)=CC=2)C(O)=CC=1C(CC(=O)O)NC(=O)CNC(=O)CCCCNC1=CC=CC=N1 YVEHIKHHTDZPHY-UHFFFAOYSA-N 0.000 description 1
• OKFCUGOSIISVFJ-UHFFFAOYSA-N 3-[4-(4-fluorophenyl)-3-hydroxyphenyl]-3-[[2-[5-(pyridin-2-ylamino)pentanoylamino]acetyl]amino]propanoic acid;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.C=1C=C(C=2C=CC(F)=CC=2)C(O)=CC=1C(CC(=O)O)NC(=O)CNC(=O)CCCCNC1=CC=CC=N1 OKFCUGOSIISVFJ-UHFFFAOYSA-N 0.000 description 1
• QEXTUXKFDKSNEU-UHFFFAOYSA-N 3-[4-(4-fluorophenyl)phenyl]-3-[[2-[4-(pyridin-2-ylamino)butanoylamino]acetyl]amino]propanoic acid Chemical compound C=1C=C(C=2C=CC(F)=CC=2)C=CC=1C(CC(=O)O)NC(=O)CNC(=O)CCCNC1=CC=CC=N1 QEXTUXKFDKSNEU-UHFFFAOYSA-N 0.000 description 1
• BNCDKHIZJPHSCN-UHFFFAOYSA-N 3-[4-(4-fluorophenyl)phenyl]-3-[[2-[4-(pyridin-2-ylamino)butanoylamino]acetyl]amino]propanoic acid;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.C=1C=C(C=2C=CC(F)=CC=2)C=CC=1C(CC(=O)O)NC(=O)CNC(=O)CCCNC1=CC=CC=N1 BNCDKHIZJPHSCN-UHFFFAOYSA-N 0.000 description 1
• OGLARCXKVCFXAV-UHFFFAOYSA-N 3-[4-(4-fluorophenyl)phenyl]-3-[[2-[4-[(4-methylpyridin-2-yl)amino]butanoylamino]acetyl]amino]propanoic acid Chemical compound CC1=CC=NC(NCCCC(=O)NCC(=O)NC(CC(O)=O)C=2C=CC(=CC=2)C=2C=CC(F)=CC=2)=C1 OGLARCXKVCFXAV-UHFFFAOYSA-N 0.000 description 1
• LSLNTGFIKURENG-UHFFFAOYSA-N 3-[4-(4-fluorophenyl)phenyl]-3-[[2-[4-[(4-methylpyridin-2-yl)amino]butanoylamino]acetyl]amino]propanoic acid;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.CC1=CC=NC(NCCCC(=O)NCC(=O)NC(CC(O)=O)C=2C=CC(=CC=2)C=2C=CC(F)=CC=2)=C1 LSLNTGFIKURENG-UHFFFAOYSA-N 0.000 description 1
• YRIQFRWJKGMKHX-UHFFFAOYSA-N 3-[4-(4-fluorophenyl)phenyl]-3-[[2-[5-(pyridin-2-ylamino)pentanoylamino]acetyl]amino]propanoic acid Chemical compound C=1C=C(C=2C=CC(F)=CC=2)C=CC=1C(CC(=O)O)NC(=O)CNC(=O)CCCCNC1=CC=CC=N1 YRIQFRWJKGMKHX-UHFFFAOYSA-N 0.000 description 1
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• KQYOIXGOGPGCQW-UHFFFAOYSA-N methyl 3-(2-nitrophenyl)-3-[[2-[5-(pyridin-2-ylamino)pentanoylamino]acetyl]amino]propanoate Chemical compound C=1C=CC=C([N+]([O-])=O)C=1C(CC(=O)OC)NC(=O)CNC(=O)CCCCNC1=CC=CC=N1 KQYOIXGOGPGCQW-UHFFFAOYSA-N 0.000 description 1
• ZIQLUVCCEZHTQC-UHFFFAOYSA-N methyl 3-(3-hydroxy-4-phenylphenyl)-3-[[2-[4-(pyridin-2-ylamino)butanoylamino]acetyl]amino]propanoate Chemical compound C=1C=C(C=2C=CC=CC=2)C(O)=CC=1C(CC(=O)OC)NC(=O)CNC(=O)CCCNC1=CC=CC=N1 ZIQLUVCCEZHTQC-UHFFFAOYSA-N 0.000 description 1
• FXVVWDUNHSBNHJ-UHFFFAOYSA-N methyl 3-(3-hydroxy-4-phenylphenyl)-3-[[2-[4-[(4-methylpyridin-2-yl)amino]butanoylamino]acetyl]amino]propanoate Chemical compound C=1C=C(C=2C=CC=CC=2)C(O)=CC=1C(CC(=O)OC)NC(=O)CNC(=O)CCCNC1=CC(C)=CC=N1 FXVVWDUNHSBNHJ-UHFFFAOYSA-N 0.000 description 1
• LVWOWCDRGMZOOH-UHFFFAOYSA-N methyl 3-(3-nitrophenyl)-3-[[2-[4-(pyridin-2-ylamino)butanoylamino]acetyl]amino]propanoate Chemical compound C=1C=CC([N+]([O-])=O)=CC=1C(CC(=O)OC)NC(=O)CNC(=O)CCCNC1=CC=CC=N1 LVWOWCDRGMZOOH-UHFFFAOYSA-N 0.000 description 1
• KSWXVLCEHKRUBR-UHFFFAOYSA-N methyl 3-(3-nitrophenyl)-3-[[2-[5-(pyridin-2-ylamino)pentanoylamino]acetyl]amino]propanoate Chemical compound C=1C=CC([N+]([O-])=O)=CC=1C(CC(=O)OC)NC(=O)CNC(=O)CCCCNC1=CC=CC=N1 KSWXVLCEHKRUBR-UHFFFAOYSA-N 0.000 description 1
• UIPNSRHYIGQRHS-UHFFFAOYSA-N methyl 3-(4-chloro-3-nitrophenyl)-3-[[2-[4-[(4-methylpyridin-2-yl)amino]butanoylamino]acetyl]amino]propanoate Chemical compound C=1C=C(Cl)C([N+]([O-])=O)=CC=1C(CC(=O)OC)NC(=O)CNC(=O)CCCNC1=CC(C)=CC=N1 UIPNSRHYIGQRHS-UHFFFAOYSA-N 0.000 description 1
• SNYILSLRLOOQJJ-UHFFFAOYSA-N methyl 3-(4-chloro-3-nitrophenyl)-3-[[2-[5-(pyridin-2-ylamino)pentanoylamino]acetyl]amino]propanoate Chemical compound C=1C=C(Cl)C([N+]([O-])=O)=CC=1C(CC(=O)OC)NC(=O)CNC(=O)CCCCNC1=CC=CC=N1 SNYILSLRLOOQJJ-UHFFFAOYSA-N 0.000 description 1
• XQRDSILMFXKKNT-UHFFFAOYSA-N methyl 3-(4-chloro-3-nitrophenyl)-3-[[2-[5-[(4-methylpyridin-2-yl)amino]pentanoylamino]acetyl]amino]propanoate Chemical compound C=1C=C(Cl)C([N+]([O-])=O)=CC=1C(CC(=O)OC)NC(=O)CNC(=O)CCCCNC1=CC(C)=CC=N1 XQRDSILMFXKKNT-UHFFFAOYSA-N 0.000 description 1
