HUP0104007A2 - Pyrimidinyloxy derivatives of new carboxylic acid derivatives carrying keto side-chain, pharmaceutical compositions containing them, their use and their intermediates - Google Patents
Pyrimidinyloxy derivatives of new carboxylic acid derivatives carrying keto side-chain, pharmaceutical compositions containing them, their use and their intermediatesInfo
- Publication number
- HUP0104007A2 HUP0104007A2 HU0104007A HUP0104007A HUP0104007A2 HU P0104007 A2 HUP0104007 A2 HU P0104007A2 HU 0104007 A HU0104007 A HU 0104007A HU P0104007 A HUP0104007 A HU P0104007A HU P0104007 A2 HUP0104007 A2 HU P0104007A2
- Authority
- HU
- Hungary
- Prior art keywords
- group
- alkyl
- optionally substituted
- halo
- atom
- Prior art date
Links
- -1 Pyrimidinyloxy Chemical class 0.000 title abstract 2
- 150000001732 carboxylic acid derivatives Chemical class 0.000 title abstract 2
- 239000000543 intermediate Substances 0.000 title 1
- 125000000468 ketone group Chemical group 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 125000001624 naphthyl group Chemical group 0.000 abstract 3
- 229910052757 nitrogen Inorganic materials 0.000 abstract 3
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000004414 alkyl thio group Chemical group 0.000 abstract 2
- 125000000304 alkynyl group Chemical group 0.000 abstract 2
- 125000003277 amino group Chemical group 0.000 abstract 2
- 125000001188 haloalkyl group Chemical group 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000001434 methanylylidene group Chemical group [H]C#[*] 0.000 abstract 2
- 125000005346 substituted cycloalkyl group Chemical group 0.000 abstract 2
- 229910052717 sulfur Inorganic materials 0.000 abstract 2
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 abstract 1
- 229940118365 Endothelin receptor antagonist Drugs 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 125000004450 alkenylene group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- IYABWNGZIDDRAK-UHFFFAOYSA-N allene Chemical group C=C=C IYABWNGZIDDRAK-UHFFFAOYSA-N 0.000 abstract 1
- 239000002308 endothelin receptor antagonist Substances 0.000 abstract 1
- 125000005678 ethenylene group Chemical group [H]C([*:1])=C([H])[*:2] 0.000 abstract 1
- 125000004438 haloalkoxy group Chemical group 0.000 abstract 1
- 125000004995 haloalkylthio group Chemical group 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 239000011593 sulfur Substances 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
- 239000000454 talc Substances 0.000 abstract 1
- 229910052623 talc Inorganic materials 0.000 abstract 1
- 125000003831 tetrazolyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/34—One oxygen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
A találmány tárgyát általános képletű karbonsavszármazékok - ahol R1tetrazolilcsoport vagy -C(=O)R általános képletű csoport, R2hidrogénatom, hidroxi-, adott esetben szubsztituált aminocsoport,halogénatom, alkil-, alkenil-, alkinil-, halogén-alkil-, alkoxi-,halogén-alkoxi- vagy alkil-tio-csoport, vagy CR2 és CR12 együtt 5-vagy 6-tagú gyűrűt alkot; X nitrogénatom vagy metincsoport; Ynitrogénatom vagy metincsoport; Z nitrogénatom vagy CR12 képletűcsoport, amelynek képletében R12 jelentése hidrogénatom vagyalkilcsoport, vagy ahol CR12 CR2-vel vagy CR3-mal együtt 5- vagy 6-tagú, adott esetben heteroatomot tartalmazó alkilén- vagyalkeniléngyűrűt alkot, R3 hidrogénatom, hidroxi-, adott esetbenszubsztituált