CO5261504A1 - NEW DERIVATIVES OF CARBOXILIC ACIDS, WHICH CARRY SIDE CHAINS, THEIR PREPARATION AND USE AS ANTAGONISTS OF ENDOTHELINE RECEPTORS - Google Patents
NEW DERIVATIVES OF CARBOXILIC ACIDS, WHICH CARRY SIDE CHAINS, THEIR PREPARATION AND USE AS ANTAGONISTS OF ENDOTHELINE RECEPTORSInfo
- Publication number
- CO5261504A1 CO5261504A1 CO99050715A CO99050715A CO5261504A1 CO 5261504 A1 CO5261504 A1 CO 5261504A1 CO 99050715 A CO99050715 A CO 99050715A CO 99050715 A CO99050715 A CO 99050715A CO 5261504 A1 CO5261504 A1 CO 5261504A1
- Authority
- CO
- Colombia
- Prior art keywords
- alkyl
- phenyl
- optionally substituted
- alkynyl
- alkenyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/34—One oxygen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Derivados de ácidos carboxílicos de la fórmula (I):<EMI FILE="99050715_1" ID="1" IMF=JPEG >en donde los sustituyentes tienen el siguiente significado:R1 significa un grupo: <EMI FILE="99050715_2" ID="2" IMF=JPEG >Ra) un resto OR9, en donde R9 significa:- hidrógeno, el catión de un metal alcalino, el catión de un metal alcalinotérreo o un ion amonio orgánico fisiológicamente tolerable;- cicloalquilo- C3-C8, alquilo C1-C8, alquenilo-C3-C6, alquinilo-C3-C6, CH2-fenilo o fenilo eventualmente sustituidos.b) un compuesto heteroaromático de 5 miembros, ligado a través de un átomo de nitrógeno, c) un grupo: <EMI FILE="99050715_3" ID="3" IMF=JPEG >En el cual k puede tomar los valores 0, 1 y 2, p los valores 1, 2, 3 y 4 y R10 representa:- alquilo C1-C4, cicloalquilo C3-C8, alquenilo C3-C6, alquinilo C3-C6 o fenilo eventualmente sustituido - 2 -d) un resto: <EMI FILE="99050715_4" ID="4" IMF=JPEG >En donde R11 significa:- alquilo-C1-C4, alquenilo-C3-C6, alquinilo-C3-C6, cicloalquilo-C3-C8, pudiendo estos restos llevar un resto alcoxi C1-C4, alquiltio C1-C4 y/o fenilo, fenilo eventualmente sustituido.R2 significa hidrógeno, hidroxi, NH2, NH(alquilo-C1-C4), N(alquilo-C1-C4)2, halógeno, alquilo-C1-C4, alquenilo-C2,C4, alquinilo-C2-C4, halógeno-alquilo-C1-C4, alcoxi-C1-C4, halógenoalcoxi-C1-C4 o alquiltio-C1-C4, o CR2 está unido con CR12 como se indica más abajo como un anillo de 5 o 6 miembros, X significa nitrógeno o metino;Y significa nitrógeno o metino;Z significa nitrógeno o CR12, en donde R12 significa hidrógeno o alquilo-C1-C4, o CR12 junto con CR2 o CR3 forma un anillo alquileno o alquenileno de 5 o 6 miembros, el cual puede estar eventualmente sustituido y en donde en cada caso uno o más grupos metileno pueden estar reemplazados por oxígeno, azufre, NH o -N(alquilo-C1-C4), R3 significa hidrógeno, hidroxi, NH2, NH(alquilo-C1-C4), N(alquilo-C1-C4)2, halógeno, alquilo-C1-C4, alquenilo-C2-C4, alquinilo-C2-C4, halógenoalquilo-C1-C4, alcoxi-C1-C4, halógenoalcoxi-C1-C4, alquiltio-C1-C4, o CR3 está unido con CR12 como se indica más arriba como un anillo de 5 o 6 miembros; R4 y R5 (que pueden ser iguales o diferentes) significan:- fenilo o naftilo, eventualmente sustituídos;- fenilo o naftilo, que pueden estar unidos entre sí en posición orto a través de una ligadura directa, un grupo metileno, etileno o etinileno, un átomo de oxígeno o azufre o un grupo SO2, o N-alquilo; - cicloalquilo C3-C8 eventualmente sustituído,R6 significa cicloalquilo C3-C8 eventualmente sustituído;- fenilo