• JEPGBGPNMQSYJP-UHFFFAOYSA-N methyl 3-(4-chloro-3-nitrophenyl)-3-[[2-[6-[(4-methylpyridin-2-yl)amino]hexanoylamino]acetyl]amino]propanoate Chemical compound C=1C=C(Cl)C([N+]([O-])=O)=CC=1C(CC(=O)OC)NC(=O)CNC(=O)CCCCCNC1=CC(C)=CC=N1 JEPGBGPNMQSYJP-UHFFFAOYSA-N 0.000 description 1
• OOYSQSMPQTUTIZ-UHFFFAOYSA-N methyl 3-(4-methyl-3-nitrophenyl)-3-[[2-[4-(pyridin-2-ylamino)butanoylamino]acetyl]amino]propanoate Chemical compound C=1C=C(C)C([N+]([O-])=O)=CC=1C(CC(=O)OC)NC(=O)CNC(=O)CCCNC1=CC=CC=N1 OOYSQSMPQTUTIZ-UHFFFAOYSA-N 0.000 description 1
• WHBCNNHVVDCHQZ-UHFFFAOYSA-N methyl 3-(4-methyl-3-nitrophenyl)-3-[[2-[4-(pyrimidin-2-ylamino)butanoylamino]acetyl]amino]propanoate Chemical compound C=1C=C(C)C([N+]([O-])=O)=CC=1C(CC(=O)OC)NC(=O)CNC(=O)CCCNC1=NC=CC=N1 WHBCNNHVVDCHQZ-UHFFFAOYSA-N 0.000 description 1
• XLSHNOANTAMNLG-UHFFFAOYSA-N methyl 3-(4-methyl-3-nitrophenyl)-3-[[2-[4-[(4-methylpyridin-2-yl)amino]butanoylamino]acetyl]amino]propanoate Chemical compound C=1C=C(C)C([N+]([O-])=O)=CC=1C(CC(=O)OC)NC(=O)CNC(=O)CCCNC1=CC(C)=CC=N1 XLSHNOANTAMNLG-UHFFFAOYSA-N 0.000 description 1
• HIEIVXFDFAHHIQ-UHFFFAOYSA-N methyl 3-(4-methyl-3-nitrophenyl)-3-[[2-[5-(pyridin-2-ylamino)pentanoylamino]acetyl]amino]propanoate Chemical compound C=1C=C(C)C([N+]([O-])=O)=CC=1C(CC(=O)OC)NC(=O)CNC(=O)CCCCNC1=CC=CC=N1 HIEIVXFDFAHHIQ-UHFFFAOYSA-N 0.000 description 1
• JBUWDJCNZJWZQN-UHFFFAOYSA-N methyl 3-(4-methyl-3-nitrophenyl)-3-[[2-[5-[(6-methylpyridin-2-yl)amino]pentanoylamino]acetyl]amino]propanoate Chemical compound C=1C=C(C)C([N+]([O-])=O)=CC=1C(CC(=O)OC)NC(=O)CNC(=O)CCCCNC1=CC=CC(C)=N1 JBUWDJCNZJWZQN-UHFFFAOYSA-N 0.000 description 1
• ACMCNOGMGHJTQF-UHFFFAOYSA-N methyl 3-(4-methyl-3-nitrophenyl)-3-[[2-[6-[(4-methylpyridin-2-yl)amino]hexanoylamino]acetyl]amino]propanoate Chemical compound C=1C=C(C)C([N+]([O-])=O)=CC=1C(CC(=O)OC)NC(=O)CNC(=O)CCCCCNC1=CC(C)=CC=N1 ACMCNOGMGHJTQF-UHFFFAOYSA-N 0.000 description 1
• ROSQUNOENZRPFX-UHFFFAOYSA-N methyl 3-(4-naphthalen-1-ylphenyl)-3-[[2-[4-(pyridin-2-ylamino)butanoylamino]acetyl]amino]propanoate Chemical compound C=1C=C(C=2C3=CC=CC=C3C=CC=2)C=CC=1C(CC(=O)OC)NC(=O)CNC(=O)CCCNC1=CC=CC=N1 ROSQUNOENZRPFX-UHFFFAOYSA-N 0.000 description 1
• UADFHEXIXAYOKD-UHFFFAOYSA-N methyl 3-(4-naphthalen-1-ylphenyl)-3-[[2-[5-(pyridin-2-ylamino)pentanoylamino]acetyl]amino]propanoate Chemical compound C=1C=C(C=2C3=CC=CC=C3C=CC=2)C=CC=1C(CC(=O)OC)NC(=O)CNC(=O)CCCCNC1=CC=CC=N1 UADFHEXIXAYOKD-UHFFFAOYSA-N 0.000 description 1
• BDSLAEMOKMXMDT-UHFFFAOYSA-N methyl 3-(4-naphthalen-2-ylphenyl)-3-[[2-[5-(pyridin-2-ylamino)pentanoylamino]acetyl]amino]propanoate Chemical compound C=1C=C(C=2C=C3C=CC=CC3=CC=2)C=CC=1C(CC(=O)OC)NC(=O)CNC(=O)CCCCNC1=CC=CC=N1 BDSLAEMOKMXMDT-UHFFFAOYSA-N 0.000 description 1
• GNZVCOIVVWGANG-UHFFFAOYSA-N methyl 3-(4-phenylphenyl)-3-[[2-[4-(pyridin-2-ylamino)butanoylamino]acetyl]amino]propanoate Chemical compound C=1C=C(C=2C=CC=CC=2)C=CC=1C(CC(=O)OC)NC(=O)CNC(=O)CCCNC1=CC=CC=N1 GNZVCOIVVWGANG-UHFFFAOYSA-N 0.000 description 1
• GTVRBOYQRBAAEE-UHFFFAOYSA-N methyl 3-(4-phenylphenyl)-3-[[2-[4-(pyrimidin-2-ylamino)butanoylamino]acetyl]amino]propanoate Chemical compound C=1C=C(C=2C=CC=CC=2)C=CC=1C(CC(=O)OC)NC(=O)CNC(=O)CCCNC1=NC=CC=N1 GTVRBOYQRBAAEE-UHFFFAOYSA-N 0.000 description 1
• YQSJYWFGXRQIBT-UHFFFAOYSA-N methyl 3-(4-phenylphenyl)-3-[[2-[5-(pyridin-2-ylamino)pentanoylamino]acetyl]amino]propanoate Chemical compound C=1C=C(C=2C=CC=CC=2)C=CC=1C(CC(=O)OC)NC(=O)CNC(=O)CCCCNC1=CC=CC=N1 YQSJYWFGXRQIBT-UHFFFAOYSA-N 0.000 description 1
• UWKXOKZNYYVCPK-UHFFFAOYSA-N methyl 3-(4-phenylphenyl)-3-[[2-[5-(pyridin-2-ylamino)pentanoylamino]acetyl]amino]propanoate;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.C=1C=C(C=2C=CC=CC=2)C=CC=1C(CC(=O)OC)NC(=O)CNC(=O)CCCCNC1=CC=CC=N1 UWKXOKZNYYVCPK-UHFFFAOYSA-N 0.000 description 1
• WOMQGDZKCHVMBP-UHFFFAOYSA-N methyl 3-(4-phenylphenyl)-3-[[2-[5-(pyrimidin-2-ylamino)pentanoylamino]acetyl]amino]propanoate Chemical compound C=1C=C(C=2C=CC=CC=2)C=CC=1C(CC(=O)OC)NC(=O)CNC(=O)CCCCNC1=NC=CC=N1 WOMQGDZKCHVMBP-UHFFFAOYSA-N 0.000 description 1