aminocsoport, halogénatom, alkil-, alkenil-, alkinil-,halogén-alkil-, alkoxi-, halogén-alkoxi-, alkil-tio-csoport, vagy CR3és CR12 együtt az előzőekben megadott módon 5- vagy 6-tagú gyűrűtalkot; R4 és R5 azonosak vagy különbözők, és jelentésük adott esetbenszubsztituált fenil- vagy naftilcsoport; olyan fenil- vagynaftilcsoportok, amelyek orto-helyzetben közvetlenül, metilén-,etilén- vagy eteniléncsoporton, illetve oxigén- vagy kénatomon vagy -SO2-, -NH- vagy N-alkil-csoporton keresztül egymássalösszekapcsolódnak, adott esetben szubsztituált cikloalkilcsoport; R6adott esetben szubsztituált cikloalkilcsoport; adott esetbenszubsztituált fenil- vagy naftilcsoport; 5- vagy 6-tagú, adott esetbenszubsztituált heteroaromás csoport; R7 és R8 azonosak vagy különbözők,és jelentésük hidrogénatom vagy alkilcsoport; W kén- vagy oxigénatom -képezik, melyek endotelin-receptorantagonistaként alkalmazhatók. ÓThe subject of the invention is carboxylic acid derivatives of the general formula - where R1 is a tetrazolyl group or a group of the general formula -C(=O)R, R2 is a hydrogen atom, a hydroxy-, optionally substituted amino group, a halogen atom, alkyl-, alkenyl-, alkynyl-, halo-alkyl-, alkoxy-, a halo-alkyl- or alkyl-thio group, or CR2 and CR12 together form a 5- or 6-membered ring; X is a nitrogen atom or a methine group; A nitrogen atom or a methine group; Z is a nitrogen atom or a group of the formula CR12, in the formula of which R12 is a hydrogen atom or an alkyl group, or where CR12 together with CR2 or CR3 forms a 5- or 6-membered alkylene or alkenylene ring, optionally containing a heteroatom, R3 is a hydrogen atom, a hydroxy, optionally substituted amino group, halogen atom, alkyl-, alkenyl-, alkynyl-, halo-alkyl-, alkoxy-, halo-alkoxy-, alkylthio group, or CR3 and CR12 together as specified above, 5- or 6-membered ring talc; R4 and R5 are the same or different and mean an optionally substituted phenyl or naphthyl group; phenyl or naphthyl groups which are directly connected in the ortho position via a methylene, ethylene or ethenylene group or an oxygen or sulfur atom or -SO2-, -NH- or N-alkyl group, optionally a substituted cycloalkyl group; R6 is optionally substituted cycloalkyl; optionally substituted phenyl or naphthyl; 5- or 6-membered, optionally substituted heteroaromatic group; R7 and R8 are the same or different and mean a hydrogen atom or an alkyl group; W is formed by sulfur or oxygen atoms, which can be used as endothelin receptor antagonists. HE
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19836044A DE19836044A1 (en) | 1998-08-10 | 1998-08-10 | New 2-(hetero)aryl-alkanoic acid derivatives, useful as mixed endothelin receptor antagonists, e.g. for treating cardiac insufficiency, restenosis, hypertension or prostate cancer |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP0104007A2 true HUP0104007A2 (en) | 2002-05-29 |
HUP0104007A3 HUP0104007A3 (en) | 2002-12-28 |
Family
ID=7876981
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0104007A HUP0104007A3 (en) | 1998-08-10 | 1999-08-07 | Pyrimidinyloxy derivatives of new carboxylic acid derivatives carrying keto side-chain, pharmaceutical compositions containing them, their use and their intermediates |
Country Status (22)
Country | Link |
---|---|
EP (1) | EP1104410A1 (en) |
JP (1) | JP2002522531A (en) |
KR (1) | KR20010072378A (en) |
CN (1) | CN1323298A (en) |
AR (1) | AR020147A1 (en) |