o naftilo, eventualmente sustituídosun compuesto heteroaromático de cinco o seis miembros que contiene uno a tres átomos de nitrógeno y/o un átomo de azufre u oxígeno, el cual puede estar eventualmente sustituido;R7 y R8 (que pueden ser iguales o diferentes): - significan hidrógeno o alquilo-C1-C4,W significa azufre u oxígeno.Carboxylic acid derivatives of the formula (I): <EMI FILE = "99050715_1" ID = "1" MFI = JPEG> where the substituents have the following meaning: R1 means a group: <EMI FILE = "99050715_2" ID = "2" IMF = JPEG> Ra) an OR9 moiety, wherein R9 means: - hydrogen, the cation of an alkali metal, the cation of an alkaline earth metal or a physiologically tolerable organic ammonium ion; - cycloalkyl- C3-C8, alkyl C1-C8, C3-C6 alkenyl, C3-C6 alkynyl, CH2-phenyl or optionally substituted phenyl. B) a 5-membered heteroaromatic compound, bound through a nitrogen atom, c) a group: <EMI FILE = "99050715_3" ID = "3" MFI = JPEG> In which k can take values 0, 1 and 2, p values 1, 2, 3 and 4 and R10 represents: - C1-C4 alkyl, C3 cycloalkyl- C8, C3-C6 alkenyl, C3-C6 alkynyl or optionally substituted phenyl - 2 -d) a moiety: <EMI FILE = "99050715_4" ID = "4" MFI = JPEG> Where R11 means: - C1-C4 alkyl , C3-C6 alkenyl, C3-C6 alkynyl, cycloalkyl -C3-C8, these moieties being able to carry a C1-C4 alkoxy, C1-C4 alkylthio and / or phenyl moiety, optionally substituted phenyl.R2 means hydrogen, hydroxy, NH2, NH (C1-C4 alkyl), N (alkyl- C1-C4) 2, halogen, C1-C4 alkyl, alkenyl-C2, C4, alkynyl-C2-C4, halogen-C1-C4 alkyl, alkoxy-C1-C4, halogenoalkoxy-C1-C4 or alkylthio-C1- C4, or CR2 is linked to CR12 as indicated below as a 5 or 6 membered ring, X means nitrogen or methine; Y means nitrogen or methine; Z means nitrogen or CR12, where R12 means hydrogen or C1-alkyl C4, or CR12 together with CR2 or CR3 forms a 5 or 6 membered alkylene or alkenylene ring, which may eventually be substituted and where in each case one or more methylene groups may be replaced by oxygen, sulfur, NH or -N (C1-C4 alkyl), R3 means hydrogen, hydroxy, NH2, NH (C1-C4 alkyl), N (C1-C4 alkyl) 2, halogen, C1-C4 alkyl, C2-C4 alkenyl, alkynyl -C2-C4, halogen-C1-C4 alkyl, C1-C4 alkoxy, h halogenoalkoxy-C1-C4, alkylthio-C1-C4, or CR3 is linked to CR12 as indicated above as a 5 or 6 membered ring; R4 and R5 (which may be the same or different) mean: - phenyl or naphthyl, optionally substituted; - phenyl or naphthyl, which may be linked to each other in an ortho position through a direct ligation, a methylene, ethylene or ethynylene group, an oxygen or sulfur atom or an SO2 group, or N-alkyl; - C3-C8 cycloalkyl optionally substituted, R6 means C3-C8 cycloalkyl optionally substituted; - phenyl or naphthyl, optionally substituted a five or six membered heteroaromatic compound containing one to three nitrogen atoms and / or one sulfur or oxygen atom, which may eventually be substituted; R7 and R8 (which may be the same or different): - mean hydrogen or C1-C4 alkyl, W means sulfur or oxygen.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19836044A DE19836044A1 (en) | 1998-08-10 | 1998-08-10 | New 2-(hetero)aryl-alkanoic acid derivatives, useful as mixed endothelin receptor antagonists, e.g. for treating cardiac insufficiency, restenosis, hypertension or prostate cancer |
