HUP0104900A2 - Tiazolidindionszármazékok alkalmazása az oxitocin hatásainak gátlására koraszülés megindulása esetén és a szoptatás alatt - Google Patents
Tiazolidindionszármazékok alkalmazása az oxitocin hatásainak gátlására koraszülés megindulása esetén és a szoptatás alattInfo
- Publication number
- HUP0104900A2 HUP0104900A2 HU0104900A HUP0104900A HUP0104900A2 HU P0104900 A2 HUP0104900 A2 HU P0104900A2 HU 0104900 A HU0104900 A HU 0104900A HU P0104900 A HUP0104900 A HU P0104900A HU P0104900 A2 HUP0104900 A2 HU P0104900A2
- Authority
- HU
- Hungary
- Prior art keywords
- lactation
- thiazolidinediones
- uterine contractions
- premature labour
- oxytocin
- Prior art date
Links
- 150000001467 thiazolidinediones Chemical class 0.000 title abstract 2
- 206010036600 Premature labour Diseases 0.000 title 1
- 208000036029 Uterine contractions during pregnancy Diseases 0.000 title 1
- 230000006651 lactation Effects 0.000 title 1
- XNOPRXBHLZRZKH-UHFFFAOYSA-N Oxytocin Natural products N1C(=O)C(N)CSSCC(C(=O)N2C(CCC2)C(=O)NC(CC(C)C)C(=O)NCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(CCC(N)=O)NC(=O)C(C(C)CC)NC(=O)C1CC1=CC=C(O)C=C1 XNOPRXBHLZRZKH-UHFFFAOYSA-N 0.000 abstract 2
- 101800000989 Oxytocin Proteins 0.000 abstract 2
- 102100031951 Oxytocin-neurophysin 1 Human genes 0.000 abstract 2
- 229940123464 Thiazolidinedione Drugs 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- XNOPRXBHLZRZKH-DSZYJQQASA-N oxytocin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CSSC[C@H](N)C(=O)N1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 XNOPRXBHLZRZKH-DSZYJQQASA-N 0.000 abstract 2
- 229960001723 oxytocin Drugs 0.000 abstract 2
- ZOBPZXTWZATXDG-UHFFFAOYSA-N 1,3-thiazolidine-2,4-dione Chemical compound O=C1CSC(=O)N1 ZOBPZXTWZATXDG-UHFFFAOYSA-N 0.000 abstract 1
- 208000004998 Abdominal Pain Diseases 0.000 abstract 1
- 208000002881 Colic Diseases 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008267 milk Substances 0.000 abstract 1
- 210000004080 milk Anatomy 0.000 abstract 1
- 235000013336 milk Nutrition 0.000 abstract 1
- 230000004118 muscle contraction Effects 0.000 abstract 1
- 230000036640 muscle relaxation Effects 0.000 abstract 1
- 210000000754 myometrium Anatomy 0.000 abstract 1
- 150000003180 prostaglandins Chemical class 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 229940125712 tocolytic agent Drugs 0.000 abstract 1
- 239000003675 tocolytic agent Substances 0.000 abstract 1
- GXPHKUHSUJUWKP-UHFFFAOYSA-N troglitazone Chemical compound C1CC=2C(C)=C(O)C(C)=C(C)C=2OC1(C)COC(C=C1)=CC=C1CC1SC(=O)NC1=O GXPHKUHSUJUWKP-UHFFFAOYSA-N 0.000 abstract 1
- 229960001641 troglitazone Drugs 0.000 abstract 1
- GXPHKUHSUJUWKP-NTKDMRAZSA-N troglitazone Natural products C([C@@]1(OC=2C(C)=C(C(=C(C)C=2CC1)O)C)C)OC(C=C1)=CC=C1C[C@H]1SC(=O)NC1=O GXPHKUHSUJUWKP-NTKDMRAZSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/06—Antiabortive agents; Labour repressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Endocrinology (AREA)
- Food Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Pregnancy & Childbirth (AREA)
- Gynecology & Obstetrics (AREA)