• IOONBLJHGZHSEW-UHFFFAOYSA-N methyl 3-[(2-aminoacetyl)amino]-3-(2-hydroxy-3-nitrophenyl)propanoate;hydrochloride Chemical compound Cl.COC(=O)CC(NC(=O)CN)C1=CC=CC([N+]([O-])=O)=C1O IOONBLJHGZHSEW-UHFFFAOYSA-N 0.000 description 1
• PSPMXXGHNOFUKD-UHFFFAOYSA-N methyl 3-[(2-aminoacetyl)amino]-3-(2-hydroxy-4-naphthalen-1-ylphenyl)propanoate;hydrochloride Chemical compound Cl.C1=C(O)C(C(NC(=O)CN)CC(=O)OC)=CC=C1C1=CC=CC2=CC=CC=C12 PSPMXXGHNOFUKD-UHFFFAOYSA-N 0.000 description 1
• MDGHMASNIIFSKM-UHFFFAOYSA-N methyl 3-[(2-aminoacetyl)amino]-3-(4-nitrophenyl)propanoate;hydrochloride Chemical compound Cl.COC(=O)CC(NC(=O)CN)C1=CC=C([N+]([O-])=O)C=C1 MDGHMASNIIFSKM-UHFFFAOYSA-N 0.000 description 1
• RGOKMLMUUWVSPC-UHFFFAOYSA-N methyl 3-[(2-aminoacetyl)amino]-3-(5-bromo-2-hydroxy-3-nitrophenyl)propanoate;hydrochloride Chemical compound Cl.COC(=O)CC(NC(=O)CN)C1=CC(Br)=CC([N+]([O-])=O)=C1O RGOKMLMUUWVSPC-UHFFFAOYSA-N 0.000 description 1
• KRWSWDRZHUJXRD-UHFFFAOYSA-N methyl 3-[(2-aminoacetyl)amino]-3-[4-(2-fluorophenyl)phenyl]propanoate;hydrochloride Chemical compound Cl.C1=CC(C(NC(=O)CN)CC(=O)OC)=CC=C1C1=CC=CC=C1F KRWSWDRZHUJXRD-UHFFFAOYSA-N 0.000 description 1
• QQYISIZLLXWAIX-UHFFFAOYSA-N methyl 3-[(2-aminoacetyl)amino]-3-[4-(3-chloro-4-fluorophenyl)phenyl]propanoate;hydrochloride Chemical compound Cl.C1=CC(C(NC(=O)CN)CC(=O)OC)=CC=C1C1=CC=C(F)C(Cl)=C1 QQYISIZLLXWAIX-UHFFFAOYSA-N 0.000 description 1
• BSPRHGLELYGBRE-UHFFFAOYSA-N methyl 3-[(2-aminoacetyl)amino]-3-[4-(3-chlorophenyl)phenyl]propanoate;hydrochloride Chemical compound Cl.C1=CC(C(NC(=O)CN)CC(=O)OC)=CC=C1C1=CC=CC(Cl)=C1 BSPRHGLELYGBRE-UHFFFAOYSA-N 0.000 description 1
• KRVFPJFETZIUJC-UHFFFAOYSA-N methyl 3-[(2-aminoacetyl)amino]-3-[4-(3-fluorophenyl)phenyl]propanoate;hydrochloride Chemical compound Cl.C1=CC(C(NC(=O)CN)CC(=O)OC)=CC=C1C1=CC=CC(F)=C1 KRVFPJFETZIUJC-UHFFFAOYSA-N 0.000 description 1
• QEQMCYAASDZNBW-UHFFFAOYSA-N methyl 3-[(2-aminoacetyl)amino]-3-[4-(4-chlorophenyl)phenyl]propanoate;hydrochloride Chemical compound Cl.C1=CC(C(NC(=O)CN)CC(=O)OC)=CC=C1C1=CC=C(Cl)C=C1 QEQMCYAASDZNBW-UHFFFAOYSA-N 0.000 description 1
• UFYCEVSWGZUJEQ-UHFFFAOYSA-N methyl 3-[(2-aminoacetyl)amino]-3-[4-(4-fluoro-2-hydroxyphenyl)phenyl]propanoate;hydrochloride Chemical compound Cl.C1=CC(C(NC(=O)CN)CC(=O)OC)=CC=C1C1=CC=C(F)C=C1O UFYCEVSWGZUJEQ-UHFFFAOYSA-N 0.000 description 1
• JNUQMZPZAAFQQV-UHFFFAOYSA-N methyl 3-[(2-aminoacetyl)amino]-3-[4-(4-fluorophenyl)-3-hydroxyphenyl]propanoate;hydrochloride Chemical compound Cl.OC1=CC(C(NC(=O)CN)CC(=O)OC)=CC=C1C1=CC=C(F)C=C1 JNUQMZPZAAFQQV-UHFFFAOYSA-N 0.000 description 1
• VSQNCPVLVXBADD-UHFFFAOYSA-N methyl 3-[(2-aminoacetyl)amino]-3-[4-(4-methylphenyl)phenyl]propanoate hydrochloride Chemical compound Cl.COC(=O)CC(NC(=O)CN)c1ccc(cc1)-c1ccc(C)cc1 VSQNCPVLVXBADD-UHFFFAOYSA-N 0.000 description 1
• JZSISVRVWMGYMM-UHFFFAOYSA-N methyl 3-[(2-aminoacetyl)amino]-3-[4-(trifluoromethoxy)phenyl]propanoate;hydrochloride Chemical compound Cl.COC(=O)CC(NC(=O)CN)C1=CC=C(OC(F)(F)F)C=C1 JZSISVRVWMGYMM-UHFFFAOYSA-N 0.000 description 1
• ZSRYVQCSTDWUJQ-UHFFFAOYSA-N methyl 3-[(2-aminoacetyl)amino]-3-[4-[4-(trifluoromethyl)phenyl]phenyl]propanoate hydrochloride Chemical compound Cl.COC(CC(C1=CC=C(C=C1)C1=CC=C(C=C1)C(F)(F)F)NC(CN)=O)=O ZSRYVQCSTDWUJQ-UHFFFAOYSA-N 0.000 description 1
• WXIWUPBVKGEPQB-UHFFFAOYSA-N methyl 3-[3-(4-fluorophenyl)phenyl]-3-[[2-[4-(pyridin-2-ylamino)butanoylamino]acetyl]amino]propanoate Chemical compound C=1C=CC(C=2C=CC(F)=CC=2)=CC=1C(CC(=O)OC)NC(=O)CNC(=O)CCCNC1=CC=CC=N1 WXIWUPBVKGEPQB-UHFFFAOYSA-N 0.000 description 1
• BWZVONXABQFFLI-UHFFFAOYSA-N methyl 3-[3-(4-fluorophenyl)phenyl]-3-[[2-[4-[(4-methylpyridin-2-yl)amino]butanoylamino]acetyl]amino]propanoate Chemical compound C=1C=CC(C=2C=CC(F)=CC=2)=CC=1C(CC(=O)OC)NC(=O)CNC(=O)CCCNC1=CC(C)=CC=N1 BWZVONXABQFFLI-UHFFFAOYSA-N 0.000 description 1
• MVQPGSCJMJRRNM-UHFFFAOYSA-N methyl 3-[3-(4-fluorophenyl)phenyl]-3-[[2-[5-(pyridin-2-ylamino)pentanoylamino]acetyl]amino]propanoate Chemical compound C=1C=CC(C=2C=CC(F)=CC=2)=CC=1C(CC(=O)OC)NC(=O)CNC(=O)CCCCNC1=CC=CC=N1 MVQPGSCJMJRRNM-UHFFFAOYSA-N 0.000 description 1