Publications (1)
Publication Number | Publication Date |
---|---|
CO5261504A1 true CO5261504A1 (en) | 2003-03-31 |
Family
ID=7876981
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO99050715A CO5261504A1 (en) | 1998-08-10 | 1999-08-10 | NEW DERIVATIVES OF CARBOXILIC ACIDS, WHICH CARRY SIDE CHAINS, THEIR PREPARATION AND USE AS ANTAGONISTS OF ENDOTHELINE RECEPTORS |
Country Status (22)
Country | Link |
---|---|
EP (1) | EP1104410A1 (en) |
JP (1) | JP2002522531A (en) |
KR (1) | KR20010072378A (en) |
CN (1) | CN1323298A (en) |
AR (1) | AR020147A1 (en) |
AU (1) | AU5374199A (en) |
BG (1) | BG105236A (en) |
BR (1) | BR9912889A (en) |
CA (1) | CA2340167A1 (en) |
CO (1) | CO5261504A1 (en) |
DE (1) | DE19836044A1 (en) |
HK (1) | HK1042086A1 (en) |
HR (1) | HRP20010164A2 (en) |
HU (1) | HUP0104007A3 (en) |
ID (1) | ID27965A (en) |
IL (1) | IL140915A0 (en) |
NO (1) | NO20010622D0 (en) |
PL (1) | PL345998A1 (en) |
SK (1) | SK832001A3 (en) |
TR (1) | TR200100427T2 (en) |
WO (1) | WO2000009489A1 (en) |
ZA (1) | ZA200101975B (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19924892A1 (en) * | 1999-06-01 | 2000-12-07 | Basf Ag | New carboxylic acid derivatives with aryl-substituted nitrogen heterocycles, their production and use as endothelin receptor antagonists |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19636046A1 (en) * | 1996-09-05 | 1998-03-12 | Basf Ag | New carboxylic acid derivatives, their production and use as mixed ET¶A¶ / ET¶B¶ receptor antagonists |
-
1998
- 1998-08-10 DE DE19836044A patent/DE19836044A1/en not_active Withdrawn
-
1999
- 1999-08-07 HU HU0104007A patent/HUP0104007A3/en unknown
- 1999-08-07 SK SK83-2001A patent/SK832001A3/en unknown
- 1999-08-07 IL IL14091599A patent/IL140915A0/en unknown
- 1999-08-07 AU AU53741/99A patent/AU5374199A/en not_active Abandoned
- 1999-08-07 PL PL99345998A patent/PL345998A1/en not_active Application Discontinuation
- 1999-08-07 TR TR2001/00427T patent/TR200100427T2/en unknown
- 1999-08-07 KR KR1020017001731A patent/KR20010072378A/en not_active Application Discontinuation
- 1999-08-07 ID IDW20010326A patent/ID27965A/en unknown
- 1999-08-07 EP EP99939457A patent/EP1104410A1/en not_active Withdrawn
- 1999-08-07 WO PCT/EP1999/005728 patent/WO2000009489A1/en not_active Application Discontinuation
- 1999-08-07 CN CN99811981A patent/CN1323298A/en active Pending
- 1999-08-07 BR BR9912889-6A patent/BR9912889A/en not_active Application Discontinuation
- 1999-08-07 CA CA002340167A patent/CA2340167A1/en not_active Abandoned
- 1999-08-07 JP JP2000564942A patent/JP2002522531A/en active Pending
- 1999-08-10 CO CO99050715A patent/CO5261504A1/en not_active Application Discontinuation
- 1999-08-10 AR ARP990103985A patent/AR020147A1/en not_active Application Discontinuation
-
2001
- 2001-02-06 NO NO20010622A patent/NO20010622D0/en not_active Application Discontinuation
- 2001-02-09 BG BG105236A patent/BG105236A/en unknown
- 2001-03-08 HR HR20010164A patent/HRP20010164A2/en not_active Application Discontinuation
- 2001-03-09 ZA ZA200101975A patent/ZA200101975B/en unknown
-
2002
- 2002-05-15 HK HK02103679.0A patent/HK1042086A1/en unknown
Also Published As
Publication number | Publication date |
---|---|
DE19836044A1 (en) | 2000-02-17 |