- Reproductive Health (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Abstract
A jelen tal lm ny elj r sokat szolg ltat oxitocin-k"zvetítette hat sokmegelőzésére vagy cs"kkentésére tiazolidindionok - mint a troglitazonvagy tiazalidindion-rokon vegyületek - alkalmaz s val. Ezek az elj rsok fel"lelik ezen vegyületek "nmagukban vagy legal bb egy szerrel -mint péld ul tokolitikus szerrel - kombin cióban való alkalmaz s t. Ezúj ter pi s stratégi t aj nl oxitocin-k"zvetítette hat sok, péld ulméhizom-"sszehúzód s kiv lt sa, prosztaglandin-felszabadul s,tejtermelés kézbentart s ra. Ennek megfelelően olyan llapotok mint akoraszülés megindul sa és a cs sz rmetszést megelőző vajúd skezelhetők ezekkel az elj r sokkal. Ó
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10613398P | 1998-10-29 | 1998-10-29 | |
| PCT/US1999/025433 WO2000025781A1 (en) | 1998-10-29 | 1999-10-29 | Use of thiazolidinediones derivatives for preventing uterine contractions in premature labour or lactation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0104900A2 true HUP0104900A2 (hu) | 2002-04-29 |
| HUP0104900A3 HUP0104900A3 (en) | 2003-02-28 |
Family
ID=22309672
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0104900A HUP0104900A3 (en) | 1998-10-29 | 1999-10-29 | Use of thiazolidinediones derivatives for preventing uterine contractions in premature labour or lactation |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US7528133B1 (hu) |
| EP (1) | EP1126844A1 (hu) |
| JP (1) | JP2002528500A (hu) |
| KR (1) | KR20010089381A (hu) |
| CN (1) | CN1328456A (hu) |
| AU (1) | AU1330800A (hu) |
| BR (1) | BR9915820A (hu) |
| CA (1) | CA2348910A1 (hu) |
| CZ (1) | CZ20011524A3 (hu) |
| HK (1) | HK1041213A1 (hu) |
| HU (1) | HUP0104900A3 (hu) |
| ID (1) | ID29352A (hu) |
| IL (1) | IL142841A0 (hu) |
| MX (1) | MXPA01004257A (hu) |
| NO (1) | NO20012090L (hu) |
| PL (1) | PL347508A1 (hu) |
| TR (1) | TR200101882T2 (hu) |
| WO (1) | WO2000025781A1 (hu) |
| ZA (1) | ZA200103999B (hu) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004062563A2 (en) * | 2003-01-16 | 2004-07-29 | Université de Lausanne | Methods for screening for therapeutic agents that are useful in the treatment of oxytocin and vasopressin-related disorders |
| US20150004144A1 (en) | 2011-12-02 | 2015-01-01 | The General Hospital Corporation | Differentiation into brown adipocytes |
| WO2014066568A1 (en) | 2012-10-24 | 2014-05-01 | Winthrop-University Hospital | Non-invasive biomarker to identify subjects at risk of preterm delivery |
| US10555934B2 (en) * | 2016-01-04 | 2020-02-11 | ObsEva S.A. | Alpha-amino esters of hydroxypropylthiazolidine carboxamide derivative and salt form, crystal polymorph thereof |
| JP2020533595A (ja) | 2017-09-13 | 2020-11-19 | プロジェニティ， インコーポレイテッド | 子癇前症バイオマーカならびに関連するシステムおよび方法 |
| EP4070113A4 (en) | 2019-12-04 | 2023-12-20 | Biora Therapeutics, Inc. | ASSESSMENT OF PREECAMPSIA USING FREE AND DISSOCIATE PLACENTAL GROWTH FACTOR ASSAYS |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5478852C1 (en) * | 1993-09-15 | 2001-03-13 | Sankyo Co | Use of thiazolidinedione derivatives and related antihyperglycemic agents in the treatment of impaired glucose tolerance in order to prevent or delay the onset of noninsulin-dependent diabetes mellitus |