• UVYWDWSZZDPESI-UHFFFAOYSA-N methyl 3-[4-(3-chloro-4-fluorophenyl)phenyl]-3-[[2-[5-(pyridin-2-ylamino)pentanoylamino]acetyl]amino]propanoate Chemical compound C=1C=C(C=2C=C(Cl)C(F)=CC=2)C=CC=1C(CC(=O)OC)NC(=O)CNC(=O)CCCCNC1=CC=CC=N1 UVYWDWSZZDPESI-UHFFFAOYSA-N 0.000 description 1
• JYMONYWNOLJBPE-UHFFFAOYSA-N methyl 3-[4-(3-chlorophenyl)phenyl]-3-[[2-[5-(pyridin-2-ylamino)pentanoylamino]acetyl]amino]propanoate Chemical compound C=1C=C(C=2C=C(Cl)C=CC=2)C=CC=1C(CC(=O)OC)NC(=O)CNC(=O)CCCCNC1=CC=CC=N1 JYMONYWNOLJBPE-UHFFFAOYSA-N 0.000 description 1
• BCXZBAPVTFOGQJ-UHFFFAOYSA-N methyl 3-[4-(3-fluorophenyl)phenyl]-3-[[2-[5-(pyridin-2-ylamino)pentanoylamino]acetyl]amino]propanoate Chemical compound C=1C=C(C=2C=C(F)C=CC=2)C=CC=1C(CC(=O)OC)NC(=O)CNC(=O)CCCCNC1=CC=CC=N1 BCXZBAPVTFOGQJ-UHFFFAOYSA-N 0.000 description 1
• XIQLXKDRSLEYMP-UHFFFAOYSA-N methyl 3-[4-(4-chlorophenyl)phenyl]-3-[[2-[5-(pyridin-2-ylamino)pentanoylamino]acetyl]amino]propanoate Chemical compound C=1C=C(C=2C=CC(Cl)=CC=2)C=CC=1C(CC(=O)OC)NC(=O)CNC(=O)CCCCNC1=CC=CC=N1 XIQLXKDRSLEYMP-UHFFFAOYSA-N 0.000 description 1
• CRUPZBUWSWATIJ-UHFFFAOYSA-N methyl 3-[4-(4-fluoro-2-hydroxyphenyl)phenyl]-3-[[2-[4-[(4-methylpyridin-2-yl)amino]butanoylamino]acetyl]amino]propanoate Chemical compound C=1C=C(C=2C(=CC(F)=CC=2)O)C=CC=1C(CC(=O)OC)NC(=O)CNC(=O)CCCNC1=CC(C)=CC=N1 CRUPZBUWSWATIJ-UHFFFAOYSA-N 0.000 description 1
• UHMMVOALUHUWIA-UHFFFAOYSA-N methyl 3-[4-(4-fluorophenyl)-3-hydroxyphenyl]-3-[[2-[5-(pyridin-2-ylamino)pentanoylamino]acetyl]amino]propanoate Chemical compound C=1C=C(C=2C=CC(F)=CC=2)C(O)=CC=1C(CC(=O)OC)NC(=O)CNC(=O)CCCCNC1=CC=CC=N1 UHMMVOALUHUWIA-UHFFFAOYSA-N 0.000 description 1
• HUGCMKBMMKOJTQ-UHFFFAOYSA-N methyl 3-[4-(4-fluorophenyl)phenyl]-3-[[2-[4-[(4-methylpyridin-2-yl)amino]butanoylamino]acetyl]amino]propanoate Chemical compound C=1C=C(C=2C=CC(F)=CC=2)C=CC=1C(CC(=O)OC)NC(=O)CNC(=O)CCCNC1=CC(C)=CC=N1 HUGCMKBMMKOJTQ-UHFFFAOYSA-N 0.000 description 1
• SLKJZLBLUDYNEZ-UHFFFAOYSA-N methyl 3-[4-(4-fluorophenyl)phenyl]-3-[[2-[5-(pyridin-2-ylamino)pentanoylamino]acetyl]amino]propanoate Chemical compound C=1C=C(C=2C=CC(F)=CC=2)C=CC=1C(CC(=O)OC)NC(=O)CNC(=O)CCCCNC1=CC=CC=N1 SLKJZLBLUDYNEZ-UHFFFAOYSA-N 0.000 description 1
• NIZNOFPBRRNJTF-UHFFFAOYSA-N methyl 3-[4-(4-methylphenyl)phenyl]-3-[[2-[5-(pyridin-2-ylamino)pentanoylamino]acetyl]amino]propanoate Chemical compound C=1C=C(C=2C=CC(C)=CC=2)C=CC=1C(CC(=O)OC)NC(=O)CNC(=O)CCCCNC1=CC=CC=N1 NIZNOFPBRRNJTF-UHFFFAOYSA-N 0.000 description 1
• UAFSMEDVWPBTGI-UHFFFAOYSA-N methyl 3-[[2-[4-[(4-methylpyridin-2-yl)amino]butanoylamino]acetyl]amino]-3-(3-nitrophenyl)propanoate Chemical compound C=1C=CC([N+]([O-])=O)=CC=1C(CC(=O)OC)NC(=O)CNC(=O)CCCNC1=CC(C)=CC=N1 UAFSMEDVWPBTGI-UHFFFAOYSA-N 0.000 description 1
• IRUHDPNLTHRFJP-UHFFFAOYSA-N methyl 3-[[2-[4-[(4-methylpyridin-2-yl)amino]butanoylamino]acetyl]amino]-3-(3-nitrophenyl)propanoate;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.C=1C=CC([N+]([O-])=O)=CC=1C(CC(=O)OC)NC(=O)CNC(=O)CCCNC1=CC(C)=CC=N1 IRUHDPNLTHRFJP-UHFFFAOYSA-N 0.000 description 1
• ZJVSUOPNDJMROE-UHFFFAOYSA-N methyl 3-[[2-[4-[(4-methylpyridin-2-yl)amino]butanoylamino]acetyl]amino]-3-(4-naphthalen-1-ylphenyl)propanoate Chemical compound C=1C=C(C=2C3=CC=CC=C3C=CC=2)C=CC=1C(CC(=O)OC)NC(=O)CNC(=O)CCCNC1=CC(C)=CC=N1 ZJVSUOPNDJMROE-UHFFFAOYSA-N 0.000 description 1
• FVRSXDVBMBAUEL-UHFFFAOYSA-N methyl 3-[[2-[4-[(4-methylpyridin-2-yl)amino]butanoylamino]acetyl]amino]-3-(4-naphthalen-2-ylphenyl)propanoate Chemical compound C=1C=C(C=2C=C3C=CC=CC3=CC=2)C=CC=1C(CC(=O)OC)NC(=O)CNC(=O)CCCNC1=CC(C)=CC=N1 FVRSXDVBMBAUEL-UHFFFAOYSA-N 0.000 description 1
• MHHKSYYYWWFSFP-UHFFFAOYSA-N methyl 3-[[2-[4-[(4-methylpyridin-2-yl)amino]butanoylamino]acetyl]amino]-3-(4-nitrophenyl)propanoate Chemical compound C=1C=C([N+]([O-])=O)C=CC=1C(CC(=O)OC)NC(=O)CNC(=O)CCCNC1=CC(C)=CC=N1 MHHKSYYYWWFSFP-UHFFFAOYSA-N 0.000 description 1
• CVOUAUIACAZGNM-UHFFFAOYSA-N methyl 3-[[2-[4-[(4-methylpyridin-2-yl)amino]butanoylamino]acetyl]amino]-3-(4-phenylphenyl)propanoate Chemical compound C=1C=C(C=2C=CC=CC=2)C=CC=1C(CC(=O)OC)NC(=O)CNC(=O)CCCNC1=CC(C)=CC=N1 CVOUAUIACAZGNM-UHFFFAOYSA-N 0.000 description 1
