BR9912889A - Carboxylic acid derivative, pharmaceutical preparation, use of carboxylic acid derivatives, use of compounds, preparation of pharmaceutical combination, use of a structural fragment, and, compound - Google Patents

Carboxylic acid derivative, pharmaceutical preparation, use of carboxylic acid derivatives, use of compounds, preparation of pharmaceutical combination, use of a structural fragment, and, compound

Info

Publication number
BR9912889A
BR9912889A BR9912889-6A BR9912889A BR9912889A BR 9912889 A BR9912889 A BR 9912889A BR 9912889 A BR9912889 A BR 9912889A BR 9912889 A BR9912889 A BR 9912889A
Authority
BR
Brazil
Prior art keywords
carboxylic acid
preparation
pharmaceutical
compounds
compound
Prior art date
Application number
BR9912889-6A
Other languages
Portuguese (pt)
Inventor
Wilheim Amberg
Rolf Jansen
Georg Kettschau
Stefan Hergenroeder
Manfred Raschack
Liliane Unger
Original Assignee
Basf Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Ag filed Critical Basf Ag
Publication of BR9912889A publication Critical patent/BR9912889A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

"DERIVADO DE áCIDO CARBOXìLICO, PREPARAçãO FARMACêUTICA, USO DOS DERIVADOS DO áCIDO CARBOXìLICO, USO DOS COMPOSTOS, PREPARAçãO DE COMBINAçãO FARMACêUTICA, USO DE UM FRAGMENTO ESTRUTURAL, E, COMPOSTO" A invenção diz respeito a novos derivados de ácido carboxílico da fórmula I onde os substituintes têm os significados explicados na descrição, à sua preparação e ao seu uso como antagonistas do receptor de endotelina."CARBOXYLIC ACID DERIVATIVE, PHARMACEUTICAL PREPARATION, USE OF CARBOXYLIC ACID DERIVATIVES, USE OF COMPOUNDS, PREPARATION OF PHARMACEUTICAL COMBINATION, USE OF A STRUCTURAL FRAGMENT, AND, COMPOUND" the invention relates to new acid derivatives substituents have the meanings explained in the description, their preparation and their use as endothelin receptor antagonists.

BR9912889-6A 1998-08-10 1999-08-07 Carboxylic acid derivative, pharmaceutical preparation, use of carboxylic acid derivatives, use of compounds, preparation of pharmaceutical combination, use of a structural fragment, and, compound BR9912889A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19836044A DE19836044A1 (en) 1998-08-10 1998-08-10 New 2-(hetero)aryl-alkanoic acid derivatives, useful as mixed endothelin receptor antagonists, e.g. for treating cardiac insufficiency, restenosis, hypertension or prostate cancer
PCT/EP1999/005728 WO2000009489A1 (en) 1998-08-10 1999-08-07 New carboxylic acid derivatives carrying keto side-chains, their production and their use as endothelin-receptor antagonists

Publications (1)

Publication Number Publication Date
BR9912889A true BR9912889A (en) 2001-05-08

Family

ID=7876981

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9912889-6A BR9912889A (en) 1998-08-10 1999-08-07 Carboxylic acid derivative, pharmaceutical preparation, use of carboxylic acid derivatives, use of compounds, preparation of pharmaceutical combination, use of a structural fragment, and, compound

Country Status (22)

Country Link
EP (1) EP1104410A1 (en)
JP (1) JP2002522531A (en)
KR (1) KR20010072378A (en)
CN (1) CN1323298A (en)
AR (1) AR020147A1 (en)
AU (1) AU5374199A (en)
BG (1) BG105236A (en)
BR (1) BR9912889A (en)
CA (1) CA2340167A1 (en)
CO (1) CO5261504A1 (en)
DE (1) DE19836044A1 (en)
HK (1) HK1042086A1 (en)
HR (1) HRP20010164A2 (en)
HU (1) HUP0104007A3 (en)
ID (1) ID27965A (en)
IL (1) IL140915A0 (en)
NO (1) NO20010622D0 (en)
PL (1) PL345998A1 (en)
SK (1) SK832001A3 (en)
TR (1) TR200100427T2 (en)
WO (1) WO2000009489A1 (en)
ZA (1) ZA200101975B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19924892A1 (en) * 1999-06-01 2000-12-07 Basf Ag New carboxylic acid derivatives with aryl-substituted nitrogen heterocycles, their production and use as endothelin receptor antagonists

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19636046A1 (en) * 1996-09-05 1998-03-12 Basf Ag New carboxylic acid derivatives, their production and use as mixed ET¶A¶ / ET¶B¶ receptor antagonists

Also Published As

Publication number Publication date
DE19836044A1 (en) 2000-02-17
PL345998A1 (en) 2002-01-14
NO20010622L (en) 2001-02-06
WO2000009489A1 (en) 2000-02-24
HUP0104007A3 (en) 2002-12-28
NO20010622D0 (en) 2001-02-06
IL140915A0 (en) 2002-02-10
TR200100427T2 (en) 2001-07-23
EP1104410A1 (en) 2001-06-06
AU5374199A (en) 2000-03-06
CA2340167A1 (en) 2000-02-24
SK832001A3 (en) 2001-11-06
HUP0104007A2 (en) 2002-05-29
AR020147A1 (en) 2002-04-10
CN1323298A (en) 2001-11-21
BG105236A (en) 2001-12-29
KR20010072378A (en) 2001-07-31
JP2002522531A (en) 2002-07-23
HRP20010164A2 (en) 2002-04-30
ID27965A (en) 2001-05-03
ZA200101975B (en) 2002-03-11
HK1042086A1 (en) 2002-08-02
CO5261504A1 (en) 2003-03-31

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Legal Events

Date Code Title Description
FA10 Dismissal: dismissal - article 33 of industrial property law
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]