| US5370135A (en) * | 1993-10-13 | 1994-12-06 | Biex, Inc. | Use of estriol measurement to monitor tocolytic therapy |
| TW438587B (en) | 1995-06-20 | 2001-06-07 | Takeda Chemical Industries Ltd | A pharmaceutical composition for prophylaxis and treatment of diabetes |
| EP0783888A1 (en) * | 1995-12-26 | 1997-07-16 | Sankyo Company Limited | Use of troglitazone and related thiazolidinediones in the manufacture of a medicament for the treatment and prophylaxis of osteoporosis |
| EP0844997A1 (en) * | 1996-06-19 | 1998-06-03 | Dr. Reddy's Research Foundation | Novel polymorphic forms of troglitazone having enhanced anti-diabetic activity and a process for their preparation |
| US5814647A (en) * | 1997-03-04 | 1998-09-29 | Board Of Regents, The University Of Texas System | Use of troglitazone and related compounds for the treatment of the climacteric symptoms |
-
1999
- 1999-10-29 WO PCT/US1999/025433 patent/WO2000025781A1/en not_active Application Discontinuation
- 1999-10-29 IL IL14284199A patent/IL142841A0/xx unknown
- 1999-10-29 MX MXPA01004257A patent/MXPA01004257A/es unknown
- 1999-10-29 EP EP99956774A patent/EP1126844A1/en not_active Withdrawn
- 1999-10-29 US US10/069,744 patent/US7528133B1/en not_active Expired - Fee Related
- 1999-10-29 BR BR9915820-5A patent/BR9915820A/pt not_active IP Right Cessation
- 1999-10-29 CN CN99813856A patent/CN1328456A/zh active Pending
- 1999-10-29 HU HU0104900A patent/HUP0104900A3/hu unknown
- 1999-10-29 JP JP2000579222A patent/JP2002528500A/ja not_active Withdrawn
- 1999-10-29 ID IDW00200101157A patent/ID29352A/id unknown
- 1999-10-29 KR KR1020017005411A patent/KR20010089381A/ko not_active Application Discontinuation
- 1999-10-29 TR TR2001/01882T patent/TR200101882T2/xx unknown
- 1999-10-29 CZ CZ20011524A patent/CZ20011524A3/cs unknown
- 1999-10-29 PL PL99347508A patent/PL347508A1/xx not_active Application Discontinuation
- 1999-10-29 CA CA002348910A patent/CA2348910A1/en not_active Abandoned
- 1999-10-29 AU AU13308/00A patent/AU1330800A/en not_active Abandoned
-
2001
- 2001-04-27 NO NO20012090A patent/NO20012090L/no not_active Application Discontinuation
- 2001-05-16 ZA ZA200103999A patent/ZA200103999B/en unknown
-
2002
- 2002-04-15 HK HK02102806.8A patent/HK1041213A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| TR200101882T2 (tr) | 2001-12-21 |
| US7528133B1 (en) | 2009-05-05 |
| KR20010089381A (ko) | 2001-10-06 |
| NO20012090D0 (no) | 2001-04-27 |
| HUP0104900A3 (en) | 2003-02-28 |
| CN1328456A (zh) | 2001-12-26 |
| PL347508A1 (en) | 2002-04-08 |
| CZ20011524A3 (cs) | 2002-01-16 |
| EP1126844A1 (en) | 2001-08-29 |
| BR9915820A (pt) | 2001-10-30 |
| ZA200103999B (en) | 2002-08-16 |
| IL142841A0 (en) | 2002-03-10 |
| CA2348910A1 (en) | 2000-05-11 |
| JP2002528500A (ja) | 2002-09-03 |
| AU1330800A (en) | 2000-05-22 |
| ID29352A (id) | 2001-08-23 |
| MXPA01004257A (es) | 2002-06-21 |
| HK1041213A1 (zh) | 2002-07-05 |
| NO20012090L (no) | 2001-06-27 |
| WO2000025781A1 (en) | 2000-05-11 |
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