• QGSNSASDNIDAHV-UHFFFAOYSA-N methyl 3-[[2-[4-[(4-methylpyridin-2-yl)amino]butanoylamino]acetyl]amino]-3-[3-(trifluoromethoxy)phenyl]propanoate Chemical compound C=1C=CC(OC(F)(F)F)=CC=1C(CC(=O)OC)NC(=O)CNC(=O)CCCNC1=CC(C)=CC=N1 QGSNSASDNIDAHV-UHFFFAOYSA-N 0.000 description 1
• DNKXIHDCFHQJIP-UHFFFAOYSA-N methyl 3-[[2-[5-(pyridin-2-ylamino)pentanoylamino]acetyl]amino]-3-[4-[4-(trifluoromethyl)phenyl]phenyl]propanoate Chemical compound C=1C=C(C=2C=CC(=CC=2)C(F)(F)F)C=CC=1C(CC(=O)OC)NC(=O)CNC(=O)CCCCNC1=CC=CC=N1 DNKXIHDCFHQJIP-UHFFFAOYSA-N 0.000 description 1
• VHVHIUPUHHFXRW-UHFFFAOYSA-N methyl 3-[[2-[5-[(4-methylpyridin-2-yl)amino]pentanoylamino]acetyl]amino]-3-(2-nitrophenyl)propanoate Chemical compound C=1C=CC=C([N+]([O-])=O)C=1C(CC(=O)OC)NC(=O)CNC(=O)CCCCNC1=CC(C)=CC=N1 VHVHIUPUHHFXRW-UHFFFAOYSA-N 0.000 description 1
• HXNPPMNMLSZLLZ-UHFFFAOYSA-N methyl 3-[[2-[5-[(4-methylpyridin-2-yl)amino]pentanoylamino]acetyl]amino]-3-(3-nitrophenyl)propanoate Chemical compound C=1C=CC([N+]([O-])=O)=CC=1C(CC(=O)OC)NC(=O)CNC(=O)CCCCNC1=CC(C)=CC=N1 HXNPPMNMLSZLLZ-UHFFFAOYSA-N 0.000 description 1
• PNZGDGYVUFAMIG-UHFFFAOYSA-N methyl 3-[[2-[5-[(4-methylpyridin-2-yl)amino]pentanoylamino]acetyl]amino]-3-(4-naphthalen-2-ylphenyl)propanoate Chemical compound C=1C=C(C=2C=C3C=CC=CC3=CC=2)C=CC=1C(CC(=O)OC)NC(=O)CNC(=O)CCCCNC1=CC(C)=CC=N1 PNZGDGYVUFAMIG-UHFFFAOYSA-N 0.000 description 1
• CGXMQXKKDBRUMR-UHFFFAOYSA-N methyl 3-[[2-[5-[(4-methylpyridin-2-yl)amino]pentanoylamino]acetyl]amino]-3-(4-phenylphenyl)propanoate Chemical compound C=1C=C(C=2C=CC=CC=2)C=CC=1C(CC(=O)OC)NC(=O)CNC(=O)CCCCNC1=CC(C)=CC=N1 CGXMQXKKDBRUMR-UHFFFAOYSA-N 0.000 description 1
• KPHTWQRIPDANPN-UHFFFAOYSA-N methyl 3-[[2-[5-[(4-methylpyridin-2-yl)amino]pentanoylamino]acetyl]amino]-3-(4-phenylphenyl)propanoate;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.C=1C=C(C=2C=CC=CC=2)C=CC=1C(CC(=O)OC)NC(=O)CNC(=O)CCCCNC1=CC(C)=CC=N1 KPHTWQRIPDANPN-UHFFFAOYSA-N 0.000 description 1
• LNIMVMBWHRKFIC-UHFFFAOYSA-N methyl 3-[[2-[5-[(4-methylpyridin-2-yl)amino]pentanoylamino]acetyl]amino]-3-[4-(trifluoromethoxy)phenyl]propanoate Chemical compound C=1C=C(OC(F)(F)F)C=CC=1C(CC(=O)OC)NC(=O)CNC(=O)CCCCNC1=CC(C)=CC=N1 LNIMVMBWHRKFIC-UHFFFAOYSA-N 0.000 description 1
• KCYHNNMTMGSSIA-UHFFFAOYSA-N methyl 3-[[2-[6-[(4-methylpyridin-2-yl)amino]hexanoylamino]acetyl]amino]-3-(3-nitrophenyl)propanoate Chemical compound C=1C=CC([N+]([O-])=O)=CC=1C(CC(=O)OC)NC(=O)CNC(=O)CCCCCNC1=CC(C)=CC=N1 KCYHNNMTMGSSIA-UHFFFAOYSA-N 0.000 description 1
• SUPMFMMJRXYOFI-UHFFFAOYSA-N methyl 3-[[2-[7-[(4-methylpyridin-2-yl)amino]heptanoylamino]acetyl]amino]-3-(3-nitrophenyl)propanoate Chemical compound C=1C=CC([N+]([O-])=O)=CC=1C(CC(=O)OC)NC(=O)CNC(=O)CCCCCCNC1=CC(C)=CC=N1 SUPMFMMJRXYOFI-UHFFFAOYSA-N 0.000 description 1
• WCYSVIMUYDWOPM-UHFFFAOYSA-N methyl 3-amino-3-(3-nitrophenyl)propanoate Chemical compound COC(=O)CC(N)C1=CC=CC([N+]([O-])=O)=C1 WCYSVIMUYDWOPM-UHFFFAOYSA-N 0.000 description 1
• KQSSATDQUYCRGS-UHFFFAOYSA-N methyl glycinate Chemical compound COC(=O)CN KQSSATDQUYCRGS-UHFFFAOYSA-N 0.000 description 1
• OJVSEHLMRCLAFY-UHFFFAOYSA-N methyl propanoate;hydrochloride Chemical compound Cl.CCC(=O)OC OJVSEHLMRCLAFY-UHFFFAOYSA-N 0.000 description 1
• 150000007522 mineralic acids Chemical class 0.000 description 1
• 150000004682 monohydrates Chemical class 0.000 description 1
• 229910000403 monosodium phosphate Inorganic materials 0.000 description 1
• 235000019799 monosodium phosphate Nutrition 0.000 description 1
• 150000004250 monothioacetals Chemical class 0.000 description 1
• 201000006417 multiple sclerosis Diseases 0.000 description 1
• 208000001491 myopia Diseases 0.000 description 1
• 230000004379 myopia Effects 0.000 description 1
• LNOPIUAQISRISI-UHFFFAOYSA-N n'-hydroxy-2-propan-2-ylsulfonylethanimidamide Chemical compound CC(C)S(=O)(=O)CC(N)=NO LNOPIUAQISRISI-UHFFFAOYSA-N 0.000 description 1
• WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 description 1
• 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