AU (1) | AU5374199A (en) |
BG (1) | BG105236A (en) |
BR (1) | BR9912889A (en) |
CA (1) | CA2340167A1 (en) |
CO (1) | CO5261504A1 (en) |
DE (1) | DE19836044A1 (en) |
HK (1) | HK1042086A1 (en) |
HR (1) | HRP20010164A2 (en) |
HU (1) | HUP0104007A3 (en) |
ID (1) | ID27965A (en) |
IL (1) | IL140915A0 (en) |
NO (1) | NO20010622D0 (en) |
PL (1) | PL345998A1 (en) |
SK (1) | SK832001A3 (en) |
TR (1) | TR200100427T2 (en) |
WO (1) | WO2000009489A1 (en) |
ZA (1) | ZA200101975B (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19924892A1 (en) * | 1999-06-01 | 2000-12-07 | Basf Ag | New carboxylic acid derivatives with aryl-substituted nitrogen heterocycles, their production and use as endothelin receptor antagonists |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19636046A1 (en) * | 1996-09-05 | 1998-03-12 | Basf Ag | New carboxylic acid derivatives, their production and use as mixed ET¶A¶ / ET¶B¶ receptor antagonists |
-
1998
- 1998-08-10 DE DE19836044A patent/DE19836044A1/en not_active Withdrawn
-
1999
- 1999-08-07 HU HU0104007A patent/HUP0104007A3/en unknown
- 1999-08-07 SK SK83-2001A patent/SK832001A3/en unknown
- 1999-08-07 IL IL14091599A patent/IL140915A0/en unknown
- 1999-08-07 AU AU53741/99A patent/AU5374199A/en not_active Abandoned
- 1999-08-07 PL PL99345998A patent/PL345998A1/en not_active Application Discontinuation
- 1999-08-07 TR TR2001/00427T patent/TR200100427T2/en unknown
- 1999-08-07 KR KR1020017001731A patent/KR20010072378A/en not_active Application Discontinuation
- 1999-08-07 ID IDW20010326A patent/ID27965A/en unknown
- 1999-08-07 EP EP99939457A patent/EP1104410A1/en not_active Withdrawn
- 1999-08-07 WO PCT/EP1999/005728 patent/WO2000009489A1/en not_active Application Discontinuation
- 1999-08-07 CN CN99811981A patent/CN1323298A/en active Pending
- 1999-08-07 BR BR9912889-6A patent/BR9912889A/en not_active Application Discontinuation
- 1999-08-07 CA CA002340167A patent/CA2340167A1/en not_active Abandoned
- 1999-08-07 JP JP2000564942A patent/JP2002522531A/en active Pending
- 1999-08-10 CO CO99050715A patent/CO5261504A1/en not_active Application Discontinuation
- 1999-08-10 AR ARP990103985A patent/AR020147A1/en not_active Application Discontinuation
-
2001
- 2001-02-06 NO NO20010622A patent/NO20010622D0/en not_active Application Discontinuation
- 2001-02-09 BG BG105236A patent/BG105236A/en unknown
- 2001-03-08 HR HR20010164A patent/HRP20010164A2/en not_active Application Discontinuation
- 2001-03-09 ZA ZA200101975A patent/ZA200101975B/en unknown
-
2002
- 2002-05-15 HK HK02103679.0A patent/HK1042086A1/en unknown
Also Published As
Publication number | Publication date |
---|---|
DE19836044A1 (en) | 2000-02-17 |
PL345998A1 (en) | 2002-01-14 |
NO20010622L (en) | 2001-02-06 |
WO2000009489A1 (en) | 2000-02-24 |
HUP0104007A3 (en) | 2002-12-28 |
NO20010622D0 (en) | 2001-02-06 |
IL140915A0 (en) | 2002-02-10 |
TR200100427T2 (en) | 2001-07-23 |
EP1104410A1 (en) | 2001-06-06 |
AU5374199A (en) | 2000-03-06 |
CA2340167A1 (en) | 2000-02-24 |
SK832001A3 (en) | 2001-11-06 |
AR020147A1 (en) | 2002-04-10 |
CN1323298A (en) | 2001-11-21 |
BG105236A (en) | 2001-12-29 |
KR20010072378A (en) | 2001-07-31 |
JP2002522531A (en) | 2002-07-23 |
HRP20010164A2 (en) | 2002-04-30 |
ID27965A (en) | 2001-05-03 |
ZA200101975B (en) | 2002-03-11 |
HK1042086A1 (en) | 2002-08-02 |
CO5261504A1 (en) | 2003-03-31 |
BR9912889A (en) | 2001-05-08 |
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