PL345998A1 (en) | 2002-01-14 |
NO20010622L (en) | 2001-02-06 |
WO2000009489A1 (en) | 2000-02-24 |
HUP0104007A3 (en) | 2002-12-28 |
NO20010622D0 (en) | 2001-02-06 |
IL140915A0 (en) | 2002-02-10 |
TR200100427T2 (en) | 2001-07-23 |
EP1104410A1 (en) | 2001-06-06 |
AU5374199A (en) | 2000-03-06 |
CA2340167A1 (en) | 2000-02-24 |
SK832001A3 (en) | 2001-11-06 |
HUP0104007A2 (en) | 2002-05-29 |
AR020147A1 (en) | 2002-04-10 |
CN1323298A (en) | 2001-11-21 |
BG105236A (en) | 2001-12-29 |
KR20010072378A (en) | 2001-07-31 |
JP2002522531A (en) | 2002-07-23 |
HRP20010164A2 (en) | 2002-04-30 |
ID27965A (en) | 2001-05-03 |
ZA200101975B (en) | 2002-03-11 |
HK1042086A1 (en) | 2002-08-02 |
BR9912889A (en) | 2001-05-08 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BRPI0606455A (en) | pharmaceutical compounds | |
AR054799A1 (en) | OXINDOL DERIVATIVES | |
AR049443A1 (en) | PIRROLPIRIDINE DERIVATIVES | |
ECSP055974A (en) | SYNTHESIS OF CHLORIDES OF 4 AMINO-2-BUTENOIL AND ITS USE IN THE PREPARATION OF 3-CYANO QUINOLINAS | |
CO5060482A1 (en) | BIARILO THERAPEUTIC DERIVATIVES | |
AR038723A1 (en) | USEFUL ROADS AS BIOMARKERS | |
ES2422204T3 (en) | Novel derivatives of imidazolidin-2-one as selective androgen receptor modulators (SARMS) | |
AR035548A1 (en) | ORGANIC COMPOUNDS | |
CO5080782A1 (en) | HETEROCICLICAL COMPOUNDS AS INHIBITORS OF ROTAMASA ENZYMES | |
CO5611131A2 (en) | DERIVATIVES OF 5-PHENYLTIAZOL AND ITS USE AS INHIBITORS OF PI3 CINASA | |
BRPI0606480A (en) | pharmaceutical compounds | |
AR044519A1 (en) | DERIVATIVES OF PIRIDIN-TIAZOL AMINA AND PIRIMIDIN-TIAZOL AMINA | |
CY1105091T1 (en) | SUBSTITUTED 2-ARYLOBENZOLE COMPOUNDS AND THEIR USE AS ANTI-TUMOR AGENTS | |
CO5070570A1 (en) | THYROSINE DERIVATIVES AS ACTIVATORS OF hPPAR AND hPPARALFA AND A PHARMACEUTICAL COMPOSITION CONTAINING THEM | |
AR006720A1 (en) | A COMPOUND DERIVED FROM HETERO-CYCLIC AZAHEXANE, ITS USE FOR THE PREPARATION OF A PHARMACEUTICAL COMPOSITION, PROCEDURE FOR PREPARING IT AND A PHARMACEUTICAL COMPOSITION THAT INCLUDES IT | |
ES2038678T3 (en) | PROCEDURE FOR THE PREPARATION OF N- (2-ALQUIL-3-MERCAPTO-GLUTARIL) -ALFAMINO-ACIDOS. | |
AR006906A1 (en) | SUBSTITUTED INDAZOL DERIVATIVES, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM, USE OF THEM AND INTERMEDIARIES OF SYNTHESIS | |
AR031597A1 (en) | PIPERIDINE COMPOUNDS, A PROCESS FOR PREPARATION, PHARMACEUTICAL COMPOSITIONS, AND THE USE OF SUCH COMPOUNDS FOR THE MANUFACTURE OF A MEDICINAL PRODUCT FOR USE AS CCR-3 INHIBITORS | |
PE20091387A1 (en) | TETRAZOL-5-IL-BIPHENYL DERIVATIVES PREPARATION PROCESS | |
CO5601021A2 (en) | DERIVATIVES OF QUINAZOLINONA, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND THEIR PREPARATION PROCESS AND ITS USE AS ANTAGONISTS CB | |
CO5080791A1 (en) | PIPERIDINE DERIVATIVES THAT HAVE EFFECTS ON SYSTEMS WITH SEROTONIN | |
AR055666A1 (en) | INNTR INHIBITORS | |
DK1189900T3 (en) | Heterocyclic aminopyrrolidine derivatives as melatonergic drugs | |
AR035650A1 (en) | PROCEDURE FOR THE PREPARATION OF PIRAZOLO COMPOUNDS [4,3-D] PIRIMIDIN-7-ONA | |
CO5261504A1 (en) | NEW DERIVATIVES OF CARBOXILIC ACIDS, WHICH CARRY SIDE CHAINS, THEIR PREPARATION AND USE AS ANTAGONISTS OF ENDOTHELINE RECEPTORS |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Application withdrawn |