• 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
• 125000001971 neopentyl group Chemical group [H]C([*])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
• 239000011664 nicotinic acid Substances 0.000 description 1
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• AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
• JXKPEJDQGNYQSM-UHFFFAOYSA-M sodium propionate Chemical compound [Na+].CCC([O-])=O JXKPEJDQGNYQSM-UHFFFAOYSA-M 0.000 description 1
• 159000000000 sodium salts Chemical class 0.000 description 1
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• ZGHKOLNGLRJTFT-UHFFFAOYSA-M sodium;3-(2-hydroxy-3-nitrophenyl)-3-[[2-[4-[(4-methylpyridin-2-yl)amino]butanoylamino]acetyl]amino]propanoate Chemical compound [Na+].CC1=CC=NC(NCCCC(=O)NCC(=O)NC(CC([O-])=O)C=2C(=C(C=CC=2)[N+]([O-])=O)O)=C1 ZGHKOLNGLRJTFT-UHFFFAOYSA-M 0.000 description 1
• ZTFAAVJKGVXFBY-UHFFFAOYSA-M sodium;3-(2-hydroxy-3-phenylphenyl)-3-[[2-[4-[(4-methylpyridin-2-yl)amino]butanoylamino]acetyl]amino]propanoate Chemical compound [Na+].CC1=CC=NC(NCCCC(=O)NCC(=O)NC(CC([O-])=O)C=2C(=C(C=CC=2)C=2C=CC=CC=2)O)=C1 ZTFAAVJKGVXFBY-UHFFFAOYSA-M 0.000 description 1
• SHFZAYIXLDBLMG-UHFFFAOYSA-M sodium;3-(2-hydroxy-4-naphthalen-1-ylphenyl)-3-[[2-[4-(pyridin-2-ylamino)butanoylamino]acetyl]amino]propanoate Chemical compound [Na+].OC1=CC(C=2C3=CC=CC=C3C=CC=2)=CC=C1C(CC([O-])=O)NC(=O)CNC(=O)CCCNC1=CC=CC=N1 SHFZAYIXLDBLMG-UHFFFAOYSA-M 0.000 description 1
• NTIBRWDDIWXKJW-UHFFFAOYSA-M sodium;3-(2-hydroxy-4-naphthalen-1-ylphenyl)-3-[[2-[4-[(4-methylpyridin-2-yl)amino]butanoylamino]acetyl]amino]propanoate Chemical compound [Na+].CC1=CC=NC(NCCCC(=O)NCC(=O)NC(CC([O-])=O)C=2C(=CC(=CC=2)C=2C3=CC=CC=C3C=CC=2)O)=C1 NTIBRWDDIWXKJW-UHFFFAOYSA-M 0.000 description 1
• AHDLDKXLMAPRTE-UHFFFAOYSA-M sodium;3-(2-nitrophenyl)-3-[[2-[4-(pyridin-2-ylamino)butanoylamino]acetyl]amino]propanoate Chemical compound [Na+].C=1C=CC=C([N+]([O-])=O)C=1C(CC(=O)[O-])NC(=O)CNC(=O)CCCNC1=CC=CC=N1 AHDLDKXLMAPRTE-UHFFFAOYSA-M 0.000 description 1
• FOVMTAXYJJZDDT-UHFFFAOYSA-M sodium;3-(2-nitrophenyl)-3-[[2-[5-(pyridin-2-ylamino)pentanoylamino]acetyl]amino]propanoate Chemical compound [Na+].C=1C=CC=C([N+]([O-])=O)C=1C(CC(=O)[O-])NC(=O)CNC(=O)CCCCNC1=CC=CC=N1 FOVMTAXYJJZDDT-UHFFFAOYSA-M 0.000 description 1
• GGQUTOOFLHJDKS-UHFFFAOYSA-M sodium;3-(3-hydroxy-4-phenylphenyl)-3-[[2-[4-(pyridin-2-ylamino)butanoylamino]acetyl]amino]propanoate Chemical compound [Na+].OC1=CC(C(CC([O-])=O)NC(=O)CNC(=O)CCCNC=2N=CC=CC=2)=CC=C1C1=CC=CC=C1 GGQUTOOFLHJDKS-UHFFFAOYSA-M 0.000 description 1
• KCPJSFFBPXUJMN-UHFFFAOYSA-M sodium;3-(3-nitrophenyl)-3-[[2-[4-(pyridin-2-ylamino)butanoylamino]acetyl]amino]propanoate Chemical compound [Na+].C=1C=CC([N+]([O-])=O)=CC=1C(CC(=O)[O-])NC(=O)CNC(=O)CCCNC1=CC=CC=N1 KCPJSFFBPXUJMN-UHFFFAOYSA-M 0.000 description 1
• JSSXHDDOLJGSCO-UHFFFAOYSA-M sodium;3-(4-chloro-3-nitrophenyl)-3-[[2-[4-[(4-methylpyridin-2-yl)amino]butanoylamino]acetyl]amino]propanoate Chemical compound [Na+].CC1=CC=NC(NCCCC(=O)NCC(=O)NC(CC([O-])=O)C=2C=C(C(Cl)=CC=2)[N+]([O-])=O)=C1 JSSXHDDOLJGSCO-UHFFFAOYSA-M 0.000 description 1
• GMBUMNNYRIIOAK-UHFFFAOYSA-M sodium;3-(4-chloro-3-nitrophenyl)-3-[[2-[5-[(4-methylpyridin-2-yl)amino]pentanoylamino]acetyl]amino]propanoate Chemical compound [Na+].CC1=CC=NC(NCCCCC(=O)NCC(=O)NC(CC([O-])=O)C=2C=C(C(Cl)=CC=2)[N+]([O-])=O)=C1 GMBUMNNYRIIOAK-UHFFFAOYSA-M 0.000 description 1
• HULOTBODQASEQM-UHFFFAOYSA-M sodium;3-(4-chloro-3-nitrophenyl)-3-[[2-[6-[(4-methylpyridin-2-yl)amino]hexanoylamino]acetyl]amino]propanoate Chemical compound [Na+].CC1=CC=NC(NCCCCCC(=O)NCC(=O)NC(CC([O-])=O)C=2C=C(C(Cl)=CC=2)[N+]([O-])=O)=C1 HULOTBODQASEQM-UHFFFAOYSA-M 0.000 description 1
• PXXSYQLFQQQLIL-UHFFFAOYSA-M sodium;3-(4-methyl-3-nitrophenyl)-3-[[2-[4-(pyridin-2-ylamino)butanoylamino]acetyl]amino]propanoate Chemical compound [Na+].C1=C([N+]([O-])=O)C(C)=CC=C1C(CC([O-])=O)NC(=O)CNC(=O)CCCNC1=CC=CC=N1 PXXSYQLFQQQLIL-UHFFFAOYSA-M 0.000 description 1
• IKXDQMOQBGUDRG-UHFFFAOYSA-M sodium;3-(4-methyl-3-nitrophenyl)-3-[[2-[4-(pyrimidin-2-ylamino)butanoylamino]acetyl]amino]propanoate Chemical compound [Na+].C1=C([N+]([O-])=O)C(C)=CC=C1C(CC([O-])=O)NC(=O)CNC(=O)CCCNC1=NC=CC=N1 IKXDQMOQBGUDRG-UHFFFAOYSA-M 0.000 description 1
• YRRGDCLETADDSZ-UHFFFAOYSA-M sodium;3-(4-methyl-3-nitrophenyl)-3-[[2-[4-[(4-methylpyridin-2-yl)amino]butanoylamino]acetyl]amino]propanoate Chemical compound [Na+].CC1=CC=NC(NCCCC(=O)NCC(=O)NC(CC([O-])=O)C=2C=C(C(C)=CC=2)[N+]([O-])=O)=C1 YRRGDCLETADDSZ-UHFFFAOYSA-M 0.000 description 1
• OVUBRDFFUVZOEC-UHFFFAOYSA-M sodium;3-(4-methyl-3-nitrophenyl)-3-[[2-[5-(pyridin-2-ylamino)pentanoylamino]acetyl]amino]propanoate Chemical compound [Na+].C1=C([N+]([O-])=O)C(C)=CC=C1C(CC([O-])=O)NC(=O)CNC(=O)CCCCNC1=CC=CC=N1 OVUBRDFFUVZOEC-UHFFFAOYSA-M 0.000 description 1
• GFPPNYUWNWBELX-UHFFFAOYSA-M sodium;3-(4-methyl-3-nitrophenyl)-3-[[2-[5-[(4-methylpyridin-2-yl)amino]pentanoylamino]acetyl]amino]propanoate Chemical compound [Na+].CC1=CC=NC(NCCCCC(=O)NCC(=O)NC(CC([O-])=O)C=2C=C(C(C)=CC=2)[N+]([O-])=O)=C1 GFPPNYUWNWBELX-UHFFFAOYSA-M 0.000 description 1
• NOMUEIYDBJTJQL-UHFFFAOYSA-M sodium;3-(4-methyl-3-nitrophenyl)-3-[[2-[5-[(6-methylpyridin-2-yl)amino]pentanoylamino]acetyl]amino]propanoate Chemical compound [Na+].CC1=CC=CC(NCCCCC(=O)NCC(=O)NC(CC([O-])=O)C=2C=C(C(C)=CC=2)[N+]([O-])=O)=N1 NOMUEIYDBJTJQL-UHFFFAOYSA-M 0.000 description 1
• KTOQHVMKDPAEQZ-UHFFFAOYSA-M sodium;3-(4-methyl-3-nitrophenyl)-3-[[2-[6-[(4-methylpyridin-2-yl)amino]hexanoylamino]acetyl]amino]propanoate Chemical compound [Na+].CC1=CC=NC(NCCCCCC(=O)NCC(=O)NC(CC([O-])=O)C=2C=C(C(C)=CC=2)[N+]([O-])=O)=C1 KTOQHVMKDPAEQZ-UHFFFAOYSA-M 0.000 description 1
• XXMDKMHAEBXWGA-UHFFFAOYSA-M sodium;3-(4-naphthalen-1-ylphenyl)-3-[[2-[4-(pyridin-2-ylamino)butanoylamino]acetyl]amino]propanoate Chemical compound [Na+].C=1C=C(C=2C3=CC=CC=C3C=CC=2)C=CC=1C(CC(=O)[O-])NC(=O)CNC(=O)CCCNC1=CC=CC=N1 XXMDKMHAEBXWGA-UHFFFAOYSA-M 0.000 description 1
• WGVVGVBMWDGHOL-UHFFFAOYSA-M sodium;3-(4-naphthalen-1-ylphenyl)-3-[[2-[5-(pyridin-2-ylamino)pentanoylamino]acetyl]amino]propanoate Chemical compound [Na+].C=1C=C(C=2C3=CC=CC=C3C=CC=2)C=CC=1C(CC(=O)[O-])NC(=O)CNC(=O)CCCCNC1=CC=CC=N1 WGVVGVBMWDGHOL-UHFFFAOYSA-M 0.000 description 1
• ZMNJRCFQQRFGRP-UHFFFAOYSA-M sodium;3-(4-naphthalen-2-ylphenyl)-3-[[2-[5-(pyridin-2-ylamino)pentanoylamino]acetyl]amino]propanoate Chemical compound [Na+].C=1C=C(C=2C=C3C=CC=CC3=CC=2)C=CC=1C(CC(=O)[O-])NC(=O)CNC(=O)CCCCNC1=CC=CC=N1 ZMNJRCFQQRFGRP-UHFFFAOYSA-M 0.000 description 1
• JTZMXMAIDOUOQJ-UHFFFAOYSA-M sodium;3-(4-phenylphenyl)-3-[[2-[4-(pyridin-2-ylamino)butanoylamino]acetyl]amino]propanoate Chemical compound [Na+].C=1C=C(C=2C=CC=CC=2)C=CC=1C(CC(=O)[O-])NC(=O)CNC(=O)CCCNC1=CC=CC=N1 JTZMXMAIDOUOQJ-UHFFFAOYSA-M 0.000 description 1
• XAQDYEKRUSJKMD-UHFFFAOYSA-M sodium;3-(4-phenylphenyl)-3-[[2-[4-(pyrimidin-2-ylamino)butanoylamino]acetyl]amino]propanoate Chemical compound [Na+].C=1C=C(C=2C=CC=CC=2)C=CC=1C(CC(=O)[O-])NC(=O)CNC(=O)CCCNC1=NC=CC=N1 XAQDYEKRUSJKMD-UHFFFAOYSA-M 0.000 description 1
• BYBHKNOTIFRHFM-UHFFFAOYSA-M sodium;3-(4-phenylphenyl)-3-[[2-[5-(pyrimidin-2-ylamino)pentanoylamino]acetyl]amino]propanoate Chemical compound [Na+].C=1C=C(C=2C=CC=CC=2)C=CC=1C(CC(=O)[O-])NC(=O)CNC(=O)CCCCNC1=NC=CC=N1 BYBHKNOTIFRHFM-UHFFFAOYSA-M 0.000 description 1
• OIEHVRPCRHGIPN-UHFFFAOYSA-M sodium;3-(5-bromo-2-hydroxy-3-nitrophenyl)-3-[[2-[4-[(4-methylpyridin-2-yl)amino]butanoylamino]acetyl]amino]propanoate Chemical compound [Na+].CC1=CC=NC(NCCCC(=O)NCC(=O)NC(CC([O-])=O)C=2C(=C(C=C(Br)C=2)[N+]([O-])=O)O)=C1 OIEHVRPCRHGIPN-UHFFFAOYSA-M 0.000 description 1
• XHHWXESWLNCSMI-UHFFFAOYSA-M sodium;3-[3-(4-fluoro-2-hydroxyphenyl)phenyl]-3-[[2-[4-[(4-methylpyridin-2-yl)amino]butanoylamino]acetyl]amino]propanoate Chemical compound [Na+].CC1=CC=NC(NCCCC(=O)NCC(=O)NC(CC([O-])=O)C=2C=C(C=CC=2)C=2C(=CC(F)=CC=2)O)=C1 XHHWXESWLNCSMI-UHFFFAOYSA-M 0.000 description 1
• FBEZOILHGVRHJS-UHFFFAOYSA-M sodium;3-[3-(4-fluorophenyl)phenyl]-3-[[2-[4-(pyridin-2-ylamino)butanoylamino]acetyl]amino]propanoate Chemical compound [Na+].C=1C=CC(C=2C=CC(F)=CC=2)=CC=1C(CC(=O)[O-])NC(=O)CNC(=O)CCCNC1=CC=CC=N1 FBEZOILHGVRHJS-UHFFFAOYSA-M 0.000 description 1
• HPRXXHFCAGASRG-UHFFFAOYSA-M sodium;3-[3-(4-fluorophenyl)phenyl]-3-[[2-[4-[(4-methylpyridin-2-yl)amino]butanoylamino]acetyl]amino]propanoate Chemical compound [Na+].CC1=CC=NC(NCCCC(=O)NCC(=O)NC(CC([O-])=O)C=2C=C(C=CC=2)C=2C=CC(F)=CC=2)=C1 HPRXXHFCAGASRG-UHFFFAOYSA-M 0.000 description 1
• HMTWUEPTRHYGRZ-UHFFFAOYSA-M sodium;3-[3-(4-fluorophenyl)phenyl]-3-[[2-[5-(pyridin-2-ylamino)pentanoylamino]acetyl]amino]propanoate Chemical compound [Na+].C=1C=CC(C=2C=CC(F)=CC=2)=CC=1C(CC(=O)[O-])NC(=O)CNC(=O)CCCCNC1=CC=CC=N1 HMTWUEPTRHYGRZ-UHFFFAOYSA-M 0.000 description 1
• IUIUDENPRDFLPE-UHFFFAOYSA-M sodium;3-[4-(2-fluorophenyl)phenyl]-3-[[2-[5-(pyridin-2-ylamino)pentanoylamino]acetyl]amino]propanoate Chemical compound [Na+].C=1C=C(C=2C(=CC=CC=2)F)C=CC=1C(CC(=O)[O-])NC(=O)CNC(=O)CCCCNC1=CC=CC=N1 IUIUDENPRDFLPE-UHFFFAOYSA-M 0.000 description 1
• DWAJEDKDLXYBRK-UHFFFAOYSA-M sodium;3-[4-(3-chloro-4-fluorophenyl)phenyl]-3-[[2-[5-(pyridin-2-ylamino)pentanoylamino]acetyl]amino]propanoate Chemical compound [Na+].C=1C=C(C=2C=C(Cl)C(F)=CC=2)C=CC=1C(CC(=O)[O-])NC(=O)CNC(=O)CCCCNC1=CC=CC=N1 DWAJEDKDLXYBRK-UHFFFAOYSA-M 0.000 description 1
• XSJADWBSPFRREV-UHFFFAOYSA-M sodium;3-[4-(3-chlorophenyl)phenyl]-3-[[2-[5-(pyridin-2-ylamino)pentanoylamino]acetyl]amino]propanoate Chemical compound [Na+].C=1C=C(C=2C=C(Cl)C=CC=2)C=CC=1C(CC(=O)[O-])NC(=O)CNC(=O)CCCCNC1=CC=CC=N1 XSJADWBSPFRREV-UHFFFAOYSA-M 0.000 description 1
• WVEMOVYXOIKJOJ-UHFFFAOYSA-M sodium;3-[4-(3-fluorophenyl)phenyl]-3-[[2-[5-(pyridin-2-ylamino)pentanoylamino]acetyl]amino]propanoate Chemical compound [Na+].C=1C=C(C=2C=C(F)C=CC=2)C=CC=1C(CC(=O)[O-])NC(=O)CNC(=O)CCCCNC1=CC=CC=N1 WVEMOVYXOIKJOJ-UHFFFAOYSA-M 0.000 description 1
• HYJQCVQRFICAFY-UHFFFAOYSA-M sodium;3-[4-(4-chlorophenyl)phenyl]-3-[[2-[5-(pyridin-2-ylamino)pentanoylamino]acetyl]amino]propanoate Chemical compound [Na+].C=1C=C(C=2C=CC(Cl)=CC=2)C=CC=1C(CC(=O)[O-])NC(=O)CNC(=O)CCCCNC1=CC=CC=N1 HYJQCVQRFICAFY-UHFFFAOYSA-M 0.000 description 1
• JUBZYUAOLRAUHH-UHFFFAOYSA-M sodium;3-[4-(4-fluoro-2-hydroxyphenyl)phenyl]-3-[[2-[4-[(4-methylpyridin-2-yl)amino]butanoylamino]acetyl]amino]propanoate Chemical compound [Na+].CC1=CC=NC(NCCCC(=O)NCC(=O)NC(CC([O-])=O)C=2C=CC(=CC=2)C=2C(=CC(F)=CC=2)O)=C1 JUBZYUAOLRAUHH-UHFFFAOYSA-M 0.000 description 1
• SHBDWZSATBLHGF-UHFFFAOYSA-M sodium;3-[4-(4-fluorophenyl)-3-hydroxyphenyl]-3-[[2-[5-(pyridin-2-ylamino)pentanoylamino]acetyl]amino]propanoate Chemical compound [Na+].OC1=CC(C(CC([O-])=O)NC(=O)CNC(=O)CCCCNC=2N=CC=CC=2)=CC=C1C1=CC=C(F)C=C1 SHBDWZSATBLHGF-UHFFFAOYSA-M 0.000 description 1
• LKOBPVDYNNLOMC-UHFFFAOYSA-M sodium;3-[4-(4-fluorophenyl)phenyl]-3-[[2-[4-(pyridin-2-ylamino)butanoylamino]acetyl]amino]propanoate Chemical compound [Na+].C=1C=C(C=2C=CC(F)=CC=2)C=CC=1C(CC(=O)[O-])NC(=O)CNC(=O)CCCNC1=CC=CC=N1 LKOBPVDYNNLOMC-UHFFFAOYSA-M 0.000 description 1
• BZAPCUFXNXPALU-UHFFFAOYSA-M sodium;3-[4-(4-methylphenyl)phenyl]-3-[[2-[5-(pyridin-2-ylamino)pentanoylamino]acetyl]amino]propanoate Chemical compound [Na+].C1=CC(C)=CC=C1C1=CC=C(C(CC([O-])=O)NC(=O)CNC(=O)CCCCNC=2N=CC=CC=2)C=C1 BZAPCUFXNXPALU-UHFFFAOYSA-M 0.000 description 1
• JGEDDEPQDDYBGK-UHFFFAOYSA-M sodium;3-[[2-[4-[(4-methylpyridin-2-yl)amino]butanoylamino]acetyl]amino]-3-(3-nitrophenyl)propanoate Chemical compound [Na+].CC1=CC=NC(NCCCC(=O)NCC(=O)NC(CC([O-])=O)C=2C=C(C=CC=2)[N+]([O-])=O)=C1 JGEDDEPQDDYBGK-UHFFFAOYSA-M 0.000 description 1
• DNGIMJFCTVZMAR-UHFFFAOYSA-M sodium;3-[[2-[4-[(4-methylpyridin-2-yl)amino]butanoylamino]acetyl]amino]-3-(4-naphthalen-1-ylphenyl)propanoate Chemical compound [Na+].CC1=CC=NC(NCCCC(=O)NCC(=O)NC(CC([O-])=O)C=2C=CC(=CC=2)C=2C3=CC=CC=C3C=CC=2)=C1 DNGIMJFCTVZMAR-UHFFFAOYSA-M 0.000 description 1
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• CRNVQEOJZNSJBY-UHFFFAOYSA-M sodium;3-[[2-[4-[(4-methylpyridin-2-yl)amino]butanoylamino]acetyl]amino]-3-(4-nitrophenyl)propanoate Chemical compound [Na+].CC1=CC=NC(NCCCC(=O)NCC(=O)NC(CC([O-])=O)C=2C=CC(=CC=2)[N+]([O-])=O)=C1 CRNVQEOJZNSJBY-UHFFFAOYSA-M 0.000 description 1
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